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Calcium Phosphate Cement in a Rabbit Femoral Canal Model and a Canine Humeral Plug Model: A Pilot Investigation

Published online by Cambridge University Press:  15 February 2011

B. R. Constantz ,
S. W. Young ,
H. Kienapfel ,
B. L. Dahlen ,
D. R. Sumner ,
T. M. Turner ,
R. M. Urban ,
J. O. Galante ,
S. B. Goodman  and
S. Gunasekaran
B. R. Constantz
Affiliation:
Norian Corporation, Mountain View, CA 94043
S. W. Young
Affiliation:
Stanford University, Dept. Diagnostic Radiology
H. Kienapfel
Affiliation:
Dept. of Orthopaedic Surgery, Rush - Presbyterian-St. Luke's Med.Center, Chicago, IL
B. L. Dahlen
Affiliation:
Norian Corporation, Mountain View, CA 94043
D. R. Sumner
Affiliation:
Dept. of Orthopaedic Surgery, Rush - Presbyterian-St. Luke's Med.Center, Chicago, IL
T. M. Turner
Affiliation:
Dept. of Orthopaedic Surgery, Rush - Presbyterian-St. Luke's Med.Center, Chicago, IL
R. M. Urban
Affiliation:
Dept. of Orthopaedic Surgery, Rush - Presbyterian-St. Luke's Med.Center, Chicago, IL
J. O. Galante
Affiliation:
Dept. of Orthopaedic Surgery, Rush - Presbyterian-St. Luke's Med.Center, Chicago, IL
S. B. Goodman
Affiliation:
Stanford University, Div. Orthopaedic Surgery
S. Gunasekaran
Affiliation:
Norian Corporation, Mountain View, CA 94043
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Abstract

A new cementitious calcium phosphate biomaterial, SuperBone®, was implanted in both a rabbit femoral canal model and a canine humeral plug model. New Zealand White rabbits were implanted with cement through a novel surgical approach where cement was introduced by injection. In the canine model, a uniform gap of 3 mm around a fiber metal porous implant was filled by the cement. Undecalcified light and backscattered electron histological evaluations indicate the cement is highly biocompatible and is replaced by new bone in concert with cell-mediated resorption. Unlike the acrylic bone cement positive controls, no evidence of fibrous tissue was found around the cement.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 79
Copyright
Copyright © Materials Research Society 1992

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References

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