- Cited by 2
Hu, Junqiang Gondarenko, Alexander A. Dang, Alex P. Bashour, Keenan T. O’Connor, Roddy S. Lee, Sunwoo Liapis, Anastasia Ghassemi, Saba Milone, Michael C. Sheetz, Michael P. Dustin, Michael L. Kam, Lance C. and Hone, James C. 2016. High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography. Nano Letters, Vol. 16, Issue. 4, p. 2198.
Eggermont, Loek J. Paulis, Leonie E. Tel, Jurjen and Figdor, Carl G. 2014. Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells. Trends in Biotechnology, Vol. 32, Issue. 9, p. 456.
Check if you have access via personal or institutional login
- Volume 1209
- January 2009, 1209-YY03-01
T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available. O. J. Finn “Cancer immunology,” New England Journal of Medicine, vol. 358, pp. 2704–15, 2008.
 N. N. Hunder H. Wallen J. Cao D. W. Hendricks J. Z. Reilly R. Rodmyre A. Jungbluth S. Gnjatic J. A. Thompson and C. Yee “Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1,” New England Journal of Medicine, vol. 358, pp. 2698–703, 2008.
 C. H. June “Adoptive T cell therapy for cancer in the clinic,“ Journal of Clinical Investigation, vol. 117, pp. 1466–76, 2007.
 L. M. Weiner “Cancer immunotherapy–the endgame begins,“ New England Journal of Medicine, vol. 358, pp. 2664–5, 2008.
 M. E. Dudley J. R. Wunderlich J. C. Yang R. M. Sherry S. L. Topalian N. P. Restifo R.E. Royal U. Kammula D. E. White S. A. Mavroukakis L. J. Rogers G. J. Gracia S. A. Jones , D. P. Mangiameli M. M. Pelletier J. Gea-Banacloche , M. R. Robinson D. M. Berman , A. C. Filie A. Abati and S. A. Rosenberg “Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma,“ Journal of Clinical Oncology, vol. 23, pp. 2346–57, 2005.
 S. R. Riddell and P. D. Greenberg “The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells,“ Journal of Immunoogicall Methods, vol. 128, pp. 189–201, 1990.
 S. A. Rosenberg N. P. Restifo J. C. Yang R. A. Morgan and M. E. Dudley “Adoptive cell transfer: a clinical path to effective cancer immunotherapy,“ Nature Reviews Cancer, vol. 8, pp. 299–308, 2008.
 J. T. Chang V. R. Palanivel I. Kinjyo F. Schambach A. M. Intlekofer A. Banerjee S. A. Longworth , K. E. Vinup P. Mrass J. Oliaro N. Killeen J. S. Orange S. M. Russell W. Weninger , and S. L. Reiner “Asymmetric T lymphocyte division in the initiation of adaptive immune responses,“ Science, vol. 315, pp. 1687–91, 2007.
 M. L. Dustin “Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion,“ Annual Review of Cell and Developmental Biology, vol. 24, pp. 577–96, 2008.
 M. L. Dustin and D. R. Colman “Neural and immunological synaptic relations,“ Science, vol. 298, pp. 785–9, 2002.
 M. L. Dustin M. W. Olszowy A. D. Holdorf J. Li S. Bromley N. Desai P. Widder F. Rosenberger , P. A. van der Merwe , P. M. Allen and A. S. Shaw “A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts,“ Cell, vol. 94, pp. 667–77, 1998.
 T. J. Thauland Y. Koguchi S. A. Wetzel M. L. Dustin and D. C. Parker “Th1 and Th2 cells form morphologically distinct immunological synapses,“ Journal of Immunology, vol. 181, pp. 393–9, 2008.
 A. Trautmann and S. Valitutti “The diversity of immunological synapses,“ Current Opinion in Immunology, vol. 15, pp. 249–54, 2003.
 S. Y. Tseng M. Liu and M. L. Dustin “CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse,“ Journal of Immunology, vol. 175, pp. 7829–36, 2005.
 S. Y. Tseng J. C. Waite M. Liu S. Vardhana and M. L. Dustin “T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta,“ Journal of Immunology, vol. 181, pp. 4852–63, 2008.
 J. Doh and D. J. Irvine “Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells,“ Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 5700–5, 2006.
 W. Senaratne P. Sengupta V. Jakubek D. Holowka C. K. Ober and B. Baird “Functionalized surface arrays for spatial targeting of immune cell signaling,“ Journal of the American Chemical Society, vol. 128, pp. 5594–5, 2006.
 K. Shen V. K. Thomas M. L. Dustin and L. C. Kam “Micropatterning of costimulatory ligands enhances CD4+ T cell function,“ Proceedings of the National Academy of Sciences of the United States of America, vol. 105, pp. 7791–6, 2008.
 K. Shen J. Qi and L. C. Kam “Microcontact printing of proteins for cell biology,“ Journal of Visualized Experiments, 2008.
 A. J. Engler S. Sen H. L. Sweeney and D. E. Discher “Matrix elasticity directs stem celllineage specification,“ Cell, vol. 126, pp. 677–89, 2006.
 G. Giannone and M. P. Sheetz “Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways,“ Trends in Cell Biology, vol. 16, pp. 213–23, 2006.
 R. J. Pelham Jr. and Y. Wang “Cell locomotion and focal adhesions are regulated by substrate flexibility,“ Proceedings of the National Academy of Sciences of the United States of America, vol. 94, pp. 13661–5, 1997.
 G. Jiang A. H. Huang Y. Cai M. Tanase and M. P. Sheetz “Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha,“ Biophysical Journal, vol. 90, pp. 1804–9, 2006.
 N. S. Astrof A. Salas M. Shimaoka J. Chen and T. A. Springer “Importance of force linkage in mechanochemistry of adhesion receptors,“ Biochemistry, vol. 45, pp. 15020–8, 2006.
 G. Campi R. Varma and M. L. Dustin “Actin and agonist MHC-peptide complexdependent T cell receptor microclusters as scaffolds for signaling,“ Journal of Experimental Medicine, vol. 202, pp. 1031–1036, 2005.
 B. A. Freiberg H. Kupfer W. Maslanik J. Delli J. Kappler D. M. Zaller and A. Kupfer “Staging and resetting T cell activation in SMACs,“ Nature Immunology, vol. 3, pp. 911–7, 2002.
 M. F. Krummel M. D. Sjaastad C. Wulfing and M. M. Davis “Differential clustering of CD4 and CD3zeta during T cell recognition,“ Science, vol. 289, pp. 1349–52, 2000.
 J. B. Huppa M. Gleimer C. Sumen and M. M. Davis “Continuous T cell receptor signaling required for synapse maintenance and full effector potential,“ Nature Immunology, vol. 4, pp. 749–55, 2003.
 S. Valitutti M. Dessing K. Aktories H. Gallati and A. Lanzavecchia “Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cellactin cytoskeleton,“ Journal of Experimental Medicine, vol. 181, pp. 577–84, 1995.
 T. Ilani G. Vasiliver-Shamis , S. Vardhana A. Bretscher and M. L. Dustin “T cell antigen receptor signaling and immunological synapse stability require myosin IIA,“ Nature Immunology, vol. 10, pp. 531–9, 2009.
 H. G. Dobereiner B. J. Dubin-Thaler , J. M. Hofman H. S. Xenias T. N. Sims G. Giannone , M. L. Dustin C. H. Wiggins and M. P. Sheetz “Lateral membrane waves constitute a universal dynamic pattern of motile cells,“ Physical Review Letters, vol. 97, p. 038102, 2006.
 M. L. Dustin “Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses,“ Current Opinion in Cell Biology, vol. 19, pp. 529–33, 2007.
 J. Tsai and L. Kam “Rigidity-dependent cross talk between integrin and cadherin signaling,“ Biophysical Journal, vol. 96, pp. L39–41, 2009.
 Y. Dori H. Bianco-Peled , S. K. Satija G. B. Fields J. B. McCarthy and M. Tirrell “Ligand accessibility as means to control cell response to bioactive bilayer membranes,“ Journal of Biomedical Materials Research, vol. 50, pp. 75–81, 2000.
 A. Grakoui S. K. Bromley C. Sumen M. M. Davis A. S. Shaw P. M. Allen and M. L. Dustin , “The immunological synapse: a molecular machine controlling T cell activation,“ Science, vol. 285, pp. 221–7, 1999.
 J. T. Groves and M. L. Dustin “Supported planar bilayers in studies on immune cell adhesion and communication,“ Journal of Immunological Methods, vol. 278, pp. 19–32, 2003.
 K. D. Mossman G. Campi J. T. Groves and M. L. Dustin “Altered TCR signaling from geometrically repatterned immunological synapses,“ Science, vol. 310, pp. 1191–3, 2005.
 S. Pautot H. Lee E. Y. Isacoff and J. T. Groves “Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers,“ Nature Chemical Biology, vol. 1, p. 283, 2005.
 T. D. Perez W. J. Nelson S. G. Boxer and L. Kam “E-Cadherin Tethered to Micropatterned Supported Lipid Bilayers as a Model for Cell Adhesion,“ Langmuir, vol. 21, pp. 11963–8, 2005.
 D. Stroumpoulis H. Zhang L. Rubalcava J. Gliem and M. Tirrell “Cell adhesion and growth to Peptide-patterned supported lipid membranes,“ Langmuir, vol. 23, pp. 3849–56, 2007.
 T. Yokosuka W. Kobayashi K. Sakata-Sogawa , M. Takamatsu A. Hashimoto-Tane , M. L. Dustin , M. Tokunaga and T. Saito “Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation,“ Immunity, vol. 29, pp. 589–601, 2008.
 P. Y. Chan M. B. Lawrence M. L. Dustin L. M. Ferguson D. E. Golan and T. A. Springer , “Influence of Receptor Lateral Mobility On Adhesion Strengthening Between Membranes Containing Lfa-3 and Cd2,“ Journal of Cell Biology;, vol. 115, pp. 245–255, 1991.
 A. L. DeMond and J. T. Groves “Interrogating the T cell synapse with patterned surfaces and photoactivated proteins,“ Current Opinion in Immunology, vol. 19, pp. 722–7, 2007.
 L. Kam and S. G. Boxer “Cell adhesion to protein-micropatterned-supported lipid bilayer membranes,“ Journal of Biomedical Materials Research, vol. 55, pp. 487–95, 2001.
 R. N. Orth M. Wu D. A. Holowka H. G. Craighead and B. A. Baird “Mast Cell Activation on Patterned Lipid Bilayers of Subcellular Dimensions,“ Langmuir, vol. 19, pp. 1599–1605, 2003.
 L. Kam and S. G. Boxer “Formation of supported lipid bilayer composition arrays by controlled mixing and surface capture,“ Journal of the American Chemical Society, vol. 122, pp. 12901–2, 2000.
 L. Kam and S. G. Boxer “Spatially selective manipulation of supported lipid bilayers by laminar flow: steps towards biomembrane microfluidics,“ Langmuir, vol. 19, pp. 1624–31, 2003.
 T. Yang E. E. Simanek and P. Cremer “Creating addressable aqueous microcompartments above solid supported phospholipid bilayers using lithographically patterned poly(dimethylsiloxane) molds,“ Analytical Chemistry, vol. 72, pp. 2587–9, 2000.
 C. Yoshina-Ishii and S. G. Boxer “Arrays of mobile tethered vesicles on supported lipid bilayers,“ Journal of the American Chemical Society, vol. 125, pp. 3696–7, 2003.
 B. L. Jackson and J. T. Groves “Scanning probe lithography on fluid lipid membranes,“ Journal of the American Chemical Society, vol. 126, pp. 13878–9, 2004.
 S. Lenhert P. Sun Y. Wang H. Fuchs and C. A. Mirkin “Massively parallel dip-pen nanolithography of heterogeneous supported phospholipid multilayer patterns,“ Small, vol. 3, pp. 71–5, 2007.
 J. Shi J. Chen and P. S. Cremer “Sub-100 nm patterning of supported bilayers by nanoshaving lithography,“ Journal of the American Chemical Society, vol. 130, pp. 2718–9, 2008.
 K. Shen J. Tsai P. Shi and L. C. Kam “Self-aligned supported lipid bilayers for patterning the cell-substrate interface,“ Journal of the American Chemical Society, vol. 131, pp. 13204–5, 2009.
 J. Tsai E. Sun Y. Gao J. C. Hone and L. C. Kam “Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers,“ Nano Letters, vol. 8, pp. 425–30, 2008.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
- ISSN: -
- EISSN: 1946-4274
- URL: /core/journals/mrs-online-proceedings-library-archive