Skip to main content Accessibility help
×
×
Home

The resistance to re-infection of cats repeatedly inoculated with infective larvae of Brugia pahangi

  • D. A. Denham (a1), P. B. McGreevy (a1), R. R. Suswillo (a1) and Rosemary Rogers (a1)

Summary

Seven microfilaraemic and five amicrofilaraemic cats which had been repeatedly infected with Brugia pahangi were challenged along with normal cats 28, 14 and 1 day before autopsy. The lymphatics of the amicrofilaraemic cats contained no female adult worms originating from the repeat infections and only two adult males (both from the same cat). Only 5·2 % of the worms in the control cats were recovered from the amicrofilaraemic cats. Most of the challenge worms were killed in the first 24 h. The microfilaraemic cats all contained fertile adult male and female worms derived from the repeated infection but in such low numbers as to indicate considerable resistance to infection. Compared to their controls 26·4% of the challenge worms were recovered. Analysis of the life-cycle stages recovered showed that in both groups there was attrition of all stages and that although a number of worms reached L5 these were all killed later in the amicrofilaraemic cats.

Copyright

References

Hide All
Denham, D. A. (1974). Studies with Brugia pahangi. 6. The susceptibility of male and female cats to infection. Journal of Parasitology 60, 642.
Denham, D. A. (1982). Methodology of experimental chemotherapy of lymphatic filariasis. In Animal Models in Parasitology (ed. Owen, D.). London: Academic Press, (in the Press.)
Denham, D. A., Dennis, D. T., Ponnudueai, T., Nelson, G. S. & Guy, F. (1971). Comparison of a counting chamber and thick smear methods of counting microfilariae. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 521–6.
Denham, D. A., Ponnudurai, T., Nelson, G. S., Guy, F. & Rogers, R. (1972 a). Studies with Brugia pahangi. 1. Parasitological observations on primary infections of cats (Felis catus). International Journal for Parasitology 2, 239–47.
Denham, D. A., Ponnudurai, T., Nelson, G. S., Rogers, R. & Guy, F. (1972 b). Studies with Brugia pahangi. II. The effect of repeated infection on parasite levels in cats. International Journal for Parasitology 2, 401–7.
Dennis, D. T. & Kean, B. H. (1971). Isolation of microfilariae: report of a new method. Journal of Parasitology 57, 1146–7.
Gusmao, R. d'A., Stanley, A. M. & Ottesen, E. A. (1981). Brugia pahangi: Immunological evaluation of the differential susceptibility to filarial infection in inbred Lewis rats. Experimental Parasitology 52, 147–59.
Rogers, R. & Denham, D. A. (1974). Studies with Brugia pahangi. 7. Changes in lymphatics of injected cats. Journal of Helminthology 48, 213–19.
Suswillo, R. R., Denham, D. A. & McGreevy, P. B. (1982). The number and distribution of Brugia pahangi in cats at different times after a primary infection. Acta Tropica 39, 151–6.
Wilson, T. & Ramachandran, C. P. (1971). Brugia infections in man and animals: long-term observations on microfilaraemia and estimates of the efficiency of transmission from mosquito vector to definitive host. Annals of Tropical Medicine and Parasitology 65, 525–46.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed