Skip to main content
×
Home
    • Aa
    • Aa

The evaluation of potential global morbidity attributable to intestinal nematode infections

  • M. S. Chan (a1), G. F. Medley (a1), D. Jamison (a2) and D. A. P. Bundy (a1)
Summary
Summary

This paper presents a method of estimating the potential global morbidity due to human intestinal nematode infections (Ascaris lumbricoides, Trichuris trichiura and hookworms), based on the observed prevalence of infection. The method relies on the observed relationships between prevalence and intensity of infection, and between worm burden and potential morbidity. This approach is shown to be sensitive to the precision of the original prevalence estimates and, in particular, to the degree of spatial heterogeneity in levels of infection. The estimates presented here indicate that several tens of millions of children are likely to suffer developmental consequences from infection, and suggest that the global disease burden of geohelminthiasis may be significantly greater than was supposed.

Copyright
References
Hide All
Anderson R. M. (1982). Transmission dynamics and control of infectious disease agents. In Population Biology of Infectious Diseases (ed. Anderson R. M. & May R. M.), pp. 149–76. Berlin: Springer.
Anderson R. M. & May R. M. (1985). Helminth infections of humans: mathematical models, population dynamics and control. Advances in Parasitology 24, 1101.
Anderson R. M. & May R. M. (1991). Infectious Diseases of Humans: Dynamics and Control. Oxford: Oxford University Press.
Anderson R. M. & Medley G. F. (1985). Community control of helminth infections of man by mass and selective chemotherapy. Parasitology 90, 629–60.
Booth M. & Bundy D. A. P. (1992). Comparative prevalences of Ascaris lumbricoides, Trichuris trichiura and hookworm infections and the prospects for combined control. Parasitology 105, 151–7.
Bundy D. A. P. (1990). Is the hookworm just another geohelminth? In Hookworm Disease, Current Status and New Directions (ed. Schad G. A. & Warren K. S.), pp. 147–64. London: Taylor & Francis.
Bundy D. A. P., Chandiwana S. K., Homeida M. M. A., Yoon S. & Mott K. E. (1991). The epidemiological implications of a multi-infection approach to the control of human helminth infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 274–6.
Bundy D. A. P. & Cooper E. S. (1989). Trichuris and trichuriasis in humans. Advances in Parasitology 28, 107–73.
Bundy D. A. P., Cooper E. S., Thompson D. E., Didier J. M. & Simmons I. (1987). Epidemiology and population dynamics of Ascaris lumbricoides and Trichuris trichiura in the same community. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 987–93.
Bundy D. A. P. & Guyatt H. L. (1990). Global distribution of parasitic worm infections. Report to the Division of Science, Technical and Environmental Education, UNESCO Project to Increase School Performance through Improved Nutrition and Health.
Bundy D. A. P. & Medley G. F. (1992). Immunoepidemiology of human geohelminthiasis: ecological and immunological determinants of worm burden. Parasitology 104, S105–S119.
Cooper E. S., Bundy D. A. P. & Henry F. J. (1986). Chronic dysentery, stunting, and whipworm infestation. Lancet ii, 280–1.
Cooper E. S., Bundy D. A. P., MacDonald T. T. & Golden M. H. N. (1990). Growth suppression in the Trichuris dysentery syndrome. European Journal of Clinical Nutrition 44, 285–91.
Crompton D. W. T. (1988). The prevalence of ascariasis. Parasitology Today 4, 162–9.
Crompton D. W. T. (1989). Prevalence of ascariasis. In Ascariasis and its Prevention and Control (ed. Crompton D. W. T., Nesheim M. C. & Pawlowski Z. S.), pp. 4569. London: Taylor & Francis.
Guyatt H. L. (1992). Parasite population biology and the design and evaluation of helminth control programmes. Ph.D. thesis, University of London.
Guyatt H. L. & Bundy D. A. P. (1991). Estimating prevalence of community morbidity due to intestinal helminths: prevalence of infection as an indicator of the prevalence of disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 778–82.
Guyatt H. L. & Bundy D. A. P. (1993). Estimation of intestinal nematode prevalence: influence of parasite mating patterns. Parasitology 107, 99106.
Guyatt H. L., Bundy D. A. P., Medley G. F. & Grenfell B. T. (1990). The relationship between the frequency distribution of Ascaris lumbricoides and the prevalence and intensity of infection in human communities. Parasitology 101, 139–43.
Guyatt H. L. & Evans D. (1992). Economic considerations for helminth control. Parasitology Today 8, 397402.
Lwambo N. J. S., Bundy D. A. P. & Medley G. F. H. (1992). A new approach to morbidity risk assessment in hookworm endemic communities. Epidemiology and Infection 108, 469–81.
May R. M. & Anderson R. M. (1984). Spatial heterogeneity and the design of immunisation programs. Mathematical Bioscience 72, 83111.
Medley G. F., Guyatt H. L. & Bundy D. A. P. (1993). A quantitative framework for evaluating the effect of community treatment on the morbidity due to ascariasis. Parasitology 106, 211–21.
Muller R. (1975). Worms and Disease: a Manual of Medical Helminthology. London: William Heinemann.
Nesheim M. C. (1989). Ascariasis and human nutrition. In Ascariasis and its Prevention and Control (ed. Crompton D. W. T., Nesheim M. C. & Pawlowski Z. S.), pp. 87100. London: Taylor & Francis.
Nokes C., Grantham-McGregor S. M., Sawyer A. W., Cooper E. S. & Bundy D. A. P. (1992). Parasitic helminth infection and cognitive function in school children. Proceedings of the Royal Society 247, 7781.
Pawlowski Z. S. & Davis A. (1989). Morbidity and mortality in ascariasis. In Ascariasis and its Prevention and Control (ed. Crompton D. W. T., Nesheim M. C. & Pawlowski Z. S.), pp. 7186. London: Taylor & Francis.
Savioli L., Bundy D. A. P. & Tomkins A. M. (1992). Intestinal parasitic infections: a soluble public health problem. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 353–4.
Stephenson L. S.. (1987). Impact of Helminth Infections on Human Nutrition: Schistosomes and Soil Transmitted Helminths. New York: Taylor & Francis.
Stephenson L. S., Latham M. C., Kurz K. M., Kinoti S. N. & Brigham H. (1989). Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura and Ascaris lumbricoides infections. American Journal of Tropical Medicine and Hygiene 41, 7887.
Stephenson L. S., Latham M. C., Kinoti S. N., Kurz K. M. & Brigham H. (1990). Improvements in physical fitness of Kenyan schoolboys infected with hookworm, Trichuris trichiura and Ascaris lumbricoides following a single dose of albendazole. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 277–82.
Stoll N. R. (1947). This wormy world. Journal of Parasitology 33, 118.
Tomkins A. & Watson F. (1989). Malnutrition and Infection: A Review. United Nations: ACC/SCN.
De Vlas S. J. & Gryseels B. (1992). Underestimation of Schistosoma mansoni prevalences. Parasitology Today 8, 274–7.
Warren K. S., Bundy D. A. P., Anderson R. M., Davis A. R., Henderson D. A., Jamison D. T., Prescott N. & Senft A. (1993). Helminth infections. In Disease Control Priorities in Developing Countries (ed. Jamison D. T., Mosley W. H., Measham A. R. & Bobadilla J. L.), pp. 131–60. Oxford: Oxford University Press.
World Health Organization (1987). Prevention and control of intestinal parasitic infections. WHO Technical Report Series No. 749. Geneva: World Health Organization.
World Health Organization (1992). Global Health Situation and Projections, Estimates. Division of Epidemiological Surveillance and Health Situation Assessment, WHO/HST/92.1. Geneva: World Health Organization.
World Bank (1993). World Development Report 1993: Investing in Health. Washington D.C.: World Bank.
Yu S. H., Jiang Z. X. & Xu L. Q. (1988). The present status of soil-transmitted helminthiases in China. In Collected Papers on the Control of Soil-Transmitted Helminthiases, vol. IV, pp. 517. Beijing: Asian Parasite Control Organization.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 15 *
Loading metrics...

Abstract views

Total abstract views: 212 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th October 2017. This data will be updated every 24 hours.