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    Muangphrom, Paskorn Seki, Hikaru Fukushima, Ery Odette and Muranaka, Toshiya 2016. Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites. Journal of Natural Medicines, Vol. 70, Issue. 3, p. 318.

    Ma, Dong-Ming Wang, Zhilong Wang, Liangjiang Alejos-Gonzales, Fatima Sun, Ming-An and Xie, De-Yu 2015. A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua. Molecular Plant, Vol. 8, Issue. 11, p. 1580.

    Muangphrom, Paskorn Suzuki, Munenori Seki, Hikaru Fukushima, Ery Odette and Muranaka, Toshiya 2014. Functional analysis of orthologous artemisinic aldehyde &#916;11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing <i>Artemisia absinthium</i>. Plant Biotechnology, Vol. 31, Issue. 5, p. 483.

    Paul, Shilpi Khanuja, Suman P.S. and Gupta, Madan M. 2014. Breeding strategy for genetic improvement up to four generations in relation to artemisinin with canopy and other secondary metabolites in Artemisia annua L. Industrial Crops and Products, Vol. 56, p. 67.

    Wang, Hongzhen Kanagarajan, Selvaraju Han, Junli Hao, Mengshu Yang, Yiyi Lundgren, Anneli and Brodelius, Peter E. 2014. Studies on the expression of linalool synthase using a promoter-β-glucuronidase fusion in transgenic Artemisia annua. Journal of Plant Physiology, Vol. 171, Issue. 2, p. 85.

    Alejos-Gonzalez, Fatima Perkins, Kelly Winston, Malcolm Isaiah and Xie, De-Yu 2013. Efficient Somatic Embryogenesis and Organogenesis of Self-Pollination &lt;i&gt;Artemisia annua&lt;/i&gt; Progeny and Artemisinin Formation in Regenerated Plants. American Journal of Plant Sciences, Vol. 04, Issue. 11, p. 2206.


Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin

  • James Cockram (a1), Colin Hill (a2), Corrinne Burns (a3), Randoph R. J. Arroo (a3), Jack G. Woolley (a3), Ian Flockart (a4), Trevor Robinson (a5), Christopher J. Atkinson (a6), Michael J. Davies (a6), Nigel Dungey (a7), Andy J. Greenland (a1), Lydia L. M. J. Smith (a1) and Steven Bentley (a1)
  • DOI:
  • Published online: 05 July 2012

The antimalarial drug artemisinin (ART) is commercially extracted from the medicinal plant Artemisia annua L. Here, we report the screening of 70 A. annua plants representing 14 diverse germplasm accessions sourced from around the world, and identify lines containing >2% ART. These extremely high-yielding individuals have been maintained as vegetative clones, and they represent promising germplasm resources for future A. annua breeding programmes.

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PS Covello , KH Teoh , DR Polichuk , DW Reed and G Nowark (2007) Functional genomics and the biosynthesis of artemisinin. Phytochemistry 68: 18641871.

MJ Davies , CJ Atkinson , C Burns , JG Woolley , NA Hipps , RRJ Arroo , N Dungey , T Robinson , P Brown , I Flockart , C Hill , L Smith and S Bentley (2009) Enhancement of artemisinin concentration and yield in response to optimisation of nitrogen and potassium supply to Artemisia annua. Annals of Botany 104: 315323.

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Plant Genetic Resources
  • ISSN: 1479-2621
  • EISSN: 1479-263X
  • URL: /core/journals/plant-genetic-resources
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