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Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case

  • Carole Mast (a1), Dominique Dardevet (a1) and Isabelle Papet (a1)
Abstract

The optimisation of nutritional support for the growing number of older individuals does not usually take into account medication. Paracetamol (acetaminophen; APAP) is the first intention treatment of chronic pain that is highly prevalent and persistent in the elderly. Detoxification of APAP occurs in the liver and utilises sulfate and glutathione (GSH), both of which are issued from cysteine (Cys), a conditionally indispensable amino acid. The detoxification-induced siphoning of Cys could reduce the availability of Cys for skeletal muscle. Consequently, APAP could worsen sarcopenia, an important component of the frailty syndrome leading to dependency. The present review provides the rationale for the potential pro-sarcopenic effect of APAP then recent results concerning the effect of chronic APAP treatment on muscle mass and metabolism are discussed. The principal findings are that chronic treatments with doses of APAP comparable with the maximum posology for humans can increase the requirement for sulfur amino acids (SAA), reduce Cys availability for muscle, reduce muscle protein synthesis and aggravate sarcopenia in animals. One clinical study is in favour of an enhanced SAA requirement in the older individual under chronic treatment with APAP. Few clinical studies investigated the effect of chronic treatment with APAP combined with exercise, in nutritional conditions that probably did not affect Cys and GSH homeostasis. Whether APAP can aggravate sarcopenia in older individuals with low protein intake remains to be tested. If true, nutritional strategies based on enhancing Cys supply could be of prime interest to cut down the pro-sarcopenic effect of chronic treatment with APAP.

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Corresponding author
* Corresponding author: Isabelle Papet, fax +33 4 73 62 47 55, email Isabelle.Papet@clermont.inra.fr
References
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1. Bonnefoy, M, Berrut, G, Lesourd, B, et al. (2015) Frailty and nutrition: searching for evidence. J Nutr Health Aging 19, 250257.
2. Clegg, A, Young, J, Iliffe, S, et al. (2013) Frailty in elderly people. Lancet 381, 752762.
3. Jyrkka, J, Enlund, H, Lavikainen, P, et al. (2011) Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population. Pharmacoepidemiol Drug Saf 20, 514522.
4. Maher, RL, Hanlon, J & Hajjar, ER (2014) Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 13, 5765.
5. Jyrkka, J, Mursu, J, Enlund, H, et al. (2012) Polypharmacy and nutritional status in elderly people. Curr Opin Clin Nutr Metab Care 15, 16.
6. Bailly, N, Maitre, I & Van Wymelbeke, V (2015) Relationships between nutritional status, depression and pleasure of eating in aging men and women. Arch Gerontol Geriatr 61, 330336.
7. Wysokiński, A, Sobów, T, Kłoszewska, I, et al. (2015) Mechanisms of the anorexia of aging – a review. Age (Dordr) 37, 81.
8. Schiffman, SS & Zervakis, J (2002) Taste and smell perception in the elderly: effect of medications and disease. Adv Food Nutr Res 44, 247346.
9. Genser, D (2008) Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 52, 2932.
10. Airaksinen, O, Brox, JI, Cedraschi, C, et al. (2006) Chapter 4. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J 15, S192S300.
11. Nalamachu, S (2013) An overview of pain management: the clinical efficacy and value of treatment. Am J Manag Care 19, s261s266.
12. Makris, UE, Abrams, RC, Gurland, B, et al. (2014) Management of persistent pain in the older patient: a clinical review. JAMA 312, 825836.
13. Jaeschke, H (2015) Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients. Dig Dis 33, 464471.
14. Chen, YG, Lin, CL, Dai, MS, et al. (2015) Risk of acute kidney injury and long-term outcome in patients with acetaminophen intoxication: a nationwide population-based retrospective cohort study. Medicine (Baltimore) 94, e2040.
15. Roberts, E, Delgado Nunes, V, Buckner, S, et al. (2016) Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis 75, 552559.
16. Forrest, JAH, Clements, JA & Prescott, LF (1982) Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet 7, 93107.
17. Hodgman, MJ & Garrard, AR (2012) A review of acetaminophen poisoning. Crit Care Clin 28, 499516.
18. Obled, C, Papet, I & Breuillé, D (2002) Metabolic bases of amino acid requirements in acute diseases. Curr Opin Clin Nutr Metab Care 5, 189197.
19. Dröge, W (2005) Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci 360, 23552372.
20. Jones, DP (2006) Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res 9, 169181.
21. Ballatori, N, Krance, SM, Notenboom, S, et al. (2009) Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 390, 191214.
22. Meng, SJ & Yu, LJ (2010) Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 11, 15091526.
23. Rosenberg, IH (1989) Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50, 12311233.
24. Cruz-Jentoft, AJ, Baeyens, JP, Bauer, JM, et al. (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39, 412423.
25. Morley, JE, Abbatecola, AM, Argiles, JM, et al. (2011) Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12, 403409.
26. Muscaritoli, M, Anker, SD, Argiles, J, et al. (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia–anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 29, 154159.
27. Fielding, RA, Vellas, B, Evans, WJ, et al. (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc 12, 249256.
28. Fearon, K, Evans, WJ & Anker, SD (2011) Myopenia – a new universal term for muscle wasting. J Cachexia Sarcopenia Muscle 2, 13.
29. United Nations, Department of Economic and Social Affairs, Population Division (2015) World Population Ageing 2015 (ST/ESA/SER.A/390). New York: United Nations.
30. Janssen, I (2011) The epidemiology of sarcopenia. Clin Geriatr Med 27, 355363.
31. Janssen, I, Shepard, DS, Katzmarzyk, PT, et al. (2004) The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 52, 8085.
32. Cooper, C, Dere, W, Evans, W, et al. (2012) Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int 23, 18391848.
33. Cesari, M, Landi, F, Vellas, B, et al. (2014) Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci 6, 192.
34. Walrand, S, Guillet, C, Salles, J, et al. (2011) Physiopathological mechanism of sarcopenia. Clin Geriatr Med 27, 365385.
35. Landi, F, Calvani, R, Tosato, M, et al. (2016) Anorexia of aging: risk factors, consequences, and potential treatments. Nutrients 8, 69.
36. Calvani, R, Miccheli, A, Landi, F, et al. (2013) Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging 2, 3853.
37. Katsanos, CS, Kobayashi, H, Sheffield-Moore, M, et al. (2005) Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82, 10651073.
38. Anthony, JC, Yoshizawa, F, Anthony, TG, et al. (2000) Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130, 24132419.
39. Anthony, JC, Anthony, TG, Kimball, SR, et al. (2001) Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr 131, 856s860s.
40. Dardevet, D, Sornet, C, Balage, M, et al. (2000) Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. J Nutr 130, 26302635.
41. Dardevet, D, Sornet, C, Bayle, G, et al. (2002) Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal. J Nutr 132, 95100.
42. Greiwe, JS, Kwon, G, McDaniel, ML, et al. (2001) Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. Am J Physiol Endocrinol Metab 281, E466E471.
43. Rieu, I, Sornet, C, Bayle, G, et al. (2003) Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats. J Nutr 133, 11981205.
44. Rieu, I, Balage, M, Sornet, C, et al. (2006) Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575, 305315.
45. Rieu, I, Balage, M, Sornet, C, et al. (2007) Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats. Nutrition 23, 323331.
46. Nakashima, K, Ishida, A, Yamazaki, M, et al. (2005) Leucine suppresses myofibrillar proteolysis by down-regulating ubiquitin–proteasome pathway in chick skeletal muscles. Biochem Biophys Res Commun 336, 660666.
47. Combaret, L, Dardevet, D, Rieu, I, et al. (2005) A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle. J Physiol 569, 489499.
48. Dardevet, D, Rieu, I, Fafournoux, P, et al. (2003) Leucine: a key amino acid in ageing-associated sarcopenia? Nutr Res Rev 16, 6170.
49. Dardevet, D, Remond, D, Peyron, MA, et al. (2012) Muscle wasting and resistance of muscle anabolism: the “anabolic threshold concept” for adapted nutritional strategies during sarcopenia. ScientificWorldJournal 2012, 269531.
50. Paddon-Jones, D, Sheffield-Moore, M, Katsanos, CS, et al. (2006) Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 41, 215219.
51. Morais, JA, Chevalier, S & Gougeon, R (2006) Protein turnover and requirements in the healthy and frail elderly. J Nutr Health Aging 10, 272283.
52. Wolfe, RR, Miller, SL & Miller, KB (2008) Optimal protein intake in the elderly. Clin Nutr 27, 675684.
53. Gaffney-Stomberg, E, Insogna, KL, Rodriguez, NR, et al. (2009) Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc 57, 10731079.
54. Morley, JE, Argiles, JM, Evans, WJ, et al. (2010) Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 11, 391396.
55. Bauer, J, Biolo, G, Cederholm, T, et al. (2013) Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 14, 542559.
56. Deutz, NE, Bauer, JM, Barazzoni, R, et al. (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr 33, 929936.
57. Wolfe, RR (2012) The role of dietary protein in optimizing muscle mass, function and health outcomes in older individuals. Br J Nutr 108, S88S93.
58. Volpi, E, Campbell, WW, Dwyer, JT, et al. (2013) Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J Gerontol A Biol Sci Med Sci 68, 677681.
59. Arnal, MA, Mosoni, L, Boirie, Y, et al. (1999) Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr 69, 12021208.
60. Arnal, MA, Mosoni, L, Dardevet, D, et al. (2002) Pulse protein feeding pattern restores stimulation of muscle protein synthesis during the feeding period in old rats. J Nutr 132, 10021008.
61. Bouillanne, O, Curis, E, Hamon-Vilcot, B, et al. (2013) Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial. Clin Nutr 32, 186192.
62. Paddon-Jones, D & Leidy, H (2014) Dietary protein and muscle in older persons. Curr Opin Clin Nutr Metab Care 17, 511.
63. Mamerow, MM, Mettler, JA, English, KL, et al. (2014) Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr 144, 876880.
64. Deer, RR & Volpi, E (2015) Protein intake and muscle function in older adults. Curr Opin Clin Nutr Metab Care 18, 248253.
65. Boirie, Y (2013) Fighting sarcopenia in older frail subjects: protein fuel for strength, exercise for mass. J Am Med Dir Assoc 14, 140143.
66. Mosoni, L & Patureau Mirand, P (2003) Type and timing of protein feeding to optimize anabolism. Curr Opin Clin Nutr Metab Care 6, 301306.
67. Dangin, M, Boirie, Y, Garcia-Rodenas, C, et al. (2001) The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrinol Metab 280, E340E348.
68. Dangin, M, Guillet, C, Garcia-Rodenas, C, et al. (2003) The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 549, 635644.
69. Pennings, B, Boirie, Y, Senden, JM, et al. (2011) Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 93, 9971005.
70. Boirie, Y, Gachon, P & Beaufrere, B (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 65, 489495.
71. Volpi, E, Mittendorfer, B, Wolf, SE, et al. (1999) Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 277, E513E520.
72. Bertin, P, Keddad, K & Jolivet-Landreau, I (2004) Acetaminophen as symptomatic treatment of pain from osteoarthritis. Joint Bone Spine 71, 266274.
73. Cavalieri, TA (2005) Management of pain in older adults. J Am Osteopath Assoc 105, S12S17.
74. Perrot, S (2006) Management strategies for the treatment of non malignant chronic pain in the elderly. Psychol Neuropsychiatr Vieil 4, 163170.
75. Fine, PG (2012) Treatment guidelines for the pharmacological management of pain in older persons. Pain Med 13, S57S66.
76. Klotz, U (2012) Paracetamol (acetaminophen) – a popular and widely used nonopioid analgesic. Arzneimittelforschung 62, 355359.
77. Abdulla, A, Adams, N, Bone, M, et al. (2013) Guidance on the management of pain in older people. Age Ageing 42, I1I57.
78. Ferrell, B, Argoff, CE, Epplin, J, et al. (2009) Pharmacological management of persistent pain in older persons. Pain Med 10, 10621083.
79. Won, AB, Lapane, KL, Vallow, S, et al. (2004) Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents. J Am Geriatr Soc 52, 867874.
80. Maxwell, CJ, Dalby, DM, Slater, M, et al. (2008) The prevalence and management of current daily pain among older home care clients. Pain 138, 208216.
81. Lawrence, RC, Helmick, CG, Arnett, FC, et al. (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41, 778799.
82. Helmick, CG, Felson, DT, Lawrence, RC, et al. (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum 58, 1525.
83. Leveille, SG, Fried, L & Guralnik, JM (2002) Disabling symptoms: what do older women report? J Gen Intern Med 17, 766773.
84. Ayres, E, Warmington, M & Reid, MC (2012) Chronic pain perspectives: managing chronic pain in older adults: 6 steps to overcoming medication barriers. J Fam Pract 61, S16S21.
85. Zhang, W, Moskowitz, RW, Nuki, G, et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16, 137162.
86. Jordan, KM, Arden, NK, Doherty, M, et al. (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62, 11451155.
87. Zhang, W, Doherty, M, Arden, N, et al. (2005) EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 64, 669681.
88. National Clinical Guideline Centre (2014) Osteoarthritis: Care and Management in Adults. National Institute for Health and Clinical Excellence: Guidance, CG177 . London: National Institute for Health and Care Excellence (NICE).
89. Kaufman, DW, Kelly, JP, Rosenberg, L, et al. (2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 287, 337344.
90. ANSM (2014) Analyse des ventes de médicaments en France en 2013 (Analysis of Drug Sales in France in 2013). Saint-Dennis: ANSM.
91. Temple, AR, Benson, GD, Zinsenheim, JR, et al. (2006) Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (6–12 months) safety of acetaminophen in adult patients with osteoarthritis. Clin Ther 28, 222235.
92. Lu, HH, Thomas, JD, Tukker, JJ, et al. (1992) Intestinal water and solute absorption studies: comparison of in situ perfusion with chronic isolated loops in rats. Pharm Res 9, 894900.
93. McGill, MR & Jaeschke, H (2013) Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res 30, 21742187.
94. Stillings, M, Havlik, I, Chetty, M, et al. (2000) Comparison of the pharmacokinetic profiles of soluble aspirin and solid paracetamol tablets in fed and fasted volunteers. Curr Med Res Opin 16, 115124.
95. Klaassen, CD & Boles, JW (1997) Sulfation and sulfotransferases. 5. The importance of 3’-phosphoadenosine 5’-phosphosulfate (PAPS) in the regulation of sulfation. FASEB J 11, 404418.
96. Jaeschke, H, McGill, MR & Ramachandran, A (2012) Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 44, 88106.
97. Prescott, LF, Park, J, Ballantyne, A, et al. (1977) Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet ii, 432434.
98. Atkuri, KR, Mantovani, JJ, Herzenberg, LA, et al. (2007) N-acetylcysteine – a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol 7, 355359.
99. Owumi, SE, Andrus, JP, Herzenberg, LA, et al. (2015) Co-administration of N-acetylcysteine and acetaminophen efficiently blocks acetaminophen toxicity. Drug Dev Res 76, 251258.
100. Heard, KJ, Green, JL, James, LP, et al. (2011) Acetaminophen–cysteine adducts during therapeutic dosing and following overdose. BMC Gastroenterol 11, 20.
101. McGill, MR, Lebofsky, M, Norris, HRK, et al. (2013) Plasma and liver acetaminophen–protein adduct levels in mice after acetaminophen treatment: dose–response, mechanisms, and clinical implications. Toxicol Appl Pharmacol 269, 240249.
102. Mast, C, Joly, C, Savary-Auzloux, I, et al. (2014) Skeletal muscle wasting occurs in adult rats under chronic treatment with paracetamol when glutathione-dependent detoxification is highly activated. J Physiol Pharmacol 65, 623631.
103. Mast, C, Lyan, B, Joly, C, et al. (2015) Assessment of protein modifications in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches. J Proteomics 120, 194203.
104. Taylor, CG, Nagy, LE & Bray, TM (1996) Nutritional and hormonal regulation of glutathione homeostasis. Curr Top Cell Regul 34, 189208.
105. Courtney-Martin, G, Ball, RO & Pencharz, PB (2012) Sulfur amino acid metabolism and requirements. Nutr Rev 70, 170175.
106. Pujos-Guillot, E, Pickering, G, Lyan, B, et al. (2012) Therapeutic paracetamol treatment in older persons induces dietary and metabolic adaptations related to sulfur amino acids. Age 34, 181193.
107. Nimni, ME, Han, B & Cordoba, F (2007) Are we getting enough sulfur in our diet? Nutr Metab (Lond) 4, 24.
108. Courtney-Martin, G & Pencharz, PB (2016) Sulfur amino acids metabolism from protein synthesis to glutathione. In The Molecular Nutrition of Amino Acids and Proteins, 1st ed, chapter 19, pp. 265286 [D Dardevet, editor]. Boston, MA: Academic Press.
109. Stipanuk, MH (2004) Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24, 539577.
110. Olson, KR, Deleon, ER, Gao, Y, et al. (2013) Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing. Am J Physiol 305, R592R603.
111. Huang, J, Khan, S & O’Brien, PJ (1998) The glutathione dependence of inorganic sulfate formation from l- or d-cysteine in isolated rat hepatocytes. Chem Biol Interact 110, 189202.
112. Lu, SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830, 31433153.
113. Cho, ES, Sahyoun, N & Stegink, LD (1981) Tissue glutathione as a cyst(e)ine reservoir during fasting and refeeding of rats. J Nutr 111, 914922.
114. Cho, ES, Johnson, N & Snider, BCF (1984) Tissue glutathione as a cyst(e)ine reservoir during cystine depletion in growing rats. J Nutr 114, 18531862.
115. Stipanuk, MH, Coloso, RM, Garcia, RA, et al. (1992) Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. J Nutr 122, 420427.
116. Lee, JI, Londono, M, Hirschberger, LL, et al. (2004) Regulation of cysteine dioxygenase and γ-glutamylcysteine synthetase is associated with hepatic cysteine level. J Nutr Biochem 15, 112122.
117. Wu, GY, Fang, YZ, Yang, S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134, 489492.
118. El-Khairy, L, Ueland, PM, Nygard, O, et al. (1999) Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study. Am J Clin Nutr 70, 10161024.
119. El-Khairy, L, Ueland, PM, Refsum, H, et al. (2001) Plasma total cysteine as a risk factor for vascular disease: The European Concerted Action Project. Circulation 103, 25442549.
120. Ozkan, Y, Ozkan, E & Simsek, B (2002) Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease. Int J Cardiol 82, 269277.
121. El-Khairy, L, Vollset, SE, Refsum, H, et al. (2003) Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. Am J Clin Nutr 77, 467472.
122. Garcia, RAG & Stipanuk, MH (1992) The splanchnic organs, liver and kidney have unique roles in the metabolism of sulfur amino-acids and their metabolites in rats. J Nutr 122, 16931701.
123. Ishii, I, Akahoshi, N, Yu, XN, et al. (2004) Murine cystathionine γ-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J 381, 113123.
124. Stipanuk, MH & Ueki, I (2011) Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J Inherit Metab Dis 34, 1732.
125. Huneau, JF, Mariotti, F, Blouet, C, et al. (2008) Implications métaboliques, physiologiques et fonctionnelles de l’apport en acides aminés soufrés et en protéines riches en acides aminés soufrés (Metabolic, physiological and functional implications of the intake of sulfur amino acids and proteins rich in sulfur amino acids). In Aliments Fonctionnels (Functional Foods), pp. 337382 [M Roberfroid, V Coxam and N Delzenne, editors]. Paris: Tec et Toc Lavoisier.
126. Rose, WC & Wixom, RL (1955) The amino acid requirements of man. XIII. The sparing effect of cystine on the methionine requirement. J Biol Chem 216, 753773.
127. Baker, DH, Becker, DE, Norton, HW, et al. (1966) Quantitative evaluation of the tryptophan, methionine and lysine needs of adult swine for maintenance. J Nutr 89, 441447.
128. Said, AK & Hegsted, DM (1970) Response of adult rats to low dietary levels of essential amino acids. J Nutr 100, 13631375.
129. Finkelstein, JD, Martin, JJ & Harris, BJ (1988) Methionine metabolism in mammals. The methionine-sparing effect of cystine. J Biol Chem 263, 1175011754.
130. Di Buono, M, Wykes, LJ, Ball, RO, et al. (2001) Dietary cysteine reduces the methionine requirement in men. Am J Clin Nutr 74, 761766.
131. Di Buono, M, Wykes, LJ, Cole, DE, et al. (2003) Regulation of sulfur amino acid metabolism in men in response to changes in sulfur amino acid intakes. J Nutr 133, 733739.
132. Ball, RO, Courtney-Martin, G & Pencharz, PB (2006) The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr 136, 1682s1693s.
133. Smith, JT (1973) An optimal level of inorganic sulfate for the diet of a rat. J Nutr 103, 10081011.
134. Sasse, CE & Baker, DH (1974) Sulfur utilization by the chick with emphasis on the effect of inorganic sulfate on the cystine–methionine interrelationship. J Nutr 104, 244251.
135. Zezulka, AY & Calloway, DH (1976) Nitrogen retention in men fed isolated soybean protein supplemented with l-methionine, d-methionine, N-acetyl-l-methionine, or inorganic sulfate. J Nutr 106, 12861291.
136. Baker, DH (2006) Comparative species utilization and toxicity of sulfur amino acids. J Nutr 136, 1670s1675s.
137. Di Buono, M, Wykes, LJ, Ball, RO, et al. (2001) Total sulfur amino acid requirement in young men as determined by indicator amino acid oxidation with l-[1-13C]phenylalanine. Am J Clin Nutr 74, 756760.
138. Kurpad, AV, Regan, MM, Varalakshmi, S, et al. (2003) Daily methionine requirements of healthy Indian men, measured by a 24-h indicator amino acid oxidation and balance technique. Am J Clin Nutr 77, 11981205.
139. Tuttle, SG, Bassett, SH, Griffith, WH, et al. (1965) Further observations on the amino acid requirements of older men. II. Methionine and lysine. Am J Clin Nutr 16, 229231.
140. Mercier, S, Breuillé, D, Buffière, C, et al. (2006) Methionine kinetics are altered in the elderly both in the basal state and after vaccination. Am J Clin Nutr 83, 291298.
141. Samiec, PS, Drews-Botsch, C, Flagg, EW, et al. (1998) Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med 24, 699704.
142. Arivazhagan, P, Ramanathan, K & Panneerselvam, C (2001) Effect of DL-α-lipoic acid on mitochondrial enzymes in aged rats. Chem Biol Interact 138, 189198.
143. Mitchell, JR, Jollow, DJ, Potter, WZ, et al. (1973) Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187, 211217.
144. Buttar, HS, Chow, AYK & Downie, RH (1977) Glutathione alterations in rat liver after acute and subacute oral administration of paracetamol. Clin Exp Pharmacol Physiol 4, 16.
145. Hjelle, JJ, Hazelton, GA & Klaassen, CD (1985) Acetaminophen decreases adenosine 3’-phosphate 5’-phosphosulfate and uridine diphosphoglucuronic acid in rat liver. Drug Metab Dispos 13, 3541.
146. Geenen, S, du Preez, FB, Snoep, JL, et al. (2013) Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy. Biochim Biophys Acta 1830, 49434959.
147. Reicks, M, Calvert, RJ & Hathcock, JN (1988) Effects of prolonged acetaminophen ingestion and dietary methionine on mouse-liver glutathione. Drug Nutr Interact 5, 351363.
148. Kondo, K, Yamada, N, Suzuki, Y, et al. (2012) Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients. J Toxicol Sci 37, 911929.
149. Reicks, M & Hathcock, JN (1989) Prolonged acetaminophen ingestion in mice – effects on the availability of methionine for metabolic functions. J Nutr 119, 10421049.
150. McLean, AEM, Armstrong, GR & Beales, D (1989) Effect of d-methionine or l-methionine and cysteine on the growth inhibitory effects of feeding 1-percent paracetamol to rats. Biochem Pharmacol 38, 347352.
151. Lauterburg, BH & Mitchell, JR (1987) Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. J Hepatol 4, 206211.
152. Mannery, YO, Ziegler, TR, Park, Y, et al. (2010) Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans. J Pharmacol Exp Ther 333, 939947.
153. Chen, TS, Richie, JP & Lang, CA (1990) Life span profiles of glutathione and acetaminophen detoxification. Drug Metab Dispos 18, 882887.
154. Pickering, G, Schneider, E, Papet, I, et al. (2011) Acetaminophen metabolism after major surgery: a greater challenge with increasing age. Clin Pharmacol Ther 90, 707711.
155. Wu, M, Desai, DH, Kakarla, SK, et al. (2009) Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2. Diabetes Metab Res Rev 25, 279286.
156. Wu, MZ, Katta, A, Gadde, MK, et al. (2009) Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS ONE 4, e6430.
157. Wu, MZ, Liu, H, Fannin, J, et al. (2010) Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res 13, 571579.
158. Muth-Selbach, US, Tegeder, I, Brune, K, et al. (1999) Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation. Anesthesiology 91, 231239.
159. Choi, SS, Lee, JK & Suh, HW (2001) Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models. Brain Res 921, 233239.
160. Mast, C, Pouyet, C, Centeno, D, et al. (2013) Le traitement par cures au paracétamol induit une réduction de la masse et la synthèse des protéines musculaires chez le rat âgé (Treatment with paracetamol induces a reduction in the mass and synthesis of muscle proteins in the elderly rat). Nutr Clin Metabol 27, S28S29.
161. Trappe, TA, Fluckey, JD, White, F, et al. (2001) Skeletal muscle PGF and PGE2 in response to eccentric resistance exercise: influence of ibuprofen and acetaminophen. J Clin Endocrinol Metab 86, 50675070.
162. Trappe, TA, White, F, Lambert, CP, et al. (2002) Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol 282, E551E556.
163. Trappe, TA, Carroll, CC, Dickinson, JM, et al. (2011) Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol 300, R655R662.
164. Trappe, TA, Standley, RA, Jemiolo, B, et al. (2013) Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol Regul Integr Comp Physiol 304, R198R205.
165. Jankowski, CM, Gozansky, WS, MacLean, PS, et al. (2013) N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training. Eur J Appl Physiol 113, 11271136.
166. Trappe, TA, Ratchford, SM, Brower, BE, et al. (2016) COX inhibitor influence on skeletal muscle fiber size and metabolic adaptations to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci 71, 12891294.
167. Graham, GG, Davies, MJ, Day, RO, et al. (2013) The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology 21, 201232.
168. Smith, RH, Palmer, RM & Reeds, PJ (1983) Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching. Biochem J 214, 153161.
169. Carroll, CC, Martineau, K, Arthur, KA, et al. (2015) The effect of chronic treadmill exercise and acetaminophen on collagen and cross-linking in rat skeletal muscle and heart. Am J Physiol Regul Integr Comp Physiol 308, R294R299.
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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
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