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Bittencourt, Clicia Ramos de Oliveira Farias, Emanuel Airton Bezerra, Karla Costa Véras, Leiz Maria Costa Silva, Vladimir Costa Costa, Carlos Henrique Nery Bemquerer, Marcelo P. Silva, Luciano Paulino Souza de Almeida Leite, José Roberto de and Eiras, Carla 2016. Immobilization of cationic antimicrobial peptides and natural cashew gum in nanosheet systems for the investigation of anti-leishmanial activity. Materials Science and Engineering: C, Vol. 59, p. 549.
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Goldman-Pinkovich, Adele Balno, Caitlin Strasser, Rona Zeituni-Molad, Michal Bendelak, Keren Rentsch, Doris Ephros, Moshe Wiese, Martin Jardim, Armando Myler, Peter J. Zilberstein, Dan and Müller, Ingrid 2016. An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion. PLOS Pathogens, Vol. 12, Issue. 4, p. e1005494.
Mittra, Bidyottam Laranjeira-Silva, Maria Fernanda Perrone Bezerra de Menezes, Juliana Jensen, Jennifer Michailowsky, Vladimir Andrews, Norma W. and Horn, David 2016. A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence. PLOS Pathogens, Vol. 12, Issue. 1, p. e1005340.
Singh, Kuljit Singh, Krishn Pratap Equbal, Asif Suman, Shashi S. Zaidi, Amir Garg, Gaurav Pandey, Krishna Das, Pradeep and Ali, Vahab 2016. Interaction between cysteine synthase and serine O-acetyltransferase proteins and their stage specific expression in Leishmania donovani. Biochimie, Vol. 131, p. 29.
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TSIGANKOV, POLINA GHERARDINI, PIER FEDERICO HELMER-CITTERICH, MANUELA and ZILBERSTEIN, DAN 2012. What has proteomics taught us about Leishmania development?. Parasitology, Vol. 139, Issue. 09, p. 1146.
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigotelike forms in Schneider's Drosophila medium supplemented with 2% (v/v) foetal calf serum. Unlike previous methods, it utilizes direct culture of parasites obtained from the lesions of infected animals rather than adaptation of promastigotes in vitro. Ultrastructural (possession of megasomes), biochemical (cysteine proteinase activity and gelatin SDS-PAGE banding pattern) and infectivity (in vivo) data are presented which show the close similarity of the cultured forms to lesion amastigotes. The axenically cultured forms grew optimally at a temperature of 32–33 °C, providing further evidence for their amastigote nature. It was found that adjustment of the pH of the growth medium to 5·4 was required in order to retain the amastigote morphology of the cultured parasites. This supports the notion that leishmanial amastigotes are acidophiles.
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