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    Wijnands, Karolina Castermans, Tessy Hommen, Merel Meesters, Dennis and Poeze, Martijn 2015. Arginine and Citrulline and the Immune Response in Sepsis. Nutrients, Vol. 7, Issue. 3, p. 1426.

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    Bender, David A 2004. Editorial. Nutrition Research Reviews, Vol. 17, Issue. 02, p. 131.


Pros and cons of L-arginine supplementation in disease

  • Yvonne L. J. Vissers (a1), Iris B. J. G. Debats (a2), Yvette C. Luiking (a1), Rajiv Jalan (a3), René R. W. J. van der Hulst (a2), Cornelis H. C. Dejong (a1) and Nicolaas E. P. Deutz (a1)
  • DOI:
  • Published online: 14 December 2007

The amino acid arginine and one of its metabolites NO have gathered broad attention in the last decade. Although arginine is regarded as a conditionally essential amino acid in disease, L-arginine supplementation in severe illness has not found its way into clinical practice. This might be due to the invalid interpretation of results from studies with immune-enhancing diets containing L-arginine amongst other pharmaconutrients. However, not much attention is given to research using L-arginine as a monotherapy and the possibility of the alternative hypothesis: that L-arginine supplementation is beneficial in disease. The present review will discuss data from studies in healthy and diseased animals and patients with monotherapy of L-arginine to come to an objective overview of positive and negative aspects of L-arginine supplementation in disease with special emphasis on sepsis, cancer, liver failure and wound healing.

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*Corresponding author: Dr Nicolaas E. P. Deutz, fax +31 43 3882126, email
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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
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