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A review of the physiology of the canine digestive tract related to the development of in vitro systems

Published online by Cambridge University Press:  14 December 2007

Marianne Smeets-Peeters
TNO Food and Nutrition Research Institute, Utrechtseweg 48, P.O. Box 360, 3700 AJ Zeist, theNetherlands Wageningen Agricultural University. Department of animal nutrition, Marijkeweg 40, 6709 PG Wageningen, theNetherlands
Tim Watson
Waltham Centre for Pet Nutrition, Waltham-on-the- Wolds, Melton Mowbray, Leicestershire LEI4 4RT, England
Mans Minekus
TNO Food and Nutrition Research Institute, Utrechtseweg 48, P.O. Box 360, 3700 AJ Zeist, theNetherlands
Robert Havenaar
TNO Food and Nutrition Research Institute, Utrechtseweg 48, P.O. Box 360, 3700 AJ Zeist, theNetherlands
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Food and nutrition studies in animals and human beings often meet with technical difficulties and sometimes with ethical questions. An alternative to research in living animals is the dynamic multicompartmental in vitro model for the gastrointestinal tract described by Minekus et al. (1995) and Havenaar & Minekus (1996). The dynamic conditions that are simulated in this model are peristaltic movements, transit times, pH responses, secretion of enzymes and electrolytes and absorption of nutrients and water. To obtain data for an in vitro model of the dog gastrointestinal tract, the literature was surveyed for physiological responses to different types of dog food. These included: values of enzyme activities, electrolyte concentrations, gastric emptying and intestinal transit times, pH values, secretion and composition of bile and absorption rates in different parts of the dog gastrointestinal tract. The review focuses on research carried out on healthy, adult dogs of 10–20 kg and on parameters related to the oral cavity, stomach and small intestine. This literature research gives sufficient data on the physiology of the canine digestive tract for the development of an in vitro dynamic model that adequately simulates the functions of the stomach and small intestine of the dog.

Research Article
Copyright © The Nutrition Society 1998


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