Skip to main content Accessibility help
×
Home
Hostname: page-component-dc8c957cd-rqfrn Total loading time: 0.225 Render date: 2022-01-27T12:36:21.433Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Article contents

In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine

Published online by Cambridge University Press:  01 December 1998

B. PRADINES
Affiliation:
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, BP 46, 13998 Marseille, France
M. MABIKA MAMFOUMBI
Affiliation:
Département de Parasitologie – Mycologie – Médecine Tropicale, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon
D. PARZY
Affiliation:
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, BP 46, 13998 Marseille, France
M. OWONO MEDANG
Affiliation:
Département de Parasitologie – Mycologie – Médecine Tropicale, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon
C. LEBEAU
Affiliation:
Service Médical, 6ème Bataillon d'Infanterie de Marine, Libreville, Gabon
J. R. MOUROU MBINA
Affiliation:
Département de Parasitologie – Mycologie – Médecine Tropicale, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon
J. C. DOURY
Affiliation:
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, BP 46, 13998 Marseille, France
M. KOMBILA
Affiliation:
Département de Parasitologie – Mycologie – Médecine Tropicale, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon

Abstract

The in vitro activity of artemether against 63 African isolates of Plasmodium falciparum from Libreville, Gabon was evaluated using an isotopic drug susceptibility semi-microtest. The 50% inhibitory concentration (IC50) values for artemether were in a narrow range from 0·8 to 34·8 nm (mean IC50 5·0 nm) and the 95% confidence interval (CI95%) was 3·6–6·3 nm. In vitro decreased susceptibility or resistance were observed with artemether (14%), to chloroquine (90%), to quinine (32%). Isolate susceptibility to amodiaquine and halofantrine was high i.e. 100% and 98%, respectively. There was a significant positive correlation between responses to artemether and amodiaquine (r2=0·45, P<0·001), artemether and chloroquine (r2=0·36, P<0·001), artemether and quinine (r2=0·31, P<0·001), and artemether and halofantrine r2=0·19, P<0·01). Positive correlation between these drugs suggests in vitro cross-resistance or at least common features in drug uptake and/or mode of action or resistance.

Type
Research Article
Copyright
1998 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
20
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *