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Re-assessing the global prevalence and distribution of lymphatic filariasis

  • E. Michael (a1), D. A. P. Bundy (a2) and B. T. Grenfell (a1)
  • DOI:
  • Published online: 06 April 2009

This paper estimates the global burden of lymphatic filariasis based on a review of the published literature on infection and disease surveys. A method for aggregating and projecting prevalence data from individual studies to national, regional and global levels, which also facilitates the estimation of gender and age-specific burdens, is presented. The method weights in favour of the larger, and hence presumbably more reliable, studies and relies on estimated empirical relationships between gender, age, infection and disease in order to correct studies with incomplete data. The results presented here suggest that although the overall prevalence of filariasis cases is 2·0% globally (approximately totalling 119 million cases), the disease continues to be of considerable local importance, particularly in India and Sub-Saharan Africa. Estimates by age and gender clearly show that, unlike other helminth infections, filariasis is mainly a disease of the adult and older age-classes and appears to be more prevalent in males. This work suggests that the derivation of more accurate estimates of the burden of filariasis will require a better understanding of both the epidemiology and the spatial aspects of infection and disease. It also suggests that filariasis is preventable based on a geographically targeted strategy for control.

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R. Barclay (1969). Filariasis in Sabah, East Malaysia. Annals of Tropical Medicine and Parasitology 63, 473–88.

D. A. P. Bundy & E. s. Cooper (1989). Trichuris and trichuriasis in humans. Advances in Parasitology 28, 107–73.

D. A. P. Bundy , B. T. Grenfell & P. K. Rajagopalan (1991). Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease. In Immunoparasitology Today, (ed. C. Ash & R. B. Gallagher ) pp. A71–A75. Cambridge: Elsevier Trends Journals.

J. L. Cartel , N. L. Nguyen , A. Spiegel , J. P. Moulia-Pelat , R. Plichart , P. M. V. Martin , A. B. Manuellan & F. Lardeux (1992). Wuchereria bancrofti infection in human and mosquito populations of a Polynesian village ten years after the interruption of mass chemoprophylaxis with diethylcarbamazine. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 414–16.

D. W. T. Crompton (1988). The prevalence of ascariasis. Parasitology Today 4, 162–9.

H. L. David & J. F. B. Edeson (1965). Filariasis in Portuguese Timor, with observations on a new microfilaria found in man. Annals of Tropical Medicine and Parasitology 59, 193207.

s. Dissanayake (1989). Microfilaraemia, serum antibody and development of clinical disease in microfilaraemic subjects infected with Wuchereria bancrofti and treated with diethylcarbamazine citrate. Transactions of the Royal Society of Tropical Medicine and Hygiene 83, 384–8.

D. B. Evans , H. Gelband & C. Vlassoff (1993). Social and economic factors and the control of lymphatic filariasis: a review. Acta Tropica 53, 126.

D. O. Freedman , P. J. Filho , S. Besh , M. Silva , C. Braga & A. Maciel (1994). Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis. Journal of Infectious Diseases 170, 927–33.

D. I. Grove (1983). Selective primary health care: strategies for the control of disease in the developing world. VII. Filariasis. Reviews of Infectious Diseases 5, 933–44.

H. L. Guyatt & D. A. P. Bundy (1991). Estimating prevalence of community morbidity due to intestinal helminths: prevalence of infection as an indicator of the prevalence of disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 778–82.

E. R. Huehns (1953). Filariasis in Mauritius. Transactions of the Royal Society of Tropical Medicine and Hygiene 47, 549–55.

B. Hyma , A. Ramesh & K. Gunasekaran (1989). Lymphatic filariasis in Madras, India. Social Science and Medicine 29, 983–90.

R. Knight , K. P. W. J. Mcadam , Y. G. Matola & V. Kirkham (1979). Bancroftian filariasis and other parasitic infections in the Middle Fly River region of Western Papua New Guinea. I. Clinical, parasitological and serological studies. Annals of Tropical Medicine and Parasitology 73, 563–76.

R. Knight (1980). Current status of filarial infections in The Gambia. Annals of Tropical Medicine and Parasitology 74, 63–8.

D. D. Mccarthy & N. Fitzgerald (1955). Researches in Western Samoa. III. Observations on filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 49, 82–9.

D. D. Mccarthy & N. Fitzgerald (1956). Habit, habitat and hyperfilariation in the epidemiology of filariasis in Western Samoa. Transactions of the Royal Society of Tropical Medicine and Hygiene 50, 5865.

J. E. Mcmahon , S. A. Magayuka , N. Kolstrup , F. W. Mosha , F. M. Bushrod & D. E. Abaru (1981). Studies on the transmission and prevalence of Bancroftian filariasis in four coastal villages of Tanzania. Annals of Tropical Medicine and Parasitology 75, 415–31.

E. Michael , B. T. Grenfell & D. A. P. Bundy (1994). The association between microfilaraemia and disease in lymphatic filariasis. Proceedings of the Royal Society of London, B 256, 3340.

S. P. Pani , N. Balakrishnan , A. Srividya , D. A. P. Bundy & B. T. Grenfell (1991). Clinical epidemiology of bancroftian filariasis: effect of age and gender. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 260–4.

S. P. Pani , J. Yuvaraj , P. Vanamail , V. Dhanda , E. Michael , B. T. Grenfell & D. A. P. Bundy (1995). Episodic adenolymphangitis and the stages of lymphoedema in bancroftian filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 72–4.

C. P. Raccurt , R. C. Lowrie Jr., S. P. Katz & Y. T. Duverseau (1988). Epidemiology of Wuchereria bancrofti in Leogane, Haiti. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 721–5.

L. E. Rozeboom & B. D. Cabrera (1964). Filariasis in mountain province, Luzon, Republic of the Philippines. Journal of Medical Entomology 1, 1828.

L. S. Self , S. Usman , H. Sajidiman , F. Partono , M. J. Nelson , C. P. Pant , T. Suzuki & H. Mechfudin (1978). A multidisciplinary study on bancroftian filariasis in Jakarta. Transactions of the Royal Society of Tropical Medicine and Hygiene 72, 581–7.

B. A. Southgate (1974). Problems of clinical and biological measurements in the epidemiology and control of filarial infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 68, 177–86.

A. Srividya , S. P. Pani , P. K. Rajagopalan , D. A. P. Bundy & B. T. Grenfell (1991 b). The dynamics of infection and disease in bancroftian filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 255–9.

G. O. Ufomadu , B. E. B. Nwoke , J. I. Akoh , Y. Sato , G. O. C. Ekejindu , A. Uchida , K. Shiwaku , M. Tumbau & K. K. Ugomo (1991). The occurrence of loiasis, mansonellosis and wuchereriasis in the Jarawa River Valley, Central Nigeria. Acta Tropica 48, 137–47.

A. L. Vincent (1987). A survey of Bancroftian filariasis in the Dominican Republic. Journal of Parasitology 73, 839–40.

M. H. Witte , S. Jamal , W. H. Williams , C. L. Witte , V. Kumaraswami , G. C. Mcneil , T. C. Case & T. M. R. Panicker (1993). Lymphatic abnormalities in human filariasis as depicted by lymphoangioscintigraphy. Archives of Internal Medicine 153, 737–44.

D. J. B. Wijers (1977). Bancroftian filariasis in Kenya 1. Prevalence survey among adult males in the Coast Province. Annals of Tropical Medicine and Parasitology 71, 313–31.

D. J. B. Wijers & H. Kinyanjui (1977). Bancroftian filariasis in Kenya II. Clinical and parasitological investigations in Mambrui, a small coastal town, and Jaribuni, a rural area more inland (coast province). Annals of Tropical Medicine and Parasitology 71, 333–45.

M. S. Wolfe & M. Aslamkhan (1971). Filariasis in East Pakistan. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 63–9.

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