Skip to main content
×
×
Home

Effects of Bleach Reprocessing on Hemodialysis Membranes

  • Susanne H. Wolff (a1) and Andrew L. Zydney (a1)
Abstract

Hemodialysis membranes are exposed to bleach during standard reprocessing methods, but there is little quantitative understanding of the effects of bleach on the mass transfer characteristics or surface properties of these membranes. A battery of experiments was used to evaluate the effects of bleach on the properties of Fresenius F80A, F80B, and Optiflux 180A dialyzers. Bleach caused a significant increase in the membrane hydraulic permeability. The clearance of urea (MW=60 Da) increased by only 3% after a 1-hour exposure to bleach at 50 °C compared to more than a 10-fold increase in the clearance of a 15 kD MW dextran. The solute clearance data were used to determine the effective membrane pore size using available hydrodynamic models. Bleach caused a significant increase in the effective pore size, which was attributed to the leaching of the polyvinylpyrrolidone (PVP) out of the polysulfone membrane. Bleach also caused a significant increase in the magnitude of the negative charge on the membrane surface; the zeta potential varied from −4.1 mV for the new membrane to −13.0 mV after a 14-hour exposure to bleach. These changes in pore size and surface properties provide important insights into the effects of bleach on hemodialysis membranes.

Copyright
References
Hide All
1. USRDS, USRDS 1997 Annual Report. 1997, National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases: Bethesda, MD.
2. Clark, W., Mueller, B., Scott, M., Bander, S., Low-molecular weight protein removal by high-flux dialyzers: basic mechanisms and effect of reprocessing. Seminars in Dialysis, 1999. 12: p. 349354.
3. Ikizler, T., Flakoll, P., Parker, R., Hakim, R., Amino acid and albumin losses during hemodialysis. Kidney International, 1994. 46: p. 830837.
4. Kaplan, A., Halley, S., Lapkin, R., Graeber, C., Dialysate protein losses with bleach processed polysuphone dialyzers. Kidney International, 1995. 47: p. 573578.
5. Ofsthun, N., Powell, P., Stroup, E. The effect of fiber crimping on solute removal in hemodialysis. in North American Membrane Society. 2001. Lexington, KY.
6. Mochizuki, S., Zydney, A., Dextran transport through asymmetric ultrafiltration membranes: comparison with hydrodynamic models. Journal of Membrane Science, 1992. 68: p. 2141.
7. Weink, I., Meuleman, E., Borneman, Z., Van Den Boomgaard, T., Smolders, C., Chemical treatment of a polymer blend: mechanism of the reaction of hypochlorite with poly(vinyl pyrrolidone). Journal of Polymer Science: Part A: Polymer Chemistry, 1995. 33: p. 4954.
8. Qin, J.-J., Wong, F.-S., Hypochlorite treatment of hydrophilic hollow fiber ultrafiltration membranes for high fluxes. Desalination, 2002. 146: p. 307309.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 9 *
Loading metrics...

Abstract views

Total abstract views: 92 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th August 2018. This data will be updated every 24 hours.