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Nutrition Research Reviews Nutrition Research Reviews

Article contents

Magnesium homeostasis in cattle: absorption and excretion

Published online by Cambridge University Press:  10 January 2018

Holger Martens ,
Sabine Leonhard-Marek ,
Monika Röntgen  and
Friederike Stumpff
Holger Martens*
Affiliation:
Institute for Veterinary Physiology, Freie Universität Berlin, Berlin, Germany
Sabine Leonhard-Marek
Affiliation:
Department of Physiology, University of Veterinary Medicine, Foundation, Hannover, Germany
Monika Röntgen
Affiliation:
Institute of Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany
Friederike Stumpff
Affiliation:
Institute for Veterinary Physiology, Freie Universität Berlin, Berlin, Germany
*
* Corresponding author: Dr Holger Martens, email Holger.Martens@fu-berlin.de
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Abstract

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Magnesium (Mg2+) is an essential mineral without known specific regulatory mechanisms. In ruminants, plasma Mg2+ concentration depends primarily on the balance between Mg2+ absorption and Mg2+ excretion. The primary site of Mg2+ absorption is the rumen, where Mg2+ is apically absorbed by both potential-dependent and potential-independent uptake mechanisms, reflecting involvement of ion channels and electroneutral transporters, respectively. Transport is energised in a secondary active manner by a basolateral Na+/Mg2+ exchanger. Ruminal transport of Mg2+ is significantly influenced by a variety of factors such as high K+ concentration, sudden increases of ammonia, pH, and the concentration of SCFA. Impaired Mg2+ absorption in the rumen is not compensated for by increased transport in the small or large intestine. While renal excretion can be adjusted to compensate precisely for any surplus in Mg2+ uptake, a shortage in dietary Mg2+ cannot be compensated for either via skeletal mobilisation of Mg2+ or via up-regulation of ruminal absorption. In such situations, hypomagnesaemia will lead to decrease of a Mg2+ in the cerebrospinal fluid and clinical manifestations of tetany. Improved knowledge concerning the factors governing Mg2+ homeostasis will allow reliable recommendations for an adequate Mg2+ intake and for the avoidance of possible disturbances. Future research should clarify the molecular identity of the suggested Mg2+ transport proteins and the regulatory mechanisms controlling renal Mg excretion as parameters influencing Mg2+ homeostasis.

Keywords

RumenEpithelial transportTetanyCowsKidneys
Type
Review Article
Information
Nutrition Research Reviews , Volume 31 , Issue 1 , June 2018 , pp. 114 - 130
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Copyright
© The Authors 2018 

References

1. Leroy, J (1926) Nécessite du magnesium pour la croissance de la souris (Requirement of magnesium for the growth of the mouse). C R Seances Soc Biol Fil 94, 432–433.Google Scholar
2. McGuigan, JA, Kay, JW, Elder, HY, et al. (2007) Comparison between measured and calculated ionised concentrations in Mg2+/ATP, Mg2+/EDTA and Ca2+/EGTA buffers; influence of changes in temperature, pH and pipetting errors on the ionised concentrations. Magnes Res 20, 72–81.Google ScholarPubMed
3. Morris, ME (1992) Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnes Res 5, 303–313.Google ScholarPubMed
4. Möykkynen, T, Uusi-Oukari, M, Heikkila, J, et al. (2001) Magnesium potentiation of the function of native and recombinant GABA(A) receptors. Neuroreport 12, 2175–2179.CrossRefGoogle ScholarPubMed
5. Lamb, GD & Stephenson, DG (1994) Effects of intracellular pH and [Mg2+] on excitation–contraction coupling in skeletal muscle fibres of the rat. J Physiol 478, 331–339.CrossRefGoogle ScholarPubMed
6. Li, FY, Chaigne-Delalande, B, Kanellopoulou, C, et al. (2011) Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature 475, 471–476.CrossRefGoogle ScholarPubMed
7. Feeney, KA, Hansen, LL, Putker, M, et al. (2016) Daily magnesium fluxes regulate cellular timekeeping and energy balance. Nature 532, 375–379.Google ScholarPubMed
8. Vemana, S, Pandey, S & Larsson, HP (2008) Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels. Am J Physiol Cell Physiol 295, C557–C565.CrossRefGoogle ScholarPubMed
9. Voets, T, Janssens, A, Prenen, J, et al. (2003) Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol 121, 245–260.CrossRefGoogle ScholarPubMed
10. Rosendahl, J, Braun, HS, Schrapers, KT, et al. (2016) Evidence for the functional involvement of members of the TRP channel family in the uptake of Na+ and NH4 + by the ruminal epithelium. Pflugers Arch 468, 1333–1352.Google ScholarPubMed
11. Stumpff, F & Martens, H (2007) The rumen and potassium homeostasis: a model. J Anim Feed Sci 16, Suppl. 2, 436–441.Google Scholar
12. Leonhard-Marek, S, Stumpff, F, Brinkmann, I, et al. (2005) Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2 +. Am J Physiol Gastrointest Liver Physiol 288, G630–G645.CrossRefGoogle ScholarPubMed
13. Sjollema, B (1930) On the nature and therapy of grass staggers. Vet Rec 10, 425–430.Google Scholar
14. Sjollema, B (1932) Untersuchungen über die Ursache der Grastetanie und der großen Frequenzzunahme dieser Krankheit (Studies on the cause of grass tetany and the large increase in the frequency of this disease). Dtsch Tierarztl Wochenschr 40, 225–250.Google Scholar
15. Meyer, TE, Verwoert, GC, Hwang, SJ, et al. (2010) Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levels. PLoS Genet 6, e1001045.CrossRefGoogle ScholarPubMed
16. Tsiamadis, V, Banos, G, Panousis, N, et al. (2016) Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows. J Dairy Sci 99, 5535–5544.Google ScholarPubMed
17. Rayssiguier, Y (1977) Hypomagnesemia resulting from adrenaline infusion in ewes: its relation to lipolysis. Horm Metab Res 9, 309–314.CrossRefGoogle ScholarPubMed
18. Persson, J & Luthman, J (1974) The effects of insulin, glucose and catecholamines on some blood minerals in sheep. Acta Vet Scand 15, 519–532.Google Scholar
19. Goff, JP, Littledike, ET & Horst, RL (1986) Effect of synthetic bovine parathyroid hormone in dairy cows: prevention of hypocalcemic parturient paresis. J Dairy Sci 69, 2278–2289.CrossRefGoogle ScholarPubMed
20. Groenestege, WM, Thebault, S, van der Wijst, J, et al. (2007) Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest 117, 2260–2267.CrossRefGoogle ScholarPubMed
21. Houillier, P (2014) Mechanisms and regulation of renal magnesium transport. Annu Rev Physiol 76, 411–430.CrossRefGoogle ScholarPubMed
22. Blaxter, KL & McGill, RF (1956) Magnesium metabolism in cattle. Vet Rev Annot 2, 35–55.Google Scholar
23. Martens, H & Stössel, EM (1988) Magnesium absorption from the temporarily isolated rumen of sheep: no effect of hyper- or hypomagnesaemia. Q J Exp Physiol 73, 217–223.CrossRefGoogle ScholarPubMed
24. Schonewille, JT, Everts, H, Jittakhot, S, et al. (2008) Quantitative prediction of magnesium absorption in dairy cows. J Dairy Sci 91, 271–278.CrossRefGoogle ScholarPubMed
25. Smith, RH (1962) Net exchange of certain inorganic ions and water in the alimentary tract of the milk-fed calf. Biochem J 83, 151–163.CrossRefGoogle ScholarPubMed
26. Storry, JE (1961) Studies on calcium and magnesium in the alimentary tract of sheep. I. The distribution of calcium and magnesium in the contents taken from various parts of the alimentary tract. J Agric Sci 57, 97–102.CrossRefGoogle Scholar
27. Harrison, FA, Hill, KJ & Mangan, JL (1963) Absorption and excretion of lithium and magnesium in the sheep. Biochem J 89, 99–100.Google Scholar
28. Marongiu, A (1971) Assorbimento del magnesio nei diversi segmenti del tubo digerente nell’ovino (Magnesium absorption in different segments of the digestive tract in sheep). Boll Soc Ital Biol Sper 47, 768–770.Google Scholar
29. Rogers, PAM & van’t Klooster, A (1969) The fate of Na, K, Ca, Mg and P in the digesta. Mededelingen Landbouwhogeschool 69, 26–39.Google Scholar
30. Martens, H (1978) Lokalisation und Mechanismen der Magnesiumresorption bei Wiederkäuern (Localization and mechanisms of magnesium absorption in ruminants). Übers Tierernähr 6, 75–90.Google Scholar
31. Martens, H (1981) Neue Erkenntnisse über den Magnesiumstoffwechsel bei Wiederkäuern (New insights into magnesium metabolism in ruminants). Übers Tierernähr 9, 233–258.Google Scholar
32. Edrise, BM & Smith, RH (1979) Absorption and secretion in the omasum of the young steer. Ann Rech Vet 10, 354–355.Google ScholarPubMed
33. Field, AC & Munro, CS (1977) The effect of site and quantity on the extent of absorption of Mg infused into the gastro-intestinal tract of sheep. J Agric Sci 89, 365–371.CrossRefGoogle Scholar
34. Martens, H & Rayssiguier, Y (1980) Magnesium metabolism and hypomagnesemia, In Digestive Physiology and Metabolism in Ruminants, pp. 447–466 [Y Ruckebusch and P Thivend, editors]. Lancaster: MTP Press.Google Scholar
35. Pfeffer, E & Rahman, KA (1974) Untersuchungen zur Lokalisierung der Magnesium Absorption beim Wiederkäuer (Studies on the localisation of magnesium absorption in ruminants). Z Tierphysiol Tierernahr Futtermittelkd 33, 209–213.Google Scholar
36. Tomas, FM & Potter, BJ (1976) The effect and site of action of potassium upon magnesium absorption in sheep. Aust J Agric Res 27, 873–880.CrossRefGoogle Scholar
37. Smith, RH (1959) The development and function of the rumen in milk-fed calves. J Agric Sci 52, 72–78.CrossRefGoogle Scholar
38. Dillon, J & Scott, D (1979) Digesta flow and mineral absorption in lambs before and after weaning. J Agric Sci 92, 289–297.CrossRefGoogle Scholar
39. Meyer, H & Busse, FW (1975) Rectal absorption of magnesium in ruminants. Brief report. Dtsch Tierarztl Wochenschr 82, 140–141.Google Scholar
40. Scott, D (1965) Factors influencing the secretion and absorption of calcium and magnesium in the small intestine of the sheep. Q J Exp Physiol Cogn Med Sci 50, 312–329.Google ScholarPubMed
41. Martens, H & Harmeyer, J (1978) Magnesium transport by isolated rumen epithelium of sheep. Res Vet Sci 24, 161–168.Google ScholarPubMed
42. Care, AD, Brown, RC, Farrar, AR, et al. (1984) Magnesium absorption from the digestive tract of sheep. Q J Exp Physiol 69, 577–587.Google ScholarPubMed
43. Martens, H (1985) The effect of dinitrophenol on magnesium transport across an isolated preparation of sheep rumen epithelium. Q J Exp Physiol 70, 567–573.CrossRefGoogle ScholarPubMed
44. Martens, H (1985) Magnesium absorption from the temporarily isolated rumen of sheep. The effect of water absorption and osmotic pressure. Zentralbl Veterinarmed A 32, 631–635.Google ScholarPubMed
45. Behar, J (1974) Magnesium absorption by the rat ileum and colon. Am J Physiol 227, 334–340.Google ScholarPubMed
46. Frizzell, RA & Schultz, SG (1972) Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences. J Gen Physiol 59, 318–346.CrossRefGoogle ScholarPubMed
47. Martens, H, Gäbel, G & Strozyk, H (1987) The effect of potassium and the transmural potential difference on magnesium transport across an isolated preparation of sheep rumen epithelium. Q J Exp Physiol 72, 181–188.CrossRefGoogle ScholarPubMed
48. Leonhard-Marek, S & Martens, H (1996) Effects of potassium on magnesium transport across rumen epithelium. Am J Physiol 271, G1034–G1038.Google ScholarPubMed
49. Schweigel, M, Lang, I & Martens, H (1999) Mg2+ transport in sheep rumen epithelium: evidence for an electrodiffusive uptake mechanism. Am J Physiol 277, G976–G982.Google Scholar
50. Hoenderop, JG & Bindels, RJ (2008) Calciotropic and magnesiotropic TRP channels. Physiology (Bethesda) 23, 32–40.CrossRefGoogle ScholarPubMed
51. Konrad, M, Schlingmann, KP & Gudermann, T (2004) Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 286, F599–F605.CrossRefGoogle ScholarPubMed
52. Schweigel, M, Kolisek, M, Nikolic, Z, et al. (2008) Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. Magnes Res 21, 118–123.Google ScholarPubMed
53. Demeuse, P, Penner, R & Fleig, A (2006) TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. J Gen Physiol 127, 421–434.CrossRefGoogle ScholarPubMed
54. Ryazanova, LV, Rondon, LJ, Zierler, S, et al. (2010) TRPM7 is essential for Mg2+ homeostasis in mammals. Nat Commun 1, 109.CrossRefGoogle Scholar
55. Dimke, H, Hoenderop, JG & Bindels, RJ (2011) Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family. J Physiol 589, 1535–1542.CrossRefGoogle ScholarPubMed
56. Schweigel, M, Kuzinski, J, Deiner, C, et al. (2009) Rumen epithelial cells adapt magnesium transport to high and low extracellular magnesium conditions. Magnes Res 22, 133–150.Google ScholarPubMed
57. Giduck, SA & Fontenot, JP (1987) Utilization of magnesium and other macrominerals in sheep supplemented with different readily-fermentable carbohydrates. J Anim Sci 65, 1667–1673.Google ScholarPubMed
58. Martens, H, Heggemann, G & Regier, K (1988) Studies on the effect of K, Na, NH4 +, VFA and CO2 on the net absorption of magnesium from the temporarily isolated rumen of heifers. Zentralbl Veterinarmed A 35, 73–80.CrossRefGoogle ScholarPubMed
59. Leonhard-Marek, S, Gäbel, G & Martens, H (1998) Effects of short chain fatty acids and carbon dioxide on magnesium transport across sheep rumen epithelium. Exp Physiol 83, 155–164.CrossRefGoogle ScholarPubMed
60. Leonhard-Marek, S (1999) Do forestomach epithelia exhibit a Mg2+/2H+-exchanger? Magnes Res 12, 99–108.Google ScholarPubMed
61. Schweigel, M & Martens, H (2003) Anion-dependent Mg2+ influx and a role for a vacuolar H+-ATPase in sheep ruminal epithelial cells. Am J Physiol Gastrointest Liver Physiol 285, G45–G53.CrossRefGoogle Scholar
62. Stumpff, F, Martens, H, Bilk, S, et al. (2009) Cultured ruminal epithelial cells express a large-conductance channel permeable to chloride, bicarbonate, and acetate. Pflugers Arch 457, 1003–1022.CrossRefGoogle ScholarPubMed
63. Georgi, MI, Rosendahl, J, Ernst, F, et al. (2014) Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short-chain fatty acids. Pflugers Arch 466, 1689–1712.CrossRefGoogle ScholarPubMed
64. Ram, L, Schonewille, JT, Martens, H, et al. (1998) Magnesium absorption by wethers fed potassium bicarbonate in combination with different dietary magnesium concentrations. J Dairy Sci 81, 2485–2492.CrossRefGoogle ScholarPubMed
65. Ussing, HH & Zerahn, K (1951) Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand 23, 110–127.CrossRefGoogle ScholarPubMed
66. Graham, C & Simmons, NL (2005) Functional organization of the bovine rumen epithelium. Am J Physiol Regul Integr Comp Physiol 288, R173–R181.CrossRefGoogle ScholarPubMed
67. Leonhard-Marek, S & Martens, H (1994) Influences of Na on Mg transport across sheep rumen epithelium. Proc Soc Nutr Physiol 3, 88.Google Scholar
68. Schweigel, M, Vormann, J & Martens, H (2000) Mechanisms of Mg2+ transport in cultured ruminal epithelial cells. Am J Physiol Gastrointest Liver Physiol 278, G400–G408.Google Scholar
69. Kolisek, M, Nestler, A, Vormann, J, et al. (2012) Human gene SLC41A1 encodes for the Na+/Mg2+ exchanger. Am J Physiol Cell Physiol 302, C318–C326.CrossRefGoogle Scholar
70. Schweigel-Röntgen, M & Kolisek, M (2014) SLC41 transporters – molecular identification and functional role. Curr Top Membr 73, 383–410.CrossRefGoogle ScholarPubMed
71. Baker, PF & Crawford, AC (1972) Mobility and transport of magnesium in squid giant axons. J Physiol 227, 855–874.CrossRefGoogle ScholarPubMed
72. Martens, H (1979) In-vivo studies on the absorption of magnesium from the ovine rumen. Estimation of the maximum absorption capacity of the rumen. Berl Munch Tierarztl Wochenschr 92, 152–155.Google ScholarPubMed
73. Martens, H (1983) Saturation kinetics of magnesium efflux across the rumen wall in heifers. Br J Nutr 49, 153–158.CrossRefGoogle ScholarPubMed
74. Weiss, WP (2004) Macromineral digestion by lactating dairy cows: factors affecting digestibility of magnesium. J Dairy Sci 87, 2167–2171.CrossRefGoogle ScholarPubMed
75. Leonhard, S, Smith, E, Martens, H, et al. (1990) Transport of magnesium across an isolated preparation of sheep rumen: a comparison of MgCl2, Mg aspartate, Mg pidolate, and Mg-EDTA. Magnes Trace Elem 9, 265–271.Google ScholarPubMed
76. Head, MJ & Rook, JAF (1955) Hypomagnesæmia in dairy cattle and its possible relationship to ruminal ammonia production. Nature 176, 262–263.CrossRefGoogle ScholarPubMed
77. Care, A, Vowles, L, Mann, S, et al. (1967) Factors affecting magnesium absorption in relation to the aetiology of acute hypomagnesemia. J Agric Sci 68, 195–204.CrossRefGoogle Scholar
78. Johnson, CL, Helliwell, SH & Jones, DA (1988) Magnesium metabolism in the rumens of lactating dairy cows fed on spring grass. Q J Exp Physiol 73, 23–31.CrossRefGoogle ScholarPubMed
79. Fontenot, JP, Miller, RW, Whitehair, CK, et al. (1960) Effect of a high-protein high-potassium ration on the mineral metabolism of lambs. J Anim Sci 19, 127–133.Google Scholar
80. Schonewille, JT, Van’t Klooster, AT, Wouterse, H, et al. (1999) Effects of intrinsic potassium in artificially dried grass and supplemental potassium bicarbonate on apparent magnesium absorption in dry cows. J Dairy Sci 82, 1824–1830.CrossRefGoogle ScholarPubMed
81. Newton, GL, Fontenot, JP, Tucker, RE, et al. (1972) Effects of high dietary potassium intake on the metabolism of magnesium by sheep. J Anim Sci 35, 440–445.Google Scholar
82. Wylie, MJ, Fontenot, JP & Greene, LW (1985) Absorption of magnesium and other macrominerals in sheep infused with potassium in different parts of the digestive tract. J Anim Sci 61, 1219–1229.Google ScholarPubMed
83. Rahnema, SH & Fontenot, JP (1986) Effect of potassium on association of minerals with various fractions of digesta and feces of sheep fed hay. J Anim Sci 63, 1491–1501.CrossRefGoogle Scholar
84. Schonewille, JT, Ram, L, van’t Kloster, AT, et al. (1997) Intrinsic potassium in grass silage and magnesium absorption in dry cows. Livest Prod Sci 48, 99–110.CrossRefGoogle Scholar
85. Lang, I & Martens, H (1999) Na transport in sheep rumen is modulated by voltage-dependent cation conductance in apical membrane. Am J Physiol 277, G609–G618.Google ScholarPubMed
86. Gesellschaft für Ernährungsphysiologie (GfE) (1978) Empfehlungen zur Mineralstoffversorgung (Recommendations for Mineral Intake). Energie- und Nährstoffbedarf landwirtschaftlicher Nutztiere 1 (Energy and Nutrient Requirements of Farm Animals 1) . Frankfurt am Main: Gesellschaft für Ernährungsphysiologie.Google Scholar
87. Schonewille, JT & Beynen, AC (2005) Reviews on the mineral provision in ruminants (III): Magnesium metabolism and requirement in ruminants. In CVB Documention Report, no. 35, pp. 13–26. Lelystad: Central Veevoederbureau Lelystad.Google Scholar
88. Bailey, CB (1961) Saliva secretion and its relation to feeding in cattle. 4. The relationship between the concentrations of sodium, potassium, chloride and inorganic phosphate in mixed saliva and rumen fluid. Br J Nutr 15, 489–498.CrossRefGoogle ScholarPubMed
89. Denton, DA (1956) The effect of Na+ depletion on the Na+:K+ ratio of the parotid saliva of the sheep. J Physiol 131, 516–525.CrossRefGoogle Scholar
90. Martens, H, Kubel, OW, Gäbel, G, et al. (1987) Effects of low sodium intake on magnesium metabolism in sheep. J Agric Sci 108, 237–243.CrossRefGoogle Scholar
91. Charlton, JA & Armstrong, DG (1989) The effect of an intravenous infusion of aldosterone upon magnesium metabolism in the sheep. Q J Exp Physiol 74, 329–337.CrossRefGoogle ScholarPubMed
92. Martens, H & Hammer, U (1981) Magnesium and sodium absorption from the isolated sheep rumen during intravenous aldosterone infusion (author’s transl). Dtsch Tierarztl Wochenschr 88, 404–407.Google Scholar
93. Kemp, A & Geurink, JH (1966) Further information on the sodium requirement and sodium supply of lactating cows. Tijdschr Diergeneeskd 91, 580–613.Google Scholar
94. Morris, JG & Gartner, RW (1975) The effect of potassium on the sodium requirements of growing steers with and without α-tocopherol supplementation. Br J Nutr 34, 1–14.Google ScholarPubMed
95. Metson, AJ, Saunders, WMA, Collie, TW, et al. (1966) Chemical composition of pastures in relation to grass tetany in beef breeding cows. NZ J Agric Res 9, 410–436.CrossRefGoogle Scholar
96. Butler, EJ (1963) The mineral element content of spring pasture in relation to the occurrence of grass tetany and hypomagnesemia in dairy cows. J Agric Sci 60, 329–340.CrossRefGoogle Scholar
97. Paterson, R & Crichton, C (1960) Grass staggers in large scale dairying on grass. J Br Grassl Soc 15, 100–105.CrossRefGoogle Scholar
98. Annison, EF, Lewis, D & Lindsay, DB (1959) The metabolic changes which occur in sheep transferred to lush spring grass. I. Changes in blood and rumen constituents. J Agric Sci 53, 34–41.CrossRefGoogle Scholar
99. Kemp, A (1960) Influence of fertiliser treatment of grassland on the incidence of hypomagnesaemic tetany (grass tetany in milking cows). Neth J Agric Sci 8, 281–304.Google Scholar
100. Moore, WF, Fontenot, JP & Webb, KE Jr (1972) Effect of form and level of nitrogen on magnesium utilization. J Anim Sci 35, 1046–1053.Google ScholarPubMed
101. Gäbel, G & Martens, H (1986) The effect of ammonia on magnesium metabolism in sheep. J Anim Physiol Anim Nutr (Berl) 55, 278–287.CrossRefGoogle Scholar
102. Abdoun, K, Stumpff, F, Wolf, K, et al. (2005) Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia. Am J Physiol Gastrointest Liver Physiol 289, G508–G520.CrossRefGoogle ScholarPubMed
103. Lu, Z, Stumpff, F, Deiner, C, et al. (2014) Modulation of sheep ruminal urea transport by ammonia and pH. Am J Physiol Regul Integr Comp Physiol 307, R558–R570.CrossRefGoogle Scholar
104. Grace, ND, Caple, IW & Care, AD (1988) Studies in sheep on the absorption of magnesium from a low molecular weight fraction of the reticulo-rumen contents. Br J Nutr 59, 93–108.CrossRefGoogle ScholarPubMed
105. Dalley, DE, Isherwood, P, Sykes, AR, et al. (1997) Effect of in vitro manipulation of pH on magnesium solubility in ruminal and caecal digesta in sheep. J Agric Sci 129, 107–111.CrossRefGoogle Scholar
106. Xin, Z, Tucker, WB & Hemken, RW (1989) Effect of reactivity rate and particle size of magnesium oxide on magnesium availability, acid–base balance, mineral metabolism, and milking performance of dairy cows. J Dairy Sci 72, 462–470.CrossRefGoogle ScholarPubMed
107. Horn, JP & Smith, RH (1978) Absorption of magnesium by the young steer. Br J Nutr 40, 473–484.Google ScholarPubMed
108. Johnson, CL & Aubrey Jones, DA (1989) Effect of change of diet on the mineral composition of rumen fluid, on magnesium metabolism and on water balance in sheep. Br J Nutr 61, 583–594.Google Scholar
109. Wilcox, GE & Hoff, JE (1974) Grass tetany: an hypothesis concerning its relationship with ammonium nutrition of spring grasses. J Dairy Sci 57, 1085–1089.CrossRefGoogle ScholarPubMed
110. Li, M, Jiang, J & Yue, L (2006) Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 127, 525–537.CrossRefGoogle ScholarPubMed
111. Nijenhuis, T, Renkema, KY, Hoenderop, JG, et al. (2006) Acid–base status determines the renal expression of Ca2+ and Mg2+ transport proteins. J Am Soc Nephrol 17, 617–626.CrossRefGoogle ScholarPubMed
112. Dai, LJ, Friedman, PA & Quamme, GA (1997) Acid–base changes alter Mg2+ uptake in mouse distal convoluted tubule cells. Am J Physiol 272, F759–F766.Google ScholarPubMed
113. Atkinson, NS, Reynolds, DJ & Travis, SP (2015) ‘Lemonade legs’: why do some patients get profound hypomagnesaemia on proton-pump inhibitors? Intest Res 13, 227–232.CrossRefGoogle ScholarPubMed
114. Balch, DA & Rowland, SJ (1957) Volatile fatty acids and lactic acid in the rumen of dairy cows receiving a variety of diets. Br J Nutr 11, 288–298.CrossRefGoogle ScholarPubMed
115. Wilson, GF, Reid, CSW, Molloy, C, et al. (1969) Influence of starch and peanut oil on plasma magnesium in grazing dairy cows. NZ J Agric Res 12, 467–488.CrossRefGoogle Scholar
116. House, WA & Mayland, HF (1976) Magnesium utilization in wethers fed diets with varying ratios of nitrogen to readily fermentable carbohydrate. J Anim Sci 43, 842–849.Google ScholarPubMed
117. Giduck, SA, Fontenot, JP & Rahnema, S (1988) Effect of ruminal infusion of glucose, volatile fatty acids and hydrochloric acid on mineral metabolism in sheep. J Anim Sci 66, 532–542.Google Scholar
118. Martens, H, Rabbani, I, Shen, Z, et al. (2012) Changes in rumen absorption processes during transition. Anim Feed Sci Technol 172, 95–102.CrossRefGoogle Scholar
119. Gäbel, G, Martens, H, Suendermann, M, et al. (1987) The effect of diet, intraruminal pH and osmolarity on sodium, chloride and magnesium absorption from the temporarily isolated and washed reticulo-rumen of sheep. Q J Exp Physiol 72, 501–511.CrossRefGoogle Scholar
120. Rayssiguier, Y & Poncet, C (1980) Effect of lactose supplement on digestion of lucerne hay by sheep. II. Absorption of magnesium and calcium in the stomach. J Anim Sci 51, 186–192.Google ScholarPubMed
121. Demigné, C, Rémésy, C & Rayssiguier, Y (1980) Effect of fermentable carbohydrates on volatile fatty acids, ammonia and mineral absorption in the rat caecum. Reprod Nutr Dev 20, 1351–1359.CrossRefGoogle ScholarPubMed
122. Rondon, LJ, Rayssiguier, Y & Mazur, A (2008) Dietary inulin in mice stimulates Mg2+ absorption and modulates TRPM6 and TRPM7 expression in large intestine and kidney. Magnes Res 21, 224–231.Google ScholarPubMed
123. Schonewille, JT, Ram, L, Van’t Klooster, AT, et al. (1997) Native corn starch versus either cellulose or glucose in the diet and the effects on apparent magnesium absorption in goats. J Dairy Sci 80, 1738–1743.CrossRefGoogle ScholarPubMed
124. Bessac, BF & Fleig, A (2007) TRPM7 channel is sensitive to osmotic gradients in human kidney cells. J Physiol 582, 1073–1086.CrossRefGoogle ScholarPubMed
125. Stumpff, F & McGuigan, JA (2014) Measuring Ca2+ binding to short chain fatty acids and gluconate with a Ca2+ electrode: role of the reference electrode. Anal Biochem 459, 46–52.CrossRefGoogle Scholar
126. Leonhard-Marek, S, Marek, M & Martens, H (1998) Effect of transmural potential difference on Mg transport across rumen epithelium from four different breeds of sheep. J Agric Sci 130, 241–247.CrossRefGoogle Scholar
127. McAleese, DM, Bell, MC & Forbes, RM (1961) Magnesium-28 studies in lambs. J Nutr 74, 505–514.Google Scholar
128. Schweigel, M, Park, HS, Etschmann, B, et al. (2006) Characterization of the Na+-dependent Mg2+ transport in sheep ruminal epithelial cells. Am J Physiol Gastrointest Liver Physiol 290, G56–G65.CrossRefGoogle ScholarPubMed
129. Allsop, TF & Rook, JA (1979) The effect of diet and blood-plasma concentration on the endogenous faecal loss of magnesium and plasma magnesium concentration in sheep. J Agric Sci 92, 403–408.CrossRefGoogle Scholar
130. Care, A (1960) The kinetic of magnesium distribution within sheep. Res Vet Sci 1, 338–349.Google Scholar
131. Dua, K & Care, AD (1998) Secretion of magnesium and calcium in the total saliva of sheep and its relevance to hypomagnesaemia. Vet J 156, 217–221.CrossRefGoogle ScholarPubMed
132. Allsop, TF & Rook, JA (1970) Influence of the diet on the relationship between endogenous faecal loss of magnesium in sheep. J Agric Sci 92, 403–408.CrossRefGoogle Scholar
133. Greene, LW, Baker, JF & Hardt, PF (1989) Use of animal breeds and breeding to overcome the incidence of grass tetany: a review. J Anim Sci 67, 3463–3469.Google ScholarPubMed
134. Schneider, KM, Parkinson, GB, Houston, JC, et al. (1985) 1,25 Dihydroxyvitamin D3 increases plasma magnesium and calcium in sheep fed liquid diets low in calcium and magnesium. Aust Vet J 62, 82–85.CrossRefGoogle ScholarPubMed
135. Moate, PJ, Schneider, KM, Leaver, DD, et al. (1987) Effect of 1,25 dihydroxyvitamin D3 on the calcium and magnesium metabolism of lactating cows. Aust Vet J 64, 73–75.CrossRefGoogle ScholarPubMed
136. Littledike, ET & Goff, J (1987) Interactions of calcium, phosphorus, magnesium and vitamin D that influence their status in domestic meat animals. J Anim Sci 65, 1727–1743.Google ScholarPubMed
137. Hardwick, LL, Jones, MR, Brautbar, N, et al. (1991) Magnesium absorption: mechanisms and the influence of vitamin D, calcium and phosphate. J Nutr 121, 13–23.Google ScholarPubMed
138. Sansom, BF, Allen, WM, Davies, DC, et al. (1976) Use of 1α-OH cholecalciferol in preventing post parturient hypocalcaemia and its potential value for the prevention of milk fever in dairy cows. Vet Rec 99, 310–312.CrossRefGoogle ScholarPubMed
139. Yano, F, Horiuchi, K, Matsui, T, et al. (1984) Effect of 1α(OH)D3 injection on Ca and Mg absorption in thyroparathyroidectomized sheep. Canad J Anim Sci 64, 223–224.CrossRefGoogle Scholar
140. Beardsworth, P (1987) Physiological factors involved in the aetiology of hypomagesaemia in sheep. PhD Thesis, University of Leeds.Google Scholar
141. Dua, K, Leonhard, S, Martens, H, et al. (1994) Effects of parathyroid hormone and parathyroid hormone-related protein on the rates of absorption of magnesium, calcium, sodium, potassium and phosphate ions from the reticulo-rumen of sheep. Exp Physiol 79, 401–408.CrossRefGoogle ScholarPubMed
142. Greene, LW, Schelling, GT & Byers, FM (1986) Effects of dietary monensin and potassium on apparent absorption of magnesium and other macroelements in sheep. J Anim Sci 63, 1960–1967.Google Scholar
143. Larvor, P (1976) 28Mg kinetics in ewes fed normal or tetany prone grass. Cornell Vet 66, 413–429.Google ScholarPubMed
144. Elliott, DA & Rizack, MA (1974) Epinephrine and adrenocorticotropic hormone-stimulated magnesium accumulation in adipocytes and their plasma membranes. J Biol Chem 249, 3985–3990.Google ScholarPubMed
145. Larvor, P & Rayssiguier, Y (1972) Hypomagnesaemia following theophylline or furosemide injection in ewes: renal versus extrarenal effect. J Physiol 227, 365–375.CrossRefGoogle ScholarPubMed
146. Takezawa, R, Schmitz, C, Demeuse, P, et al. (2004) Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci U S A 101, 6009–6014.CrossRefGoogle ScholarPubMed
147. Ali, BH, Al-Qarawi, AA & Mousa, HM (2006) Stress associated with road transportation in desert sheep and goats, and the effect of pretreatment with xylazine or sodium betaine. Res Vet Sci 80, 343–348.CrossRefGoogle ScholarPubMed
148. Murayama, I, Miyano, A, Sasaki, Y, et al. (2013) Glomerular filtration rate in Holstein dairy cows estimated from a single blood sample using iodixanol. J Dairy Sci 96, 5120–5128.CrossRefGoogle ScholarPubMed
149. Günzel, D & Yu, AS (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93, 525–569.CrossRefGoogle ScholarPubMed
150. Konrad, M, Schaller, A, Seelow, D, et al. (2006) Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet 79, 949–957.CrossRefGoogle Scholar
151. Quamme, GA (1981) Effect of furosemide on calcium and magnesium transport in the rat nephron. Am J Physiol 241, F340–F347.Google ScholarPubMed
152. Shareghi, GR & Agus, ZS (1982) Magnesium transport in the cortical thick ascending limb of Henle’s loop of the rabbit. J Clin Invest 69, 759–769.CrossRefGoogle ScholarPubMed
153. Efrati, E, Hirsch, A, Kladnitsky, O, et al. (2010) Transcriptional regulation of the claudin-16 gene by Mg2+ availability. Cell Physiol Biochem 25, 705–714.CrossRefGoogle ScholarPubMed
154. Kladnitsky, O, Rozenfeld, J, Azulay-Debby, H, et al. (2015) The claudin-16 channel gene is transcriptionally inhibited by 1,25-dihydroxyvitamin D. Exp Physiol 100, 79–94.CrossRefGoogle ScholarPubMed
155. Quamme, GA (1997) Renal magnesium handling: new insights in understanding old problems. Kidney Int 52, 1180–1195.CrossRefGoogle ScholarPubMed
156. Ikari, A, Hirai, N, Shiroma, M, et al. (2004) Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. J Biol Chem 279, 54826–54832.CrossRefGoogle ScholarPubMed
157. Ferrè, S, Hoenderop, JG & Bindels, RJ (2012) Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis. Kidney Int 82, 1157–1166.CrossRefGoogle ScholarPubMed
158. Kausalya, PJ, Amasheh, S, Günzel, D, et al. (2006) Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of claudin-16. J Clin Invest 116, 878–891.CrossRefGoogle ScholarPubMed
159. Ohba, Y, Kitagawa, H, Kitoh, K, et al. (2000) A deletion of the paracellin-1 gene is responsible for renal tubular dysplasia in cattle. Genomics 68, 229–236.CrossRefGoogle ScholarPubMed
160. Hirano, T, Kobayashi, N, Itoh, T, et al. (2000) Null mutation of PCLN-1/claudin-16 results in bovine chronic interstitial nephritis. Genome Res 10, 659–663.CrossRefGoogle ScholarPubMed
161. Ohba, Y, Kitoh, K, Nakamura, H, et al. (2002) Renal reabsorption of magnesium and calcium by cattle with renal tubular dysplasia. Vet Rec 151, 384–387.CrossRefGoogle ScholarPubMed
162. Groenestege, WM, Hoenderop, JG, van den Heuvel, L, et al. (2006) The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens. J Am Soc Nephrol 17, 1035–1043.CrossRefGoogle ScholarPubMed
163. Rondon, LJ, Groenestege, WM, Rayssiguier, Y, et al. (2008) Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Am J Physiol Regul Integr Comp Physiol 294, R2001–R2007.CrossRefGoogle ScholarPubMed
164. Yamazaki, D, Funato, Y, Miura, J, et al. (2013) Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. PLoS Genet 9, e1003983.CrossRefGoogle ScholarPubMed
165. Cole, DE & Quamme, GA (2000) Inherited disorders of renal magnesium handling. J Am Soc Nephrol 11, 1937–1947.Google ScholarPubMed
166. Stuiver, M, Lainez, S, Will, C, et al. (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet 88, 333–343.CrossRefGoogle ScholarPubMed
167. Sponder, G, Mastrototaro, L, Kurth, K, et al. (2016) Human CNNM2 is not a Mg2+ transporter per se . Pflugers Arch 468, 1223–1240.Google ScholarPubMed
168. Schonewille, JT, van‘t Klooster, AT, Wouterse, H, et al. (2000) Time courses of plasma magnesium concentrations and urinary magnesium excretion in cows subjected to acute changes in potassium intake. Vet Q 22, 136–140.CrossRefGoogle ScholarPubMed
169. Holtenius, K, Kronqvist, C, Briland, E, et al. (2008) Magnesium absorption by lactating dairy cows on a grass silage-based diet supplied with different potassium and magnesium levels. J Dairy Sci 91, 743–748.CrossRefGoogle ScholarPubMed
170. Storry, JE & Rook, JAF (1963) Magnesium metabolism in the dairy cow. V. Experimental observations with a purified diet low in magnesium. J Agric Sci 61, 167–171.CrossRefGoogle Scholar
171. Zhang, X, Del Gobbo, LC, Hruby, A, et al. (2016) The circulating concentration and 24-h urine excretion of magnesium dose- and time-dependently respond to oral magnesium supplementation in a meta-analysis of randomized controlled trials. J Nutr 146, 595–602.Google Scholar
172. Rook, JAF & Balch, CC (1958) Magnesium metabolism in the dairy cow. II. Metabolism during the spring grazing season. J Agric Sci 51, 199–207.Google Scholar
173. Kemp, A (1983) The effect of fertilizer treatment of grassland on the biological availability of magnesium to ruminants. In Proceedings of John Lee Pratt International Symposium on the Role of Magnesium in Animal Nutrition, pp. 143–157 [JP Fontenot, GE Bunce, KE Webb Jr and VG Allen, editors]. Blacksburg, VA: Virginia Polytechnic Institute and State University.Google Scholar
174. Quamme, GA (1982) Effect of hypercalcemia on renal tubular handling of calcium and magnesium. Can J Physiol Pharmacol 60, 1275–1280.CrossRefGoogle ScholarPubMed
175. Bonny, O, Rubin, A, Huang, CL, et al. (2008) Mechanism of urinary calcium regulation by urinary magnesium and pH. J Am Soc Nephrol 19, 1530–1537.CrossRefGoogle Scholar
176. Roche, JR, Morton, J & Kolver, ES (2002) Sulfur and chlorine play a non-acid base role in periparturient calcium homeostasis. J Dairy Sci 85, 3444–3453.CrossRefGoogle ScholarPubMed
177. Oehlschlaeger, V, Wilkens, M, Schroeder, B, et al. (2014) Effects of 25-hydroxyvitamin D3 on localisation and extent of gastrointestinal calcium absorption in dairy cattle. Anim Prod Sci 54, 1394–1398.Google Scholar
178. van Hulzen, KJ, Sprong, RC, van der Meer, R, et al. (2009) Genetic and nongenetic variation in concentration of selenium, calcium, potassium, zinc, magnesium, and phosphorus in milk of Dutch Holstein–Friesian cows. J Dairy Sci 92, 5754–5759.CrossRefGoogle ScholarPubMed
179. Cerbulis, J & Farrell, J (1976) Composition of the milk of dairy cows. II. Ash, calcium, magnesium, and phosphorous. J Dairy Sci 59, 589–593.CrossRefGoogle Scholar
180. Rook, JAF & Storry, JE (1962) Magnesium in nutrition of ruminants. Nutr Abstr Rev 32, 1055–1076.Google Scholar
181. Goff, JP & Horst, RL (1997) Physiological changes at parturition and their relationship to metabolic disorders. J Dairy Sci 80, 1260–1268.CrossRefGoogle ScholarPubMed
182. Shappell, NW, Herbein, JH, Deftos, LJ, et al. (1987) Effects of dietary calcium and age on parathyroid hormone, calcitonin and serum and milk minerals in the periparturient dairy cow. J Nutr 117, 201–207.Google ScholarPubMed
183. Kehoe, SI, Jayarao, BM & Heinrichs, AJ (2007) A survey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farms. J Dairy Sci 90, 4108–4116.CrossRefGoogle ScholarPubMed
184. Halse, K (1970) Individual variation in blood magnesium and susceptibility to hypomagnesaemia in cows. Acta Vet Scand 11, 394–414.Google ScholarPubMed
185. Allcroft, R & Burns, KN (1968) Hypomagnesaemia in cattle. NZ Vet J 16, 109–128.CrossRefGoogle ScholarPubMed
186. Schweigel, M, Voigt, J & Mohr, E (2009) Indication of intracellular magnesium deficiency in lactating dairy cows revealed by magnesium loading and renal fractional excretion. J Anim Physiol Anim Nutr (Berl) 93, 105–112.CrossRefGoogle ScholarPubMed
187. Fontenot, JP, Allen, VG, Bunce, GE, et al. (1989) Factors influencing magnesium absorption and metabolism in ruminants. J Anim Sci 67, 3445–3455.Google ScholarPubMed
188. Kopic, S & Geibel, JP (2013) Gastric acid, calcium absorption, and their impact on bone health. Physiol Rev 93, 189–268.CrossRefGoogle ScholarPubMed
189. Meyer, H (1977) Pathogenesis of the clinical symptoms of hypomagneaemia in ruminants. Vet Sci Commun 1, 43–50.CrossRefGoogle Scholar
190. Hemingway, RG & Ritchie, NS (1965) The importance of hypocalcaemia in the development of hypomagnesaemic tetany. Proc Nutr Soc 24, 54–63.CrossRefGoogle ScholarPubMed
191. Todd, JR & Horvath, DJ (1970) Magnesium and neuromuscular irritability in calves, with particular reference to hypomagnesaemic tetany. Br Vet J 126, 333–346.Google ScholarPubMed
192. Chutkow, JG & Meyers, S (1968) Chemical changes in the cerebrospinal fluid and brain in magnesium deficiency. Neurology 18, 963–974.CrossRefGoogle ScholarPubMed
193. Meyer, H & Scholz, H (1972) Research into the pathogenesis of hypomagnesaemic tetany. I. Relationships between the magnesium content of blood and cerebrospinal fluid in sheep. Dtsch Tierarztl Wochenschr 79, 55–61.Google Scholar
194. Allsop, TF & Pauli, JV (1975) Responses to the lowering of magnesium and calcium concentrations in the cerebrospinal fluid of unanesthetized sheep. Aust J Biol Sci 28, 475–481.Google ScholarPubMed
195. Reynolds, CK, Bell, MC & Sims, MH (1984) Changes in plasma, red blood cell and cerebrospinal fluid mineral concentrations in calves during magnesium depletion followed by repletion with rectally infused magnesium chloride. J Nutr 114, 1334–1341.Google ScholarPubMed
196. Thomson, AM (1986) A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate. J Physiol 370, 531–549.CrossRefGoogle ScholarPubMed
197. Mayer, ML, Westbrook, GL & Guthrie, PB (1984) Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309, 261–263.CrossRefGoogle ScholarPubMed
198. Allen, WM, Sansom, BF & Davies, DC (1981) Hypomagnesaemia in cows. Vet Rec 109, 342.CrossRefGoogle ScholarPubMed
199. Anast, CS, Mohs, JM, Kaplan, SL, et al. (1972) Evidence for parathyroid failure in magnesium deficiency. Science 177, 606–608.CrossRefGoogle ScholarPubMed
200. Rayssiguier, Y, Garel, JM, Davicco, MJ, et al. (1977) Parathyroid hormone and calcitonin in magnesium-deficient calves. Horm Metab Res 9, 438–439.CrossRefGoogle ScholarPubMed
201. MacManus, J, Heaton, FW & Lucas, PW (1971) A decreased response to parathyroid hormone in magnesium deficiency. J Endocrinol 49, 253–258.CrossRefGoogle ScholarPubMed
202. Goff, JP (2008) The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J 176, 50–57.CrossRefGoogle ScholarPubMed
203. Horsting, M & DeLuca, HF (1969) In vitro production of 25-hydroxycholecalciferol. Biochem Biophys Res Commun 36, 251–256.CrossRefGoogle ScholarPubMed
204. Johannesson, AJ & Raisz, LG (1983) Effects of low medium magnesium concentration on bone resorption in response to parathyroid hormone and 1,25-dihydroxyvitamin D in organ culture. Endocrinology 113, 2294–2298.CrossRefGoogle Scholar
205. Sansom, BF, Manston, R & Vagg, MJ (1983) Magnesium and milk fever. Vet Rec 112, 447–449.CrossRefGoogle ScholarPubMed
206. van de Braak, AE, van’t Klooster, AT & Malestein, A (1987) Influence of a deficient supply of magnesium during the dry period on the rate of calcium mobilisation by dairy cows at parturition. Res Vet Sci 42, 101–108.Google ScholarPubMed
207. House, WA & Bell, AW (1993) Mineral accretion in the fetus and adnexa during late gestation in Holstein cows. J Dairy Sci 76, 2999–3010.CrossRefGoogle ScholarPubMed
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