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Towards Heterogeneous Biodegradable Nanorods for Controlled Drug Delivery

Published online by Cambridge University Press:  01 February 2011

Shelley Dougherty  and
Jianyu Liang
Shelley Dougherty
Affiliation:
sad5@wpi.edu, Worcester Polytechnic Institute, Material Science and Engineering, Worcester, Massachusetts, United States
Jianyu Liang
Affiliation:
jianyul@wpi.edu, Worcester Polytechnic Institute, Material Science and Engineering, Worcester, Massachusetts, United States
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Abstract

Heterogeneous, one-dimensional (1D) nanomaterials, such as nanorods and nanowires, have been utilized for a variety of different biomedical applications because they offer a unique combination of properties and provide a material platform for integrating multiple functions. In this paper, we propose a template-assisted wetting approach to fabricate segmented polymer nanorods using biodegradable polymers for controlled drug delivery. Our previous work with polystyrene (PS) and poly(methyl methacrylate) (PMMA) heterogeneous, segmented nanorods is described briefly to introduce our current preliminary work with the fabrication of homogeneous biodegradable nanorods and drug release from polymer thin films. Since the template-assisted fabrication approach provides us unprecedented control over the size, spacing, and length of the heterogeneous polymer nanorods, this technique will provide for the opportunity to evaluate drug release kinetics as a function of the segment spacing, size of the nanorods, and aspect ratio in the future.

Keywords

biomaterialnanostructurepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1138: Symposium FF – Nanofunctional Materials, Structures and Devices for Biomedical Applications , 2008 , 1138-FF02-08
Copyright
Copyright © Materials Research Society 2009

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References

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