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The Evaluation of Alpha Plaster of Paris as a Osteoconductive Material in the Adult Cat Calvarium

Published online by Cambridge University Press:  15 February 2011

N. W. Knuckey ,
H. Saskin ,
R. Yanagasawa  and
M. Flanagan
N. W. Knuckey
Affiliation:
Institutions: Department of Clinical Neuroscience
H. Saskin
Affiliation:
Institutions: Department of Clinical Neuroscience and Pathology
R. Yanagasawa
Affiliation:
Institutions: Department of Clinical Neuroscience
M. Flanagan
Affiliation:
Brown University/Rhode Island Hospital, Codman Company.
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Abstract

Spontaneous new bone formation does not occur in the adult calvarium. In humans, cranial defects may require repair for brain protection, headaches or cosmetic. Over the years the search for the ideal cranioplasty material to repair such cranial defects has been extensive. We report an evaluation of alpha plaster of paris as an osteoconductive material in a cat craniectomy defect.

Adult cats of either sex were anesthetized with ketamine/halothane and a 15mm biparietal craniectomy defect created. The right side was filled with alpha plaster of paris and the left served as a control. There were 4 animals in each time cohort and animals were sacrificed at 6 weeks, 6 or 12 months. The cranium was removed, fixed, stained, histologically studied and analysised for the percentage of trabecular bone formation. At all durations the control defects were bridged by proliferative fibrous tissue membrane and less than 1% trabecular bone. At six weeks the plaster of paris filled defects were either totally or nearly totally replaced by new bone formation. The plaster was completely resorbed. At 6 wks there was 28% trabecular bone which increased to 93% at 52 wks. Our experiments demonstrate the oeteoconductive potential of alpha plaster of paris in the adult calvarium. This material needs to be evaluated in humans to ascertain its potential as a biocompatible cranioplasty material.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 99
Copyright
Copyright © Materials Research Society 1992

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References

REFERENCES

1. Bahn, S.: Plaster: a bone substitute. Oral Surg Oral Med Oral Pathol. 21: 672–681, 1966.Google Scholar
2. Beeson, W.: Plaster of Paris as an alloplastic implant in the frontal sinus. Arch Otolaryngol 107: 664–669, 1981.Google Scholar
3. Coetzee, A.: Regeneration of bone in the presence of calcium sulfate. Arch Otolaryngol 106: 405–409, 1980.Google Scholar
4. Daien, J.R., Parsons, J.J., Benedict, J.J., and Weisman, D.S. Investigation of a hydroxyapatite and calcium sulfate composite supplemented with an osteoinductive factor. J Biomed Mat Res 24: 639–654, 1990.Google Scholar
5. Frame, J., Rout, P., and Browne, R.: Ridge augmentation using solid and porous hydroxylapatite particles with and without autogenous bone or plaster. J Oral Maxillofac Surg 45: 771–777, 1987.Google Scholar
6. Hanker, J., Tucker, M., Terry, B., Carnevale, R., and Giammara, B.: Composite plaster/hydroxylapatite implants for jaw bone restoration. Biomed Mater Mater Res Soc Symp Proc 55: 77–96, 1986.Google Scholar
7. McKee, C., and Bailey, B.: Calcium sulfate as a mandibular implant. Otolaryngol Head Neck Surg 92: 277–286, 1984.Google Scholar
8. Peltier, L., Bickel, E., Lillo, R., and Thein, M.: The use of plaster of Paris to fill defects in bone. Ann of Surgery 146: 61–69, 1957.Google Scholar
9. Peltier, L. and Jones, R.: Treatment of unicameral bone cysts by curettage and packing with Plaster of Paris pellets. J Bone and Joint Surg 60-A: 820–822, 1978.Google Scholar
10. Peltier, L,: The use of plaster of Paris to fill the defects in bone. Clin Orthop 21:61–69, 1961.Google Scholar
11. Stula, D.: Cranioplasty, New York: Springer-Verlag Wien, 1987.Google Scholar