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Magnetite-PLGA Microparticles for Oral Delivery of Insulin

Published online by Cambridge University Press:  01 February 2011

Jianjun Cheng
Department of Chemical Engineering
Christopher H. Yim
Department of Chemical Engineering
Benjamin A. Teply
Department of Chemical Engineering
Dennis Ho
Department of Biology
Omid C. Farokhzad
Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
Robert S. Langer
Department of Chemical Engineering
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Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6 ± 2.2 μm average particle size) through the double-emulsion method. The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetitePLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin Rmagnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field.

Research Article
Copyright © Materials Research Society 2005

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