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The development and validation of an age-structured model for the evaluation of disease control strategies for intestinal helminths

  • M. S. Chan (a1), H. L. Guyatt (a2), D. A. P. Bundy (a1) and G. F. Medley (a3)
  • DOI:
  • Published online: 01 April 2009

Epidemiological modelling can be a useful tool for the evaluation of parasite control strategies. An age-structured epidemiological model of intestinal helminth dynamics is developed. This model includes the explicit representation of changing worm distributions between hosts as a result of treatment, and estimates the morbidity due to heavy infections. The model is used to evaluate the effectiveness of different programmes of age-targeted community chemotherapy in reducing the amount of morbidity due to helminth infection. The magnitude of age-related heterogeneities is found to be very important in determining the results of age-targeted treatment programmes. The model was verified using field data from control programmes for Ascaris lumbricoides and Trichuris trichiura, and was found to provide accurate predictions of prevalence and mean intensities of infection during and following different control regimes.

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H. L. Guyatt , D. A. P. Bundy & D. Evans (1993). A population dynamic approach to the cost-effectiveness analysis of community-based anthelmintic treatment: Effects of treatment frequency. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).

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Hlaing Thein , Than-Saw & Myat-Lay-Kyin (1991). The impact of three monthly age-targeted chemotherapy on Ascaris lumbricoides infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 519&22.

M. E. J. Woolhouse (1991). On the application of mathematical models of schistosome dynamics. 1. Natural transmission. Acta tropica 49, 241–70.

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