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Associations between maternal serum concentrations of polyunsaturated fatty acids and C - reactive protein among a high-fish eating cohort in the Republic of the Seychelles

Published online by Cambridge University Press:  24 September 2014

E. Corbett ,
M. S. Mulhern ,
A. J. Yeates ,
E. M. McSorley ,
G. E. Watson ,
G. J. Myers ,
E. van Wijngaarden ,
C. F. Shamlaye ,
P. W. Davidson  and
J. J. Strain
E. Corbett
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
M. S. Mulhern
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
A. J. Yeates
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
E. M. McSorley
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
G. E. Watson
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
G. J. Myers
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
E. van Wijngaarden
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
C. F. Shamlaye
Affiliation:
Ministry of Health, Victoria, Mahé, Republic of Seychelles
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Abstract

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Proceedings of the Nutrition Society , Volume 73 , Issue OCE2: Irish Section Meeting, 18–20 June 2014, Changing Dietary Behaviour: Physiology Through to Practice , 2014 , E89
Copyright
Copyright © The Authors 2014 

C- reactive protein (CRP) is an acute-phase protein secreted by the liver in response to inflammation( Reference Du Clos 1 ). Circulating concentrations of n-3 polyunsaturated fatty acids (PUFA), particularly eicosapentaenoic acid (EPA) are known to exert anti-inflammatory effects. Studies have previously shown higher dietary intakes of n-3 PUFA and oily fish to be inversely associated with serum CRP concentrations, albeit in low fish-eating populations( Reference Niu, Hozawa and Kuriyama 2 ). Fewer studies have investigated these relationships in high fish-eating populations or in pregnant women. The aim of this study was to investigate associations of maternal serum concentrations of PUFA and reported fish consumption with serum concentrations of CRP within a high-fish eating cohort of pregnant women in the Republic of Seychelles.

Serum samples were previously collected from pregnant women at 28 weeks gestation (n = 1160) as part of the Seychelles Child Development Study Nutrition Cohort 2 (SCDS NC2). These samples were analysed using the iLab 650 Chemistry Analyser to quantify serum CRP concentrations (μg/dl), using a CRP diagnostic kit. Data were available for the reported number of fish meals per week from Fish Use Questionnaires (FUQ) administered during pregnancy. Multiple linear regression analyses were performed to investigate associations of PUFA status and reported fish consumption with serum CRP concentrations, whilst adjusting for maternal BMI and maternal age at enrolment.

Model was adjusted for maternal BMI and maternal age at enrolment. ALA: Alpha-linolenic acid; EPA:Eicosapentaenoic acid; DHA: Docosahexaenoic acid; n-3 PUFA: sum of ALA+EPA+DHA

The mean (SD) number of fish meals consumed per week by women during pregnancy was 8·52 (4·51). Results show that the n-3 PUFA, EPA is a significant negative predictor of CRP concentrations. There were no significant associations between CRP and concentrations of DHA, total n-3 PUFA, totaln-6 PUFA or with reported fish consumption in these models. In conclusion, these results agree with previous studies ( Reference Muarakami, Sasaki and Takahashi 3 ) and confirm our hypothesis that increasing serum concentrations of EPA are exerting anti-inflammatory effects, as shown by lower serum CRP concentrations, within this high-fish eating cohort of pregnant women.

References

1. Du Clos, TW (2000) Ann Med 32 (4), 274–8.Google Scholar
2. Niu, K, Hozawa, A, Kuriyama, S, et al. (2006) Amer J Clin Nutr 84, 223–9.Google Scholar
3. Muarakami, K, Sasaki, S, Takahashi, Y, et al. (2008) Nutr Res 2, 309–14.CrossRefGoogle Scholar