Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 23
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ghosh, Soumita Sengupta, Arjun Sharma, Shobhona and Sonawat, Haripalsingh M. 2016. Early prediction of cerebral malaria by 1H NMR based metabolomics. Malaria Journal, Vol. 15, Issue. 1,


    Shears, Melanie J. MacRae, James I. Mollard, Vanessa Goodman, Christopher D. Sturm, Angelika Orchard, Lindsey M. Llinás, Manuel McConville, Malcolm J. Botté, Cyrille Y. and McFadden, Geoffrey I. 2016. Characterization of thePlasmodium falciparumandP. bergheiglycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cellular Microbiology,


    Shears, Melanie J. Botté, Cyrille Y. and McFadden, Geoffrey I. 2015. Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts. Molecular and Biochemical Parasitology, Vol. 199, Issue. 1-2, p. 34.


    Subudhi, Amit Kumar Boopathi, Pon Arunachalam Pandey, Isha Kaur, Ramandeep Middha, Sheetal Acharya, Jyoti Kochar, Sanjay K. Kochar, Dhanpat K. and Das, Ashis 2015. Disease specific modules and hub genes for intervention strategies: A co-expression network based approach for Plasmodium falciparum clinical isolates. Infection, Genetics and Evolution, Vol. 35, p. 96.


    Goodman, Christopher D. Mollard, Vanessa Louie, Theola Holloway, Georgina A. Watson, Keith G. and McFadden, Geoffrey I. 2014. Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides. International Journal for Parasitology, Vol. 44, Issue. 5, p. 285.


    Qidwai, Tabish Jamal, Farrukh Khan, Mohd Y. and Sharma, Bechan 2014. Exploring Drug Targets in Isoprenoid Biosynthetic Pathway forPlasmodium falciparum. Biochemistry Research International, Vol. 2014, p. 1.


    Ramakrishnan, Srinivasan Serricchio, Mauro Striepen, Boris and Bütikofer, Peter 2013. Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans. Progress in Lipid Research, Vol. 52, Issue. 4, p. 488.


    Lakshmanan, V. Rhee, K. Y. Wang, W. Yu, Y. Khafizov, K. Fiser, A. Wu, P. Ndir, O. Mboup, S. Ndiaye, D. and Daily, J. P. 2012. Metabolomic Analysis of Patient Plasma Yields Evidence of Plant-Like  -Linolenic Acid Metabolism in Plasmodium falciparum. Journal of Infectious Diseases, Vol. 206, Issue. 2, p. 238.


    Oluba, Olarewaju M. Olusola, Augustine O. Eidangbe, George O. Babatola, Leye J. and Onyeneke, E. Chukwu 2012. Modulation of Lipoprotein Cholesterol Levels inPlasmodium bergheiMalarial Infection by Crude Aqueous Extract ofGanoderma lucidum. Cholesterol, Vol. 2012, p. 1.


    Asahi, Hiroko Izumiyama, Shinji Tolba, Mohammed Essa Marghany and Kwansa-Bentum, Bethel 2011. Plasmodium falciparum: Differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium. Experimental Parasitology, Vol. 127, Issue. 3, p. 708.


    Lakshmanan, Viswanathan Rhee, Kyu Y. and Daily, Johanna P. 2011. Metabolomics and malaria biology. Molecular and Biochemical Parasitology, Vol. 175, Issue. 2, p. 104.


    Olszewski, Kellen L. and Llinás, Manuel 2011. Central carbon metabolism of Plasmodium parasites. Molecular and Biochemical Parasitology, Vol. 175, Issue. 2, p. 95.


    Déchamps, Sandrine Shastri, Shilpa Wengelnik, Kai and Vial, Henri J. 2010. Glycerophospholipid acquisition in Plasmodium – A puzzling assembly of biosynthetic pathways. International Journal for Parasitology, Vol. 40, Issue. 12, p. 1347.


    Olszewski, Kellen L. Mather, Michael W. Morrisey, Joanne M. Garcia, Benjamin A. Vaidya, Akhil B. Rabinowitz, Joshua D. and Llinás, Manuel 2010. Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature, Vol. 466, Issue. 7307, p. 774.


    Plata, Germán Hsiao, Tzu-Lin Olszewski, Kellen L Llinás, Manuel and Vitkup, Dennis 2010. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Molecular Systems Biology, Vol. 6,


    Asahi, Hiroko 2009. Plasmodium falciparum: Chemically defined medium for continuous intraerythrocytic growth using lipids and recombinant albumin. Experimental Parasitology, Vol. 121, Issue. 1, p. 22.


    LeRoux, Michele Lakshmanan, Viswanathan and Daily, Johanna P. 2009. Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions. Trends in Parasitology, Vol. 25, Issue. 10, p. 474.


    Tarun, Alice S. Vaughan, Ashley M. and Kappe, Stefan H.I. 2009. Redefining the role of de novo fatty acid synthesis in Plasmodium parasites. Trends in Parasitology, Vol. 25, Issue. 12, p. 545.


    Vaughan, Ashley M. O'Neill, Matthew T. Tarun, Alice S. Camargo, Nelly Phuong, Thuan M. Aly, Ahmed S. I. Cowman, Alan F. and Kappe, Stefan H. I. 2009. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cellular Microbiology, Vol. 11, Issue. 3, p. 506.


    SATO, S. HIRAYAMA, T. and HIRAZAWA, N. 2008. Lipid content and fatty acid composition of the monogenean Neobenedenia girellae and comparison between the parasite and host fish species. Parasitology, Vol. 135, Issue. 08,


    ×

Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth

  • F. MI-ICHI (a1) (a2), K. KITA (a2) and T. MITAMURA (a1)
  • DOI: http://dx.doi.org/10.1017/S0031182006000540
  • Published online: 01 June 2006
Abstract

Plasmodium falciparum causes the most severe form of malaria. Utilization of fatty acids in serum is thought to be necessary for survival of this parasite in erythrocytes, and thus characterization of the parasite fatty acid metabolism is important in developing a new strategy for controlling malaria. Here, we examined which combinations of fatty acids present in human serum support the continuous culture of P. falciparum in serum-free medium. Metabolic labelling and gas chromatography analyses revealed that, despite the need for particular fatty acids for the growth of intraerythrocytic P. falciparum, it can metabolize a broad range of serum-derived fatty acids into the major lipid species of their membranes and lipid bodies. In addition, these analyses showed that the parasite's overall fatty acid composition reflects that of the medium, although the parasite has a limited capacity to desaturate and elongate serum-derived fatty acids. These results indicate that the Plasmodium parasite is distinct from most cells, which maintain their fatty acid composition by coordinating de novo biosynthesis, scavenging, and modification (desaturation and elongation).

Copyright
Corresponding author
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Tel: +81 6 6879 8279. Fax: +81 6 6879 8281. E-mail: mitamura@biken.osaka-u.ac.jp
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: