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    MEJRI, N. and GOTTSTEIN, B. 2006. Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation. Parasite Immunology, Vol. 28, Issue. 8, p. 373.
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    Macintyre, Andrew R Dixon, John B and Green, Jack R 2001. Mitosis and differentiation in T-cells under cytotoxic action of Echinococcus granulosus hydatid fluid. Veterinary Parasitology, Vol. 96, Issue. 4, p. 277.
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    Kadian, S. K. Dixon, J. B. Green, J. R. Carter, S.D. and Jenkins, P. 1994. Modification of macrophage – T cell interaction during infection of mice with Mesocestoides corti (Cestoda). Parasitology, Vol. 109, Issue. 05, p. 591.
    Rakha, N.K. Dixon, J.B. Skerritt, G.C. Carter, S.D. and Jenkins, P. 1992. Modification of accessory activity of sheep monocytes in vitro by a coenurus antigen from Taenia multiceps. Veterinary Immunology and Immunopathology, Vol. 30, Issue. 2-3, p. 293.
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Modification of cellular immunity by Taenia multiceps (Cestoda): accessory macrophages and CD4+ lymphocytes are affected by two different coenurus factors

  • N. K. Rakha (a1), J. B. Dixon (a1), P. Jenkins (a1), S. D. Carter (a1) (a2), G. C. Skerritt (a3) and S. Marshall-Clarke (a4)...
Extract

Taenia multiceps coenurus fluid was analysed by fast protein liquid chromatography in order to separate the factors responsible for previously reported modification of immunological activity in macrophages and T-cells. One factor, F7, was found to be mitogenic for murine L3T4+ T-cells, to be macrophage dependent, to require macrophage compatibility at the I region of the H2 complex, to increase the sensitivity of T-cells to regulatory signals from macrophages and to increase the rate of generation of splenic rosette-forming cells (RFC) against sheep red cells. A second factor, F24, was found to alter macrophages so as to render them suppressive, rather than stimulatory, for parasite-activated and Con A-activated lymphocyte transformation, to depress the rate of generation of RFC and to antagonize the mitogenic effect of F7. The combined actions of these two factors are, therefore, sufficient to explain the known immunomodulatory effects of the metacestode.

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COPYRIGHT: © Cambridge University Press 1991
References
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