Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 8
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kumar, Hariom and Sharma, Bhupesh 2016. Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats. Brain Research, Vol. 1630, p. 83.


    Li, Teng-Fei Fan, Hui and Wang, Yong-Xiang 2016. Aconitum-Derived Bulleyaconitine A Exhibits Antihypersensitivity Through Direct Stimulating Dynorphin A Expression in Spinal Microglia. The Journal of Pain, Vol. 17, Issue. 5, p. 530.


    Reglodi, Dora Renaud, Justine Tamas, Andrea Tizabi, Yousef Socías, Sergio B. Del-Bel, Elaine and Raisman-Vozari, Rita 2015. Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides. Progress in Neurobiology,


    Dansie, L.E. Phommahaxay, K. Okusanya, A.G. Uwadia, J. Huang, M. Rotschafer, S.E. Razak, K.A. Ethell, D.W. and Ethell, I.M. 2013. Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Neuroscience, Vol. 246, p. 186.


    Garrido-Mesa, N Zarzuelo, A and Gálvez, J 2013. Minocycline: far beyond an antibiotic. British Journal of Pharmacology, Vol. 169, Issue. 2, p. 337.


    Chen, Xiaohong Ma, Xiaomeng Jiang, Ying Pi, Rongbiao Liu, Yingying and Ma, Lili 2011. The prospects of minocycline in multiple sclerosis. Journal of Neuroimmunology, Vol. 235, Issue. 1-2, p. 1.


    Gray, Elizabeth Ginty, Mark Kemp, Kevin Scolding, Neil and Wilkins, Alastair 2011. Peroxisome proliferator-activated receptor-α agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function. European Journal of Neuroscience, Vol. 33, Issue. 8, p. 1421.


    Nie, H. Zhang, H. and Weng, H.R. 2010. Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats. Neuroscience, Vol. 170, Issue. 3, p. 901.


    ×

Minocycline attenuates nitric oxide-mediated neuronal and axonal destruction in vitro

  • ALASTAIR WILKINS (a1) (a2), MARIA NIKODEMOVA (a2), ALASTAIR COMPSTON (a1) and IAN DUNCAN (a2)
  • DOI: http://dx.doi.org/10.1017/S1740925X05000104
  • Published online: 01 August 2004
Abstract

Minocycline, a tetracycline derivative with pleiotropic biological effects, exhibits anti-inflammatory properties in several models of CNS disease. In addition to reducing production of inflammatory mediators, it has been postulated that minocycline might also be directly neuroprotective under these circumstances. Therefore, we investigated the effect of minocycline on primary cortical neuronal cultures exposed to a nitric oxide (NO)-donor. Cultures were assessed for neuronal survival, axon survival and markers of intracellular signaling pathways. The NO donor significantly increased neuronal death and minocycline was protective under these conditions. Furthermore NO-induced reductions in axonal length were significantly attenuated by minocycline. Improvements in axonal length were dependent on mitogen-activated protein kinase (MAP kinase)/extracellular signal-related kinase (Erk) signaling, whereas phosphatidylinositol 3-kinase (PI 3-kinase)/Akt signaling was important in neuronal survival. Further investigation into MAP kinase signaling pathways revealed inhibition of p38 MAP kinase and c-jun N-terminal kinase (JNK) signaling by minocycline. JNK pathways were activated by trophic factor-withdrawal and minocycline attenuated neuronal death induced by trophic withdrawal. These results indicate that, in addition to anti-inflammatory properties, minocycline has direct protective effects on neurons and provides further evidence for its use in disorders of the CNS.

Copyright
Corresponding author
Alastair Wilkins, Dept of Clinical Neurosciences and Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK. phone: +44 1223 331186; fax: +44 1223 331174. email: aw255@cam.ac.uk
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Neuron Glia Biology
  • ISSN: 1740-925X
  • EISSN: 1741-0533
  • URL: /core/journals/neuron-glia-biology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: