This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
1N Papageorgiou , D Tousoulis , E Androulakis , et al. (2012) The role of microRNAs in cardiovascular disease. Curr Med Chem 19, 2605–2610.
2J Lorenzen , R Kumarswamy , S Dangwal , et al. (2012) MicroRNAs in diabetes and diabetes-associated complications. RNA Biol 9, 820–827.
(2006) MicroRNA signatures in human cancers. Nat Rev Cancer
4R Lee , R Feinbaum & V Ambros (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843–854.
7J Brennecke , A Stark , R Russell , et al. (2005) Principles of microRNA-target recognition. PLoS Biol 3, e85.
8R Friedman , K Farh , C Burge , et al. (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19, 92–105.
10H Wang , W Peng , X Ouyang , et al. (2012) Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus. Transl Res 160, 198–206.
12S Gilad , E Meiri , Y Yogev , et al. (2008) Serum microRNAs are promising novel biomarkers. PLoS ONE 3, e3148.
13D Bartel (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–297.
14V Patil , R Zhou & T Rana (2014) Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol 49, 16–32.
16E Davis , F Caiment , X Tordoir , et al. (2005) RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol 15, 743–749.
19L Wu , J Fan & J Belasco (2006) MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci U S A 103, 4034–4039.
20S Vasudevan , Y Tong & J Steitz (2007) Switching from repression to activation: microRNAs can up-regulate translation. Science 318, 1931–1934.
22R Place , L Li , D Pookot , et al. (2008) MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A 105, 1608–1613.
(2013) The evolving epigenome. Hum Mol Genet
25J Chuang & P Jones (2007) Epigenetics and microRNAs. Pediatr Res 61, 24R–29R.
26P Saetrom , OJ Snøve & J Rossi (2007) Epigenetics and microRNAs. Pediatr Res 61, 17R–23R.
31A Deaton & A Bird (2011) CpG islands and the regulation of transcription. Genes Dev 25, 1010–1022.
33J Costello , M Krzywinski & M Marra (2009) A first look at entire human methylomes. Nat Biotechnol 27, 1130–1132.
34B Christensen , E Houseman , C Marsit , et al. (2009) Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5, e1000602.
, et al. (2010) A microRNA targeting dicer for metastasis control. Cell
37A Lujambio , G Calin , A Villanueva , et al. (2008) A microRNA DNA methylation signature for human metastasis. Proc Natl Acad Sci U S A 105, 13556–13561.
38A Lujambio & M Esteller (2009) How epigenetics can explain human metastisis: a new role for microRNAs. Cell Cycle 8, 377–382.
39Y Saito , G Liang , G Egger , et al. (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin modifiying drugs in human cancer cells. Cancer Cell 9, 435–443.
42J Datta , H Kutay , M Nasser , et al. (2008) Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68, 5049–5058.
44M Nasser , J Datta , G Nuovo , et al. (2008) Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apotosis by miR-1. J Biol Chem 283, 33394–33405.
46T Wada , J Kikuchi & Y Furukawa (2012) Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8. EMBO Rep 13, 142–149.
49S Zhao , Y Wang , Y Liang , et al. (2011) MicroRNA-126 regulates DNA methylation in CD4+T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 63, 1376–1386.
50W Pan , S Zhu , M Yuan , et al. (2010) MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184, 6773–6781.
, et al. (2008) miR-148 targets human DNMR3b protein coding region. RNA Biol
53S Varambally , Q Cao , R Mani , et al. (2008) Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695–1699.
54J Friedman , G Liang , C Liu , et al. (2009) The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res 69, 2623–2629.
58J Sluijter , A van Mil , P van Vliet , et al. (2010) MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arterioscler Thromb Vasc Biol 30, 859–868.
59Y Zhao , J Ransom , A Li , et al. (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129, 303–317.
60J-F Chen , E Mandel , J Thomson , et al. (2006) The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 38, 228–233.
63R Buurman , E Gürlevik , V Schäffer , et al. (2012) Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology 143, 811–820e15.
64A Roccaro , A Sacco , X Jia , et al. (2010) MicroRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. Blood 116, 1506–1514.
65D Barker (1995) Fetal origins of coronary heart disease. BMJ 311, 171–174.
66D Barker (1995) Intrauterine programming of adult disease. Mol Med Today 1, 418–423.
69E Tobi , P Slagboom , J van Dongen , et al. (2012) Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19. PLOS ONE 7, e37933.
70L Lumey , M Terry , L Delgado-Cruzata , et al. (2012) Adult global DNA methylation in relation to pre-natal nutrition. Int J Epidemiol 41, 116–123.
71B Heijmans , E Tobi , A Stein , et al. (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 105, 17046–17049.
72M Fraga , E Ballestar , M Paz , et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102, 10604–10609.
73J Mill , E Dempster , A Caspi , et al. (2006) Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet 141B, 421–425.
75J Zhao , J Goldberg & V Vaccarino (2013) Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study. Int J Obes (Lond) 37, 140–145.
76C Roberts & R Barnard (2005) Effects of exercise and diet on chronic disease. J Appl Physiol 98, 3–30.
78S Teunissen , W Wesker , C Kruitwagen , et al. (2007) Symptom prevalance in patients with incurable cancer: a systematic review. J Pain Symptom Manage 34, 94–104.
82A Pittas , J Lau , F Hu , et al. (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92, 2017–2029.
83T Wang , M Pencina , S Booth , et al. (2008) Vitamin D deficiency and risk of cardiovascular disease. Circulation 117, 503–511.
84L Adorini (2008) Penna G Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4, 404–412.
86S Lamprecht & M Lipkin (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 3, 601–614.
87C Carlberg (2003) Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands. Recent Results Cancer Res 164, 29–42.
88E Sonkoly , J Lovén , N Xu , et al. (2012) MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis 1, e3.
92S Alvarez-Díaz , N Valle , G Ferrer-Mayorga , et al. (2012) MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Hum Mol Genet 21, 2157–2165.
94J Zhang , Y Yang , T Yang , et al. (2010) MicroRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 103, 1215–1220.
96S Padi , Q Zhang , Y Rustum , et al. (2013) MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. Gastroenterology 145, 437–446.
99X Wang , E Gocek , C Liu , et al. (2009) MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle 8, 736–741.
100X Peng , A Vaishnav , G Murillo , et al. (2010) Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells. J Cell Biochem 110, 1324–1333.
, et al. (2010) Cellular stress responses: cell survival and cell death. Int J Cell Biol
102Y Jia , R Cong , R Li , et al. (2012) Maternal low-protein diet induces gender-dependent changes in epigenetic regulation of the glucose-6-phosphatase gene in newborn piglet liver. J Nutr 142, 1659–1665.
, et al. (2011) Global maternal early pregnancy peripheral blood mRNA and miRNA expression profiles according to plasma 25-hydroxyvitamin D concentrations. J Matern Fetal Neonatal Med
106M Lucock (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71, 121–138.
108Y Lianga , Y Lib , Z Liub , et al. (2012) Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2. Int J Biochem Cell Biol 44, 1750–1760.
110V Tryndyak , S Ross , F Beland , et al. (2009) Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog 48, 479–487.
, et al. (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res
112H Kutay , S Bai , et al. (2006) Datta J,./i} Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 99, 671–678.
, et al. (2008) Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats. Nutr Rev
66, Suppl. 1, S33–S35.
114B Wang , S Majumder , G Nuovo , et al. (2009) Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL6 mice. Hepatology 50, 1152–1161.
115G Duester (2008) Retinoic acid synthesis and signaling during early organogenesis. Cell 134, 921–931.
117D Annibali , U Gioia , M Savino , et al. (2012) A new module in neural differentiation control: two microRNAs upregulated by retinoic acid, miR-9 and -103, target the differentiation inhibitor ID2. PLOS ONE 7, e40269.
118S Das , N Foley , K Bryan , et al. (2010) MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation. Cancer Res 70, 7874–7881.
119N Beveridge , P Tooney , A Carroll , et al. (2009) Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation. Cell Signal 21, 1837–1845.
120J Zhao , D Sun , J Wang , et al. (2008) Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model. Childs Nerv Syst 24, 495–492.
122F Yang , Y Yin , F Wang , et al. (2010) miR-17-5p promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology 51, 1614–1623.
123X Wang , JN Gong , J Yu , et al. (2012) MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood 119, 4992–5004.
124P Jian , Z Li , T Fang , et al. (2011) Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. J Hematol Oncol 4, 20.
125R Garzon , F Pichiorri , T Palumbo , et al. (2007) MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 26, 4148–4157.
126A Rossi , O D'Urso , G Gatto , et al. (2010) Non-coding RNAs change their expression profile after retinoid induced differentiation of the promyelocytic cell line NB4. BMC Res Notes 3, 24.
127S Juraschek , E Guallar , L Appel , et al. (2012) Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr 95, 1079–1088.
128L Da Costa , A Badawi & A El-Sohemy (2012) Nutrigenetics and modulation of oxidative stress. Ann Nutr Metab 60, Suppl. 3, 27–36.
132K Woodson , J Tangrea , M Barrett , et al. (1999) Serum α-tocopherol and subsequent risk of lung cancer among male smokers. J Natl Cancer Inst 91, 1738–1743.
133H Huang , A Alberg , E Norkus , et al. (2003) Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol 157, 335–344.
135M Longnecker , J Martin-Moreno , P Knekt , et al. (1992) Serum α-tocopherol concentration in relation to subsequent colorectal cancer: pooled data from five cohorts. J Natl Cancer Inst 84, 430–435.
138M Ocké , H Bueno-de-Mesquita , E Feskens , et al. (1997) Repeated measurements of vegetables, fruits, β-carotene, and vitamins C and E in relation to lung cancer. The Zutphen Study. Am J Epidemiol 145, 358–365.
141E Miller , R Pastor-Barriuso , D Dalal , et al. (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142, 37–46.
, et al. (2010) Gene-regulatory activity of α-tocopherol. Molecules
144J Elmén , M Lindow , A Silahtaroglu , et al. (2008) Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 36, 1153–1162.
(2012) Selenium and human health. Lancet
146M Rayman , G Blundell-Pound , R Pastor-Barriuso , et al. (2012) A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PLOS ONE 7, e45269.
148M Laclaustra , A Navas-Acien , S Stranges , et al. (2009) Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environ Health Perspect 117, 1409–1413.
154I Barr , A Smith , Y Chen , et al. (2012) Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A 109, 1919–1924.
155Z Ma , Z Xue , H Zhang , et al. (2012) Local and global effects of Mg2+ on Ago and miRNA-target interactions. J Mol Model 18, 3769–3781.
156L Zhang , D Hou , X Chen , et al. (2012) Exogenous plant miR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 22, 107–126.
157P Newmark , P Reddien , F Cebrià , et al. (2003) Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A 100, Suppl. 1, 11861–11865.
158O Terenius , A Papanicolaou , J Garbutt , et al. (2011) RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol 57, 231–245.
(2012) Biological chemistry of virus-encoded suppressors of RNA silencing: an overview. Methods Mol Biol
160Q Zhou , M Li , X Wang , et al. (2012) Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci 8, 118–123.
161H Izumi , N Kosaka , T Shimizu , et al. (2012) Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci 95, 4831–4841.
162N Kosaka , H Izumi , K Sekine , et al. (2010) MicroRNA as a new immune-regulatory agent in breast milk. Silence 1, 7.
, et al. (2013) Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol
166Y Zhang , B Wiggins , C Lawrence , et al. (2012) Analysis of plant-derived miRNAs in animal small RNA datasets. BMC Genomics 13, 381.
167J Petrick , B Brower-Toland , A Jackson , et al. (2013) Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: a scientific review. Regul Toxicol Pharmacol 66, 167–186.