Skip to main content Accessibility help
×
Home
Hostname: page-component-dc8c957cd-nh2gz Total loading time: 0.298 Render date: 2022-01-28T16:19:22.752Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Article contents

Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea

Published online by Cambridge University Press:  16 October 2000

M. C. BRUCE
Affiliation:
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY
C. A. DONNELLY
Affiliation:
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY
M. PACKER
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
M. LAGOG
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
N. GIBSON
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
A. NARARA
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
D. WALLIKER
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JN
M. P. ALPERS
Affiliation:
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
K. P. DAY
Affiliation:
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY

Abstract

The burden and duration of asymptomatic malaria infections were measured in residents of the malaria endemic village of Gonoa, Madang Province, Papua New Guinea. Plasmodium falciparum, P. vivax and P. malariae infections in people aged 4 years to adulthood were compared. Frequent sampling at 3-day intervals for up to 61 days allowed assessment of individual episodes of infection. Statistical assessment of P. falciparum detection revealed a periodicity consistent with synchronous replication of this species over periods up to 27 days. The duration of P. falciparum episodes was longer across all age groups than that of P. vivax and P. malariae. A trend for decreasing duration with age was also noted in data from each species. This was most prominent in P. falciparum infections: median duration in 4-year-olds was > 48 days compared with a median between 9 and 15 days in older children and adults. The results are consistent with the slow acquisition of immunity to antigenically diverse Plasmodium populations and suggest a faster rate of acquisition to P. vivax and P. malariae than to P. falciparum.

Type
Research Article
Copyright
2000 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
49
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *