Background: An epidemic of Ebola virus disease (EVD) occurred in West Africa in 2014. In Catalonia, primary care is the first level of healthcare so it has a key role in the detection and initial management of possible cases of EVD and in identifying contacts. Aim: This study aimed to find out how the staff of primary care centers perceived the measures for dealing with EVD. Method: An online questionnaire was distributed to all primary care workers in Catalonia during the period February–March 2015. Findings: The estimated response rate was 10.1%. They reported having received training/information, that a specific circuit had been organized and that the necessary equipment was available. They considered it unlikely that a patient with suspected EVD would present at the center and were aware of the action to take but were worried about this possibility. Rigorous scientific training in international health is essential to take on new global health challenges.