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A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya

  • H. KIARA (a1), A. JENNINGS (a2), B. M. DE C. BRONSVOORT (a3), I. G. HANDEL (a3), S. T. MWANGI (a4), M. MBOLE-KARIUKI (a5), I. CONRADIE VAN WYK (a6), E. J. POOLE (a1), O. HANOTTE (a5), J. A. W. COETZER (a6), M. E. J. WOOLHOUSE (a4) and P. G. TOYE (a1)...
Summary
SUMMARY

Tick-borne diseases are a major impediment to improved productivity of livestock in sub-Saharan Africa. Improved control of these diseases would be assisted by detailed epidemiological data. Here we used longitudinal, serological data to determine the patterns of exposure to Theileria parva, Theileria mutans, Babesia bigemina and Anaplasma marginale from 548 indigenous calves in western Kenya. The percentage of calves seropositive for the first three parasites declined from initial high levels due to maternal antibody until week 16, after which the percentage increased until the end of the study. In contrast, the percentage of calves seropositive for T. mutans increased from week 6 and reached a maximal level at week 16. Overall 423 (77%) calves seroconverted to T. parva, 451 (82%) to T. mutans, 195 (36%) to B. bigemina and 275 (50%) to A. marginale. Theileria parva antibody levels were sustained following infection, in contrast to those of the other three haemoparasites. Three times as many calves seroconverted to T. mutans before seroconverting to T. parva. No T. parva antibody response was detected in 25 calves that died of T. parva infection, suggesting that most deaths due to T. parva are the result of acute disease from primary exposure.

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      A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya
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      A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya
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Copyright
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence http://creativecommons.org/licenses/by/3.0/
Corresponding author
* Corresponding author: ILRI, PO Box 30709, Nairobi-00100, Kenya. E-mail: p.toye@cgiar.org
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B. B. Asiimwe , W. Weir , A. Tait , G. W. Lubega and C. A. L. Oura (2013). Haemoparasite infection kinetics and the population structure of Theileria parva on a single farm in Uganda. Veterinary Parasitology 193, 814.

B. M. de C. Bronsvoort , S. T. Mwangi , E. J. Poole , H. Kiara , O. Tosas-Auguet , I. G. Handel , A. Jennings , I. Conradie , M. D. Mbole-Kariuki , P. G. Toye , O. Hanotte , J. A. W. Coetzer and M. E. J. Woolhouse (2013). Design and descriptive epidemiology of the Infectious Diseases of East African Livestock (IDEAL) project, a longitudinal calf cohort study in western Kenya. BMC Veterinary Research 9, 171. www.biomedcentral.com/1746-6148/9/171.

J. J. de Castro (1997). Sustainable tick and tick-borne disease control in livestock improvement in developing countries. Veterinary Parasitology 71, 7797.

G. K. Gitau , B. D. Perry , J. M. Katende , J. J. McDermott , S. P. Morzaria and A. S. Young (1997). The prevalence of serum antibodies to tick-borne infections in cattle in smallholder dairy farms in Murang'a District, Kenya; a cross-sectional study. Preventive Veterinary Medicine 30, 95107.

J. M. Katende , B. M. Goddeeris , S. P. Morzaria , C. G. Nkonge and A. J. Musoke (1990). Identification of a Theileria mutans-specific antigen for use in an antibody and antigen detection ELISA. Parasite Immunology 12, 419433.

J. M. Katende , S. Morzaria , P. Toye , R. Skilton , V. Nene , C. Nkonge and A. Musoke (1998). An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule. Parasitology Research 84, 408416.

T. Lumley (2004). Analysis of complex survey samples. Journal of Statistical Software 9, 119.

S. Maloo , G. Rowlands , W. Thorpe , G. Gettinby and B. Perry (2001). A longitudinal study of disease incidence and case-fatality risks on small-holder dairy farms in coastal Kenya. Preventive Veterinary Medicine 52, 1729.

G. Moll and A. Lohding (1984). Epidemiology of theileriosis in the Trans-Mara division, Kenya: husbandry and disease background and preliminary investigations on theileriosis in calves. Preventive Veterinary Medicine 2, 801831.

G. Moll and A. Lohding (1986). Epidemiology of theileriosis in calves in an endemic area of Kenya. Veterinary Parasitology 19, 255273.

G. R. Muraguri , A. McLeod , J. J. McDermott and N. Taylor (2005). The incidence of calf morbidity and mortality due to vector-borne infections in smallholder dairy farms in Kwale District, Kenya. Veterinary Parasitology 130, 305315.

S. G. Ndungu , C. G. D. Brown and T. T. Dolan (2005). In vivo comparison of susceptibility between Bos indicus and Bos taurus cattle types to Theileria parva infection. Onderstepoort Journal of Veterinary Research 72, 1322.

O. S. Okuthe and G. E. Buyu (2006). Prevalence and incidence of tick-borne diseases in smallholder farming systems in the western Kenya highlands. Veterinary Parasitology 141, 307312.

P-P. Pastoret (2007). Challenges and issues of early life vaccination in animals and humans. Journal of Comparative Pathology 137, S2S3.

R. Pelle , S. P. Graham , M. N. Njahira , J. Osaso , R. M. Saya , D. O. Odongo , P. G. Toye , P. R. Spooner , A. J. Musoke , D. M. Mwangi , E. L. N. Taracha , W. I. Morrison , W. Weir , J. C. Silva and R. P. Bishop (2011). Two Theileria parva CD8T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS One 6, e19015. doi: 10.1371/journal.pone.0019015.

B. Perry and A. Young (1995). The past and future roles of epidemiology and economics in the control of tick-borne diseases of livestock in Africa: the case of theileriosis. Preventive Veterinary Medicine 25, 107120.

J. B. Singer and J. D. Willett (2003). Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. Oxford University Press, New York, NY, USA.

E. S. Swai , E. D. Karimuribo , D. M. Kambarage , W. E. Moshy and A. N. Mbise (2007). A comparison of seroprevalence and risk factors for Theileria parva and T. mutans in smallholder dairy cattle in the Tanga and Iringa regions of Tanzania. Veterinary Journal 174, 390396.

S. M. Thumbi , M. B. Bronsvoort , H. Kiara , P. G. Toye , J. Poole , M. Ndila , I. Conradie , A. Jennings , I. G. Handel , J. A. W. Coetzer , J. Steyl , O. Hanotte and M. E. J. Woolhouse (2013). Mortality in East African shorthorn zebu cattle under one year: predictors of infectious-disease mortality. BMC Veterinary Research 9, 175. www.biomedcentral.com/1746-6148/9/175.

P. Toye , I. Handel , J. Gray , H. Kiara , S. Thumbi , A. Jennings , I. Conradie van Wyk , M. Ndila , O. Hanotte , K. Coetzer , M. Woolhouse and M. Bronsvoort (2013). Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya. Veterinary Immunology and Immunopathology 155, 129134.

G. Uilenberg (1995). International collaborative research: significance of tick-borne hemoparasitic diseases to world animal health. Veterinary Parasitology 57, 1941.

H. Wickham (2007). Reshaping data with the reshape package. Journal of Statistical Software 21, 120.

H. Wickham (2009). ggplot2: Elegant Graphics for Data Analysis. Springer, New York, NY, USA.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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