Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-24T03:07:08.253Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of organic functionalities linked to alkoxysilane precursors in nanomaterials synthesis and their biomedical applications

Published online by Cambridge University Press:  22 June 2015

P. C. Pandey  and
Govind Pandey
P. C. Pandey
Affiliation:
Department of Chemistry, Indian Institute of technology(BHU), Varanasi-221005, India,
Govind Pandey
Affiliation:
BRD Medical College, Gorakhpur, Uttar Pradesh 273013, India
Get access

Abstract

The synthesis of biocompatible noble metal nanoparticles dispersible in a wide range of biological media with control of polycrystalinity and nanogeometry, pH sensitivity and salt tolerance has been a challenging requirements. The role of 3-aminopropyltrimethoxysilane (3-APTMS) and organic reducing reagents for real time synthesis of amphilic noble metal nanoparticles meeting these requirements are demonstrated justifying the following; (1) 3-APTMS capped noble metal ions are converted into respective metal nanoparticles in the presence of one of organic reducing agents i.e., cyclohexanone, tetrahydrofuran hydroperoxide (THF-HPO), formaldehyde, acetaldehyde, acetone, t-buty dimethyl keotone, 3-Glycidoxy-propyltrimethoxysilane (3-GPTMS); (2) 3-APTMS acts as micelle, promotes the interaction of metal ions with organic reducing agent, precisely controls the size of metal nanoparticles, pH sensititvity and salt tolerance and also provides a suitable medium for nanoparticles suspension, (3) the use of suitable organic reagent precisely controls the polarity of as made noble metal nanoparticles allowing specific biological interactions, and (4) 3-APTMS significantly increases the stability and controls the pH sensitivity and salt tolerance of metal nanoparticles. The as synthesized nanomaterials show potential viability in biomedical applications from many angles i.e. (a) as potential bioelectrocatalyst, (b) selective interaction with active proteins and cellular components, and (c) peroxidase mimetic.

Keywords

biomaterialbiomedicalsensor
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1719: Symposium C – Medical Applications of Noble Metal Nanoparticles (NMNPs) , 2015 , mrsf14-1719-c06-10
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Leff, D. V., Brandt, L. and Heath, J. R., Langmuir, 12, 4723–4730 (1996).CrossRefGoogle Scholar
Jain, S., Hirst, D. G. and O'Sullivan, J. M., The British Journal of Radiology, 85, 101–113(2012).CrossRefGoogle Scholar
Xu, C., Xu, K., Gu, H., Zhong, X., Guo, Z., Zheng, R., Zhang, X. and Xu, B., J. Am. Chem. Soc., 126, 3392–3393(2004).CrossRefGoogle Scholar
Mirzabekov, T., Kontos, H., Farzan, M., Marasco, W. and Sodroski, J., Nat. Biotechnol., 18, 649–654(2000).CrossRefGoogle Scholar
Jv, Y., Li, B. and Cao, R., Chem. Commun., 46, 8017–8019(2010).CrossRefGoogle Scholar
Bhargava, S. K., Booth, J. M., Agrawal, S., Coloe, P. and Kar, G., Langmuir, 21, 5949–5956(2005).CrossRefGoogle Scholar
Pandey, P. C., Upadhyay, S., and Sharma, S., J. Electrochem. Soc., 150, H85–H91 (2003).CrossRefGoogle Scholar
Pandey, P. C. and Chauhan, D. S., Analyst, 137, 376–385(2012).CrossRefGoogle Scholar
Pandey, P. C. and Pandey, G., Journal of Materials Chemistry B, 2, 3383–3390(2014).CrossRefGoogle Scholar
Pandey, P. C., Pandey, A. K. and Pandey, G., J. Nanosci. Nanotech., 14, 6606–6613. (2014).CrossRefGoogle Scholar
Pandey, P. C. and Chauhan, D. S., Analyst, 137, 376–385(2012).CrossRefGoogle Scholar
Pandey, P. C., Singh, R. and Pandey, A. K., Electochimica Acta., 138, 163–173(2014).CrossRefGoogle Scholar
Pandey, P. C., Pandey, D. and Pandey, G.. RSC Advances, 4, 60563–60570(2014).CrossRefGoogle Scholar
Pandey, P. C.,and Singh, R., J. Nanosci. Nanotech., 15, 5749–5759(2015).CrossRefGoogle Scholar
Pandey, P. C., and Singh, R., RSC Adv., 15, 10964–10973(2015).CrossRefGoogle Scholar
Pandey, P. C., Pandey, Gunjan, Haider, J. and Pandey, Govind, J. Nanosci. Nanotech., in press, doi:10.1166/jnn.2014.9378.Google Scholar
Pandey, P. C., and Pandey, Ashish, Electrochim.Acta, 87, 1–8(2013).CrossRefGoogle Scholar