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Can satellite glial cells be therapeutic targets for pain control?

Published online by Cambridge University Press:  22 June 2010

Luc Jasmin*
Department of Anatomy, University of California, San Francisco, CA, USA Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Jean-Philippe Vit
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Aditi Bhargava
Department of Surgery, University of California, San Francisco, CA, USA
Peter T. Ohara
Department of Anatomy, University of California, San Francisco, CA, USA
Correspondence should be addressed to: Luc Jasmin, Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue San Francisco, CA 94143-0452, USA phone: (415) 476-3761 fax: (415) 476-4845 email:


Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.

Research Article
Copyright © Cambridge University Press 2010

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Can satellite glial cells be therapeutic targets for pain control?
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