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The canine model of dietary hypersensitivity

Published online by Cambridge University Press:  07 March 2007

Michael J. Day
Michael J. Day
Affiliation:
Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5D, UK
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Abstract

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IgE-mediated dietary hypersensitivity affects approximately 1% of the canine population. There are no breed associations and ≤50% of the patients are aged <1 year at presentation. The most common causative allergens are beef, chicken, milk, eggs, maize, wheat and soyabean. Affected dogs generally display cutaneous disease and 10–15% of the patients may have concurrent alimentary involvement. Diagnosis is currently based on dietary restriction followed by provocation. Procedures for the detection of serum allergen-specific IgE and IgG antibodies are widely available, but these tests correlate poorly with clinical presentation and dietary testing. Recent studies have demonstrated the allergen specificity of IgE antibodies by immunoblotting and have described blood lymphocyte proliferative responses to food allergens. In addition to investigations of spontaneously-arising dietary hypersensitivity, it has also proved possible to study this disorder experimentally. Small colonies of dogs sensitive to particular dietary proteins have been used to study clinical and serological responses to allergen challenge. Hypersensitivity has been experimentally induced in dogs of an atopic phenotype by repeated subcutaneous injection of alum-adjuvanted dietary allergen during neonatal life. These models have been used to trial a range of modified protein or hydrolysate diets. The dog provides a unique large-animal model for investigation of the immunopathogenesis of human dietary hypersensitivity. The dog is closely related genetically to man and shares environmental disease triggers with man. Spontaneously arising canine dietary hypersensitivity is a good clinical mimic of the human disease, and ability to therapeutically manipulate this adverse response in the dog might lead to benefits for human patients.

Keywords

DogFood allergy
Type
Symposium on ‘Reacting to allergy’
Information
Proceedings of the Nutrition Society , Volume 64 , Issue 4 , November 2005 , pp. 458 - 464
Copyright
Copyright © The Nutrition Society 2005

References

Allenspach, K, Vaden, SL, Harris, T, Grone, A, Doherr, M, Griot-Wenk, M, Bishcoff, SC & Gaschen, F (2004) Validation of colonoscopic allergen provocation (COLAP) as a diagnostic tool in dogs with proven food hypersensitivity reactions. Journal of Veterinary Internal Medicine 18, 789.Google Scholar
August, JR (1985) Dietary hypersensitivity in dogs: cutaneous manifestations, diagnosis and management. Compendium of Continuing Education for the Practising Veterinarian 7, 469–477.Google Scholar
Blakemore, JC (1994) Gastrointestinal allergy. Veterinary Clinics of North America Small Animal Practice 24, 655–695.CrossRefGoogle ScholarPubMed
Carter, SD, Barnes, A, May, C, Hall, EJ & Batt, RM (1991) Antibody responses to BSA in dogs: a source of error in diagnostic immunoassays. Veterinary Record 129, 220–221.CrossRefGoogle ScholarPubMed
Cave, NJ & Guilford, WG (2004) A method for in vitro evaluation of protein hydrolysates for potential inclusion in veterinary diets. Research in Veterinary Science 77, 231–238.CrossRefGoogle ScholarPubMed
Chesney, CJ (2001) Systematic review of evidence for the prevalence of food sensitivity in dogs. Veterinary Record 148, 445–448.CrossRefGoogle ScholarPubMed
Chesney, CJ (2002) Food sensitivity in the dog: a quantitative study. Journal of Small Animal Practice 43, 203–207.CrossRefGoogle ScholarPubMed
Cobbold, SP & Metcalfe, S (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the first international canine leukocyte antigen workshop (CLAW). Tissue Antigens 43, 137–154.CrossRefGoogle ScholarPubMed
del Val, G, Yee, BC, Lozano, RM, Buchanan, BB, Ermel, RW, Lee, YM & Frick, OL (1999) Thioredoxin treatment increases digestibility and lowers allergenicity of milk. Journal of Allergy and Clinical Immunology 103, 690–697.CrossRefGoogle Scholar
Deplazes, P, Penhale, WJ, Greene, WK & Thompson, RCA (1995) Effect on humoral tolerance (IgG and IgE) in dogs by oral administration of ovalbumin and Der pI. Veterinary Immunology and Immunopathology 45, 361–367.CrossRefGoogle ScholarPubMed
Ermel, RW, Kock, M, Griffey, SM, Reinhart, GA & Frick, OL (1997) The atopic dog: a model for food allergy. Laboratory Animal Science 47, 40–49.Google Scholar
Foster, AP, Knowles, TG, Hotston, A, Cousins, PDG, Day, MJ & Hall, EJ (2003) Serum IgE and IgG responses to food antigens in normal and atopic dogs, and dogs with gastrointestinal disease. Veterinary Immunology and Immunopathology 92, 113–124.CrossRefGoogle ScholarPubMed
Garden, OA, Pidduck, H, Lakhani, KH, Walker, D, Wood, JLN & Batt, RM (2000) Inheritance of gluten-sensitive enteropathy in Irish setters. American Journal of Veterinary Research 61, 462–468.CrossRefGoogle ScholarPubMed
German, AJ, Hall, EJ & Day, MJ (2001) Characterization of immune cell populations within the duodenal mucosa of dogs with enteropathies. Journal of Veterinary Internal Medicine 15, 14–25.CrossRefGoogle Scholar
German, AJ, Helps, CR, Hall, EJ & Day, MJ (2000) Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies. Digestive Diseases and Sciences 45, 7–17.CrossRefGoogle ScholarPubMed
Groh, M & Moser, E (1998) Diagnosis of food allergy in the non-seasonally symptomatic dog using a novel antigen, low molecular weight diet: a prospective study of 29 cases. Veterinary Allergy and Clinical Immunology 6, 5–6.Google Scholar
Guilford, WG & Badcoe, LM (1991) Development of a model of food allergy in the dog. Journal of Veterinary Internal Medicine 6, 128.Google Scholar
Hall, EJ (1994) Gastrointestinal aspects of food allergy: a review. Journal of Small Animal Practice 35, 145–152.CrossRefGoogle Scholar
Hall, EJ & Batt, RM (1990a) Development of wheat-sensitive enteropathy in Irish setters: morphological changes. American Journal of Veterinary Research 51, 978–982.CrossRefGoogle Scholar
Hall, EJ & Batt, RM (1990b) Development of wheat-sensitive enteropathy in Irish setters: biochemical changes. American Journal of Veterinary Research 51, 983–989.CrossRefGoogle ScholarPubMed
Harvey, RG (1993) Food allergy and dietary intolerance in dogs: a report of 25 cases. Journal of Small Animal Practice 34, 175–179.CrossRefGoogle Scholar
Helm, RM, Ermel, RW & Frick, OL (2003) Nonmurine animal models of food allergy. Environmental Health Perspectives 111, 239–244.CrossRefGoogle ScholarPubMed
Hill, P (1999) Diagnosing cutaneous food allergies in dogs and cats – some practical considerations. In Practice 21, 287–294.CrossRefGoogle Scholar
Hillier, A & Griffin, CE (2001) The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Veterinary Immunology and Immunopathology 81, 227–231.CrossRefGoogle Scholar
HogenEsch, H, Dunham, AD, Scott-Moncrieff, C, Glickman, LT & DeBoer, DJ (2002) Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs. American Journal of Veterinary Research 63, 611–616.CrossRefGoogle ScholarPubMed
Ishida, R, Masuda, K, Kurata, K, Ohno, K & Tsujimoto, H (2004) Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity. Journal of Veterinary Internal Medicine 18, 25–30.CrossRefGoogle ScholarPubMed
Ishida, R, Masuda, K, Sakaguchi, M, Ohno, K, Hasegawa, A & Tsujimoto, H (2000) In vivo and in vitro evidence of type I hypersensitivity to food allergens in atopic dogs. Veterinary Dermatology 11, Suppl. 1, 32.Google Scholar
Jackson, HA & Hammerberg, B (2002) Evaluation of a spontaneous canine model of immunoglobulin E-mediated food hypersensitivity: dynamic changes in serum and fecal allergen specific immunoglobulin E values relative to dietary change. Comparative Medicine 52, 316–321.Google ScholarPubMed
Jackson, HA, Jackson, MW, Coblentz, L & Hammerberg, B (2003) Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and soy hydrolysate diet in dogs with spontaneous food allergy. Veterinary Dermatology 14, 181–187.CrossRefGoogle ScholarPubMed
Jeffers, JG, Meyer, EK & Sosis, EJ (1996) Responses of dogs with food allergies to single-ingredient dietary provocation. Journal of the American Veterinary Medical Association 209, 608–611.CrossRefGoogle ScholarPubMed
Jeffers, JG, Shanley, KJ & Myer, EK (1991) Diagnostic testing of dogs for food hypersensitivity. Journal of the American Veterinary Medical Association 198, 245–250.CrossRefGoogle ScholarPubMed
Kennedy, LJ, Barnes, A, Happ, GM, Quinnell, RJ, Bennett, D, Angles, JM et al. . (2002) Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs. Tissue Antigens 59, 194–204.CrossRefGoogle ScholarPubMed
Kennis, RA, Tizard, I, Hannah, S, Ermel, R, Dziezyc, J & Bauer, JE (2002) Changes in IgE antibodies to soy in sensitized and control dogs after challenge using three diets in a crossover design. Veterinary Dermatology 13, 218.CrossRefGoogle Scholar
Kircher, PR, Spaudling, KA, Vaden, S, Lang, J, Doherr, M & Gaschen, L (2004) Doppler ultrasonographic evaluation of gastrointestinal hemodynamics in food hypersensitivities: a canine model. Journal of Veterinary Internal Medicine 18, 605–611.CrossRefGoogle ScholarPubMed
Kirkness, EF, Bafna, V, Halpern, AL, Levy, S, Remington, K, Rusch, DB, Delcher, AL, Pop, M, Wang, W, Fraser, SM & Venter, JC (2003) The dog genome: survey sequencing and comparative analysis. Science 301, 1898–1903.CrossRefGoogle ScholarPubMed
Leistra, MHG, Markwell, PJ & Willemse, T (2001) Evaluation of selected-protein-source diets for management of dogs with adverse reactions to foods. Journal of the American Veterinary Medical Association 219, 1411–1414.CrossRefGoogle ScholarPubMed
Littman, MP, Dambach, DM, Vaden, SL & Giger, U (2000) Familial protein-losing enteropathy and protein-losing nephropathy in soft coated wheaten terriers: 222 cases (1983–1997). Journal of Veterinary Internal Medicine 14, 68–80.Google ScholarPubMed
Manners, HK, Hart, CA, Getty, B, Kelly, DF, Sorenson, SH & Batt, RM (1998) Characterization of intestinal morphologic, biochemical, and ultrastructural features in gluten-sensitive Irish setters during controlled oral gluten challenge exposure after weaning. American Journal of Veterinary Research 59, 1435–1440.CrossRefGoogle ScholarPubMed
Martin, A, Sierra, M-P, Gonzalez, JL & Arevalo, M-A (2004) Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk. Veterinary Dermatology 15, 349–356.CrossRefGoogle ScholarPubMed
Mueller, R & Tsohalis, J (1998) Evaluation of serum allergen-specific IgE for the diagnosis of food adverse reactions in the dog. Veterinary Dermatology 9, 167–171.CrossRefGoogle ScholarPubMed
Olsen, ME, Hardin, JA, Buret, AG, Gall, DG & Hayek, MG (2000) Hypersensitivity reactions to dietary antigens in atopic dogs. In Recent Advances in Canine and Feline Nutrition, vol. III, 69 – 77 [Reinhart, GA and Carey, DP, editors]. Wilmington OH: Orange Frazer Press.Google Scholar
Peters, IR, Helps, CR, Calvert, EL, Hall, EJ & Day, MJ (2005) Cytokine mRNA quantification in histologically normal canine duodenal mucosa by real-time RT-PCR. Veterinary Immunology and Immunopathology 103, 101–111.CrossRefGoogle ScholarPubMed
Polvi, A, Garden, OA, Elwood, CM, Sorenson, SH, Batt, RM, Maki, M & Partanen, J (1997) Canine major histocompatibility complex genes DQA and DQB in Irish setter dogs. Tissue Antigens 49, 236–243.CrossRefGoogle ScholarPubMed
Rosser, EJ (1998) Food allergy in dogs and cats: a review. Veterinary Allergy and Clinical Immunology 6, 21–24.Google Scholar
Sutter, NB & Ostrander, EA (2004) Dog star rising: the canine genetic system. Nature Reviews Genetics 5, 900–910.CrossRefGoogle ScholarPubMed
Teuber, SS, del Val, G, Morigasaki, S, Jung, HR, Eisele, PH, Frick, OL & Buchanan, BB (2002) The atopic dog as a model of peanut and tree nut food allergy. Journal of Allergy and Clinical Immunology 110, 921–927.CrossRefGoogle Scholar
Vaden, SL, Hammerberg, B, Davenport, DJ, Orton, SM, Trogdon, MM, Melgarejo, LT, VanCamp, SD & Williams, DA (2000a) Food hypersensitivity reactions in soft coated wheaten terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E. Journal of Veterinary Internal Medicine 14, 60–67.Google ScholarPubMed
Vaden, SL, Sellon, RK, Melgarejo, T, Williams, DA, Trogdon, MM, VanCamp, SD & Argenzio, RA (2000b) Evaluation of intestinal permeability and gluten sensitivity in soft-coated wheaten terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. American Journal of Veterinary Research 61, 518–524.CrossRefGoogle ScholarPubMed
Walton, GS (1967) Skin responses in the dog and cat to ingested allergens. Veterinary Record 81, 709–713.CrossRefGoogle ScholarPubMed
White, SD (1998) Food allergy in dogs. Compendium of Continuing Education for the Practising Veterinarian 20, 261–268.Google Scholar
Wills, J & Harvey, R (1994) Diagnosis and management of food allergy and intolerance in dogs and cats. Australian Veterinary Journal 71, 322–326.CrossRefGoogle ScholarPubMed
Zemann, B, Schwaerzier, C, Griot-Wenk, M, Nefzger, M, Mayer, P, Schneider, H, de Weck, A, Carballido, JM & Liehl, E (2003) Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-β expression and prevents allergy in adult life. Journal of Allergy and Clinical Immunology 111, 1069–1075.CrossRefGoogle ScholarPubMed