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Toxoplasma gondii infection in pregnant women in China

Published online by Cambridge University Press:  07 November 2011

X.-J. GAO ,
Z.-J. ZHAO ,
Z.-H. HE ,
T. WANG ,
T.-B. YANG ,
X.-G. CHEN ,
J.-L. SHEN ,
Y. WANG ,
F.-L. LV  and
G. HIDE
...Show all authors
X.-J. GAO
Affiliation:
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China
Z.-J. ZHAO
Affiliation:
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China
Z.-H. HE
Affiliation:
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, P. R. China
T. WANG
Affiliation:
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China
T.-B. YANG
Affiliation:
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China
X.-G. CHEN
Affiliation:
Department of Parasitology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, P. R. China
J.-L. SHEN
Affiliation:
The Key Laboratories of Pathogen Biology and Zoonoses of Anhui Province and Department of Parasitology, Anhui Medical University, Hefei 230032, China
Y. WANG
Affiliation:
Department of Pathogen Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, P. R. China
F.-L. LV
Affiliation:
Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
G. HIDE
Affiliation:
Centre for Parasitology and Disease Research, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK
Z.-R. LUN*
Affiliation:
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China Centre for Parasitology and Disease Research, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK
*
*Corresponding author: Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510275, China. Tel: +86 20 8411 5079. Fax: +86 20 8403 6215. E-mail: lsslzr@mail.sysu.edu.cn
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Summary

Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasitic infections in humans. Primary infection in pregnant women can be transmitted to the fetus leading to miscarriage or congenital toxoplasmosis. Carefully designed nationwide seroprevalence surveys and case-control studies of risk factors conducted primarily in Europe and America, have shaped our view of the global status of maternal and congenital infection, directing approaches to disease prevention. However, despite encompassing 1 in 5 of the world's population, information is limited on the status of toxoplasmosis in China, partly due to the linguistic inaccessibility of the Chinese literature to the global scientific community. By selection and analysis of studies and data, reported within the last 2 decades in China, this review summarizes and renders accessible a large body of Chinese and other literature and aims to estimate the seroprevalence in Chinese pregnant women. It also reviews the prevalence trends, risk factors, and clinical manifestations. The key findings are (1) the majority of studies show that the overall seroprevalence in Chinese pregnant women is less than 10%, considerably lower than a recently published global analysis; and (2) the few available appropriate studies on maternal acute infection suggested an incidence of 0·3% which is broadly comparable to studies from other countries.

Keywords

Toxoplasma gondiiChinese pregnant womenseroprevalencerisk factorsChinapregnancy
Type
Review Article
Information
Parasitology , Volume 139 , Issue 2 , February 2012 , pp. 139 - 147
Copyright
Copyright © Cambridge University Press 2011

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