Abdel Aziz, N. Tallima, H. Hafez, E. A. and El Ridi, R. 2016. Papain-Based Vaccination ModulatesSchistosoma mansoniInfection-Induced Cytokine Signals. Scandinavian Journal of Immunology, Vol. 83, Issue. 2, p. 128.
Kašný, Martin Haas, Wilfried Jamieson, Barrie and Horâk, Petr 2016. Schistosoma.
Leontovyč, Roman Young, Neil D. Korhonen, Pasi K. Hall, Ross S. Tan, Patrick Mikeš, Libor Kašný, Martin Horák, Petr Gasser, Robin B. and Knight, Matty 2016. Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host. PLOS Neglected Tropical Diseases, Vol. 10, Issue. 2, p. e0004406.
Ahammed Shareef, P. A. and Abidi, S. M. A. 2014. Cysteine protease is a major component in the excretory/secretory products of Euclinostomum heterostomum (Digenea: Clinostomidae). Parasitology Research, Vol. 113, Issue. 1, p. 65.
Aires, André de Lima Ximenes, Eulália Camelo Pessoa Azevedo Barbosa, Vanessa Xavier Góes, Alexandre José da Silva Souza, Valdênia Maria Oliveira and Albuquerque, Mônica Camelo Pessôa de Azevedo 2014. β-Lapachone: A naphthoquinone with promising antischistosomal properties in mice. Phytomedicine, Vol. 21, Issue. 3, p. 261.
Aires, André de Lima Ximenes, Eulália Camelo Pessoa Azevedo Silva, Renata Alexandre Ramos Barbosa, Vanessa Xavier Góes, Alexandre José da Silva Peixoto, Christina Alves Souza, Valdênia Maria Oliveira and Albuquerque, Mônica Camelo Pessôa de Azevedo 2014. Ultrastructural analysis of β-lapachone-induced surface membrane damage in male adult Schistosoma mansoni BH strain worms. Experimental Parasitology, Vol. 142, p. 83.
El Ridi, Rashika Tallima, Hatem Dalton, John P. and Donnelly, Sheila 2014. Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases. Frontiers in Genetics, Vol. 5,
Kolářová, Libuše Horák, Petr Skírnisson, Karl Marečková, Helena and Doenhoff, Michael 2013. Cercarial Dermatitis, a Neglected Allergic Disease. Clinical Reviews in Allergy & Immunology, Vol. 45, Issue. 1, p. 63.
Robinson, Mark W. Brindley, Paul J. McKerrow, James H. and Dalton, John P. 2013. Handbook of Proteolytic Enzymes.
Zawistowska-Deniziak, A. Wasyl, K. Norbury, L.J. Wesołowska, A. Bień, J. Grodzik, M. Wiśniewski, M. Bąska, P. and Wędrychowicz, H. 2013. Characterization and differential expression of cathepsin L3 alleles from Fasciola hepatica. Molecular and Biochemical Parasitology, Vol. 190, Issue. 1, p. 27.
Lucie, Lichtenbergová and Petr, Horák 2012. Pathogenicity ofTrichobilharziaspp. for Vertebrates. Journal of Parasitology Research, Vol. 2012, p. 1.
Dolečková, Kateřina Kašný, Martin Mikeš, Libor Cartwright, Jared Jedelský, Petr Schneider, Eric L. Dvořák, Jan Mountford, Adrian P. Craik, Charles S. and Horák, Petr 2009. The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. International Journal for Parasitology, Vol. 39, Issue. 2, p. 201.
Haas, Wilfried and Haeberlein, Simone 2009. Penetration of cercariae into the living human skin: Schistosoma mansoni vs. Trichobilharzia szidati. Parasitology Research, Vol. 105, Issue. 4, p. 1061.
Kašný, Martin Mikeš, Libor Hampl, Vladimír Dvořák, Jan Caffrey, Conor R. Dalton, John P. and Horák, Petr 2009. Advances in Parasitology Volume 69.
Cancela, Martín Acosta, Daniel Rinaldi, Gabriel Silva, Edileusa Durán, Rosario Roche, Leda Zaha, Arnaldo Carmona, Carlos and Tort, Jose F. 2008. A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica. Biochimie, Vol. 90, Issue. 10, p. 1461.
Pleass, Richard J. Aboobaker, A. Aziz and Schmitt, Armin O. 2008. Piggybacking schistosome invasion: similarities are only skin deep. Trends in Parasitology, Vol. 24, Issue. 4, p. 153.
Cercariae of the bird schistosome Trichobilharzia regenti and of the human schistosome Schistosoma mansoni employ proteases to invade the skin of their definitive hosts. To investigate whether a similar proteolytic mechanism is used by both species, cercarial extracts of T. regenti and S. mansoni were biochemically characterized, with the primary focus on cysteine peptidases. A similar pattern of cysteine peptidase activities was detected by zymography of cercarial extracts and their chromatographic fractions from T. regenti and S. mansoni. The greatest peptidase activity was recorded in both species against the fluorogenic peptide substrate Z-Phe-Arg-AMC, commonly used to detect cathepsins B and L, and was markedly inhibited (>96%) by Z-Phe-Ala-CHN2 at pH 4·5. Cysteine peptidases of 33 kDa and 33–34 kDa were identified in extracts of T. regenti and S. mansoni cercariae employing a biotinylated Clan CA cysteine peptidase-specific inhibitor (DCG-04). Finally, cercarial extracts from both T. regenti and S. mansoni were able to degrade native substrates present in skin (collagen II and IV, keratin) at physiological pH suggesting that cysteine peptidases are important in the pentration of host skin.
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