Castillo-Acosta, Víctor M. Ruiz-Pérez, Luis M. Etxebarria, Juan Reichardt, Niels C. Navarro, Miguel Igarashi, Yasuhiro Liekens, Sandra Balzarini, Jan González-Pacanowska, Dolores and Sacks, David 2016. Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models. PLOS Pathogens, Vol. 12, Issue. 9, p. e1005851.
Opperdoes, Fred R. Butenko, Anzhelika Flegontov, Pavel Yurchenko, Vyacheslav and Lukeš, Julius 2016. Comparative Metabolism of Free-livingBodo saltansand Parasitic Trypanosomatids. Journal of Eukaryotic Microbiology, Vol. 63, Issue. 5, p. 657.
Bringaud, Frédéric Biran, Marc Millerioux, Yoann Wargnies, Marion Allmann, Stefan and Mazet, Muriel 2015. Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways. Molecular Microbiology, Vol. 96, Issue. 5, p. 917.
Castillo-Acosta, Víctor M. Ruiz-Pérez, Luis M. Van Damme, Els J. M. Balzarini, Jan González-Pacanowska, Dolores and Raper, Jayne 2015. Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity. PLOS Neglected Tropical Diseases, Vol. 9, Issue. 3, p. e0003612.
de Macêdo, Juan P. Schumann Burkard, Gabriela Niemann, Moritz Barrett, Michael P. Vial, Henri Mäser, Pascal Roditi, Isabel Schneider, André Bütikofer, Peter and Horn, David 2015. An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLOS Pathogens, Vol. 11, Issue. 5, p. e1004875.
Moreno, S. Andrea Molinari, Jesús and Nava, Mayerly 2015. From population ecology to metabolism: growth of Trypanosoma evansi, and implications of glucose depletion, in a live host. Biochemical Systematics and Ecology, Vol. 63, p. 119.
Ong, Han B. Lee, Wai S. Patterson, Stephen Wyllie, Susan and Fairlamb, Alan H. 2015. Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stageTrypanosoma brucei. Molecular Microbiology, Vol. 95, Issue. 1, p. 143.
De Paula Lima, Carla V Batista, Michel Kugeratski, Fernanda G Vincent, Isabel M Soares, Maurilio J Probst, Christian M Krieger, Marco A and Marchini, Fabricio K 2014. LM14 defined medium enables continuous growth of Trypanosoma cruzi. BMC Microbiology, Vol. 14, Issue. 1,
Vasquez, J.-J. Hon, C.-C. Vanselow, J. T. Schlosser, A. and Siegel, T. N. 2014. Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages. Nucleic Acids Research, Vol. 42, Issue. 6, p. 3623.
Alves, João MP Klein, Cecilia C da Silva, Flávia Costa-Martins, André G Serrano, Myrna G Buck, Gregory A Vasconcelos, Ana Tereza R Sagot, Marie-France Teixeira, Marta MG Motta, Maria Cristina M and Camargo, Erney P 2013. Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers. BMC Evolutionary Biology, Vol. 13, Issue. 1, p. 190.
Mazet, Muriel Morand, Pauline Biran, Marc Bouyssou, Guillaume Courtois, Pierrette Daulouède, Sylvie Millerioux, Yoann Franconi, Jean-Michel Vincendeau, Philippe Moreau, Patrick Bringaud, Frédéric and Salavati, Reza 2013. Revisiting the Central Metabolism of the Bloodstream Forms of Trypanosoma brucei: Production of Acetate in the Mitochondrion Is Essential for Parasite Viability. PLoS Neglected Tropical Diseases, Vol. 7, Issue. 12, p. e2587.
Millerioux, Yoann Ebikeme, Charles Biran, Marc Morand, Pauline Bouyssou, Guillaume Vincent, Isabel M. Mazet, Muriel Riviere, Loïc Franconi, Jean-Michel Burchmore, Richard J. S. Moreau, Patrick Barrett, Michael P. and Bringaud, Frédéric 2013. The threonine degradation pathway of theTrypanosoma bruceiprocyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, p. n/a.
Creek, Darren J. Anderson, Jana McConville, Malcolm J. and Barrett, Michael P. 2012. Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, Vol. 181, Issue. 2, p. 73.
Haanstra, Jurgen R. van Tuijl, Arjen van Dam, Jan van Winden, Wouter Tielens, Aloysius G.M. van Hellemond, Jaap J. and Bakker, Barbara M. 2012. Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes. International Journal for Parasitology, Vol. 42, Issue. 7, p. 667.
Heddergott, Niko Krüger, Timothy Babu, Sujin B. Wei, Ai Stellamanns, Erik Uppaluri, Sravanti Pfohl, Thomas Stark, Holger Engstler, Markus and Beverley, Stephen M. 2012. Trypanosome Motion Represents an Adaptation to the Crowded Environment of the Vertebrate Bloodstream. PLoS Pathogens, Vol. 8, Issue. 11, p. e1003023.
Weiße, Sebastian Heddergott, Niko Heydt, Matthias Pflästerer, Daniel Maier, Timo Haraszti, Tamás Grunze, Michael Engstler, Markus Rosenhahn, Axel and Li, Ziyin 2012. A Quantitative 3D Motility Analysis of Trypanosoma brucei by Use of Digital In-line Holographic Microscopy. PLoS ONE, Vol. 7, Issue. 5, p. e37296.
Mazet, Muriel Harijan, Rajesh K. Kiema, Tiila-Riika Haapalainen, Antti M. Morand, Pauline Morales, Jorge Bringaud, Frédéric Wierenga, Rik K. and Michels, Paul A.M. 2011. The characterization and evolutionary relationships of a trypanosomal thiolase. International Journal for Parasitology, Vol. 41, Issue. 12, p. 1273.
BRINGAUD, F. EBIKEME, C. and BOSHART, M. 2010. Acetate and succinate production in amoebae, helminths, diplomonads, trichomonads and trypanosomatids: common and diverse metabolic strategies used by parasitic lower eukaryotes. Parasitology, Vol. 137, Issue. 09, p. 1315.
Tielens, Aloysius G.M. and van Hellemond, Jaap J. 2009. Surprising variety in energy metabolism within Trypanosomatidae. Trends in Parasitology, Vol. 25, Issue. 10, p. 482.
Chambers, Jeremy W. Fowler, Matthew L. Morris, Meredith T. and Morris, James C. 2008. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. Molecular and Biochemical Parasitology, Vol. 158, Issue. 2, p. 202.
The amino acid compositions of several culture media have been analysed and compared. The utilization and excretion of amino acids and other metabolites have been followed during growth of Trypanosoma brucei S42 in a defined medium. All of the added L-threonine was metabolized by the cells, even when it was present at elevated concentrations. Glucose was consumed throughout the growth cycle: glutamine was consumed more rapidly than glutamic acid, which was itself used at about the same rate as proline. Threonine was cleaved to form glycine and acetate, both of which accumulated in the medium. Alanine and succinate were excreted together with a small amount of pyruvate, but these three products accounted for less than half of the glucose used. CO2 production from glucose was not measured, but insignificant amounts of CO2 were produced from threonine. Tetraethylthiuram disulphide blocked the cleavage of threonine and was a potent inhibitor of trypanosome growth.
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