Skip to main content Accessibility help

Enhancing cell culture in magnetic vesicle gels

  • Felicity Leng (a1), Julie E Gough (a2) and Simon J Webb (a3)


Several different hydrogel compositions have been incorporated into magnetic vesicle gels and the resulting “smart” biomaterials assessed as cell culture scaffolds. The compatibility of these hydrogels with the “smart” component of these biomaterials, thermally sensitive vesicles (TSVs) crosslinked by magnetic nanoparticles, was assessed by the leakage of fluorescent 5/6-carboxyfluorescein from the TSVs under cell culture conditions. Subsequently the ability of the hydrogels to support 3T3 fibroblast and chondrocyte viability was assessed. These studies revealed that alginate-based gels were the most compatible with both the TSVs and the cultured cells, with an alginate:fibronectin mix proving to be the most versatile. Nonetheless these studies also suggest that TSV composition needs to be modified to improve the performance of these “smart” cell culture scaffolds in future applications.



Hide All
1 Mart, R.J., Liem, K.P. and Webb, S.J., Chem. Commun., 2287, (2009).
2 Liem, K.P., Mart, R.J. and Webb, S.J., J. Am. Chem. Soc, 129, 12080, (2007).
3 Gu, H., Yang, Z., Gao, J., Chang, C. K., and Xu, B., J. Am. Chem. Soc. 127, 34, (2005).
4 Mosahebi, A., Wiberg, M and Terenghi, G., Tissue Eng, 9, 2, 209 (2003).
5 Huang, C.L., Liao, J.D., Yang, C.F., Chang, C.W., Ju, M.S. and Lin, C.C.K., Thin Solid Films 517, 5386 (2009).
6 Khan, F., Tore, R. and Bradley, M., Angew. Chem. Int. Ed., 47, 1, (2008).
7 Rathna, G.V.N., J. Mater. Sci. - Mater. M., 19, 2351 (2008).
8 Suh, J.K. Francis and Matthew, H.W.T., Biomaterials, 21, 2589, (2000).
9 Lin, Y.J., Yen, C.N., Hu, Y.C., Wu, Y.C., Liao, C.J. and Chu., I.M., J. Biomed. Mater. Res. A 88A, 23, (2009).


Related content

Powered by UNSILO

Enhancing cell culture in magnetic vesicle gels

  • Felicity Leng (a1), Julie E Gough (a2) and Simon J Webb (a3)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.