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Immunodiagnosis of taeniasis by coproantigen detection

  • J. C. Allan (a1), G. Avila (a2), J. Garcia Noval (a3), A. Flisser (a2) and P. S. Craig (a1)...
Abstract
SUMMARY

Immunodiagnostic tests for Taenia-specific faecal antigen based on polyclonal rabbit antisera against Taenia saginata or Taenia solium proglottid extracts in capture-type ELISA assays have been developed. Taenia-specific antigen was detected in detergent-solubilized faecal extracts from T. solium- and T. saginata-infected hosts. Coproantigen from T. solium-infected hamsters did not cross-react with faeces from rodents infected with Hymenolepis diminuta, H. citelli, H. micro-stoma, Necator americanus, Strongyloides ratti or Nematospiroides dubius and faeces from uninfected animals. When the T. saginata-capture ELISA was tested with faecal samples positive for T. solium antigen, no cross-reactions were obtained. However, faecal samples from humans infected with T. solium or T. saginata, including some with extremely low egg counts, were cross-reactive by either test. Nevertheless, considerably higher O.D. values were obtained with stool samples from Taenia patients compared to Hymenolepis nana-infected or uninfected individuals. Two individuals, infected with Taenia sp. and positive for coproantigens by ELISA, became antigen-negative 6 days after treatment with Niclosamide. The possibility of developing species-specific immunodiagnostic tests for human taeniasis through coproantigen detection is discussed.

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J. C. Allan & P. S. Craig (1989). Corproantigens in gut tapeworm infections: Hymenolepis diminuta in rats. Parasitology Research 76, 6873.

R. B. Gasser , M. W. Lightowlers , D. F. Obendorf , D. J. Jenkins & M. D. Rickard (1988). Evaluation of a serological test system for the diagnosis of natural Echinococcus granulosus infection in dogs using E. granulosus protoscolex and oncosphere antigens. Australian Veterinary Journal 65, 369–73.

D. D. Heath , B. Lawrence , A. Glennie & H. Twaalfhoven (1985). The use of excretory and secretory antigens of the scolex of Taenia ovis for the serodiagnosis of infection in dogs. Journal of Parasitology 71, 192–9.

D. J. Jenkins & M. D. Rickard (1985). Specific antibody responses to Taenia hydatigena, Taenia pisiformis and Echinococcus granulosus infection in dogs. Australian Veterinary Journal 62, 72–8.

R. Viscidi , B. E. Laughon , M. Hanvanich & R. H. Bartlett (1984). Improved enzyme immunoassays for the detection of antigens in fecal specimens. Investigation and correction of interfering factors. Journal of Immunological Methods 67, 129–43.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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