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HW Baik & RM Russell (1999) Vitamin B12 deficiency in the elderly. Annual Review of Nutrition 19, 357–377.
M Benderitter , F Hadj-Saad , M Lhuissier , V Maupoil , JC Guilland & L Rochette (1996) Effects of exhaustive exercise and vitamin B6 deficiency on free radical oxidative process in male trained rats. Free Radical Biology and Medicine 21, 541–549.
MA Bernstein , KL Tucker , ND Ryan , EF O'Neill , KM Clements , ME Nelson , WJ Evans & MA Fiatarone Singh (2002) Higher dietary variety is associated with better nutritional status in frail elderly people. Journal of the American Dietetic Association 102, 1096–1104.
K Björkegren & K Svärdsudd (2001) Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes – a population–based study. Journal of Internal Medicine 249, 423–432.
CJ Boushey , SA Beresford , GS Omenn & AG Motulsky (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Journal of the American Medical Association 274, 1049–1057.
IA Brouwer , M van Dusseldorp , CE West & RPM Steegers-Theunissen (2001) Bioavailability and bioefficacy of folate and folic acid in man. Nutrition Research Reviews 14, 267–293.
E Camilo , J Zimmerman , JB Mason , B Golner , R Russell , J Selhub & IH Rosenberg (1996) Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Gastroenterology 110, 991–998.
L Chasan-Taber , J Selhub , IH Rosenberg , MR Malinow , P Terry , PV Tishler , W Willett , CH Hennekens & MJ Stampfer (1996) A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. Journal of the American College of Nutrition 15, 136–143.
C Desouza , M Keebler , DB McNamara & V Fonseca (2002) Drugs affecting homocysteine metabolism: impact on cardiovascular risk. Drugs 62, 605–616.
SN Doshi , IF McDowell , SJ Moat , N Payne , HJ Durrant , MJ Lewis & J Goodfellow (2002) Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 105, 22–26.
W Duan , B Ladenheim , RG Cutler , Kruman II, JL Cadet & MP Mattson (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. Journal of Neurochemistry 80, 101–110.
PB Duell & MR Malinow (1997) Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Current Opinion in Lipidology 8, 28–34.
JC Essama-Tjani , JC Guilland , G Potier de Courcy , F Fuchs & D Richard (2000) Folate status worsens in recently institutionalized elderly people without evidence of functional deterioration. Journal of the American College of Nutrition 19, 392–404.
M Fenech (2002) Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food and Chemical Toxicology 40, 1113–1117.
D Feskanich , V Singh , WC Willett & GA Colditz (2002) Vitamin A intake and hip fractures among postmenopausal women. Journal of the American Medical Association 287, 47–54.
JD Finkelstein (1998) The metabolism of homocysteine: pathways and regulation. European Journal of Pediatrics 157, Suppl. 2, S40–S44.
VM Flood , KL Webb , W Smith , P Mitchell , JM Bantick , R Macintyre , D Sindhusake & GL Rubin (2001) Folate fortification: potential impact on folate intake in an older population. European Journal of Clinical Nutrition 55, 793–800.
AR Folsom , FJ Nieto , PG McGovern , MY Tsai , MR Malinow , JH Eckfeldt , DL Hess & CE Davis (1998) Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 98, 204–210.
G Gastaldi , U Laforenza , G Ferrari , A Casasco & G Rindi (1992) Age–related thiamin transport by small intestinal microvillous vesicles of rat. Biochimica Biophysica Acta 1105, 271–277.
WH Giles , SJ Kittner , JB Croft , RF Anda , ML Casper & ES Ford (1998) Serum folate and risk for coronary heart disease: results from a cohort of US adults. Annals of Epidemiology 8, 490–496.
M Gold , MF Chen & K Johnson (1995) Plasma and red blood cell thiamine deficiency in patients with dementia of the Alzheimer's type. Archives of Neurology 52, 1081–1086.
JF Gregory III & EP Quinlivan (2002) In vivo kinetics of folate metabolism. Annual Review of Nutrition 22, 199–220.
J Haller (1999) The vitamin status and its adequacy in the elderly: an international overview. International Journal for Vitamin and Nutrition Research 69, 160–168.
W Herrmann , S Quast , M Ullrich , H Schultze , M Bodis & J Geisel (1999) Hyperhomocysteinemia in high–aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation. Atherosclerosis 144, 91–101.
S Hirsch , P de la Maza , L Mendoza , M Petermann , A Glasinovic , P Paulinelli , G Barrera , IH Rosenberg & D Bunout (2002 b) Endothelial function in healthy younger and older hyperhomocysteinemic subjects. Journal of the American Geriatrics Society 50, 1019–1023.
Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta–analysis of randomised trials. British Medical Journal 316, 894–898.
JM Howard , C Azen , DW Jacobsen , R Green & R Carmel (1998) Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels. European Journal of Clinical Nutrition 52, 582–587.
PF Jacques , J Selhub , AG Bostom , PW Wilson & IH Rosenberg (1999 b) The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New England Journal of Medicine 340, 1449–1454.
A Jatoi , BD Daly , G Kramer & JB Mason (2001) Folate status among patients with non–small cell lung cancer: a case–control study. Journal of Surgery and Oncology 77, 247–252.
FJ Jimenez-Jimenez , JA Molina , A Hernanz , E Fernandez-Vivancos , F de Bustos , B Barcenilla , C Gomez-Escalonilla , M Zurdo , A Berbel & C Villanueva (1999) Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. Neuroscience Letters 271, 33–36.
R Joshi , S Adhikari , BS Patro , S Chattopadhyay & T Mukherjee (2001) Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radical Biology and Medicine 30, 1390–1399.
S Kalmijn , LJ Launer , J Lindemans , ML Bots , A Hofman & MM Breteler (1999) Total homocysteine and cognitive decline in a community–based sample of elderly subjects: the Rotterdam Study. American Journal of Epidemiology 150, 283–289.
K Khosraviani , HP Weir , P Hamilton , J Moorehead & K Williamson (2002) Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 51, 195–199.
M Klerk , P Verhoef , R Clarke , HJ Blom , FJ Kok & EG Schouten (2002) MTHFR 677C → T polymorphism and risk of coronary heart disease: a meta–analysis. Jama 288, 2023–2031.
EJ Konings , RA Goldbohm , HA Brants , WH Saris & PA Van Den Brandt (2002) Intake of dietary folate vitamers and risk of colorectal carcinoma. Cancer 95, 1421–1433.
SA Lamprecht & M Lipkin (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nature Reviews. Cancer 3, 601–614.
D Lang , MB Kredan , SJ Moat , SA Hussain , CA Powell , MF Bellamy , HJ Powers & MJ Lewis (2000) Homocysteine–induced inhibition of endothelium–dependent relaxation in rabbit aorta: role for superoxide anions. Arteriosclerosis, Thrombosis and Vascular Biology 20, 422–427.
L Le Marchand , T Donlon , JH Hankin , LN Kolonel , LR Wilkens & A Seifried (2002) B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes and Control 13, 239–248.
KJ Lievers , LA Kluijtmans & HJ Blom (2003) Genetics of hyperhomocysteinaemia in cardiovascular disease. Annals of Clinical Biochemistry 40, 46–59.
RD Lindeman , LJ Romero , KM Koehler , HC Liang , A LaRue , RN Baumgartner & PJ Garry (2000) Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions. Journal of the American College of Nutrition 19, 68–76.
MR Malinow , PB Duell , DL Hess , PH Anderson , WD Kruger , BE Phillipson , RA Gluckman , PC Block & BM Upson (1998) Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. New England Journal of Medicine 338, 1009–1015.
MP Mattson , Kruman II & W Duan (2002) Folic acid and homocysteine in age–related disease. Ageing Research Reviews 1, 95–111.
CJ Maxwell , DB Hogan & EM Ebly (2002) Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. Dementia and Geriatric Cognitive Disorders 13, 225–234.
JW Miller , R Green , DM Mungas , BR Reed & WJ Jagust (2002) Homocysteine, vitamin B6, and vascular disease in AD patients. Neurology 58, 1471–1475.
SJ Moat , JR Bonham , RA Cragg & HJ Powers (2000) Elevated plasma homocysteine elicits an increase in antioxidant enzyme activity. Free Radical Research 32, 171–179.
SJ Moat , MH Hill , IF McDowell , CH Pullin , PA Ashfield-Watt , ZE Clark , JM Whiting , RG Newcombe , MJ Lewis & HJ Powers (2003) Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage. European Journal of Clinical Nutrition 57, 483–489.
HK Nichols & TK Basu (1994) Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response. Journal of the American College of Nutrition 13, 57–61.
M Olivares , E Hertrampf , MT Capurro & D Wegner (2000) Prevalence of anemia in elderly subjects living at home: role of micronutrient deficiency and inflammation. European Journal of Clinical Nutrition 54, 834–839.
AJ Olszewski & KS McCully (1993) Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radical Biololgy and Medicine 14, 683–693.
G Raghuveer , CA Sinkey , C Chenard , P Stumbo & WG Haynes (2001) Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine. American Journal of Cardiology 88, 285–290.
K Robinson , K Arheart , H Refsum , L Brattstrom , G Boers , P Ueland , P Rubba , R Palma-Reis , R Meleady , L Daly , J Witteman & I Graham (1998) Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC group. Circulation 97, 437–443.
DG Savage , J Lindenbaum , SP Stabler & RH Allen (1994) Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. American Journal of Medicine 96, 239–246.
A Seekamp , DE Hultquist & GO Till (1999) Protection by vitamin B2 against oxidant–mediated acute lung injury. Inflammation 23, 449–460.
J Selhub , PF Jacques , PW Wilson , D Rush & IH Rosenberg (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Journal of the American Medical Association 270, 2693–2698.
ML Selley , DR Close & SE Stern (2002) The effect of increased concentrations of homocysteine on the concentration of (E)–4–hydroxy–2–nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiology of Aging 23, 383–388.
S Seshadri , A Beiser , J Selhub , PF Jacques , IH Rosenberg , RB D'Agostino , PW Wilson & PA Wolf (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer·s disease. New England Journal of Medicine 346, 476–483.
B Shannon , S Gnanasampanthan , J Beilby & B Iacopetta (2002) A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50, 520–524.
H Shimizu , Y Kiyohara , I Kato , Y Tanizaki , H Ueno , Y Kimura , H Iwamoto , M Kubo , H Arima , S Ibayashi & M Fujishima (2002) Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study. Cerebrovascular Diseases 13, 9–15.
LJ Smidt , FM Cremin , LE Grivetti & AJ Clifford (1991) Influence of thiamin supplementation on the health and general well–being of an elderly Irish population with marginal thiamin deficiency. Journal of Gerontology 46, M16–M22.
RZ Stolzenberg-Solomon , D Albanes , FJ Nieto , TJ Hartman , JA Tangrea , M Rautalahti , J Sehlub , J Virtamo & PR Taylor (1999) Pancreatic cancer risk and nutrition–related methyl–group availability indicators in male smokers. Journal of the National Cancer Institute 91, 535–541.
LJ Su & L Arab (2001) Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow–up study. Annals of Epidemiology 11, 65–72.
K Sydow , E Schwedhelm , N Arakawa , SM Bode-Boger , D Tsikas , B Hornig , JC Frolich & RH Boger (2003) ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovascular Research 57, 244–252.
JD Symons , AE Mullick , JL Ensunsa , AA Ma & JC Rutledge (2002) Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function. Arteriosclerosis, Thrombosis and Vascular Biology 22, 772–780.
H Tiemeier , HR van Tuijl , A Hofman , J Meijer , AJ Kiliaan & MM Breteler (2002) Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. American Journal of Psychiatry 159, 2099–2101.
H van den Berg , M van der Gaag & H Hendriks (2002) Influence of lifestyle on vitamin bioavailability. International Journal for Vitamin and Nutrition Research 72, 53–59.
P Ventura , R Panini , C Verlato , G Scarpetta & G Salvioli (2001) Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects. Metabolism 50, 1466–1471.
MC Verhaar , RM Wever , JJ Kastelein , T van Dam , HA Koomans & TJ Rabelink (1998) 5–methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97, 237–241.
DS Wald , M Law & JK Morris (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta–analysis. British Medical Journal 325, 1202.
TJ Wilkinson , HC Hanger , PM George & R Sainsbury (2000) Is thiamine deficiency in elderly people related to age or co–morbidity? Age and Ageing 29, 111–116.
KS Woo , P Chook , LL Chan , AS Cheung , WH Fung , M Qiao , YI Lolin , GN Thomas , JE Sanderson , C Metreweli & DS Celermajer (2002) Long–term improvement in homocysteine levels and arterial endothelial function after 1–year folic acid supplementation. American Journal of Medicine 112, 535–539.
SM Zhang , WC Willett , J Selhub , DJ Hunter , EL Giovannucci , MD Holmes , GA Colditz & SE Hankinson (2003) Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. Journal of the National Cancer Institute 95, 373–380.