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Effects of Bleach Reprocessing on Hemodialysis Membranes

Published online by Cambridge University Press:  11 February 2011

Susanne H. Wolff  and
Andrew L. Zydney
Susanne H. Wolff
Affiliation:
The Pennsylvania State University, Department of Chemical Engineering, University Park, PA 16802
Andrew L. Zydney
Affiliation:
The Pennsylvania State University, Department of Chemical Engineering, University Park, PA 16802
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Abstract

Hemodialysis membranes are exposed to bleach during standard reprocessing methods, but there is little quantitative understanding of the effects of bleach on the mass transfer characteristics or surface properties of these membranes. A battery of experiments was used to evaluate the effects of bleach on the properties of Fresenius F80A, F80B, and Optiflux 180A dialyzers. Bleach caused a significant increase in the membrane hydraulic permeability. The clearance of urea (MW=60 Da) increased by only 3% after a 1-hour exposure to bleach at 50 °C compared to more than a 10-fold increase in the clearance of a 15 kD MW dextran. The solute clearance data were used to determine the effective membrane pore size using available hydrodynamic models. Bleach caused a significant increase in the effective pore size, which was attributed to the leaching of the polyvinylpyrrolidone (PVP) out of the polysulfone membrane. Bleach also caused a significant increase in the magnitude of the negative charge on the membrane surface; the zeta potential varied from −4.1 mV for the new membrane to −13.0 mV after a 14-hour exposure to bleach. These changes in pore size and surface properties provide important insights into the effects of bleach on hemodialysis membranes.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 752: Symposium AA – Membranes–Preparation, Properties and Applications , 2002 , AA14.3
Copyright
Copyright © Materials Research Society 2003

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References

REFERENCES

1. USRDS, USRDS 1997 Annual Report. 1997, National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases: Bethesda, MD.Google Scholar
2. Clark, W., Mueller, B., Scott, M., Bander, S., Low-molecular weight protein removal by high-flux dialyzers: basic mechanisms and effect of reprocessing. Seminars in Dialysis, 1999. 12: p. 349–354.Google Scholar
3. Ikizler, T., Flakoll, P., Parker, R., Hakim, R., Amino acid and albumin losses during hemodialysis. Kidney International, 1994. 46: p. 830–837.Google Scholar
4. Kaplan, A., Halley, S., Lapkin, R., Graeber, C., Dialysate protein losses with bleach processed polysuphone dialyzers. Kidney International, 1995. 47: p. 573–578.Google Scholar
5. Ofsthun, N., Powell, P., Stroup, E. The effect of fiber crimping on solute removal in hemodialysis. in North American Membrane Society. 2001. Lexington, KY.Google Scholar
6. Mochizuki, S., Zydney, A., Dextran transport through asymmetric ultrafiltration membranes: comparison with hydrodynamic models. Journal of Membrane Science, 1992. 68: p. 21–41.Google Scholar
7. Weink, I., Meuleman, E., Borneman, Z., Van Den Boomgaard, T., Smolders, C., Chemical treatment of a polymer blend: mechanism of the reaction of hypochlorite with poly(vinyl pyrrolidone). Journal of Polymer Science: Part A: Polymer Chemistry, 1995. 33: p. 49–54.Google Scholar
8. Qin, J.-J., Wong, F.-S., Hypochlorite treatment of hydrophilic hollow fiber ultrafiltration membranes for high fluxes. Desalination, 2002. 146: p. 307–309.Google Scholar