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Anti-inflammatory and antioxidant therapies for chagasic myocarditis: a systematic review

Published online by Cambridge University Press:  13 February 2020

Dayanne S. Freitas ,
Andressa S. Silva Godinho ,
Renata Mondêgo-Oliveira ,
Flávia de Oliveira Cardoso Open the ORCID record for Flávia de Oliveira Cardoso [Opens in a new window] ,
Ana Lucia Abreu-Silva  and
Lucilene A. Silva
Dayanne S. Freitas
Affiliation:
Programa de Pós-Graduação em Ciências da Saúde, Federal University of Maranhão, São Luís, Maranhão, 65080-805, Brazil
Andressa S. Silva Godinho
Affiliation:
Programa de Pós-Graduação em Ciências da Saúde, Federal University of Maranhão, São Luís, Maranhão, 65080-805, Brazil
Renata Mondêgo-Oliveira
Affiliation:
Departamento de Patologia, Universidade Estadual do Maranhão. Cidade Universitária Paulo VI. São Luís, Maranhão, 65055-970, Brazil
Flávia de Oliveira Cardoso*
Affiliation:
Laboratório de Imunomodulação e Protozoologia, Instituto Oswaldo Cruz, FIOCRUZ. Rio de Janeiro – RJ, 21.040-360, Brazil
Ana Lucia Abreu-Silva
Affiliation:
Departamento de Patologia, Universidade Estadual do Maranhão. Cidade Universitária Paulo VI. São Luís, Maranhão, 65055-970, Brazil
Lucilene A. Silva
Affiliation:
Programa de Pós-Graduação em Ciências da Saúde, Federal University of Maranhão, São Luís, Maranhão, 65080-805, Brazil
*
Author for correspondence: Flávia de Oliveira Cardoso, E-mail: flaviaoc09@gmail.com
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Abstract

The aim of this review was to identify anti-inflammatory and antioxidant therapeutic agents and their effects on patients with chagasic myocarditis. A systematic review of the MEDLINE, EMBASE, WEB OF SCIENCE, SCOPUS, LILACS and CENTRAL databases (Cochrane Library) was carried out without language restrictions. The descriptors used were: ‘Chagas cardiomyopathy’, ‘treatment’, ‘Chagas disease’, ‘anti-inflammatory agents’, ‘Trypanosoma cruzi’ and ‘antioxidants’. A total of 4,138 articles was identified, six of which were selected for data extraction. Of these, four were related to antioxidant therapy with vitamins C and E supplementation, and two using anti-inflammatory therapy. The studies were carried out in Brazil and were published between 2002 and 2017. Antioxidant therapy with vitamin C and E supplementation increases the activity of antioxidant enzymes and reduces the oxidative markers. There is no conclusive data to support the use of vitamin supplementation and anti-inflammatory therapy in the treatment of chagasic cardiomyopathy. However, the studies indicate the possibility of vitamin supplementation as a new approach to the treatment of Chagas disease. Antioxidant therapy was proven to be a viable alternative for attenuating the oxidative damage caused by chronic chagasic cardiopathy, leading to a better prognosis for patients.

Keywords

Anti-inflammatory agentsantioxidantsChagas cardiomyopathyChagas disease treatmentTrypanosoma cruzi
Type
Review Article
Information
Parasitology , Volume 147 , Issue 6 , May 2020 , pp. 603 - 610
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Copyright
Copyright © Cambridge University Press 2020

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Footnotes

*

These authors contributed equally to this work

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