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    Meuwesen, Willem P. du Plessis, Jesslee M. Burger, Johanita R. Lubbe, Martie S. and Cockeran, Marike 2016. Prescribing patterns of non-steroidal anti-inflammatory drugs in chronic kidney disease patients in the South African private sector. International Journal of Clinical Pharmacy, Vol. 38, Issue. 4, p. 863.

    Nderitu, P. Doos, L. Strauss, V. Y. Lambie, M. Davies, S. J. and Kadam, U. T. 2014. Analgesia dose prescribing and estimated glomerular filtration rate decline: a general practice database linkage cohort study. BMJ Open, Vol. 4, Issue. 8, p. e005581.

    Nderitu, P. Doos, L. Jones, P. W. Davies, S. J. and Kadam, U. T. 2013. Non-steroidal anti-inflammatory drugs and chronic kidney disease progression: a systematic review. Family Practice, Vol. 30, Issue. 3, p. 247.

  • Primary Health Care Research & Development, Volume 11, Issue 3
  • July 2010, pp. 280-284

Non-steroidal anti-inflammatory drugs prescribing in chronic kidney disease: an observational study

  • Sunil Bhopal (a1), James Chan (a1), Oliver Ellis (a1), Sarah Graham (a1), Stephen Halpin (a1), Thomas Lawrence (a1), Joseph Laws (a1) and Anne-Marie Howes (a2)
  • DOI:
  • Published online: 10 March 2010

This study assessed the prescription of potentially nephrotoxic non-steroidal anti-inflammatory drugs (NSAIDs) to patients with chronic kidney disease (CKD) in general practice.


CKD poses a considerable disease burden in the UK. Guidelines state that caution should be exercised when prescribing NSAIDs to CKD patients, due to increased risk of rapid kidney disease progression.


We reviewed the medical records of 1427 patients with CKD Stages 3–5 in seven general practices in West Yorkshire.


A total of 792 (55.5%) were prescribed NSAIDs; 128 (9%) of these were prescribed NSAIDs excluding low-dose aspirin. Twenty-three (20.2%) patients who were prescribed NSAIDs had no record of CKD monitoring in the preceding year.


Prescription of NSAIDs is likely to be contributing to unnecessary renal impairment.

Corresponding author
Correspondence to: Thomas Lawrence, Room 7.09 Worsley Building, University of Leeds, Leeds, LS2 9JT, UK. Email:
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P.E. Stevens , D.J. O’Donoghue , S. de Lusignan , J. Van Vlymen , B. Klebe , R. Middleton , N. Hague , J. New C.K.T. Farmer 2007: Chronic kidney disease management in the United Kingdom: NEOERICA project results. Kidney International 72, 9299.

N.A. Wong H.W. Jones 1998: An analysis of discharge drug prescribing amongst elderly patients with renal impairment. Postgraduate Medical Journal 74, 420422.

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Primary Health Care Research & Development
  • ISSN: 1463-4236
  • EISSN: 1477-1128
  • URL: /core/journals/primary-health-care-research-and-development
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