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Drug resistance maps to guide intermittent preventive treatment of malaria in African infants

  • INBARANI NAIDOO (a1) (a2) and CALLY ROPER (a1)

Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is not compromised by SP resistance. A significant obstacle in implementing SP-IPTi, is in establishing the degree of resistance in an area. Since SP monotherapy is discontinued, no contemporary measures of in vivo efficacy can be made, so the World Health Organisation has recommended a cut-off based upon molecular markers, stating that SP-IPTi should not be implemented when the prevalence of the dhps 540E mutation among infections exceeds 50%. We created a geo-referenced database of SP resistance markers in Africa from published literature. By selecting surveys of malaria infected blood samples conducted since 2004 we have mapped the contemporary prevalence of dhps 540E. Additional maps are freely available in interactive form at Eight countries in East Africa are classified as unsuitable for SP-IPTi when data are considered at a national level. Fourteen countries in Central and West Africa were classified as suitable while seven countries had no available contemporary data to guide policy. There are clear deficiencies in molecular surveillance data coverage. We discuss requirements for ongoing surveillance of SP resistance markers in support of the use of SP-IPTi.

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*Corresponding author: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom Tel.: +44 (0) 207 927 2331 Fax: +44 (0) 207 636 8739. Email:
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A. P. Alker , V. Mwapasa , A. Purfield , S. J. Rogerson , M. E. Molyneux , D. D. Kamwendo , E. Tadesse , E. Chaluluka and S. R. Meshnick (2005). Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrobial Agents and Chemotherapy 49, 39193921.

V. Andriantsoanirina , A. Ratsimbasoa , C. Bouchier , M. Jahevitra , S. Rabearimanana , R. Radrianjafy , V. Andrianaranjaka , T. Randriantsoa , M. A. Rason , M. Tichit , L. P. Rabarijaona , O. Mercereau-Puijalon , R. Durand and D. Menard (2009). Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility. Antimicrobial Agents and Chemotherapy 53, 45884597.

J. J. Aponte , D. Schellenberg , A. Egan , A. Breckenridge , I. Carneiro , J. Critchley , I. Danquah , A. Dodoo , R. Kobbe , B. Lell , J. May , Z. Premji , S. Sanz , E. Sevene , R. Soulaymani-Becheikh , P. Winstanley , S. Adjei , S. Anemana , D. Chandramohan , S. Issifou , F. Mockenhaupt , S. Owusu-Agyei , B. Greenwood , M. P. Grobusch , P. G. Kremsner , E. Macete , H. Mshinda , R. D. Newman , L. Slutsker , M. Tanner , P. Alonso and C. Menendez (2009). Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet 374, 15331542.

D. J. Bell , S. K. Nyirongo , M. Mukaka , E. E. Zijlstra , C. V. Plowe , M. E. Molyneux , S. A. Ward and P. A. Winstanley (2008). Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. PLoS ONE 3, e1578.

M. Bonizzoni , Y. Afrane , F. N. Baliraine , D. A. Amenya , A. K. Githeko and G. Yan (2009). Genetic structure of Plasmodium falciparum populations between lowland and highland sites and antimalarial drug resistance in Western Kenya. Infection, Genetics and Evolution 9, 806812.

D. J. Bridges , M. Molyneux and S. Nkhoma (2009). Low level genotypic chloroquine resistance near Malawi's northern border with Tanzania. Tropical Medicine and International Health 14, 10931096.

D. R. Brooks , P. Wang , M. Read , W. M. Watkins , P. F. Sims and J. E. Hyde (1994). Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. European Journal of Biochemistry 224, 397405.

B. Bwijo , A. Kaneko , M. Takechi , I. L. Zungu , Y. Moriyama , J. K. Lum , T. Tsukahara , T. Mita , N. Takahashi , Y. Bergqvist , A. Bjorkman and T. Kobayakawa (2003). High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Tropica 85, 363373.

L. K. Certain , M. Briceno , S. M. Kiara , A. M. Nzila , W. M. Watkins and C. H. Sibley (2008). Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987–2006. Journal of Infectious diseases 197, 17431751.

D. Chandramohan , S. Owusu-Agyei , I. Carneiro , T. Awine , K. Amponsa-Achiano , N. Mensah , S. Jaffar , R. Baiden , A. Hodgson , F. Binka and B. Greenwood (2005). Cluster randomised trial of intermittent preventive treatment of malaria in infants in area of high, seasonal transmission in Ghana. British Medical Journal 331, 727733.

A. F. Cowman , M. J. Morry , B. A. Biggs , G. A. Cross and S. J. Foote (1988). Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proceedings of the National Academy of Sciences, USA 85, 91099113.

A. Dicko , I. Sagara , A. A. Djimde , S. O. Toure , M. Traore , S. Dama , A. I. Diallo , A. Barry , M. Dicko , O. M. Coulibaly , C. Rogier , A. De Sousa and O. K. Doumbo (2010). Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali. Malaria Journal 9, 9.

S. Dunyo , R. Ord , R. Hallett , M. Jawara , G. Walraven , E. Mesa , R. Coleman , M. Sowe , N. Alexander , G. A. Targett , M. Pinder and C. J. Sutherland (2006). Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. PLoS Clinical Trials 1, e14.

A. Enevold , W. M. Nkya , M. Theisen , L. S. Vestergaard , A. T. Jensen , T. Staalsoe , T. G. Theander , I. C. Bygbjerg and M. Alifrangis (2007). Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum. Malaria Journal 6, 153.

S. Enosse , P. Magnussen , F. Abacassamo , X. Gomez-Olive , A. M. Ronn , R. Thompson and M. Alifrangis (2008). Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique. Malaria Journal 7, 115.

N. Fernandes , P. Figueiredo , V. E. Do Rosario and P. Cravo (2007). Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant. Malaria Journal 6, 35.

D. Francis , S. L. Nsobya , A. Talisuna , A. Yeka , M. R. Kamya , R. Machekano , C. Dokomajilar , P. J. Rosenthal and G. Dorsey (2006). Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. Journal of Infectious Diseases 193, 978986.

S. Gesase , R. D. Gosling , R. Hashim , R. Ord , I. Naidoo , R. Madebe , J. F. Mosha , A. Joho , V. Mandia , H. Mrema , E. Mapunda , Z. Savael , M. Lemnge , F. W. Mosha , B. Greenwood , C. Roper and D. Chandramohan (2009). High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. PLoS ONE 4, e4569.

R. D. Gosling , S. Gesase , J. F. Mosha , I. Carneiro , R. Hashim , M. Lemnge , F. W. Mosha , B. Greenwood and D. Chandramohan (2009). Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet 374, 15211532.

J. T. Griffin , M. Cairns , A. C. Ghani , C. Roper , D. Schellenberg , I. Carneiro , R. D. Newman , M. P. Grobusch , B. Greenwood , D. Chandramohan and R. D. Gosling (2010). Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. PLoS ONE 5, e12618.

M. P. Grobusch , A. Egan , R. D. Gosling and R. D. Newman (2007 a). Intermittent preventive therapy for malaria: progress and future directions. Current Opinion in Infectious Diseases 20, 613620.

M. P. Grobusch , B. Lell , N. G. Schwarz , J. Gabor , J. Dornemann , M. Potschke , S. Oyakhirome , G. C. Kiessling , M. Necek , M. U. Langin , P. Klein Klouwenberg , A. Klopfer , B. Naumann , H. Altun , S. T. Agnandji , J. Goesch , M. Decker , C. L. Salazar , C. Supan , D. U. Kombila , L. Borchert , K. B. Koster , P. Pongratz , A. A. Adegnika , I. Glasenapp , S. Issifou and P. G. Kremsner (2007 b). Intermittent preventive treatment against malaria in infants in Gabon – a randomized, double-blind, placebo-controlled trial. Journal of Infectious diseases 196, 15951602.

W. E. Harrington , T. K. Mutabingwa , A. Muehlenbachs , B. Sorensen , M. C. Bolla , M. Fried and P. E. Duffy (2009). Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment. Proceedings of the National Academy, USA 106, 90279032.

C. Karema , M. Imwong , C. I. Fanello , K. Stepniewska , A. Uwimana , S. Nakeesathit , A. Dondorp , N. P. Day and N. J. White (2010). Molecular correlates of high level antifolate resistance in Rwandan children with Plasmodium falciparum malaria. Antimicrobial Agents and Chemotherapy 54, 477483.

R. Kobbe , C. Kreuzberg , S. Adjei , B. Thompson , I. Langefeld , P. A. Thompson , H. H. Abruquah , B. Kreuels , M. Ayim , W. Busch , F. Marks , K. Amoah , E. Opoku , C. G. Meyer , O. Adjei and J. May (2007). A randomized controlled trial of extended intermittent preventive antimalarial treatment in infants. Clinical Infectious Diseases 45, 1625.

J. G. Kublin , F. K. Dzinjalamala , D. D. Kamwendo , E. M. Malkin , J. F. Cortese , L. M. Martino , R. A. Mukadam , S. J. Rogerson , A. G. Lescano , M. E. Molyneux , P. A. Winstanley , P. Chimpeni , T. E. Taylor and C. V. Plowe (2002). Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. Journal of Infectious Diseases 185, 380388.

E. R. Lozovsky , T. Chookajorn , K. M. Brown , M. Imwong , P. J. Shaw , S. Kamchonwongpaisan , D. E. Neafsey , D. M. Weinreich and D. L. Hartl (2009). Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proceedings of the National Academy of Sciences, USA 106, 1202512030.

C. Lynch , R. Pearce , H. Pota , J. Cox , T. A. Abeku , J. Rwakimari , I. Naidoo , J. Tibenderana and C. Roper (2008). Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda. Journal of Infectious Diseases 197, 15981604.

E. Macete , P. Aide , J. J. Aponte , S. Sanz , I. Mandomando , M. Espasa , B. Sigauque , C. Dobano , S. Mabunda , M. Dgedge , P. Alonso and C. Menendez (2006). Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trial. Journal of Infectious Diseases 194, 276285.

O. Maiga , A. A. Djimde , V. Hubert , E. Renard , A. Aubouy , F. Kironde , B. Nsimba , K. Koram , O. K. Doumbo , J. Le Bras and J. Clain (2007). A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. Journal of Infectious Diseases 196, 165172.

A. L. Malisa , R. J. Pearce , S. Abdulla , H. Mshinda , P. S. Kachur , P. Bloland and C. Roper (2010). Drug coverage in treatment of malaria and the consequences for resistance evolution – evidence from the use of sulphadoxine/pyrimethamine. Malaria Journal 9, 190.

F. Marks , J. Evans , C. G. Meyer , E. N. Browne , C. Flessner , V. Von Kalckreuth , T. A. Eggelte , R. D. Horstmann and J. May (2005). High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of Ghana. Antimicrobial Agents and Chemotherapy 49, 11011105.

A. M. McCollum , A. C. Poe , M. Hamel , C. Huber , Z. Zhou , Y. P. Shi , P. Ouma , J. Vulule , P. Bloland , L. Slutsker , J. W. Barnwell , V. Udhayakumar and A. A. Escalante (2006). Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. Journal of Infectious Diseases 194, 189197.

M. Menegon , R. J. Pearce , W. O. Inojosa , V. Pisani , P. M. Abel , A. Matondo , Z. Bisoffi , G. Majori , R. Ord , D. C. Warhurst , C. Roper and C. Severini (2009). Monitoring for multidrug-resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola. Tropical Medicine and International Health 14, 12511257.

M. A. Mkulama , S. Chishimba , J. Sikalima , P. Rouse , P. E. Thuma and S. Mharakurwa (2008). Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia. Malaria Journal 7, 87.

F. P. Mockenhaupt , K. Reither , P. Zanger , F. Roepcke , I. Danquah , E. Saad , P. Ziniel , S. Y. Dzisi , M. Frempong , P. Agana-Nsiire , F. Amoo-Sakyi , R. Otchwemah , J. P. Cramer , S. D. Anemana , E. Dietz and U. Bienzle (2007). Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana. Antimicrobial Agents and Chemotherapy 51, 32733281.

F. P. Mockenhaupt , J. Teun Bousema , T. A. Eggelte , J. Schreiber , S. Ehrhardt , N. Wassilew , R. N. Otchwemah , R. W. Sauerwein and U. Bienzle (2005). Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana. Tropical Medicine and International Health 10, 901908.

I. Naidoo and C. Roper (2010). Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum. Trends in Parasitology 26, 447456.

M. Ndounga , R. Tahar , L. K. Basco , P. N. Casimiro , D. A. Malonga and F. Ntoumi (2007). Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. Tropical Medicine and International Health 12, 11641171.

S. Nkhoma , M. Molyneux and S. Ward (2007). Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi. Acta Tropica 102, 138142.

E. Ochong , D. J. Bell , D. J. Johnson , U. D'alessandro , M. Mulenga , S. Muangnoicharoen , J. P. Van Geertruyden , P. A. Winstanley , P. G. Bray , S. A. Ward and A. Owen (2008). Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure. Antimicrobial Agents and Chemotherapy 52, 38833888.

S. A. Omar , I. S. Adagu and D. C. Warhurst (2001). Can pretreatment screening for dhps and dhfr point mutations in Plasmodium falciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure? Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 315319.

R. J. Pearce , H. Pota , M. S. Evehe , H. Ba El , G. Mombo-Ngoma , A. L. Malisa , R. Ord , W. Inojosa , A. Matondo , D. A. Diallo , W. Mbacham , I. V. Van Den Broek , T. D. Swarthout , A. Getachew , S. Dejene , M. P. Grobusch , F. Njie , S. Dunyo , M. Kweku , S. Owusu-Agyei , D. Chandramohan , M. Bonnet , J. P. Guthmann , S. Clarke , K. I. Barnes , E. Streat , S. T. Katokele , P. Uusiku , C. O. Agboghoroma , O. Y. Elegba , B. Cisse , A. E. Ie , H. A. Giha , S. P. Kachur , C. Lynch , J. B. Rwakimari , P. Chanda , M. Hawela , B. Sharp , I. Naidoo and C. Roper (2009). Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PLoS Medicine 6, e1000055.

D. S. Peterson , D. Walliker and T. E. Wellems (1988). Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proceedings of the National Academy of Sciences, USA 85, 91149118.

C. V. Plowe , J. F. Cortese , A. Djimde , O. C. Nwanyanwu , W. M. Watkins , P. A. Winstanley , J. G. Estrada-Franco , R. E. Mollinedo , J. C. Avila , J. L. Cespedes , D. Carter and O. K. Doumbo (1997). Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Journal of Infectious diseases 176, 15901596.

J. Raman , F. Little , C. Roper , I. Kleinschmidt , Y. Cassam , R. Maharaj and K. I. Barnes (2010). Five years of large-scale dhfr and dhps mutation surveillance following the phased implementation of artesunate plus sulfadoxine-pyrimethamine in Maputo Province, Southern Mozambique. American Journal of Tropical Medicine and Hygiene 82, 788794.

C. Rogier , B. Pradines , H. Bogreau , J. L. Koeck , M. A. Kamil and O. Mercereau-Puijalon (2005). Malaria epidemic and drug resistance, Djibouti. Emerging Infectious Diseases 11, 317321.

C. Roper , R. Pearce , S. Nair , B. Sharp , F. Nosten and T. Anderson (2004). Intercontinental spread of pyrimethamine-resistant malaria. Science 305, 1124.

D. Schellenberg , C. Menendez , J. J. Aponte , E. Kahigwa , M. Tanner , H. Mshinda and P. Alonso (2005). Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365, 14811483.

D. Schellenberg , C. Menendez , E. Kahigwa , J. Aponte , J. Vidal , M. Tanner , H. Mshinda and P. Alonso (2001). Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial. Lancet 357, 14711477.

M. Schunk , W. P. Kumma , I. B. Miranda , M. E. Osman , S. Roewer , A. Alano , T. Loscher , U. Bienzle and F. P. Mockenhaupt (2006). High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia. In Malaria Journal 5, 54.

S. G. Staedke , H. Sendagire , S. Lamola , M. R. Kamya , G. Dorsey and P. J. Rosenthal (2004). Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Tropical Medicine and International Health 9, 624629.

M. Tekete , A. A. Djimde , A. H. Beavogui , H. Maiga , I. Sagara , B. Fofana , D. Ouologuem , S. Dama , A. Kone , D. Dembele , M. Wele , A. Dicko and O. K. Doumbo (2009). Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali. Malaria Journal 8, 34.

M. A. Thera , P. S. Sehdev , D. Coulibaly , K. Traore , M. N. Garba , Y. Cissoko , A. Kone , A. Guindo , A. Dicko , A. H. Beavogui , A. A. Djimde , K. E. Lyke , D. A. Diallo , O. K. Doumbo and C. V. Plowe (2005). Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease. Journal of Infectious Diseases 192, 18231829.

T. Triglia and A. F. Cowman (1994). Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proceedings of the National Academy of Sciences, USA 91, 71497153.

T. Triglia , J. G. Menting , C. Wilson and A. F. Cowman (1997). Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proceedings of the National Academy of Sciences, USA 94, 1394413949.

P. Wang , C. S. Lee , R. Bayoumi , A. Djimde , O. Doumbo , G. Swedberg , L. D. Dao , H. Mshinda , M. Tanner , W. M. Watkins , P. F. Sims and J. E. Hyde (1997). Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Molecular and Biochemical Parasitology 89, 161177.

D. Zhong , Y. Afrane , A. Githeko , L. Cui , D. M. Menge and G. Yan (2008). Molecular epidemiology of drug-resistant malaria in western Kenya highlands. In BMC Infectious Diseases 8, 105.

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