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The population ecology of infectious diseases: pertussis in Thailand as a case study

  • J. C. BLACKWOOD (a1), D. A. T. CUMMINGS (a2) (a3), H. BROUTIN (a4), S. IAMSIRITHAWORN (a5) and P. ROHANI (a1) (a3)...

Many of the fundamental concepts in studying infectious diseases are rooted in population ecology. We describe the importance of population ecology in exploring central issues in infectious disease research including identifying the drivers and dynamics of host-pathogen interactions and pathogen persistence, and evaluating the success of public health policies. The use of ecological concepts in infectious disease research is demonstrated with simple theoretical examples in addition to an analysis of case notification data of pertussis, a childhood respiratory disease, in Thailand as a case study. We stress that further integration of these fields will have significant impacts in infectious diseases research.

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Altizer, S., Dobson, A., Hosseini, P., Hudson, P., Pascual, M. and Rohani, P. (2006). Seasonality and the dynamics of infectious diseases. Ecology Letters 9, 467484.
Anderson, R. M. and May, R. M. (1979). Population biology of infectious diseases: Part I. Nature 280, 361367.
Anderson, R. M. and May, R. M. (1991). Infectious Diseases of Humans. Oxford University Press, New York.
Bailey, N. T. J. (1975). The Mathematical Theory of Infectious Diseases and its Applications. Griffin, London.
Bartlett, M. S. (1957). Measles periodicity and community size. Journal of the Royal Statistical Society Series A (General) 120(1), 4870.
Bass, J. W. and Stephenson, S. R. (1987). The return of pertussis. Pediatric Infectious Disease Journal 6, 141144.
Bauch, C. T. and Earn, D. J. D. (2003). Transients and attractors in epidemics. Proceedings of the Royal Society London B: Biological Sciences 270, 15731578.
Bharti, N., Tatem, A. J., Ferrari, M. J., Grais, R. F., Djibo, A. and Grenfell, B. T. (2011). Explaining seasonal fluctuations of Measles in Niger using nighttime lights imagery. Science 334, 14241427.
Bhunbhu, T. (1989). Expanded programme on immunization in Thailand. Reviews of Infectious Diseases 11, Supplement 3: S514S517.
Bjørnstad, O. N. and Falck, W. (2001). Nonparametric spatial covariance functions: Estimation and testing. Environmental and Ecological Statistics 8, 5370.
Bolker, B. M. and Grenfell, B. T. (1996). Impact of vaccination on the spatial correlation and persistence of measles dynamics. Proceedings of the National Academy of Sciences, USA 93, 1264812653.
Breban, R., Drake, J. M., Stallknecht, D. E. and Rohani, P. (2009). The role of environmental transmission in recurrent avian influenza epidemics. PLoS Computational Biology 5, e1000346.
Broutin, H., Guegan, J. F., Elguero, E., Simondon, F. and Cazelles, B. (2005). Large-scale comparative analysis of pertussis population dynamics: periodicity, synchrony, and impact of vaccination. American Journal of Epidemiology 161, 11591167.
Broutin, H., Simondon, F. and Guegan, J.-F. (2004). Whooping cough metapopulation dynamics in tropical conditions: disease persistence and impact of vaccination. Proceedings of the Royal Society Series B Biological Sciences 271, SupplementS302S305.
Broutin, H., Viboud, C., Grenfell, B. T., Miller, M. A. and Rohani, P. (2010). Impact of vaccination and birth rate on the epidemiology of pertussis: a comparative study in 64 countries. Proceedings of the Royal Society B Biological Sciences 277, 32393245.
Brown, J. H. and Kodric-Brown, A. (1977). Turnover rates in insular biogeography: effect of immigration on extinction. Ecology 58, 445449.
Celentano, L. P., Massari, M., Paramatti, D., Salmaso, S. and Tozzi, A. E. (2005). Resurgence of pertussis in Europe. The Pediatric Infectious Disease Journal 24, 761765.
Chatfield, C. (1996). The Analysis of Time Series – An Introduction. 5th ed. Chapman and Hall, London.
Choisy, M., Guégan, J.-F., and Rohani, P. (2006). Dynamics of infectious diseases and pulse vaccination: Teasing apart the embedded resonance effects. Physica D: Nonlinear Phenomena 223, 2635.
Conlan, A. J. K., Rohani, R., Lloyd, A. L., Keeling, M. and Grenfell, B. T. (2010). Resolving the impact of waiting time distributions on the persistence of measles. Journal of the Royal Society Interface 7, 623640.
Crowcroft, N. S. and Pebody, R. G. (2006). Recent developments in pertussis. Lancet 367, 19261936.
Crowcroft, N. S., Stein, C., Duclos, P. and Birmingham, M. (2003). How to best estimate the global burden of pertussis? The Lancet Infectious Diseases 3, 413418.
Cummings, D. A. T., Iamsirithaworn, S., Lessler, J. T., McDermott, A., Prasanthong, R., Nisalak, A., Jarman, R. G., Burke, D. S. and Gibbons, R. V. (2009). The impact of the demographic transition on dengue in Thailand: Insights from a statistical analysis and mathematical modeling. PLoS Medicine 6(9), e1000139.
Cummings, D. A. T., Irizarry, R. A., Huang, N. E., Endy, T. P., Nisalak, A., Ungchusak, K. and Burke, D. S. (2004). Travelling waves in the occurrence of dengue haemorrhagic fever in Thailand. Nature 427, 344347.
Dietz, K. (1976). The incidence of infectious diseases under the influence of seasonal fluctuations. In Lecture Notes in Biomathematics, vol. 11 (ed. Berger, J. et al. ), pp. 115. Springer, Berlin.
Dowell, S. F. (2001). Seasonal variation in host susceptibility and cycles of certain infectious diseases. Emerging Infectious Diseases 7, 369374.
Earn, D. J. D., Rohani, P., Bolker, B. M. and Grenfell, B. T. (2000). A simple model for complex dynamical transitions in epidemics. Science 287, 667670.
Earn, D. J. D., Rohani, P. and Grenfell, B. T. (1998). Synchronicity in ecology and epidemiology. Proceedings of the Royal Society of London B: Biological Sciences 265, 710.
Ferrari, M. J., Grais, R. F., Bharti, N., Conlan, A. J. K., Bjørnstad, O. N., Wolfson, L. J., Guerin, P. J., Djibo, A. and Grenfell, B. T. (2008). The dynamics of measles in sub-Saharan Africa. Nature 451, 679684.
Fine, P. E. M. and Clarkson, J. A. (1982). Measles in England and Wales–i: An analysis of factors underlying seasonal patterns. International Journal of Epidemiology 11(1), 514.
Finkenstädt, B. F., Bjørnstad, O. N. and Grenfell, B. T. (2002). A stochastic model for extinction and recurrence of epidemics: estimation and inference for measles outbreaks. Biostatistics 3, 493510.
Finkenstädt, B. F. and Grenfell, B. T. (2000). Time series modelling of childhood diseases: a dynamical systems approach. Applied Statistics 49, 187205.
Grassly, N. C. and Fraser, C. (2006). Seasonal infectious disease epidemiology. Proceedings of the Royal Society B: Biological Sciences 273, 25412550.
Grenfell, B. T., Bjørnstad, O. N. and Kappey, J. (2001). Travelling waves and spatial hierarchies in measles epidemics. Nature 414, 716723.
Grenfell, B. T. and Harwood, J. (1997). (Meta)population dynamics of infectious diseases. Trends in Ecology and Evolution 12, 395399.
Hamer, W. H. (1906). Epidemic disease in England. Lancet i, 733739.
Hethcote, H. W. (1998). Oscillations in an endemic model for pertussis. Canadian Applied Mathematics Quarterly 6, 6188.
Heymann, D. L. and Aylward, R. B. (2004). Eradicating polio. New England Journal of Medicine 351(13), 12751277.
Hoshen, M. B. and Morse, A. P. (2004). A weather-driven model of malaria transmission. Malaria Journal 3, 3246.
Johansson, M. A., Cummings, D. A. T. and Glass, G. E. (2009). Multiyear climate variability and dengue? El Nino southern oscillation, weather, and dengue incidence in Puerto Rico, Mexico, and Thailand: A longitudinal data analysis. PLoS Medicine 6, e1000168.
Keeling, M. J. and Rohani, P. (2008). Modeling Infectious Diseases in Humans and Animals, Princeton University Press, Princeton.
London, W. P. and York, J. A. (1973). Recurrent outbreaks of measles, chickenpox and mumps I: seasonal variation in contact rates. American Journal of Epidemiology 98, 453468.
Mantilla-Beniers, N. B., Bjørnstad, O. N., Grenfell, B. T. and Rohani, P. (2010). Decreasing stochasticicty through enhanced seasonality in measles epidemics. Journal of the Royal Society Interface 7, 727739.
Metcalf, C. J. E., Bjørnstad, O. N., Grenfell, B. T. and Andreasen, V. (2009). Seasonality and comparative dynamics of six childhood infections in pre-vaccination Copenhagen. Proceedings of the Royal Society B: Biological Sciences 276, 41114118.
Metcalf, C. J. E., Munayco, C. V., Chowell, G., Grenfell, B. T. and Bjørnstad, O. N. (2010). Rubella metapopulation dynamics and the importance of spatial coupling to the risk of congenital rubella syndrome in Peru. Journal of the Royal Society Interface 8, 369376. doi: 10.1098/rsif.2010.0320
National Statistical Office of Thailand (1980). 1980 census. Technical report, Bangkok: National Statistical Office of Thailand.
National Statistical Office of Thailand (1991). 1990 census. Technical report, Bangkok: National Statistical Office of Thailand.
National Statistical Office of Thailand (2001). 2000 census. Technical report, Bangkok: National Statistical Office of Thailand.
Nee, S. (1994). How populations persist. Nature 367, 123124.
Nokes, D. J. and Swinton, J. (1997). Vaccination in pulses: a strategy for global eradication of measles and polio? Trends in Microbiology 5, 1419.
Rohani, P., Earn, D. J. D. and Grenfell, B. T. (1999). Opposite patterns of synchrony in sympatric disease metapopulations. Science 286, 968971.
Rohani, P., Earn, D. J. D. and Grenfell, B. T. (2000). Impact of immunisation on pertussis transmission in England and Wales. Lancet 355, 285286.
Rohani, P. and King, A. A. (2010). Never mind the length, feel the quality: Long-term epidemiological data in theory, application and policy. Trends in Ecology and Evolution 25, 611618.
Shaman, J., Pitzer, V. E., Viboud, C., Grenfell, B. T. and Lipsitch, M. (2010). Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biology 8(2), e1000316.
Soper, H. E. (1929). The interpretation of periodicity in disease prevalence. Journal of the Royal Statistical Society 92(1), 3473.
Thai, K. T. D., Cazelles, B., Nguyen, N. V., Vo, L. T., Boni, M. F., Farrar, J., Simmons, C. P., Rogier van Doorn, H. and de Vries, P. J. (2010). Dengue dynamics in Binh Thuan province, southern Vietnam: Periodicity, synchronicity and climate variability. PLoS Neglected Tropical Diseases 4(7), e747.
Torrence, C. and Compo, G. P. (1998 a). Wavelet Software, available at
Torrence, C. and Compo, G. P. (1998 b). A practical guide to wavelet analysis. Bulletin of the American Meteorological Society 79, 6178.
Viboud, C., Bjørnstad, O. N., Smith, D. L., Simonsen, L., Miller, M. A. and Grenfell, B. T. (2006). Synchrony, waves, and spatial hierarchies in the spread of influenza. Science, 312, 447451.
Watts, D., Burke, D., Harrison, B., Whitmore, R. and Nisalak, A. (1987). Effect of temperature on the vector efficiency of Aedes aegypt} for dengue 2 virus. American Journal of Tropical Medicine and Hygiene 36, 143152.
Wearing, H. J. and Rohani, P. (2009). Estimating the duration of pertussis immunity using epidemiological signatures. PLoS Pathogens 5(10), e1000647.
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