DE CASTRO CÔRTES, LUZIA MONTEIRO DE SOUZA PEREIRA, MIRIAN CLAUDIA DE OLIVEIRA, FRANCISCO ODÊNCIO RODRIGUES CORTE-REAL, SUZANA DA SILVA, FRANKLIN SOUZA PEREIRA, BERNARDO ACÁCIO SANTINI DE FÁTIMA MADEIRA, MARIA DE MORAES, MARCIA TEREZINHA BARONI BRAZIL, REGINALDO PEÇANHA and ALVES, CARLOS ROBERTO 2012. Leishmania (Viannia) braziliensis: insights on subcellular distribution and biochemical properties of heparin-binding proteins. Parasitology, Vol. 139, Issue. 02, p. 200.
Reyes-Uribe, Patrícia Pereira-dos-Santos, Taissa De Jesus, Jose B. Mesquita-Rodrigues, Camila Arevalo, Jorge Cupolillo, Elisa and Cuervo, Patricia 2012. Comparative zymographic analysis of metallopeptidase of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis isolates from Peru. Parasitology International, Vol. 61, Issue. 4, p. 513.
Cuervo, Patricia De Jesus, Jose B. Saboia-Vahia, Leonardo Mendonça-Lima, Leila Domont, Gilberto B. and Cupolillo, Elisa 2009. Proteomic characterization of the released/secreted proteins of Leishmania (Viannia) braziliensis promastigotes. Journal of Proteomics, Vol. 73, Issue. 1, p. 79.
LIMA, A. K. C. ELIAS, C. G. R. SOUZA, J. E. O. SANTOS, A. L. S. and DUTRA, P. M. L. 2009. Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages. Parasitology, Vol. 136, Issue. 10, p. 1179.
Rebello, Karina M. Côrtes, Luzia M. C. Pereira, Bernardo A. S. Pascarelli, Bernardo M. O. Côrte-Real, Suzana Finkelstein, Léa C. Pinho, Rosa T. d’Avila-Levy, Claudia M. and Alves, Carlos R. 2009. Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis. Parasitology Research, Vol. 106, Issue. 1, p. 95.
Ansari, N. A. Katara, G. K. Ramesh, V. and Salotra, P. 2008. Evidence for involvement of TNFR1 and TIMPs in pathogenesis of post-kala-azar dermal leishmaniasis. Clinical & Experimental Immunology, Vol. 154, Issue. 3, p. 391.
Cuervo, Patricia Santos, André L.S. Alves, Carlos R. Menezes, Gustavo C. Silva, Bianca A. Britto, Constança Fernandes, Octavio Cupolillo, Elisa and De Jesus, Jose Batista 2008. Cellular localization and expression of gp63 homologous metalloproteases in Leishmania (Viannia) braziliensis strains. Acta Tropica, Vol. 106, Issue. 3, p. 143.
Cuervo, Patricia de Jesus, Jose Batista Junqueira, Magno Mendonça-Lima, Leila González, Luis Javier Betancourt, Lázaro Grimaldi, Gabriel Domont, Gilberto Barbosa Fernandes, Octavio and Cupolillo, Elisa 2007. Proteome analysis of Leishmania (Viannia) braziliensis by two-dimensional gel electrophoresis and mass spectrometry. Molecular and Biochemical Parasitology, Vol. 154, Issue. 1, p. 6.
Proteolytic activities of 5 strains of Leishmania (Viannia) braziliensis isolated from Brazilian and Colombian patients, presenting distinct clinical manifestations, were characterized and compared using whole-promastigote extracts and extracellular secretions. Zymographic assays concerning whole-cell extracts and supernatants resulted in the detection of high molecular weight bands, ranging from 50 to 125 kDa. Proteolytic activities from both whole-cell extracts and supernatants were optimal in a pH range 5·5 to 9·0 for all analysed strains. Such protease activities were inhibited when 10 mM 1,10-phenanthroline was assayed, strongly suggesting that the enzymes responsible for hydrolysis of the substrate belong to the metalloproteases class. Distinct profiles of metalloproteases were observed among the studied L. (V.) braziliensis strains. Differences among the microorganisms might be related to the geographical origin of the strains and/or to the clinical presentation.
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