Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 33
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bischel, Lindsey E. Ritchie, Christine Kober, Kord M. Paul, Steven M. Cooper, Bruce A. Chen, Lee-May Levine, Jon D. Hammer, Marilyn Wright, Fay and Miaskowski, Christine 2016. Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy. European Journal of Oncology Nursing, Vol. 23, p. 115.


    Blackhall, Leslie J. Read, Paul Stukenborg, George Dillon, Patrick Barclay, Joshua Romano, Andrew and Harrison, James 2016. CARE Track for Advanced Cancer: Impact and Timing of an Outpatient Palliative Care Clinic. Journal of Palliative Medicine, Vol. 19, Issue. 1, p. 57.


    Dong, Skye T. Butow, Phyllis N. Tong, Allison Agar, Meera Boyle, Frances Forster, Benjamin C. Stockler, Martin and Lovell, Melanie R. 2016. Patients’ experiences and perspectives of multiple concurrent symptoms in advanced cancer: a semi-structured interview study. Supportive Care in Cancer, Vol. 24, Issue. 3, p. 1373.


    Dong, Skye T. Costa, Daniel S.J. Butow, Phyllis N. Lovell, Melanie R. Agar, Meera Velikova, Galina Teckle, Paulos Tong, Allison Tebbutt, Niall C. Clarke, Stephen J. van der Hoek, Kim King, Madeleine T. and Fayers, Peter M. 2016. Symptom Clusters in Advanced Cancer Patients: An Empirical Comparison of Statistical Methods and the Impact on Quality of Life. Journal of Pain and Symptom Management, Vol. 51, Issue. 1, p. 88.


    Dong, Skye T. Butow, Phyllis N. Agar, Meera Lovell, Melanie R. Boyle, Frances Stockler, Martin Forster, Benjamin C. and Tong, Allison 2016. Clinicians' Perspectives on Managing Symptom Clusters in Advanced Cancer: A Semistructured Interview Study. Journal of Pain and Symptom Management, Vol. 51, Issue. 4, p. 706.


    Kim, Hee Sun Kim, Miok and Lee, Seon Heui 2016. Symptom Clusters in Korean Patients With Metastatic Cancer Undergoing Palliative Chemotherapy. Journal of Hospice & Palliative Nursing, Vol. 18, Issue. 4, p. 292.


    Lowe, Sonya S. Tan, Maria Faily, Joan Watanabe, Sharon M. and Courneya, Kerry S. 2016. Physical activity in advanced cancer patients: a systematic review protocol. Systematic Reviews, Vol. 5, Issue. 1,


    Meneses, Karen Landier, Wendy and Dionne-Odom, J. Nicholas 2016. Vulnerable Population Challenges in the Transformation of Cancer Care. Seminars in Oncology Nursing, Vol. 32, Issue. 2, p. 144.


    Van Lancker, Aurélie Beeckman, Dimitri Verhaeghe, Sofie Van Den Noortgate, Nele Grypdonck, Mieke and Van Hecke, Ann 2016. An instrument to collect data on frequency and intensity of symptoms in older palliative cancer patients: A development and validation study. European Journal of Oncology Nursing, Vol. 21, p. 38.


    Arrieta, Enrique Gómez de Caso (†), José Ángel Vega, Tomás Lozano, José E. and Zuriaga, Oscar 2015. Pacientes que reciben atención sanitaria paliativa y de soporte de los equipos de atención primaria en el domicilio. Estudio APASO, mediante Redes Centinelas Sanitarias. Medicina Paliativa,


    Lee, Yi-Hui Chu, Dachen Yang, Nan-Ping Chan, Chien-Lung Cheng, Shun-Ping Pai, Jih-Tung and Chang, Nien-Tzu 2015. Emergency visits among end-of-life cancer patients in Taiwan: a nationwide population-based study. BMC Palliative Care, Vol. 14, Issue. 1,


    Coyle, Nessa and Glajchen, Myra 2014. Practical Management of Pain.


    Dong, Skye Tian Butow, Phyllis N. Costa, Daniel S.J. Lovell, Melanie R. and Agar, Meera 2014. Symptom Clusters in Patients With Advanced Cancer: A Systematic Review of Observational Studies. Journal of Pain and Symptom Management, Vol. 48, Issue. 3, p. 411.


    Götze, Heide Brähler, Elmar Gansera, Lutz Polze, Nina and Köhler, Norbert 2014. Psychological distress and quality of life of palliative cancer patients and their caring relatives during home care. Supportive Care in Cancer, Vol. 22, Issue. 10, p. 2775.


    Guner, C.K. Akin, S. and Durna, Z. 2014. Comparison of the symptoms reported by post-operative patients with cancer and nurses’ perception of patient symptoms. European Journal of Cancer Care, Vol. 23, Issue. 4, p. 523.


    Lloyd-Williams, Mari Payne, Sheila Reeve, Joanne and Dona, Ruwanthi Kolamunnage 2014. Thoughts of self-harm and depression as prognostic factors in palliative care patients. Journal of Affective Disorders, Vol. 166, p. 324.


    Reeve, B. B. Mitchell, S. A. Dueck, A. C. Basch, E. Cella, D. Reilly, C. M. Minasian, L. M. Denicoff, A. M. O'Mara, A. M. Fisch, M. J. Chauhan, C. Aaronson, N. K. Coens, C. and Bruner, D. W. 2014. Recommended Patient-Reported Core Set of Symptoms to Measure in Adult Cancer Treatment Trials. JNCI Journal of the National Cancer Institute, Vol. 106, Issue. 7, p. dju129.


    Sizoo, Eefje M. Pasman, H. Roeline W. Dirven, Linda Marosi, Christine Grisold, Wolfgang Stockhammer, Günther Egeter, Jonas Grant, Robin Chang, Susan Heimans, Jan J. Deliens, Luc Reijneveld, Jaap C. and Taphoorn, Martin J. B. 2014. The end-of-life phase of high-grade glioma patients: a systematic review. Supportive Care in Cancer, Vol. 22, Issue. 3, p. 847.


    Van Lancker, Aurélie Velghe, Anja Van Hecke, Ann Verbrugghe, Mathieu Van Den Noortgate, Nele Grypdonck, Mieke Verhaeghe, Sofie Bekkering, Geertruida and Beeckman, Dimitri 2014. Prevalence of Symptoms in Older Cancer Patients Receiving Palliative Care: A Systematic Review and Meta-Analysis. Journal of Pain and Symptom Management, Vol. 47, Issue. 1, p. 90.


    Wengström, Yvonne Geerling, Jenske and Rustøen, Tone 2014. European Oncology Nursing Society breakthrough cancer pain guidelines. European Journal of Oncology Nursing, Vol. 18, Issue. 2, p. 127.


    ×

A review of the literature on multiple symptoms, their predictors, and associated outcomes in patients with advanced cancer

  • Stephanie Gilbertson-White (a1), Bradley E. Aouizerat (a2), Thierry Jahan (a3) and Christine Miaskowski (a1)
  • DOI: http://dx.doi.org/10.1017/S147895151000057X
  • Published online: 25 February 2011
Abstract
AbstractObjective:

The findings from several studies suggest that palliative care patients with advanced cancer experience multiple symptoms, and that these symptoms may be related to demographic and clinical factors as well as to patient outcomes. However, no systematic review has summarized the findings from studies that assessed multiple symptoms, predictors, and outcomes in these patients. The purposes of this review, focused on palliative care patients with advanced cancer, are to: 1) describe the relationships among multiple symptoms; 2) describe the predictors of multiple symptoms; and 3) describe the relationships between multiple symptoms and patient outcomes.

Method:

Comprehensive literature searches were completed using the following databases: PubMed, Cumulative Index to Nursing and Allied Health Literature, and PsychInfo. The key words: cancer or advanced cancer or neoplasm, AND palliative care or terminal care or hospice or end-of-life, AND symptoms or multiple symptoms or symptom clusters were combined.

Results:

Twenty-two studies met the inclusion criteria and examined at least one of our purposes. The majority of these studies were descriptive and used one of four common symptom assessment scales. Fifty-six different signs and symptoms were evaluated across various dimensions (i.e., prevalence, severity, distress, frequency, control). Pain, dyspnea, and nausea were the only symptoms measured in all 22 studies. Relationships among concurrent symptoms were examined in nine studies. Relationships among symptoms and predictors (i.e., demographics, cancer type, healthcare delivery environment) were examined in seven studies. Relationships among symptoms and outcomes (i.e., functional status, psychological status, quality-of-life, survival time) were examined in 14 studies. Significant methodological variation was found among these studies.

Significance of results:

It is difficult to draw conclusions about the relationships among multiple symptoms, predictors, and outcomes due to the heterogeneity of these studies. Future research is needed to determine which symptoms and symptom dimensions to assess in order to better understand how multiple symptoms relate to each other as well to as predictors and outcomes in palliative care patients with advanced cancer.

Copyright
Corresponding author
Address correspondence and reprint requests to: Stephanie Gilbertson–White, Department of Physiological Nursing, University of California, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610. E-mail: stephanie.gilbertson-white@ucsf.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. Bakitas , K.D. Lyons , M.T. Hegel , (2009). Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: The Project ENABLE II randomized controlled trial. Journal of the American Medical Association, 302, 741749.

W.Y. Cheung , L.W. Le & C Zimmermann . (2009). Symptom clusters in patients with advanced cancers. Supportive Care in Cancer, 17, 12231230.

M. Dodd , S. Janson , N. Facione , (2001). Advancing the science of symptom management. Journal of Advanced Nursing, 33, 668676.

A.Z. Doorenbos , C.W. Given , B. Given , (2006). Symptom experience in the last year of life among individuals with cancer. J Pain Symptom Manage, 32, 403412.

R.B Francoeur . (2005). The relationship of cancer symptom clusters to depressive affect in the initial phase of palliative radiation. Journal of Pain and Symptom Management, 29, 130155.

J. Hearn & I.J Higginson . (1998). Do specialist palliative care teams improve outcomes for cancer patients? A systematic literature review. Palliative Medicine, 12, 317332.

G. Irving & M Lloyd–Williams . (2010). Depression in advanced cancer. European Journal of Oncology Nursing, doi: 10.1016/j.ejon.2010.01.026.

S.C. McMillan & B.J Small . (2002). Symptom distress and quality of life in patients with cancer newly admitted to hospice home care. Oncology Nursing Forum, 29, 14211428.

S. Mercadante , A. Casuccio & F Fulfaro . (2000). The course of symptom frequency and intensity in advanced cancer patients followed at home. Journal of Pain and Symptom Management, 20, 104112.

C. Modonesi , E. Scarpi , M. Maltoni , (2005). Impact of palliative care unit admission on symptom control evaluated by the edmonton symptom assessment system. Journal of Pain and Symptom Management, 30, 367373.

G. Morasso , M. Capelli , P. Viterbori , (1999). Psychological and symptom distress in terminal cancer patients with met and unmet needs. Journal of Pain and Symptom Management, 17, 402409.

A.A. O'Connell & D.B McCoach . (2004). Applications of hierarchical linear models for evaluations of health interventions: demystifying the methods and interpretations of multilevel models. Evaluation and the Health Professions, 27, 119151.

C. Peruselli , E. Camporesi , A.M. Colombo , (1993). Quality-of-life assessment in a home care program for advanced cancer patients: a study using the Symptom Distress Scale. J Pain and Symptom Management, 8, 306311.

C. Peruselli , E. Paci , P. Franceschi , (1997). Outcome evaluation in a home palliative care service. Journal of Pain and Symptom Management, 13, 158165.

L. Peters & K Sellick . (2006). Quality of life of cancer patients receiving inpatient and home-based palliative care. Journal of Advanced Nursing, 53, 524533.

D.B. Reuben , V. Mor & J Hiris . (1988). Clinical symptoms and length of survival in patients with terminal cancer. Archives of Internal Medicine, 148, 15861591.

G. Rodin , C. Zimmermann , A. Rydall , (2007). The desire for hastened death in patients with metastatic cancer. Journal of Pain and Symptom Management, 33, 661675.

A.S. Stromgren , P. Sjogren , D. Goldschmidt , (2005). A longitudinal study of palliative care: Patient-evaluated outcome and impact of attrition. Cancer, 103, 17471755.

S.C. Teunissen , A. de Graeff , H.C. de Haes , (2006). Prognostic significance of symptoms of hospitalised advanced cancer patients. European Journal of Cancer, 42, 25102516.

S.C. Teunissen , W. Wesker , C. Kruitwagen , (2007). Symptom prevalence in patients with incurable cancer: A systematic review. Journal of Pain and Symptom Management, 34, 94104.

J.S. Tsai , C.H. Wu , T.Y. Chiu , (2006). Symptom patterns of advanced cancer patients in a palliative care unit. Palliative Medicine, 20, 617622.

A. Vainio & A Auvinen . (1996). Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence Group. Journal of Pain and Symptom Management, 12, 310.

V.E. von Gruenigen , J.R. Hutchins , A.M. Reidy , (2006). Gynecologic oncology patients' satisfaction and symptom severity during palliative chemotherapy. Health and Quality of Life Outcomes, 4, 84.

D. Walsh , S. Donnelly & L Rybicki . (2000). The symptoms of advanced cancer: Relationship to age, gender, and performance status in 1,000 patients. Supportive Care in Cancer, 8, 175179.

D. Walsh & L Rybicki . (2006). Symptom clustering in advanced cancer. Supportive Care in Cancer, 14, 831836.

D. Walsh , L. Rybicki , A.N. Nelson , (2002). Symptoms and prognosis in advanced cancer. Supportive Care in Cancer, 10, 385388.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Palliative & Supportive Care
  • ISSN: 1478-9515
  • EISSN: 1478-9523
  • URL: /core/journals/palliative-and-supportive-care
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: