Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 14
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cormick, Gabriela Ciapponi, Agustín Minckas, Nicole Althabe, Fernando Belizán, José M and Cormick, Gabriela 2016. Cochrane Database of Systematic Reviews.


    Amalraj, Augustine and Pius, Anitha 2015. Bioavailability of calcium and its absorption inhibitors in raw and cooked green leafy vegetables commonly consumed in India – An in vitro study. Food Chemistry, Vol. 170, p. 430.


    Hofmeyr, G.J. Seuc, A.H. Betrán, A.P. Purnat, T.D. Ciganda, A. Munjanja, S.P. Manyame, S. Singata, M. Fawcus, S. Frank, K. Hall, D.R. Cormick, G. Roberts, J.M. Bergel, E.F. Drebit, S.K. Von Dadelszen, P. and Belizan, J.M. 2015. The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Vol. 5, Issue. 4, p. 273.


    Mitchell, P. J. Cooper, C. Dawson-Hughes, B. Gordon, C. M. and Rizzoli, R. 2015. Life-course approach to nutrition. Osteoporosis International, Vol. 26, Issue. 12, p. 2723.


    Rivoira, María Rodríguez, Valeria López, María Peralta and Tolosa de Talamoni, Nori 2015. Time dependent changes in the intestinal Ca2+ absorption in rats with type I diabetes mellitus are associated with alterations in the intestinal redox state. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1852, Issue. 3, p. 386.


    Hofmeyr, G Justus Manyame, Sarah and Hofmeyr, G Justus 2014. Cochrane Database of Systematic Reviews.


    Hofmeyr, GJ Belizán, JM and von Dadelszen, P 2014. Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary. BJOG: An International Journal of Obstetrics & Gynaecology, Vol. 121, Issue. 8, p. 951.


    Khan, S.A. Mulvaney, R.L. and Ellsworth, T.R. 2014. The potassium paradox: Implications for soil fertility, crop production and human health. Renewable Agriculture and Food Systems, Vol. 29, Issue. 01, p. 3.


    Wang, Haiyuan Bua, Peter and Capodice, Jillian 2014. A comparative study of calcium absorption following a single serving administration of calcium carbonate powder versus calcium citrate tablets in healthy premenopausal women. Food & Nutrition Research, Vol. 58,


    Kim, Youjin Kelly, Owen J. and Ilich, Jasminka Z. 2013. Synergism of α-Linolenic Acid, Conjugated Linoleic Acid and Calcium in Decreasing Adipocyte and Increasing Osteoblast Cell Growth. Lipids, Vol. 48, Issue. 8, p. 787.


    Bu, So-Young Kang, Myung-Hwa Kim, Eun-Jin and Choi, Mi-Kyeong 2012. Dietary Intake Ratios of Calcium-to-Phosphorus and Sodium-to-Potassium Are Associated with Serum Lipid Levels in Healthy Korean Adults. Preventive Nutrition and Food Science, Vol. 17, Issue. 2, p. 93.


    Centeno, Viviana Picotto, Gabriela Pérez, Adriana Alisio, Arturo and Tolosa de Talamoni, Nori 2011. Intestinal Na+/Ca2+ exchanger protein and gene expression are regulated by 1,25(OH)2D3 in vitamin D-deficient chicks. Archives of Biochemistry and Biophysics, Vol. 509, Issue. 2, p. 191.


    Dayod, Maclin Tyerman, Stephen Donald Leigh, Roger Allen and Gilliham, Matthew 2010. Calcium storage in plants and the implications for calcium biofortification. Protoplasma, Vol. 247, Issue. 3-4, p. 215.


    Younger, K. M. 2009. Editorial. Nutrition Research Reviews, Vol. 22, Issue. 02, p. 109.


    ×

Molecular mechanisms triggered by low-calcium diets

  • Viviana Centeno (a1), Gabriela Díaz de Barboza (a1), Ana Marchionatti (a1), Valeria Rodríguez (a1) and Nori Tolosa de Talamoni (a1)
  • DOI: http://dx.doi.org/10.1017/S0954422409990126
  • Published online: 19 October 2009
Abstract

Ca is not only essential for bone mineralisation, but also for regulation of extracellular and intracellular processes. When the Ca2+ intake is low, the efficiency of intestinal Ca2+ absorption and renal Ca2+ reabsorption is increased. This adaptive mechanism involves calcitriol enhancement via parathyroid hormone stimulation. Bone is also highly affected. Low Ca2+ intake is considered a risk factor for osteoporosis. Patients with renal lithiasis may be at higher risk of recurrence of stone formation when they have low Ca2+ intake. The role of dietary Ca2+ on the regulation of lipid metabolism and lipogenic genes in adipocytes might explain an inverse relationship between dairy intake and BMI. Dietary Ca2+ restriction produces impairment of the adipocyte apoptosis and dysregulation of glucocorticosteroid metabolism in the adipose tissue. An inverse relationship between hypertension and a low-Ca2+ diet has been described. Ca2+ facilitates weight loss and stimulates insulin sensitivity, which contributes to the decrease in the blood pressure. There is also evidence that dietary Ca2+ is associated with colorectal cancer. Dietary Ca2+ could alter the ratio of faecal bile acids, reducing the cytotoxicity of faecal water, or it could activate Ca2+-sensing receptors, triggering intracellular signalling pathways. Also it could bind luminal antigens, transporting them into mucosal mononuclear cells as a mechanism of immunosurveillance and promotion of tolerance. Data relative to nutritional Ca2+ and incidences of other human cancers are controversial. Health professionals should be aware of these nutritional complications and reinforce the dairy intakes to ensure the recommended Ca2+ requirements and prevent diseases.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Molecular mechanisms triggered by low-calcium diets
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Molecular mechanisms triggered by low-calcium diets
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Molecular mechanisms triggered by low-calcium diets
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Nori Tolosa de Talamoni, fax +54 351 4333072,email ntolosa@biomed.uncor.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

6E Giovannucci , Y Liu , MJ Stampfer , . (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 15, 203210.

8M Lipkin (1999) Preclinical and early human studies of calcium and colon cancer prevention. Ann N Y Acad Sci 889, 120127.

15A Pérez , M Ulla , B García , . (2008) Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab 26, 358365.

20R Swaminathan , BA Sommerville & AD Care (1977) The effect of dietary calcium on the activity of 25-hydroxycholecalciferol-1-hydroxylase and Ca absorption in vitamin D-replete chicks. Br J Nutr 38, 4754.

22MR Hughes , PF Brumbaugh , MR Hussler , . (1975) Regulation of serum 1α,25-dihydroxyvitamin D3 by calcium and phosphate in the rat. Science 190, 578580.

23HP Schedl , T Conway , RL Horst , . (1996) Effects of dietary calcium and phosphorus on vitamin D metabolism and calcium absorption in hamster. Proc Soc Exp Biol Med 211, 281286.

28AJ Brown , I Krits & HJ Armbrecht (2005) Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 437, 5158.

33EM Brown , G Gamba , D Riccardi , . (1993) Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366, 575580.

34N Chattopadhyay (2006) Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. Am J Physiol Endocrinol Metab 290, E761E770.

36S Bas , A Bas , I López , . (2005) Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrinol 28, 380390.

37EM Brown (1983) Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab 56, 572581.

39D Miao , J Li , Y Xue , . (2004) Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology 145, 35543562.

41T Naveh-Many , F Raue , A Grauer , . (1992) Regulation of calcitonin gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Bone Miner Res 7, 12331237.

42S Ferrari , JP Bonjour & R Rizzoli (1998) The vitamin D receptor gene and calcium metabolism. Trends Endocrinol Metab 9, 259265.

45BS Benn , D Ajibade , A Porta , . (2008) Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology 149, 31963205.

47Y Kasukawa , DJ Baylink , JE Wergedal , . (2003) Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice. Endocrinology 144, 46824689.

54A Mavroeidi , AD Stewart , DM Reid , . (2009) Physical activity and dietary calcium interactions in bone mass in Scottish postmenopausal women. Osteoporos Int 20, 409416.

57PH Anderson , PD O'Loughlin , BK May , . (2003) Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase-polymerase chain reaction. J Mol Endocrinol 31, 123132.

59A Bajwa , RL Horst & MJ Beckman (2005) Gene profiling the effects of calcium deficiency versus 1,25-dihydroxyvitamin D induced hypercalcemia in rat kidney cortex. Arch Biochem Biophys 438, 182194.

61A Pasch , FJ Frey , U Eisenberger , . (2008) PTH and 1.25 vitamin D response to a low-calcium diet is associated with bone mineral density in renal stone formers. Nephrol Dial Transplant 23, 25632570.

62HB MacDonald (2008) Dairy nutrition: what we knew then to what we know now. Int Dairy J 18, 774777.

68GC Major , JP Chaput , M Ledoux , . (2008) Recent developments in calcium-related obesity research. Obes Rev 9, 428445.

75MA Della-Fera , H Qian & CA Baile (2001) Adipocyte apoptosis in the regulation of body fat mass by leptin. Diabetes Obes Metab 3, 299310.

80CJ Heiss , SE Shaw & L Carothers (2008) Association of calcium intake and adiposity in postmenopausal women. J Am Coll Nutr 27, 260266.

83DA McCarron , CD Morris & C Cole (1982) Dietary calcium in human hypertension. Science 217, 267269.

87LM Resnick (1999) The role of dietary calcium in hypertension: a hierarchical overview. Am J Hypertens 12, 99112.

89LJ Appel , TJ Moore , E Obarzanek , . (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336, 11171124.

92HK Vyas & PS Tong (2003) Process for calcium retention during skim milk ultrafiltration. J Dairy Sci 86, 27612766.

100PR Holt , EO Atillasoy , J Gilman , . (1998) Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized controlled trial. JAMA 280, 10741079.

104R Järvinen , P Knekt , T Hakulinen , . (2001) Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr 55, 10001007.

107PM Marcus & PA Newcomb (1998) The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Int J Epidemiol 27, 788793.

111E Cho , SA Smith-Warner , D Spiegelman , . (2004) Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies. J Natl Cancer Inst 96, 10151022.

114A Shaukat , N Scouras & HJ Schünemann (2005) Role of supplemental calcium in the recurrence of colorectal adenomas: a metaanalysis of randomized controlled trials. Am J Gastroenterol 100, 390394.

120CM Kemmis & J Welsh (2008) Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem 105, 980988.

121S Mordan-McCombs , T Brown , G Zinser , . (2007) Dietary calcium does not affect prostate tumor progression in LPB-Tag transgenic mice. J Steroid Biochem Mol Biol 103, 747751.

125L Xue , K Yang , H Newmark , . (1996) Epithelial cell hyperproliferation induced in the exocrine pancreas of mice by a Western-style diet. J Natl Cancer Inst 88, 15861590.

127RZ Stolzenberg-Solomon , R Vieth , A Azad , . (2006) A prospective nested case–control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res 66, 1021310219.

128RZ Stolzenberg-Solomon , RB Hayes , RL Horst , . (2009) Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial. Cancer Res 69, 14391447.

131M Kuokkanen , R Butzow , H Rasinperä , . (2005) Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden. Int J Cancer 117, 9094.

135JM Genkinger , DJ Hunter , D Spiegelman , . (2006) Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev 15, 364372.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: