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Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges

  • ABEBE GENETU BAYIH (a1) (a2) and DYLAN R. PILLAI (a1) (a2)
Summary
SUMMARY

This review highlights studies conducted in murine models to evaluate the efficacy of compounds targeting Heat shock protein (Hsp) 90 of malaria. Both advances achieved and limitations that exist are highlighted.

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* Corresponding author: University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada. E-mail: dylanrpillai@gmail.com
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P. Acharya , R. Kumar and U. Tatu (2007). Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum. Molecular and Biochemical Parasitology 153, 8594. doi: 10.1016/j.molbiopara.2007.01.009.

C. Ancolio , N. Azas , V. Mahiou , E. Ollivier , C. Di Giorgio , A. Keita , P. Timon-David and G. Balansard (2002). Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome. Phytotherapy Research 16, 646649. doi: 10.1002/ptr.1025.

I. Angulo-Barturen , M. B. Jimenez-Diaz , T. Mulet , J. Rullas , E. Herreros , S. Ferrer , E. Jimenez , A. Mendoza , J. Regadera , P. J. Rosenthal , I. Bathurst , D. L. Pompliano , F. Gomez de las Heras and D. Gargallo-Viola (2008). A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PloS One 3, e2252. doi: 10.1371/journal.pone.0002252.

N. Azas , N. Laurencin , F. Delmas , G. C. Di , M. Gasquet , M. Laget and P. Timon-David (2002). Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitology Research 88, 165171.

G. Banumathy , V. Singh , S. R. Pavithra and U. Tatu (2003). Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. Journal of Biological Chemistry 278, 1833618345. doi: 10.1074/jbc.M211309200.

J. G. Beeson and G. V. Brown (2002). Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation. Cellular and Molecular Life Sciences 59, 258271.

S. Bonnefoy , G. Attal , G. Langsley , F. Tekaia and O. Mercereau-Puijalon (1994). Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum . Molecular and Biochemical Parasitology 67, 157170.

A. Bracher and F. U. Hartl (2006). Hsp90 structure: when two ends meet. Nature Structural and Molecular Biology 13, 478480. doi: 10.1038/nsmb0606-478.

P. Csermely , T. Schnaider , C. Soti , Z. Prohaszka and G. Nardai (1998). The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacology and Therapeutics 79, 129168.

C. DeBoer , P. A. Meulman , R. J. Wnuk and D. H. Peterson (1970). Geldanamycin, a new antibiotic. Journal of Antibiotics 23, 442447.

D. A. Fidock , P. J. Rosenthal , S. L. Croft , R. Brun and S. Nwaka (2004). Antimalarial drug discovery: efficacy models for compound screening. Nature Reviews. Drug Discovery 3, 509520. doi: 10.1038/nrd1416.

H. He , D. Zatorska , J. Kim , J. Aguirre , L. Llauger , Y. She , N. Wu , R. M. Immormino , D. T. Gewirth and G. Chiosis (2006). Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. Journal of Medicinal Chemistry 49, 381390. doi: 10.1021/jm0508078.

K. Jhaveri , T. Taldone , S. Modi and G. Chiosis (2012). Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. Biochimica et Biophysica Acta 1823, 742755. doi: 10.1016/j.bbamcr.2011.10.008.

M. B. Jimenez-Diaz , T. Mulet , S. Viera , V. Gomez , H. Garuti , J. Ibanez , A. Alvarez-Doval , L. D. Shultz , A. Martinez , D. Gargallo-Viola and I. Angulo-Barturen (2009). Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes. Antimicrobial Agents and Chemotherapy 53, 45334536. doi: 10.1128/AAC.00519-09.

R. Kumar , A. Musiyenko and S. Barik (2003). The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin. Malaria Journal 2, 30. doi: 10.1186/1475-2875-2-30.

S. Lindquist and E. A. Craig (1988). The heat-shock proteins. Annual Review of Genetics 22, 631677. doi: 10.1146/annurev.ge.22.120188.003215.

R. Mout , Z. D. Xu , A. K. Wolf , V. Jo Davisson and G. K. Jarori (2012). Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii . Malaria Journal 11, 54. doi: 10.1186/1475-2875-11-54.

L. Neckers and U. Tatu (2008). Molecular chaperones in pathogen virulence: emerging new targets for therapy. Cell Host and Microbe 4, 519527. doi: 10.1016/j.chom.2008.10.011.

R. Pallavi , N. Roy , R. K. Nageshan , P. Talukdar , S. R. Pavithra , R. Reddy , S. Venketesh , R. Kumar , A. K. Gupta , R. K. Singh , S. C. Yadav and U. Tatu (2010). Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. Journal of Biological Chemistry 285, 3796437975. doi: 10.1074/jbc.M110.155317.

W. Peters , R. E. Howells , J. Portus , B. L. Robinson , S. Thomas and D. C. Warhurst (1977). The chemotherapy of rodent malaria, XXVII. Studies on mefloquine (WR 142,490). Annals of Tropical Medicine and Parasitology 71, 407418.

C. Prodromou , S. M. Roe , R. O'Brien , J. E. Ladbury , P. W. Piper and L. H. Pearl (1997). Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell 90, 6575.

K. Sasaki , H. Yasuda and K. Onodera (1979). Growth inhibition of virus transformed cells in vitro and antitumor activity in vivo of geldanamycin and its derivatives. Journal of Antibiotics 32, 849851.

T. Scheibel and J. Buchner (1998). The Hsp90 complex – a super-chaperone machine as a novel drug target. Biochemical Pharmacology 56, 675682.

D. Shahinas , M. Liang , A. Datti and D. R. Pillai (2010). A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90. Journal of Medicinal Chemistry 53, 35523557. doi: 10.1021/jm901796s.

D. Shahinas , G. Macmullin , C. Benedict , I. Crandall and D. R. Pillai (2012). Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin. Antimicrobial Agents and Chemotherapy 56, 42074213. doi: 10.1128/AAC.00328-12.

D. Shahinas , A. Folefoc , T. Taldone , G. Chiosis , I. Crandall and D. R. Pillai (2013). A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). PloS One 8, e75446. doi: 10.1371/journal.pone.0075446.

A. Shonhai (2010). Plasmodial heat shock proteins: targets for chemotherapy. FEMS Immunology and Medical Microbiology 58, 6174. doi: 10.1111/j.1574-695X.2009.00639.x.

L. Whitesell , E. G. Mimnaugh , B. De Costa , C. E. Myers and L. M. Neckers (1994). Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proceedings of the National Academy of Sciences USA 91, 83248328.

H. Wiech , J. Buchner , R. Zimmermann and U. Jakob (1992). Hsp90 chaperones protein folding in vitro . Nature 358, 169170. doi: 10.1038/358169a0.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
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