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    Weiler, Anelyse M. Hergesheimer, Chris Brisbois, Ben Wittman, Hannah Yassi, Annalee and Spiegel, Jerry M. 2015. Food sovereignty, food security and health equity: a meta-narrative mapping exercise. Health Policy and Planning, Vol. 30, Issue. 8, p. 1078.

    Johnson, Casey R. Thavarajah, Dil and Thavarajah, Pushparajah 2013. The influence of phenolic and phytic acid food matrix factors on iron bioavailability potential in 10 commercial lentil genotypes (Lens culinaris L.). Journal of Food Composition and Analysis, Vol. 31, Issue. 1, p. 82.


Iron biofortification of maize grain

  • Owen A. Hoekenga (a1), Mercy G. Lung'aho (a2), Elad Tako (a2), Leon V. Kochian (a1) and Raymond P. Glahn (a1)
  • DOI:
  • Published online: 25 March 2011

Mineral nutrient deficiencies are a worldwide problem that is directly correlated with poverty and food insecurity. The most common of these is iron deficiency; more than one-third of the world's population suffer from iron deficiency-induced anaemia, 80% of which are in developing countries. The consequences of iron deficiency include increased mortality and morbidity rates, diminished cognitive abilities in children and reduced labour productivity, which in turn stagnates national development. The developed world has made tremendous success in alleviating nutrient deficiencies through dietary diversification, food product fortification, improved public health care and supplementation. In developing countries, these strategies are often expensive and difficult to sustain, especially in rural areas. The rural poor typically consume what they grow and are dependent upon a small number of staple crops for the vast majority of their nutrition. Therefore, genetic improvement of staple crops (biofortification) is the most cost-effective and sustainable solution to this global health problem. In this study, we describe a strategy to enhance iron nutritional quality in maize using a human cell culture (Caco-2)-based bioassay as a phenotyping tool to guide genetic analysis of the trait. We also report validation of this approach using an animal feeding study.

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E Tako , MA Rutzke and RP Glahn (2010) Using the domestic chicken (Gallus gallus) as an in vivo model for iron bioavailability. Poultry Science 89: 514521.

RM Welch and RD Graham (2000) Breeding crops for enhanced micronutrient content. Plant and Soil 245: 205214.

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Plant Genetic Resources
  • ISSN: 1479-2621
  • EISSN: 1479-263X
  • URL: /core/journals/plant-genetic-resources
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