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Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation

  • Michelle L. Sleeth (a1), Emily L. Thompson (a1), Heather E. Ford (a1), Sagen E. K. Zac-Varghese (a1) and Gary Frost (a1)...
Abstract

The way in which the composition of the diet may affect appetite, food intake and body weight is now receiving considerable attention in a bid to halt the global year-on-year rise in obesity prevalence. Epidemiological evidence suggests that populations who follow a fibre-rich, traditional diet are likely to have a lower body weight and improved metabolic parameters than their Western-diet counterparts. The colonic effects of fibre, and more specifically the SCFA that the fermentation process produces, may play a role in maintaining energy homeostasis via their action on the G-coupled protein receptor free fatty acid receptor 2 (FFA2; formerly GPR43). In the present review, we summarise the evidence for and against the role of FFA2 in energy homeostasis circuits and the possible ways that these could be exploited therapeutically. We also propose that the decline in fibre content of the diet since the Industrial Revolution, particularly fermentable fractions, may have resulted in the FFA2-mediated circuits being under-utilised and hence play a role in the current obesity epidemic.

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Corresponding author
*Corresponding author: Professor G. Frost, fax +44 20 8383 8320, email g.frost@imperial.ac.uk
References
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1WHO Consultation on Obesity (2000) Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation. World Health Organization Technical Report Series no. 894. Geneva: WHO.
2Joint Health Surveys Unit (2008) Health Survey for England 2006. Cardiovascular Disease and Risk Factors. Leeds: The Information Centre.
3McPherson, K, Marsh, T & Brown, M (2008) Foresight. Tackling Obesities: Future Choices – Modelling Future Trends in Obesity and the Impact on Health, 2nd ed.London: Government Office for Science.
4Must, A, Spadano, J, Coakley, EH, et al. . (1999) The disease burden associated with overweight and obesity. JAMA 282, 15231529.
5Butland, B, Jebb, S, Kopelman, P, et al. . (2008) Foresight. Tackling Obesities: Future Choices – Project Report. http://www.foresight.gov.uk/Obesity/17.pdf.
6Dansinger, ML, Tatsioni, A, Wong, JB, et al. . (2007) Meta-analysis: the effect of dietary counseling for weight loss. Ann Intern Med 147, 4150.
7Wing, RR & Phelan, S (2005) Long-term weight loss maintenance. Am J Clin Nutr 82, 222S225S.
8Field, AE, Wing, RR, Manson, JE, et al. . (2001) Relationship of a large weight loss to long-term weight change among young and middle-aged US women. Int J Obes Relat Metab Disord 25, 11131121.
9Sarlio-Lahteenkorva, S, Rissanen, A & Kaprio, J (2000) A descriptive study of weight loss maintenance: 6 and 15 year follow-up of initially overweight adults. Int J Obes Relat Metab Disord 24, 116125.
10Stalonas, PM, Perri, MG & Kerzner, AB (1984) Do behavioral treatments of obesity last? A five-year follow-up investigation. Addict Behav 9, 175183.
11Wadden, TA, Sternberg, JA, Letizia, KA, et al. . (1989) Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective. Int J Obes 13, Suppl. 2, 3946.
12Rucker, D, Padwal, R, Li, SK, et al. . (2007) Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 335, 11941199.
13Sjostrom, L, Lindroos, AK, Peltonen, M, et al. . (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351, 26832893.
14Eaton, SB (1990) Fibre intakes in prehistoric times. In Dietary Fibre Perspectives, pp. 2740 [Leeds, AR, editor]. London: John Libbey.
15Institute of Medicine (2005) Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: The National Academies Press.
16Eaton, SB (2006) The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition? Proc Nutr Soc 65, 16.
17Eaton, SB & Konner, M (1985) Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 312, 283289.
18World Health Organization (2003) Diet, Nutrition and the Prevention of Chronic Diseases. Joint WHO/FAO Expert Consultation. WHO Technical Report Series no. 916. Geneva: WHO.
19Appleby, PN, Thorogood, M, Mann, JI, et al. . (1998) Low body mass index in non-meat eaters: the possible roles of animal fat, dietary fibre and alcohol. Int J Obes 22, 454460.
20Ludwig, DS, Pereira, MA, Kroenke, CH, et al. . (1999) Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA 282, 15391546.
21Maskarinec, G, Takata, Y, Pagano, I, et al. . (2006) Trends and dietary determinants of overweight and obesity in a multiethnic population. Obesity (Silver Spring) 14, 717726.
22Nelson, LH & Tucker, LA (1996) Diet composition related to body fat in a multivariate study of 203 men. J Am Diet Assoc 96, 771777.
23Kromhout, D, Bloemberg, B, Seidell, JC, et al. . (2001) Physical activity and dietary fiber determine population body fat levels: the Seven Countries Study. Int J Obes 25, 301306.
24Ryttig, KR, Tellnes, G, Haegh, L, et al. . (1989) A dietary fibre supplement and weight maintenance after weight reduction: a randomized, double-blind, placebo-controlled long-term trial. Int J Obes 13, 165171.
25Rigaud, D, Ryttig, KR, Angel, LA, et al. . (1990) Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial. Int J Obes 14, 763769.
26Tucker, LA & Thomas, KS (2009) Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr 139, 576581.
27Haber, GB, Heaton, KW, Murphy, D, et al. . (1977) Depletion and disruption of dietary fibre: effects on satiety, plasma-glucose, and serum-insulin. Lancet 310, 679682.
28Liu, S, Willett, WC, Manson, JE, et al. . (2003) Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr 78, 920927.
29Howarth, NC, Saltzman, E, McCrory, MA, et al. . (2003) Fermentable and nonfermentable fiber supplements did not alter hunger, satiety or body weight in a pilot study of men and women consuming self-selected diets. J Nutr 133, 31413144.
30Howarth, N (2001) Dietary fiber and weight regulation. Nutr Rev 59, 129139.
31Heaton, KW (1973) Food fibre as an obstacle to energy intake. Lancet ii, 14181421.
32Slavin, JL (2005) Dietary fiber and body weight. Nutrition 21, 411418.
33Roy, HJ, Keenan, MJ, Zablah-Pimentel, E, et al. . (2003) Adult female rats defend appropriate energy intake after adaptation to dietary energy. Obes Res 11, 12141222.
34Keenan, MJ, Zhou, J, McCutcheon, KL, et al. . (2006) Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat. Obesity (Silver Spring) 14, 15231534.
35Cani, PD, Neyrinck, AM, Maton, N, et al. . (2005) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13, 10001007.
36Perrigue, MM, Monsivais, P & Drewnowski, A (2009) Added soluble fiber enhances the satiating power of low-energy-density liquid yogurts. J Am Diet Assoc 109, 18621868.
37Hamer, HM, Jonkers, D, Venema, K, et al. . (2008) Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27, 104119.
38Macfarlane, S & Macfarlane, GT (2003) Regulation of short-chain fatty acid production. Proc Nutr Soc 62, 6772.
39Ballard, FJ (1972) Supply and utilization of acetate in mammals. Am J Clin Nutr 25, 773779.
40Pouteau, E, Nguyen, P, Ballevre, O, et al. . (2003) Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes. Proc Nutr Soc 62, 8793.
41Cummings, JH, Pomare, EW, Branch, WJ, et al. . (1987) Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 12211227.
42Roediger, WE (1980) Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21, 793798.
43Hong, YH, Nishimura, Y, Hishikawa, D, et al. . (2005) Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 146, 50925099.
44Siler, SQ, Neese, RA & Hellerstein, MK (1999) De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am J Clin Nutr 70, 928936.
45Topping, DL & Clifton, PM (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81, 10311064.
46Roediger, WE (1982) Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83, 424429.
47Wolever, TM, Spadafora, P & Eshuis, H (1991) Interaction between colonic acetate and propionate in humans. Am J Clin Nutr 53, 681687.
48Wolever, TM (1995) Short-chain fatty acids and carbohydrate metabolism. In Physiological and Clinical Aspects of Short-Chain Fatty Acids, 1st ed., pp. 483493 [Cummings, JH and Rombeau, JL, editors]. Cambridge: Cambridge University Press.
49Topping, DL & Pant, I (1995) Short-chain fatty acids and hepatic lipid metabolism: experimental studies. In Physiological and Clinical Aspects of Short-Fatty Acids, 1st ed., pp. 495507 [Cummings, JH, Rombeau, JL and Sakata, T, editors]. Cambridge: Cambridge University Press.
50Kvietys, PR & Granger, DN (1981) Effect of volatile fatty acids on blood flow and oxygen uptake by the dog colon. Gastroenterology 80, 962969.
51Binder, HJ & Mehta, P (1989) Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 96, 989996.
52Yajima, T (1984) Effect of sodium propionate on the contractile response of the rat ileum in situ. Jpn J Pharmacol 35, 265271.
53Brown, AJ, Goldsworthy, SM, Barnes, AA, et al. . (2003) The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278, 1131211319.
54Le Poul, E, Loison, C, Struyf, S, et al. . (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278, 2548125489.
55Nilsson, NE, Kotarsky, K, Owman, C, et al. . (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Comm 303, 10471052.
56Karaki, SS, Mitsui, R, Hayashi, H, et al. . (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324, 353360.
57Dass, NB, John, AK, Bassil, AK, et al. . (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 19, 6674.
58Karaki, Si, Tazoe, H, Hayashi, H, et al. . (2008) Expression of the short-chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 39, 135142.
59Regard, JB, Sato, IT & Coughlin, SR (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135, 561571.
60Greeley, GH Jr, Jeng, YJ, Gomez, G, et al. . (1989) Evidence for regulation of peptide-YY release by the proximal gut. Endocrinology 124, 14381443.
61Adrian, TE, Ferri, GL, Bacarese-Hamilton, AJ, et al. . (1985) Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89, 10701077.
62Pedersen-Bjergaard, U, Host, U, Kelbaek, H, et al. . (1996) Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man. Scand J Clin Lab Invest 56, 497503.
63Broome, M, Hokfelt, T & Terenius, L (1985) Peptide YY (PYY)-immunoreactive neurons in the lower brain stem and spinal cord of rat. Acta Physiol Scand 125, 349352.
64Broberger, C, Landry, M, Wong, H, et al. . (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66, 393408.
65Batterham, RL, Cowley, MA, Small, CJ, et al. . (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418, 650654.
66Chelikani, PK, Haver, AC & Reidelberger, RD (2005) Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats. Endocrinology 146, 879888.
67Koda, S, Date, Y, Murakami, N, et al. . (2005) The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146, 23692375.
68Delzenne, NM, Cani, PD, Daubioul, C, et al. . (2005) Impact of inulin and oligofructose on gastrointestinal peptides. Br J Nutr 93, Suppl. 1, S157S161.
69Zhou, J, Martin, RJ, Tulley, RT, et al. . (2008) Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab 295, E1160E1166.
70Greenway, F, O'Neil, CE, Stewart, L, et al. . (2007) Fourteen weeks of treatment with Viscofiber increased fasting levels of glucagon-like peptide-1 and peptide-YY. J Med Food 10, 720724.
71Longo, WE, Ballantyne, GH, Savoca, PE, et al. . (1991) Short-chain fatty-acid release of peptide-YY in the isolated rabbit distal colon. Scand J Gastroenterol 26, 442448.
72Cherbut, C, Ferrier, L, Roze, C, et al. . (1998) Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am J Physiol 275, G1415G1422.
73Gee, JM & Johnson, IT (2005) Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans. Nutrition 21, 10361043.
74Kim, BJ, Carlson, OD, Jang, HJ, et al. . (2005) Peptide YY is secreted after oral glucose administration in a gender-specific manner. J Clin Endocrinol Metab 90, 66656671.
75Elliott, RM, Morgan, LM, Tredger, JA, et al. . (1993) Glucagon-like peptide-1 (7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol 138, 159166.
76Turton, MD, O'Shea, D, Gunn, I, et al. . (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 6972.
77Davis, HR Jr, Mullins, DE, Pines, JM, et al. . (1998) Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats. Obes Res 6, 147156.
78Verdich, C, Flint, A, Gutzwiller, JP, et al. . (2001) A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab 86, 43824389.
79Bullock, BP, Heller, RS & Habener, JF (1996) Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137, 29682978.
80Shimizu, I, Hirota, M, Ohboshi, C, et al. . (1987) Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 121, 10761082.
81Goke, R, Larsen, PJ, Mikkelsen, JD, et al. . (1995) Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 7, 22942300.
82Abbott, CR, Monteiro, M, Small, CJ, et al. . (2005) The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway. Brain Res 1044, 127131.
83Cohen, MA, Ellis, SM, Le Roux, CW, et al. . (2003) Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 88, 46964701.
84Dakin, CL, Small, CJ, Batterham, RL, et al. . (2004) Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 145, 26872695.
85Baggio, LL, Huang, Q, Brown, TJ, et al. . (2004) Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 127, 546558.
86Schjoldager, BT, Baldissera, FG, Mortensen, PE, et al. . (1988) Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. Eur J Clin Invest 18, 499503.
87Delmee, E, Cani, PD, Gual, G, et al. . (2006) Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice. Life Sci 79, 10071013.
88Cani, PD, Dewever, C & Delzenne, NM (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521526.
89Massimino, SP, McBurney, MI, Field, CJ, et al. . (1998) Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr 128, 17861793.
90Zhou, J, Hegsted, M, McCutcheon, KL, et al. . (2006) Peptide YY and proglucagon mRNA expression patterns and regulation in the gut. Obesity (Silver Spring) 14, 683689.
91Piche, T, des Varannes, SB, Sacher-Huvelin, S, et al. . (2003) Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology 124, 894902.
92Robertson, MD, Bickerton, AS, Dennis, AL, et al. . (2005) Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 82, 559567.
93Frost, G, Brynes, A & Leeds, A (1999) Effect of large bowel fermentation on insulin, glucose, free fatty acids, and glucagon-like peptide 1 (7-36) amide in patients with coronary heart disease. Nutrition 15, 183188.
94May, T, Mackie, RI, Fahey, GC Jr, et al. . (1994) Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile. Scand J Gastroenterol 29, 916922.
95Shen, L, Keenan, MJ, Martin, RJ, et al. . (2009) Dietary resistant starch increases hypothalamic POMC expression in rats. Obesity (Silver Spring) 17, 4045.
96Oldendorf, WH (1973) Carrier-mediated blood–brain barrier transport of short-chain monocarboxylic organic acids. Am J Physiol 224, 14501453.
97Cordain, L, Eaton, SB, Sebastian, A, et al. . (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81, 341354.
98Van Citters, GW & Lin, HC (1999) The ileal brake: a fifteen-year progress report. Curr Gastroenterol Rep 1, 404409.
99Kendall, PE & McLeay, LM (1996) Excitatory effects of volatile fatty acids on the in vitro motility of the rumen of sheep. Res Vet Sci 61, 16.
100Bergman, EN (1990) Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 70, 567590.
101Tazoe, H, Otomo, Y, Kaji, I, et al. . (2008) Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 59, Suppl. 2, 251262.
102Cherbut, C (1995) Effects of short-chain fatty acids on gastrointestinal motility. In Physiological and Clinical Aspects of Short-Chain Fatty Acids, 1st ed., pp. 191207 [Cummings, JH, Rombeau, JL and Sakata, T, editors]. Cambridge: Cambridge University Press.
103Berger, M, Gray, JA & Roth, BL (2009) The expanded biology of serotonin. Ann Rev Med 60, 355.
104Kim, DY & Camilleri, M (2000) Serotonin: a mediator of the brain–gut connection. Am J Gastroenterol 95, 26982709.
105Zhu, JX, Wu, XY, Owyang, C, et al. . (2001) Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol 530, 431442.
106Martin, DC, Magnant, AD & Kellum, JM Jr (1989) Luminal hypertonic solutions stimulate concentration-dependent duodenal serotonin release. Surgery 106, 325331.
107Fukumoto, S, Tatewaki, M, Yamada, T, et al. . (2003) Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 284, R1269R1276.
108Grundy, SM, Brewer, HB Jr, Cleeman, JI, et al. . (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 24, e13e18.
109Tilg, H & Moschen, AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772783.
110Goossens, GH (2008) The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 94, 206218.
111Robertson, M (2007) Metabolic cross talk between the colon and the periphery: implications for insulin sensitivity. Proc Nutr Soc 66, 351361.
112Frayn, KN (2003) Integration of fat, carbohydrate and protein metabolism in the whole body. In Metabolic Regulation: a Human Perspective, pp. 151191 [Frayn, KN, editor]. Oxford: Blackwell Science.
113Ge, H, Li, X, Weiszmann, J, et al. . (2008) Activation of GPR43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 149, 45194526.
114Chandalia, M, Garg, A, Lutjohann, D, et al. . (2000) Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 342, 13921398.
115Leonard, JN & Hakak, Y (2006) (WO/2006/036688) GPR43 and modulators thereof for the treatment of metabolic-related disorders. http://www.wipo.int/pctdb/en/wo.jsp?wo = 2006036688.
116Stoddart, LA, Smith, NJ & Milligan, G (2008) International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev 60, 405417.
117Tazoe, H, Otomo, Y, Karaki, S, et al. . (2009) Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 30, 149156.
118Samuel, BS, Shaito, A, Motoike, T, et al. . (2008) Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 105, 1676716772.
119Xiong, Y, Miyamoto, N, Shibata, K, et al. . (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A 101, 10451050.
120Maffei, M, Halaas, J, Ravussin, E, et al. . (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1, 11551161.
121Lee, T, Schwandner, R, Swaminath, G, et al. . (2008) Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2. Mol Pharmacol 74, 15991609.
122Le Blay, G, Michel, C, Blottière, HM, et al. . (1999) Enhancement of butyrate production in the rat caecocolonic tract by long-term ingestion of resistant potato starch. Br J Nutr 82, 419426.
123Pomare, EW, Branch, WJ & Cummings, JH (1985) Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J Clin Invest 75, 14481454.
124Wolever, TMS, Josse, RG, Leiter, LA, et al. . (1997) Time of day and glucose tolerance status affect serum short-chain fatty concentrations in humans. Metabolism 46, 805811.
125Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. . (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 10271031.
126Samuel, BS & Gordon, JI (2006) A humanized gnotobiotic mouse model of host–archaeal–bacterial mutualism. Proc Natl Acad Sci U S A 103, 1001110016.
127Turnbaugh, PJ, Hamady, M, Yatsunenko, T, et al. . (2009) A core gut microbiome in obese and lean twins. Nature 457, 480484.
128Davidson, MH & Maki, KC (1999) Effects of dietary inulin on serum lipids. J Nutr 129, 1474.
129Hsia, YE, Scully, KJ & Rosenberg, LE (1971) Inherited propionyl-CoA carboxylase deficiency in ‘ketotic hyperglycinemia’. J Clin Invest 50, 127130.
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