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B Adamik , J Kubler-Kielb , B Golebiowska , A Gamian , & A Kubler (2000) Effect of sepsis and cardiac surgery with cardiopulmonary bypass on plasma level of nitric oxide metabolites, neopterin, and procalcitonin: correlation with mortality and postoperative complications. Intensive Care Medicine 26, 1259–1267.
D Adawi , FB Kasravi , G Molin , & B Jeppsson (1996) Oral arginine supplementation in acute liver injury. Nutrition 12, 529–533.
S Aggarwal , Y Kang , JA Freeman , FL Fortunato Jr & MR Pinsky (1993) Postreperfusion syndrome: hypotension after reperfusion of the transplanted liver. Journal of Critical Care 8, 154–160.
MK Angele , SM Nitsch , RA Hatz , P Angele , T Hernandez-Richter , MW Wichmann , IH Chaudry & FW Schildberg (2002) L -Arginine: a unique amino acid for improving depressed wound immune function following hemorrhage. European Surgical Research 34, 53–60.
D Annane , S Sanquer , V Sebille , A Faye , D Djuranovic , JC Raphael , P Gajdos & E Bellissant (2000) Compartmentalised inducible nitric-oxide synthase activity in septic shock. Lancet 355, 1143–1148.
Z Argaman , VR Young , N Noviski , L Castillo-Rosas , XM Lu , D Zurakowski , M Cooper , C Davison , JF Tharakan , A Ajami & L Castillo (2003) Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Critical Care Medicine 31, 591–597.
JF Arnal , AT Dinh-Xuan , M Pueyo , B Darblade , & J Rami (1999) Endothelium-derived nitric oxide and vascular physiology and pathology. Cellular and Molecular Life Sciences 55, 1078–1087.
S Baltaci , D Orhan , C Gogus , K Turkolmez , O Tulunay & O Gogus (2001) Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma. BJU International 88, 100–103.
SM Bode-Boger , RH Boger , A Galland , D Tsikas & JC Frolich (1998) L -Arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. British Journal of Clinical Pharmacology 46, 489–497.
RH Boger & SM Bode-Boger (2001) The clinical pharmacology of L -arginine. Annual Review of Pharmacology and Toxicology 41, 79–99.
P Boros , A Tarcsafalvi , L Wang , J Megyesi , J Liu & CM Miller (2001) Intrahepatic expression and release of vascular endothelial growth factor following orthotopic liver transplantation in the rat. Transplantation 72, 805–811.
V Bronte , P Serafini , A Mazzoni , DM Segal & P Zanovello (2003) L -Arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends in Immunology 24, 302–306.
JT Brosnan (1987) The 1986 Borden Award Lecture. The role of the kidney in amino acid metabolism and nutrition. Canadian Journal of Physiology and Pharmacology 65, 2355–2362.
MJ Bruins , WH Lamers , AJ Meijer , PB Soeters & NE Deutz (2002 a) In vivo measurement of nitric oxide production in porcine gut, liver and muscle during hyperdynamic endotoxaemia. British Journal of Pharmacology 137, 1225–1236.
MJ Bruins , PB Soeters , WH Lamers , AJ Meijer , & NEP Deutz (2002 c) L -Arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by the different organs. Critical Care Medicine 30, 508–517.
P Burra , L Chirizzi , R Cardin , R Cadrobbi , N Baldan , F Calabrese , E Pettenazzo , L Calo , M Plebani & P Rigotti (2001) Warm hepatic ischemia in pigs: effects of L -arginine and oligotide treatment. Journal of Investigative Surgery 14, 303–312.
L Castillo , L Beaumier , AM Ajami & VR Young (1996) Whole body nitric oxide synthesis in healthy men determined from [ 15N] arginine-to-[ 15N]citrulline labeling. Proceedings of the National Academy of Sciences USA 93, 11460–11465.
RAFM Chamuleau , NEP Deutz , JG de Haan & J van Gool (1987) Correlation between electroencephalographic and biochemical indices in acute hepatic encephalopathy in rats. Journal of Hepatology 4, 299–306.
K Chen , M Inoue , M Wasa , M Fukuzawa , S Kamata & A Okada (1997) Expression of endothelial constitutive nitric oxide synthase mRNA in gastrointestinal mucosa and its downregulation by endotoxin. Life Sciences 61, 1323–1329.
W Choe , S Kim , TS Hwang & SS Lee (2003) Expression of inducible nitric oxide synthase in thyroid neoplasms: immunohistochemical and molecular analysis. Pathology International 53, 434–439.
LM Colletti , SL Kunkel , A Walz , MD Burdick , RG Kunkel , CA Wilke & RM Strieter (1995) Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. Journal of Clinical Investigations 95, 134–141.
P Crenn , C Coudray-Lucas , F Thuillier , L Cynober & B Messing (2000) Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 119, 1496–1505.
P Crenn , K Vahedi , A Lavergne-Slove , L Cynober , C Matuchansky & B Messing (2003) Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124, 1210–1219.
L Cynober (1994) Can arginine and ornithine support gut functions? Gut 35, Suppl. 1, S42–S45.
L Cynober , J Le Boucher & M-P Vasson (1995) Arginine metabolism in mammals. Journal of Nutritional Biochemistry 6, 402–403.
JM Daly , J Reynolds , A Thom , L Kinsley , M Dietrick-Gallagher , J Shou & B Ruggieri (1988) Immune and metabolic effects of arginine in the surgical patient. Annals of Surgery 208, 512–523.
D De Backer , J Creteur JC Preiser , MJ Dubois & JL Vincent (2002) Microvascular blood flow is altered in patients with sepsis. American Journal of Respiratory and Critical Care Medicine 166, 98–104.
RJ de Knegt , SW Schalm , CC van der Rijt , D Fekkes , E Dalm & I Hekking-Weyma (1994) Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. Journal of Hepatology 20, 19–26.
NEP Deutz , CHC Dejong , G Athanasas & PB Soeters (1992) Partial enterectomy in the rat does not diminish muscle glutamine production. Metabolism 41, 1343–1350.
I de Werra , C Jaccard , SB Corradin , R Chiolero , B Yersin , H Gallati , M Assicot , C Bohuon , JD Baumgartner , MP Glauser & D Heumann (1997) Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Critical Care Medicine 25, 607–613.
PD Edwards , D Topping , MI Kontaridis , LL Moldawer , 3 Copeland EM & DS Lind (1997) Arginine-enhanced enteral nutrition augments the growth of a nitric oxide-producing tumor. Journal of Parenteral and Enteral Nutrition 21, 215–219.
NE Flynn , CJ Meininger , TE Haynes & G Wu (2002) The metabolic basis of arginine nutrition and pharmacotherapy. Biomedicine and Pharmacotherapy 56, 427–438.
O Gallo , N Schiavone , L Papucci , I Sardi , L Magnelli , A Franchi , E Masini & S Capaccioli (2003) Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by P53 in squamous cell carcinoma. American Journal of Pathology 163, 723–732.
MT Gewaltig & G Kojda (2002) Vasoprotection by nitric oxide: mechanisms and therapeutic potential. Cardiovascular Research 55, 250–260.
RE Glass , AW Goode , BJ Houghton & LW Rowell (1986) Plasma arginine in cancer of the gastrointestinal tract: effect of surgical treatment. Gut 27, 844–848.
SS Gokmen , AC Aygit , MS Ayhan , F Yorulmaz & S Gulen (2001) Significance of arginase and ornithine in malignant tumors of the human skin. Journal of Laboratory and Clinical Medicine 137, 340–344.
J Gomez-Jimenez , A Salgado , M Mourelle , MC Martin , RM Segura , R Peracaula , & S Moncada (1995) L -Arginine: nitric oxide pathway in endotoxemia and human septic shock. Critical Care Medicine 23, 253–258.
SJ Gonce , MD Peck , JW Alexander , PW Miskell (1990) Arginine supplementation and its effect on established peritonitis in guinea pigs. Journal of Parenteral and Enteral Nutrition 14, 237–244.
AB Groeneveld , KJ Hartemink , MC de Groot , J Visser & LG Thijs (1999) Circulating endothelin and nitrate-nitrite relate to hemodynamic and metabolic variables in human septic shock. Shock 11, 160–166.
PH Groeneveld , KM Kwappenberg , JA Langermans , PH Nibbering & L Curtis (1996) Nitric oxide (NO) production correlates with renal insufficiency and multiple organ dysfunction syndrome in severe sepsis. Intensive Care Medicine 22, 1197–1202.
PH Groeneveld , KM Kwappenberg , JA Langermans , PH Nibbering & L Curtis (1997) Relation between pro- and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis. Cytokine 9, 138–142.
RJ Groszmann (1993) Hyperdynamic state in chronic liver diseases. Journal of Hepatology 17, Suppl. 2, S38–S40.
C Guarner , G Soriano , A Tomas , O Bulbena , MT Novella , J Balanzo , F Vilardell , M Mourelle & S Moncada (1993) Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 18, 1139–1143.
MM Hallemeesch , WH Lamers & NE Deutz (2002 b) Reduced arginine availability and nitric oxide production. Clinical Nutrition 21, 273–279.
F Hammarqvist , J Wernerman , R Ali , A von der Decken & E Vinnars (1989) Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves n balance. Annals of Surgery 209, 455–461.
DG Harrison & H Cai (2003) Endothelial control of vasomotion and nitric oxide production. Cardiology Clinics 21, 289–302.
AS Hazell & MD Norenberg (1998) Ammonia and manganese increase arginine uptake in cultured astrocytes. Neurochemical Research 23, 869–873.
KS Helmer , SD West , GL Shipley , L Chang , Y Cui , D Mailman & DW Mercer (2002) Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats. Gastroenterology 123, 173–186.
A Helmy , DE Newby , R Jalan , NR Johnston , PC Hayes & DJ Webb (2003) Nitric oxide mediates the reduced vasoconstrictor response to angiotensin ii in patients with preascitic cirrhosis. Journal of Hepatology 38, 44–50.
DK Heyland , F Novak , JW Drover , M Jain , X Su & U Suchner (2001) Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. Journal of the American Medical Association 286, 944–953.
DK Heyland & A Samis (2003) Does immunonutrition in patients with sepsis do more harm than good? Intensive Care Medicine 29, 669–671.
SD Heys & F Ashkanani (1999) Glutamine. British Journal of Surgery 86, 289–290.
SD Heys , A Segar , S Payne , DM Bruce , N Kernohan & O Eremin (1997) Dietary supplementation with L -arginine: modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer. British Journal of Surgery 84, 238–241.
M Ikemoto , S Tsunekawa , K Tanaka , A Tanaka , Y Yamaoka , K Ozawa , Y Fukuda , F Moriyasu , M Totani , Y Kasai , T Mori & K Ueda (1998) Liver-type arginase in serum during and after liver transplantation: a novel index in monitoring conditions of the liver graft and its clinical significance. Clinica Chimica Acta 271, 11–23.
A Ito , PS Tsao , S Adimoolam , M Kimoto , T Ogawa & JP Cooke (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99, 3092–3095.
M Jalkanen , H Larjava , J Heino , T Vihersaari , J Peltonen & R Penttinen (1982) Arginine depletion in macrophage medium inhibits collagen synthesis by fibroblasts. Immunology Letters 4, 259–261.
A Jayasurya , ST Dheen , WM Yap , NG Tan , YK Ng & BH Bay (2003) Inducible nitric oxide synthase and bcl-2 expression in nasopharyngeal cancer: correlation with outcome of patients after radiotherapy. International Journal of Radiation Oncology, Biology, Physics 56, 837–845.
E Kelly , SM Morris Jr & TR Billiar (1995) Nitric oxide, sepsis, and arginine metabolism. Journal of Parenteral and Enteral Nutrition 19, 234–238.
JT Kielstein , SM Bode-Boger , JC Frolich , E Ritz , H Haller & D Fliser (2003) Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation 107, 1891–1895.
R Kilbourn (1999) Nitric oxide synthase inhibitors – a mechanism-based treatment of septic shock. Critical Care Medicine 27, 857–858.
KA Kirkeboen & OA Strand (1999) The role of nitric oxide in sepsis – an overview. Acta Anaesthesiologica 43, 275–288.
VS Klimberg , RM Salloum , M Kasper , DA Plumley , DJ Dolson , RD Hautamaki , WR Mendenhall , FC Bova , KI Bland , EM Copeland & WW Souba (1990 a) Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Archives of Surgery 125, 1040–1045.
VS Klimberg , WW Souba , RM Salloum , DT Holley , RD Hautamaki , DJ Dolson & EM Copeland (1990 b) Intestinal glutamine metabolism after massive small bowel resection. American Journal of Surgery 159, 27–33.
G Kong , EK Kim , WS Kim , KT Lee , YW Lee , JK Lee , SW Paik & JC Rhee (2002) Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. Journal of Gastroenterology and Hepatology 17, 914–921.
A Kubota , MM Meguid & DC Hitch (1992) Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors. Cancer 69, 2343–2348.
J Lavoie , JF Giguere , GP Layrargues & RF Butterworth (1987) Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Journal of Neurochemistry 49, 692–697.
RH Lee , D Efron , U Tantry & A Barbul (2001) Nitric oxide in the healing wound: a time-course study. Journal of Surgical Research 101, 104–108.
TW Lee , GG Chen , H Xu , JH Yip , EC Chak , TS Mok & AP Yim (2003) Differential expression of inducible nitric oxide synthase and peroxisome proliferator-activated receptor gamma in non-small cell lung carcinoma. European Journal of Cancer 39, 1296–1301.
AB Lentsch , H Yoshidome , WG Cheadle , FN Miller & MJ Edwards (1998) Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and Kc. Hepatology 27, 1172–1177.
KY Lin , A Ito , T Asagami , PS Tsao , S Adimoolam , M Kimoto , H Tsuji , GM Reaven , JP Cooke & (2002) Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 106, 987–992.
Q Liu , ST Chan & R Mahendran (2003) Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. Carcinogenesis 24, 637–642.
JA Lorente , MA Delgado , C Tejedor , E Mon , M Hervas , T Pascual , P Fernandez-Segoviano , G Rieppi , A Soler , D Ayuso & A Esteban (1999) Modulation of systemic hemodynamics by exogenous L -arginine in normal and bacteremic sheep. Critical Care Medicine 27, 2474–2479.
JA Lorente , L Landin , R De Pablo , E Renes , D Liste (1993 a) L -Arginine pathway in the sepsis syndrome. Critical Care Medicine 21, 1287–1295.
JA Lorente , L Landin , E Renes , R De Pablo , P Jorge , E Rodena & D Liste (1993 b) Role of nitric oxide in the hemodynamic changes of sepsis. Critical Care Medicine 21, 759–767.
YC Luiking & NE Deutz (2003) Isotopic investigation of nitric oxide metabolism in disease. Current Opinion in Clinical Nutrition and Metabolic Care 6, 103–108.
RJ MacAllister , H Parry , M Kimoto , T Ogawa , RJ Russell , H Hodson , GS Whitley & P Vallance (1996) Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. British Journal of Pharmacology 119, 1533–1540.
RV Mendes , AR Martins , G de Nucci , F Murad & FA Soares (2001) Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma. Histopathology 39, 172–178.
RM Millis , CA Diya , ME Reynolds , O Dehkordi & V Bond Jr (1998) Growth inhibition of subcutaneously transplanted hepatomas without cachexia by alteration of the dietary arginine-methionine balance. Nutrition and Cancer 31, 49–55.
FL Moffat Jr, T Han , ZM Li , MD Peck , W Jy , YS Ahn , AJ Chu & LY Bourguignon (1996) Supplemental L -arginine HCl augments bacterial phagocytosis in human polymorphonuclear leukocytes. Journal of Cellular Physiology 168, 26–33.
F Morel , A Hus-Citharel & O Levillain (1996) Biochemical heterogeneity of arginine metabolism along the kidney proximal tubules. Kidney International 49, 1608–1610.
IN Mungrue , DS Bredt , DJ Stewart & M Husain (2003) From molecules to mammals: what's NOS got to do with it? Acta Physiologica Scandinavica 179, 123–135.
T Murohara , T Asahara , M Silver , C Bauters , H Masuda , C Kalka , M Kearney , D Chen , JF Symes , MC Fishman , PL Huang & JM Isner (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. Journal of Clinical Investigations 101, 2567–2578.
GA Murrell , C Szabo , JA Hannafin , D Jang , MM Dolan , XH Deng , DF Murrell & RF Warren (1997) Modulation of tendon healing by nitric oxide. Inflammation Research 46, 19–27.
AB Naini , JW Dickerson & MM Brown (1988) Preoperative and postoperative levels of plasma protein and amino acid in esophageal and lung cancer patients. Cancer 62, 355–360.
H Nakae , S Endo , M Kikuchi , Y Yamada , M Shibata , H Ishikura , T Tanaka , G Wakabayashi , T Kawamura , K Inada & S Sato (2000) Nitrite/nitrate (NOx) levels and hemodynamics during septic shock. Surgery Today 30, 683–688.
C Napoli (2002) Nitric oxide and atherosclerotic lesion progression: an overview. Journal of Cardiac Surgery 17, 355–362.
C Napoli & LJ Ignarro (2001) Nitric oxide and atherosclerosis. Nitric Oxide 5, 88–97.
RJ Nijveldt , T Teerlink , MP Siroen , AA van Lambalgen , JA Rauwerda & PA van Leeuwen (2003 a) The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA). Clinical Nutrition 22, 17–22.
JG Nirgiotis , PJ Hennessey & RJ Andrassy (1991) The effects of an arginine-free enteral diet on wound healing and immune function in the postsurgical rat. Journal of Pediatric Surgery 26, 936–941.
JB Ochoa , AO Udekwu , TR Billiar , RD Curran , FB Cerra , RL Simmons & AB Peitzman (1991) Nitrogen oxide levels in patients after trauma and during sepsis. Annals of Surgery 214, 621–626.
T Ogawa , M Kimoto & K Sasaoka (1987) Occurrence of a new enzyme catalyzing the direct conversion of NG, NG-dimethyl- L -arginine to L -citrulline in rats. Biochemical and Biophysical Research Communications 148, 671–677.
IMJ Oudenhoven , HLBM Klaasen , JA Lapre , AH Weerkamp & R Van der Meer (1994 b) Nitric oxide-derived urinary nitrate as a marker of intestinal bacterial translocation in rats. Gastroenterology 107, 47–53.
KG Park , SD Heys , K Blessing , P Kelly , MA McNurlan , O Eremin & PJ Garlick (1992) Stimulation of human breast cancers by dietary L -arginine. Clinical Science (London) 82, 413–417.
A Patel , C Fenton , R Terrell , PA Powers , C Dinauer , RM Tuttle & GL Francis (2002) Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. Journal of Endocrinological Investigation 25, 675–683.
M Poeze , JW Greve & G Ramsay (1999) Oxygen delivery in septic shock. Chest 116, 1145.
JC Preiser , D De Backer & JL Vincent (2003) Nitroglycerin for septic shock. Lancet 361, 880.
RB Preli , KP Klein & DM Herrington (2002) Vascular effects of dietary L -arginine supplementation. Atherosclerosis 162, 1–15.
BM Prior , PG Lloyd , J Ren , Z Li , HT Yang , MH Laughlin & RL Terjung (2003) Arteriogenesis: role of nitric oxide. Endothelium 10, 207–216.
VL Rao , RM Audet & RF Butterworth (1997) Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis. Brain Research 765, 169–172.
MC Reade , MF Clark , JD Young & CA Boyd (2002) Increased cationic amino acid flux through a newly expressed transporter in cells overproducing nitric oxide from patients with septic shock. Clinical Science (London) 102, 645–650.
EA Rekka & MC Chrysselis (2002) Nitric oxide in atherosclerosis. Mini Reviews in Medicinal Chemistry 2, 585–593.
JV Reynolds , AK Thom , SM Zhang , MM Ziegler , A Naji & JM Daly (1988 b) Arginine, protein malnutrition, and cancer. Journal of Surgical Research 45, 513–522.
S Riso , P Aluffi , M Brugnani , F Farinetti , F Pia & F D'Andrea (2000) Postoperative enteral immunonutrition in head and neck cancer patients. Clinical Nutrition 19, 407–412.
DC Rockey (2003) Vascular mediators in the injured liver. Hepatology 37, 4–12.
WC Rose (1976) Nutrition Classics. Federation Proceedings 8(2) 546–52, June 1949. Amino acid requirements of man. William C. Rose. Nutrition Reviews 34, 307–309.
E Roth (1998) L -Arginine-nitric oxide metabolism. Clinical Nutrition 17, 1–2.
AI Sarela , FM Mihaimeed , JJ Batten , BR Davidson & RT Mathie (1999) Hepatic and splanchnic nitric oxide activity in patients with cirrhosis. Gut 44, 749–753.
MR Schaffer , U Tantry , RA van Wesep & A Barbul (1997) Nitric oxide metabolism in wounds. Journal of Surgical Research 71, 25–31.
W Scheppach , C Loges , P Bartram , SU Christl , F Richter , G Dusel , P Stehle , P Furst & H Kaspar (1994) Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology 107, 429–434.
JA Scott , S Mehta , M Duggan , A Bihari & DG McCormack (2002) Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis. American Journal of Respiratory and Critical Care Medicine 165, 1426–1432.
V Shah , M Toruner , F Haddad , G Cadelina , A Papapetropoulos , K Choo , WC Sessa & RJ Groszmann (1999) Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 117, 1222–1228.
HP Shi , DT Efron , D Most , US Tantry & A Barbul (2000) Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice. Surgery 128, 374–378.
RK Sigal , J Shou & JM Daly (1992) Parenteral arginine infusion in humans: nutrient substrate or pharmacologic agent? Journal of Parenteral and Enteral Nutrition 16, 423–428.
OA Strand , A Leone , KE Giercksky & KA Kirkeboen (2000) Nitric oxide indices in human septic shock. Critical Care Medicine 28, 2779–2785.
P Sukumar , A Loo , E Magur , J Nandi , A Oler & RA Levine (1997) Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. Digestive Diseases and Sciences 42, 1530–1536.
S Symeonides & RA Balk (1999) Nitric oxide in the pathogenesis of sepsis. Infectious Disease Clinics of North America 13, 449–463.
C Szabo (1996) The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6, 79–88.
B Szende , E Tyihak & L Trezl (2001) Role of arginine and its methylated derivatives in cancer biology and treatment. Cancer Cell International 1, 3.
K Tachibana , K Mukai , I Hiraoka , S Moriguchi , S Takama & Y Kishino (1985) Evaluation of the effect of arginine-enriched amino acid solution on tumor growth. Journal of Parenteral and Enteral Nutrition 9, 428–434.
C Tentolouris , D Tousoulis , G Goumas , C Stefanadis , G Davies & P Toutouzas (2000) L -Arginine in coronary atherosclerosis. International Journal of Cardiology 75, 123–128.
LL Thomsen , DW Miles , L Happerfield , LG Bobrow , RG Knowles & S Moncada (1995) Nitric oxide synthase activity in human breast cancer. British Journal of Cancer 72, 41–44.
A Tizianello , G de Ferrari , G Garibotto , G Guerreri & C Robaudo (1980) Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. Journal of Clinical Investigations 65, 1162–1173.
A Tizianello , G Deferrari , G Garibotto , C Robaudo , G Salvidio & S Saffiotti (1985) Renal ammoniagenesis in the postprandial period. Contributions to Nephrology 47, 44–57.
D Tousoulis , C Antoniades , C Tentolouris , G Goumas , C Stefanadis & P Toutouzas (2002) L -Arginine in cardiovascular disease: dream or reality? Vascular Medicine 7, 203–211.
JA Ulibarri , PE Mozdziak , E Schultz , C Cook & TM Best (1999) Nitric oxide donors, sodium nitroprusside and S-nitroso-N-acetylpencillamine, stimulate myoblast proliferation in vitro. In Vitro Cellular and Development Biology. Animal 35, 215–218.
N Unno , H Wang , MJ Menconi , SH Tytgat , V Larkin , M Smith , MJ Morin , A Chavez , RA Hodin & MP Fink (1997) Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 113, 1246–1257.
P Vallance , A Leone , A Calver , J Collier & S Moncada (1992) Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. Journal of Cardiovascular Pharmacology 20, Suppl. 12, S60–S62.
RR van der Hulst , MF von Meyenfeldt , NE Deutz & PB Soeters (1997) Glutamine extraction by the gut is reduced in depleted [corrected] patients with gastrointestinal cancer. Annals of Surgery 225, 112–121.
RRWJ van der Hulst , NEP Deutz , MF von Meyenfeldt , JMH Elbers , RW Stockbrugger & PB Soeters (1994) Decrease of mucosal glutamine concentration in the nutritionally depleted patient. Clinical Nutrition 13, 228–233.
RRWJ van der Hulst , BK van Kreel , MF von Meyenfeldt , R-JM Brummer , J-W Arends , NEP Deutz & PB Soeters (1993) Glutamine and the preservation of gut integrity. Lancet 341, 1363–1365.
J Wang , M Torbenson , Q Wang , JY Ro & M Becich (2003) Expression of inducible nitric oxide synthase in paired neoplastic and non-neoplastic primary prostate cell cultures and prostatectomy specimen. Urologic Oncology 21, 117–122.
U Wenzel , S Kuntz , UJ De Sousa & H Daniel (2003) Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. International Journal of Cancer 106, 666–675.
J Wernerman (1998) Glutamine-containing TPN: a question of life and death for intensive care unit-patients? Clinical Nutrition 17, 3–6.
MF White (1985) The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochimica et Biophysica Acta 822, 355–374.
HG Windmueller & AE Spaeth (1975) Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Archives of Biochemistry and Biophysics 171, 662–672.
DA Wink , JA Cook , R Pacelli , W DeGraff , J Gamson , J Liebmann , MC Krishna & JB Mitchell (1996) The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Archives of Biochemistry and Biophysics 331, 241–248.
DA Wink , Y Vodovotz , J Laval , F Laval , MW Dewhirst & JB Mitchell (1998) The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19, 711–721.
MB Witte , A Barbul , MA Schick , N Vogt & D Becker H (2002 a) Upregulation of arginase expression in wound-derived fibroblasts. Journal of Surgical Research 105, 35–42.
H Wolf , C Haeckel & A Roessner (2000) Inducible nitric oxide synthase expression in human urinary bladder cancer. Virchows Archiv 437, 662–666.
G Wu & SM Morris Jr (1998) Arginine metabolism: nitric oxide and beyond. Biochemical Journal 336, 1–17.
Y Xia , VL Dawson , TM Dawson , SH Snyder & JL Zweier (1996) Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proceedings of the National Academy of Sciences USA 93, 6770–6774.
GP Yagnik , Y Takahashi , G Tsoulfas , K Reid , N Murase & DA Geller (2002) Blockade of the L -arginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury. Hepatology 36, 573–581.
TJ Yeatman , GL Risley & ME Brunson (1991) Depletion of dietary arginine inhibits growth of metastatic tumor. Archives of Surgery 126,1376–1381, discussion 1381–1382.
CL Yeh , SL Yeh , MT Lin & WJ Chen (2002) Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic rats. Nutrition 18, 631–635.
Y Yoshie & H Ohshima (1997) Nitric oxide synergistically enhances DNA strand breakage induced by polyhydroxyaromatic compounds, but inhibits that induced by the Fenton reaction. Archives of Biochemistry and Biophysics 342, 13–21.
JC Zhuang , TL Wright , T deRojas-Walker , SR Tannenbaum , GN Wogan (2000) Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium. Environmental and Molecular Mutagenesis 35, 39–47.
K Zimmermann , N Opitz , J Dedio , C Renne W Muller-Esterl & S Oess (2002) NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences USA 99, 17167–17172.