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Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye

Published online by Cambridge University Press:  07 March 2007

Norma McGough
Coeliac UK, Suite A-D, Octagon Court, High Wycombe, Bucks, HP11 2HS, UK
John H. Cummings*
Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
*Corresponding author: fax +44 1382 633952, email
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Coeliac disease is a lifelong intolerance to the gluten found in wheat, barley and rye, and some patients are also sensitive to oats. The disease is genetically determined, with 10% of the first-degree relatives affected and 75% of monozygotic twins being concordant. Of the patients with coeliac disease 95% are human leucocyte antigen (HLA)-DQ2 or HLA-DQ8 positive. Characteristically, the jejunal mucosa becomes damaged by a T-cell-mediated autoimmune response that is thought to be initiated by a 33-mer peptide fragment in A2 gliadin, and patients with this disorder have raised levels of anti-endomysium and tissue transglutaminase antibodies in their blood. Coeliac disease is the major diagnosable food intolerance and, with the advent of a simple blood test for case finding, prevalence rates are thought to be approximately 1:100. Classically, the condition presented with malabsorption and failure to thrive in infancy, but this picture has now been overtaken by the much more common presentation in adults, usually with non-specific symptoms such as tiredness and anaemia, disturbance in bowel habit or following low-impact bone fractures. Small intestinal biopsy is necessary for diagnosis and shows a characteristically flat appearance with crypt hypoplasia and infiltration of the epithelium with lymphocytes. Diet is the key to management and a gluten-free diet effectively cures the condition. However, this commitment is lifelong and many aisles in the supermarket are effectively closed to individuals with coeliac disease. Compliance can be monitored by measuring antibodies in blood, which revert to negative after 6–9 months. Patients with minor symptoms, who are found incidentally to have coeliac disease, often ask whether it is necessary to adhere to the diet. Current advice is that dietary adherence is necessary to avoid the long-term complications, which are, principally, osteoporosis and small bowel lymphoma. However, risk of these complications diminishes very considerably in patients who are on a gluten-free diet.

Symposium on ‘Reacting to allergy’
Copyright © The Nutrition Society 2005


Abdulkarim, AS & Murray, JA (2003) Review article: the diagnosis of coeliac disease. Alimentary Pharmacology and Therapeutics 17, 987995.CrossRefGoogle Scholar
Addolorato, G, Capristo, E, Ghittoni, G, Valeri, C, Masciana, R, Ancona, C & Gasbarrini, G (2001) Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet: A longitudinal study. Scandinavian Journal of Gastroenterology 36, 502506.CrossRefGoogle Scholar
Ahmad, S, Abdulkarim, MD, Lawrence, J, Burgart, MD, Jacalyn, AJ & Murray, MD (2002) Etiology of nonresponsive celiac disease: results of a systematic approach. American Journal of Gastroenterology 97, 20162021.Google Scholar
Alaedini, A & Green, PHR (2005) Narrative review: Celiac disease: Understanding a complex autoimmune disorder. Annals of Internal Medicine 142, 289298.CrossRefGoogle ScholarPubMed
Anderson, RP (2005) Coeliac disease. Australian Family Physician 34, 239242.Google ScholarPubMed
Anderson, RP, Degano, P, Godkin, AJ, Jewell, DP & Hill, AVS (2000) In vivo antigen challenge in coeliac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nature Medicine 6, 337342.CrossRefGoogle ScholarPubMed
Arato, A, Korner, A, Veres, G, Dezsofi, A, Ujpal, I & Madacsy, L (2003) Frequency of coeliac disease in Hungarian children with type 1 diabetes mellitus. European Journal of Pediatrics 162, 15.Google ScholarPubMed
Ascher, H, Krantz, I, Rydberg, L, Nordin, P & Kristiansson, B (1997) Influence of infant feeding and gluten intake on coeliac disease. Archives of Disease in Childhood 76, 113117.CrossRefGoogle ScholarPubMed
Ashabani, A, Abushofa, U, Abusrewill, S, Abdelazez, M, Tuckova, L, Tlaskalova-Hogenova, H (2003) The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus. Diabetes/Metabolism Research and Reviews 19, 6975.CrossRefGoogle ScholarPubMed
Askling, J, Linet, M, Gridley, G & Halstensen, TS (2002) Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 123, 14281435.CrossRefGoogle ScholarPubMed
Auricchio, S, Troncone, R & Maurano, F (1999) Coeliac disease in the year 2000. Italian Journal of Gastroenterology and Hepatology 31, 773780.Google ScholarPubMed
Austin, AS, Logan, RFA, Thomason, K & Holmes, GKT (2002) Cigarette smoking and adult coeliac disease. Scandinavian Journal of Gastroenterology 37, 978982.CrossRefGoogle ScholarPubMed
Bardella, MT, Fredella, C, Prampolini, L, Molteni, N, Giunta, AM & Bianchi, PA (2000) Body composition and dietary intakes in adult celiac disease patients consuming a strict gluten-free diet. American Journal of Clinical Nutrition 72, 937939.Google ScholarPubMed
Bardella, MT, Molteni, N, Prampolini, L, Giunta, AM, Baldassarri, AR, Morganti, D & Bianchi, PA (1994) Need for follow-up in celiac-disease. Archives of Disease in Childhood 70, 211213.CrossRefGoogle Scholar
Bardella, MT, Valenti, L, Pagliari, C, Peracchi, M, Fare, M, Fracanzani, AL & Fargion, S (2004) Searching for coeliac disease in patients with non-alcoholic fatty liver disease. Digestive and Liver Disease 36, 333336.CrossRefGoogle ScholarPubMed
Bazzigaluppi, E, Lampasona, V, Barera, G, Venerando, A, Bianchi, C, Chiumello, G, Bonifacio, E & Bosi, E (1999) Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. Journal of Autoimmunity 12, 5156.CrossRefGoogle ScholarPubMed
Bennet, TI, Hunter, D & Vaughan, JM (1932) Idiopathic steatorrhea (Gee's disease). A nutritional disturbance associated with tetany, osteomalacia and anemia. Quarterly Journal of Medicine 1, 603677.Google Scholar
Berger, R & Schmidt, G (1996) Evaluation of six antigliadin antibody assays. Journal of Immunological Methods 91, 7786.CrossRefGoogle Scholar
Biagi, F, Campanella, J, Martucci, S, Pezzimenti, D, Ciclitira, PJ, Ellis, HJ & Corazza, GR (2004) A milligram of gluten a day keeps the mucosal recovery away: A case report. Nutrition Reviews 6, 360363.CrossRefGoogle Scholar
Biagi, F, Ellis, HJ, Parnell, NDJ, Shidrawi, RG, Thomas, PD, O'Reilly, N, Corazza, GR & Ciclitira, PJ (1999) A non-toxic analogue of a coeliac-activating gliadin peptide: a basis for immunomodulation. Alimentary Pharmacology and Therapeutics 13, 945950.CrossRefGoogle ScholarPubMed
Bingley, PJ, Williams, AJK, Norcross, AJ, Unsworth, DJ, Lock, RJ, Ness, AR & Jones, RW (2004) Undiagnosed coeliac disease at age seven: population based prospective birth cohort study. British Medical Journal 328, 322323.CrossRefGoogle ScholarPubMed
Bottaro, G, Cataldo, F, Rotolo, N, Spina, M & Corazza, GR (1999) The clinical pattern of subclinical silent celiac disease: An analysis on 1026 consecutive cases. American Journal of Gastroenterology 94, 691696.Google ScholarPubMed
British Dietetic Association (2005) Paediatric Group Position Statement on breastfeeding and weaning on to solid foods. Dietetics Today 40(3) 7.Google Scholar
British, Society & of, Gastroenterology (2002) Guidelines for the management of patients with coeliac disease – Google Scholar
Burgin-Wolff, A, Dahlbom, I, Hadziselimovic, F & Petersson, CJ (2002) Antibodies against human tissue transglutaminase and endomysium in diagnosing and monitoring coeliac disease. Scandinavian Journal of Gastroenterology 37, 685691.CrossRefGoogle ScholarPubMed
Butcher, GP, Banks, LM & Walters, JRF (1992) Reduced bone mineral density in coeliac disease – the need for bone densitometry estimations. Gut 33, S54.Google Scholar
Caraceni, MP, Molteni, N, Bardella, MT, Ortolani, S, Nogara, A & Bianchi, PA (1988) Bone and mineral metabolism in adult celiac disease. American Journal of Gastrenterology 83, 274277.Google ScholarPubMed
Card, TR, West, J & Holmes, GK (2004) Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study. Alimentary Pharmacology and Therapeutics 20, 769775.Google ScholarPubMed
Case, S (2005) The gluten-free diet: How to provide effective education and resources. Gastroenterology 128, S128S134.CrossRefGoogle ScholarPubMed
Castano, L, Ortiz, L, Blarduni, E, Nunez, J, Bilbao, J, Rica, I, Martul, P & Vitoria, JC (2003) Three-year follow-up of healthy newborns for celiac disease diagnosis. Journal of Pediatric Gastroenterology and Nutrition 36, 536.Google Scholar
Cataldo, F, Bottaro, G, Magazzu, G, Distefano, P, Paternostro, D, Rotolo, N, Spina, M, Traverso, G & Violante, M (1995) Influence of infant-feeding practices in the first year of life on celiac-disease – results of a Sicilian collaborative study. Rivista Italiana di Pediatria–Italian Journal of Pediatrics 21, 185190.Google Scholar
Cataldo, F, Lio, D, Marino, V, Picarelli, A, Ventura, A & Corazza, GR (2000) IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgG deficiency. Gut 47, 366369.CrossRefGoogle Scholar
Catassi, C, Fabiani, E, Corrao, G, Barbato, M, De Renzo, A, Carella, AM et al. (2002) Risk of non-Hodgkin lymphoma in celiac disease. Journal of the American Medical Association 287, 14131419.CrossRefGoogle ScholarPubMed
Cellier, C, Flobert, C, Cormier, C, Roux, C & Schmitz, J (2000) Severe osteopenia in symptom-free adults with a childhood diagnosis of coeliac disease. Lancet 355, 806.CrossRefGoogle ScholarPubMed
Chartrand, LJ, Augulnik, J, Vanounou, T, Russo, PA, Baehler, P & Seidman, EG (1997) Effectiveness of antigliadin antibodies as a screening test for celiac disease in children. Canadian Medical Association Journal 157, 527533.Google ScholarPubMed
Ch'ng, CL, Biswas, M, Benton, A, Jones, MK & Kingham, JGC (2005) Prospective screening for coeliac disease in patients with Graves' hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clinical Endocrinology 66, 303306.CrossRefGoogle Scholar
Chorzelski, TP, Beutner, EH, Sulej, J, Tchorzewska, H, Jablonska, S, Kumar, V & Kapuscinska, A (1984) IgA anti-endomysium antibody – a new immunological marker of dermatitis herpetiformis and coeliac disease. British Journal of Dermatology 111, 395402.CrossRefGoogle ScholarPubMed
Ciacci, C, Cavallardo, R, della Valle, N, d'Argenio, G (2002) The use of serum tTG-ab assay in patients on gluten-free diet as a measure of dietetic compliance. Gastroenterology 122, 588.CrossRefGoogle Scholar
Ciacci, C, Cirillo, M, Auriemma, G, DiDato, G, Sabbatini, F & Mazzacca, G (1996) Celiac disease and pregnancy outcome. American Journal of Gastroenterology 91, 718722.Google ScholarPubMed
Ciacci, C, Iovino, P, Amoruso, D, Siniscalchi, M, Tortora, R, Di Gilio, A, Fusco, M, Mazzacca, G (2005) Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood. Alimentary Pharmacology and Therapeutics 21, 421429.CrossRefGoogle Scholar
Ciacci, C & Mazzacca, G (1998) Unintentional gluten ingestion in celiac patients. Gastroenterology 155, 243250.CrossRefGoogle Scholar
Ciclitira, PJ (2001) AGA technical review on celiac sprue. Gastroenterology 120, 15261540.CrossRefGoogle ScholarPubMed
Ciclitira, PJ, Cerio, R, Ellis, HJ, Maxton, D, Nelufer, JM & Macartney, JM (1985) Evaluation of a gliadin containing gluten-free product in coeliac patients. Human Nutrition Clinical Nutrition 39, 303308.Google ScholarPubMed
Ciclitira, PJ, Ellis, HJ & Fagg, NL (1984) Evaluation of a gluten-free product containing wheat gliadin in patients with coeliac disease. British Medical Journal 289, 83.CrossRefGoogle ScholarPubMed
Ciclitira, PJ, Ellis, HJ & Lundin, KE (2005) Gluten-free diet – what is toxic. Best Practice and Research in Clinical Gastroenterology 19, 359371.CrossRefGoogle ScholarPubMed
Codex Alimentarius Commission (1981) Codex Standard for ‘Gluten-Free Foods’. Codex stan 118 1981. Google Scholar
Codex Alimentarius Commission (1983) Codex Standard for ‘Gluten-Free Foods’. Codex stan 118 1981 (amended 1983). Google Scholar
Codex Alimentarius Commission (2004a) Report of the 25th Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses. ALINORM 03/27/26. Appendix III Revised Draft Standard for Gluten-Free Foods. pp. 4243. Rome: FAO.Google Scholar
Codex Alimentarius Commission (2004b) Report of the 26th Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses. ALINORM 05/28/26. para 5–7. pp. 117–118. Rome: FAO.Google Scholar
Coeliac, UK (2005a) Coeliac UK's Food and Drink Directory. Your Essential Guide to Gluten-free Food CoeliacUK High Wycombe, Bucks.Google Scholar
Coeliac, UK (2005b) Food and Drink Directory monthly updates. Google Scholar
Collin, P, Reunala, T, Pukkala, E, Laippala, P, Keyrilainen, O & Pasternack, A (1994) Coeliac disease – associated disorders and survival. Gut 35, 12151218.CrossRefGoogle Scholar
Collin, P, Thorell, L, Kaukinen, K & Maki, M (2004) The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease. Alimentary Pharmacology and Therapeutics 19, 12771283.CrossRefGoogle ScholarPubMed
Corazza, GR, Andreani, ML, Biagi, F, Corrao, G, Pretolani, S, Giulianelli, G, Ghironzi, G & Gasbarrini, G (1997) The smaller size of the ‘coeliac iceberg’ in adults. Scandinavian Journal of Gastroenterology 32, 917919.CrossRefGoogle ScholarPubMed
Corazza, GR, Di Sario, A, Cecchetti, L, Jorizzo, RA, Di Stefano, M, Minguzzi, L, Brusco, G, Bernardi, M & Gasbarrini, A (1996) Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease. Bone 18, 525530.CrossRefGoogle Scholar
Corazza, GR, Di Sario, A, Cecchetti, L, Tarozzi, C, Corrao, G, Bernardi, M, Gasbarrini, G (1995) Bone mass and metabolism in patients with celiac disease. Gastroenterology 109, 122128.CrossRefGoogle ScholarPubMed
Corrao, G, Corazza, GR, Bagnardi, V, Brusco, G, Ciacci, C, Cottone, M et al. (2001) Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 358, 356361.CrossRefGoogle ScholarPubMed
Csizmadia, CGDS, Mearin, ML, von Blomberg, MBE, Brand, R, Verloove-Vanhorick, SP (1999) An iceberg of childhood coeliac disease in the Netherlands. Lancet 353, 813814.CrossRefGoogle ScholarPubMed
D'Amico, MA, Stavropoulos, SN, Frederick, M, Levy, J, Holmes, J, Defelice, AR & Green, PHR (2003) The effect of breastfeeding on pediatric celiac disease in the USA. Gastroenterology 124 A-516.CrossRefGoogle Scholar
Dahele, A & Ghosh, S (2000) The role of serological tests in redefining coeliac disease. Proceedings of the Royal College of Physicians of Edinburgh 30, 100113.Google Scholar
Department of Health (1994) Weaning and the Weaning Diet. Report on Health and Social Subjects no. 45. London: H. M. Stationery Office.Google Scholar
Department of Health (1995) Sensible drinking. The report of an Inter-departmental Working Group. Google Scholar
Department of Health (1996) While You are Pregnant How to Avoid Infection from Food and from Contact with Animals. London: Department of Health.Google Scholar
Department of Health (2000) Folic acid and the Prevention of Disease. Report on Health and Social Subjects no. 50, London: H. M. Stationery Office.Google Scholar
Dickey, W, Hughes, DF & McMillan, SA (2000a) Reliance on serum endomysial antibody testing underestimates the true prevalence of coeliac disease by one fifth. Scandinavian Journal of Gastroenterology 35, 181183.Google ScholarPubMed
Dickey, W, Hughes, DF & McMillan, SA (2000b) Disappearance of endomysial antibodies in treated celiac disease does not indicate histological recovery. American Journal of Gastroenterology 95, 712714.CrossRefGoogle Scholar
Dieterich, W, Ehnis, T, Bauer, M, Donner, P, Volta, U, Riecken, EO & Schuppan, D (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nature Medicine 3, 797801.CrossRefGoogle ScholarPubMed
Diosdado, B, Wapenaar, MC, Franke, L, Duran, KJ, Goerres, MJ, Hadithi, M et al. (2004) A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut 53, 944951.CrossRefGoogle ScholarPubMed
Di Stefano, M, Jorizzo, RA, Veneto, G, Cecchetti, L, Gasbarrini, G, Corazza, GR (1999) Bone mass and metabolism in dermatitis herpetiformis. Digestive Diseases and Sciences 44, 21392143.CrossRefGoogle ScholarPubMed
Dube, C, Rostom, A, Sy, R, Cranney, A, Saloojee, N, Garritty, C et al. (2005) The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology 128, S57S67.CrossRefGoogle ScholarPubMed
Duggan, JM & Duggan, AE (2005) Systematic review: the liver in coeliac disease. Alimentary Pharmacology and Therapeutics 21, 515518.CrossRefGoogle ScholarPubMed
Elsurer, R, Tatar, G, Simsek, H, Balaban, YH, Aydinli, M & Sokmensuer, C (2005) Celiac disease in the Turkish population. Digestive Diseases and Sciences 50, 136142.CrossRefGoogle ScholarPubMed
European Commission (2000) Directive 2000/13/EC of the European Parliament and of the Council of 20 March 2000 on the approximation of the laws of the Member States relating to the labelling, presentation and advertising of foodstuffs. Official Journal of the European Union L109, 2942.Google Scholar
European Commission (2003) Directive 2003/89/EC of the European Parliament and of the Council of 10 November 2003 amending Directive200/13/EC as regards indication of the ingredients present in foodstuffs. Official Journal of the European Union L308, 1518.Google Scholar
Fabiani, E, Peruzzi, E, Mandolesi, A, Garbuglia, G, Fanciulli, G, D'Appello, AR, Gasparin, M, Bravi, E, Bearzi, I, Galeazzi, R & Catassi, C (2004) Anti-human versus anti-guinea pig tissue transglutaminase antibodies as the first-level serological screening test for coeliac disease in the general population. Digestive and Liver Disease 36, 671676.CrossRefGoogle ScholarPubMed
Fabiani, E, Taccari, LM, Ratsch, IM, DiGiuseppe, S, Coppa, GV, Catassi, C (2000) Compliance with gluten-free diet in adolescents with screening-detected celiac disease: A 5-year follow-up study. Journal of Pediatrics 136, 841843.CrossRefGoogle ScholarPubMed
Fasano, A, Berti, I, Gerarduzzi, T, Not, T, Colletti, RB, Drago, S et al. (2003) Prevalence of celiac disease in at-risk and not-at-risk groups in the United States – a large multicenter study. Archives of Internal Medicine 163, 286292.CrossRefGoogle ScholarPubMed
Faulkner-Hogg, KB, Selby, WS & Loblay, RH (1999) Dietary analysis in symptomatic patients with coeliac disease on a gluten-free diet: the role of trace amounts of gluten and non-gluten food intolerances. Gastroenterology 34, 784789.Google ScholarPubMed
Feighery, C (1999) Coeliac disease. British Medical Journal 319, 236239.CrossRefGoogle ScholarPubMed
Floreani, A, Betterle, C, Baragiotta, A, Martini, S, Venturi, C, Basso, D, Pittoni, M, Chiarelli, S & Guidetti, CS (2002) Prevalence of coeliac disease in primary biliary cirrhosis and of antimitochondrial antibodies in adult coeliac disease patients in Italy. Digestive and Liver Disease 34, 258261.CrossRefGoogle ScholarPubMed
Food and Agriculture Organization/World & Health Organization (2003) Draft revised standard for gluten-free foods. Report of the twenty-fifth session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, paragraphs 9 and 10. Scholar
Food Standards Agency (2002) Feeding your Baby. From Breastfeeding to Solid Foods London: The Stationery Office.Google Scholar
Fraser, JS, Engel, W, Ellis, HJ, Pollock, EL, Wieser, H & Ciclitira, PJ (2003) Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut 52, 16981702.CrossRefGoogle ScholarPubMed
Gandolfi, L, Pratesi, R, Cordoba, JCM, Tauil, PL, Gasparin, M & Catassi, C (2000) Prevalence of celiac disease among blood donors in Brazil. American Journal of Gastroenterology 95, 689692.CrossRefGoogle Scholar
Gillett, H, Drummond, H, Goddard, C, Shand, A & Satsangi, J (2003) Complications of coeliac disease – how common and can they be prevented. Gut 52, A10.Google Scholar
Gillett, HR & Freeman, HJ (2000a) Comparison of IgA endomysium antibody and IgA tissue transglutaminase antibody in celiac disease. Canadian Journal of Gastroenterology 14, 668671.CrossRefGoogle ScholarPubMed
Gillett, HR & Freeman, HJ (2000b) Prevalence of celiac disease in collagenous and lymphocytic colitis. Canadian Journal of Gastroenterology 14, 919921.CrossRefGoogle ScholarPubMed
Gillett, PM, Gillett, HR, Israel, DM, Metzger, DL, Stewart, L, Chanoine, JP & Freeman, HJ (2000) Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 14, 915918.CrossRefGoogle ScholarPubMed
Gillett, PM, Gillett, HR, Israel, DM, Metzger, DL, Stewart, L, Chanoine, JP & Freeman, HJ (2001) High prevalence of a celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 15, 297301.CrossRefGoogle ScholarPubMed
Goldacre, MJ, Wotton, CJ, Seagroatt, V & Yeates, D (2004) Cancers and immune related diseases associated with Down's syndrome: a record linkage study. Archives of Disease in Childhood 89, 10141017.CrossRefGoogle ScholarPubMed
Gomez, JC, Selvaggio, GS, Viola, M, Pizarro, B, la Motta, G, de Barrio, S et al. (2001) Prevalence of celiac disease in Argentina: Screening of an adult population in the La Planta area. American Journal of Gastroenterology 96, 27002704.CrossRefGoogle Scholar
Good Relations Healthcare(2004) Gluten-free Foods: A Prescribing Guide London: Good Relations Healthcare.Google Scholar
Gough, KR, Read, AE & Naish, JM (1962) Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut 3, 232239.CrossRefGoogle ScholarPubMed
Greco, L, Romino, R, Coto, I, Di Cosmo, N, Percopo, S, Maglio, M et al. (2002) The first large population based twin study of coeliac disease. Gut 50, 624628.CrossRefGoogle ScholarPubMed
Greco, L, Veneziano, A, DiDonato, L, Zampella, C, Pecoraro, M, Paladini, D, Paparo, F, Vollaro, A, Martinelli, P (2004) Undiagnosed coeliac disease does not appear to be associated with unfavourable outcome of pregnancy. Gut 53, 149151.CrossRefGoogle Scholar
Green, PHR, Fleischauer, AT, Bhagat, G, Goyal, R, Jabri, B & Neugut, AI (2003) Risk of malignancy in patients with celiac disease. American Journal of Medicine 115, 191195.CrossRefGoogle ScholarPubMed
Green, PHR & Jabri, B (2003) Coeliac disease. Lancet 362, 383392.CrossRefGoogle ScholarPubMed
Green, PHR, Stavropoulos, SN, Panagi, SG, Goldstein, SL, McMahon, DJ, Absan, H & Neugut, AI (2001) Characteristics of adult celiac disease in the USA: results of a national survey. American Journal of Gastroenterology 96, 126131.CrossRefGoogle ScholarPubMed
Habior, A, Lewartowska, A, Orlowska, J, Zych, W, Sandowska, M, Bauer, A & Butruk, E (2003) Association of coeliac disease with primary biliary cirrhosis in Poland. European Journal of Gastroenterology and Hepatology 15, 159164.CrossRefGoogle ScholarPubMed
Hallert, C, Grant, C, Grehn, S, Granno, C, Hulten, S, Midhagen, G, Strom, M, Svensson, H & Valdimarsson, T (2002) Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Alimentary Pharmacology and Therapeutics 16, 13331339.CrossRefGoogle ScholarPubMed
Hansen, D, Bennedbaek, FN, Hansen, LK, Hoier-Madsen, M, Hegedus, L, Jacobsen, B & Husby, S (2001) High prevalence of coeliac disease in Danish children with type I diabetes mellitus. Acta Paediatrica 90, 12381243.CrossRefGoogle ScholarPubMed
Henderson, L, Irving, K, Gregory, J, Bates, CJ, Prentice, A, Perks, J, Swan, G & Farron, M (2003)The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. Vol. 3: Vitamin and Mineral Intake and Urinary Analytes. London: The Stationery Office.Google Scholar
Hervonen, K, Viljamaa, M, Collin, P, Knip, M & Reunala, T (2004) The occurrence of type 1 diabetes in patients with dermatitis herpetiformis and their first-degree relatives. British Journal of Dermatology 150, 136138.CrossRefGoogle ScholarPubMed
Hervonen, K, Vornanen, M, Kautiainen, H, Collin, P & Reunala, T (2005) Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives. British Journal of Dermatology 152, 8286.CrossRefGoogle ScholarPubMed
Hill, ID, Dirks, MH, Liptak, GS, Colletti, RB, Fasano, A, Guandalini, S, Hoffenberg, EJ, Horvarth, K, Murray, JA, Pivor, M & Seidman, EG (2005) Guidelines for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition 40, 119.CrossRefGoogle ScholarPubMed
Hill, PG, Semeraro, D & Holmes, GKT (2004) IgA antibodies to human tissue transglutaminase: Audit of routine practice confirms high diagnostic accuracy. Scandinavian Journal of Gastroenterology 39, 10781082.CrossRefGoogle ScholarPubMed
Hin, H, Bird, G, Fisher, P, Mahy, N & Jewell, D (1999) Coeliac disease in primary care: case finding study. British Medical Journal 318, 164167.CrossRefGoogle ScholarPubMed
Hogberg, L, Laurin, P, Falth-Magnusson, K, Grant, C, Grodzinsky, E, Jansson, G et al. (2004) Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut 53, 649654.CrossRefGoogle ScholarPubMed
Holmes, GKT, Prior, P, Lane, MR, Pope, D & Allan, RN (1989) Malignancy in coeliac disease – effect of a gluten free diet. Gut 30, 333338.CrossRefGoogle ScholarPubMed
Hovell, CJ, Collett, JA, Vautier, G, Cheng, AJP, Sutanto, E, Mallon, DF, Olynyk, JK & Cullen, DJE (2001) High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening. Medical Journal of Australia 175, 247250.Google Scholar
Howdle, PD, Jalal, PK, Holmes, GKT & Houlston, RS (2003) Primary small-bowel malignancy in the UK and its association with coeliac disease. QJM: An International Journal of Medicine 96, 345353.CrossRefGoogle ScholarPubMed
Ivarsson, A, Hernell, O, Stenlund, H & Persson, LA (2002) Breast-feeding protects against celiac disease. American Journal of Clinical Nutrition 75, 914921.Google ScholarPubMed
Ivarsson, A, Persson, LA & Hernell, O (2000) Short and long term effects of breast feeding on child health. Advances in Experimental Medicine and Biology 478, 139149.CrossRefGoogle Scholar
James, S (2005) Celiac disease: Proceedings of the NIH Consensus Conference on Celiac Disease. Gastroenterology 128, S1S141 Suppl. 1.CrossRefGoogle Scholar
Janatuinen, EK, Kemppainen, TA, Julkunen, RJK, Kosma, V-M, Maki, M, Heikkinen, M & Uusitupa, MIJ (2002) No harm from five year ingestion of oats in coeliac disease. Gut 50, 332335.CrossRefGoogle ScholarPubMed
Johnston, SD, Watson, RGP, McMillan, SA, Sloan, J & Love, AHG (1997) Prevalence of coeliac disease in Northern Ireland. Lancet 350, 1370.CrossRefGoogle ScholarPubMed
Kaukinen, K, Collin, P, Holm, K, Rantala, I, Vuolteenaho, N, Renunala, T & Maki, M (1999) Wheat starch-containing gluten-free flour products in the treatment of coeliac disease and dermatitis herpetiformis. A long-term follow-up study. Scandinavian Journal of Gastroenterology 34, 163169.CrossRefGoogle ScholarPubMed
Kemppainen, TA, Kosma, V-M, Janatuinen, E, Julkunen, RJ, Pikkarainen, PH & Uusitupa, MIJ (1998) Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet – association with the grade of mucosal villous atrophy. American Journal of Clinical Nutrition 67, 482487.Google ScholarPubMed
Kemppainen, TA, Kroger, H, Janatuinen, E, Arnala, I, Kosma, VM, Pikkarainen, P, Julkunen, R, Jurvelin, J, Alhava, E & Uusitupa, M (1999a) Osteoporosis in adult patients with celiac disease. Bone 24, 249255.CrossRefGoogle ScholarPubMed
Kemppainen, TA, Kroger, H, Janatuinen, E, Arnala, I, Lamberg-Allardt, C, Karkkainen, M, Kosma, VM, Julkunen, R, Jurvelin, J, Alhava, E & Uusitupa, M (1999b) Bone recovery after a gluten-free diet: A 5-year follow-up study. Bone 25, 355360.CrossRefGoogle ScholarPubMed
Kerins, DM, Koury, MJ, Capdevila, A, Rana, S & Wagner, C (2001) Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. American Journal of Clinical Nutrition 74, 723729.Google ScholarPubMed
Kluge, F, Koch, HK, Grossewilde, H, Lesch, R & Gerok, W (1982) Follow-up of treated adult celiac disease: clinical and morphological studies. Hepatogastroenterology 29, 1723.Google ScholarPubMed
Kolho, KL, Farkkila, MA & Savilahti, E (1998) Undiagnosed coeliac disease is common in Finnish adults. Scandinavian Journal of Gastroenterology 33, 12801283.Google ScholarPubMed
Korponay-Szabo, IR, Dahlbom, I, Laurila, K, Koskinen, S, Woolley, N, Partanen, J, Kovacs, JB, Maki, M & Hansson, T (2003) Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 52, 15671571.CrossRefGoogle ScholarPubMed
Kotze, LMS (2004) Gynecologic and obstetric findings related to nutritional status and adherence to a gluten-free diet in Brazilian patients with celiac disease. Journal of Clinical Gastroenterology 38, 567574.CrossRefGoogle ScholarPubMed
Kramer, MS & Kakuma, R (2002) The Optimal Duration of Exclusive Breastfeeding: A Systematic Review Rome WHO Google Scholar
Kumar, V, Lerner, A, Valeski, JE, Beutner, EH, Chorzelski, TP & Rossi, T (1989) Endomysial antibodies in the diagnosis of celiac-disease and the effect of gluten on antibody-titers. Immunological Investigations 18, 533544.CrossRefGoogle Scholar
Lagerqvist, C, Ivarsson, A, Juto, P, Persson, LA & Hernell, O (2001) Screening for adult coeliac disease – which serological marker(s) to use. Journal of Internal Medicine 250, 241248.CrossRefGoogle ScholarPubMed
Lawson, A, West, J, Aithal, GP & Logan, RFA (2005) Autoimmune cholestatic liver disease in people with coeliac disease: a population-based study of their association. Alimentary Pharmacology and Therapeutics 21, 401405.CrossRefGoogle ScholarPubMed
Lenhardt, A, Plebani, A, Marcheti, F, Gerarduzi, T, Not, T, Meini, A, Villanacci, V, Martelossi, S & Ventura, A (2004) Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Digestive and Liver Disease 36, 730734.CrossRefGoogle Scholar
Lerner, A, Kumar, V & Iancu, TC (1994) Immunological diagnosis of childhood coeliac disease: comparison between antigliadin, antireticulin and antiendomysial antibodies. Clinical and Experimental Immunology 95, 7882.CrossRefGoogle ScholarPubMed
Lo, W, Sano, K, Lebwohl, B, Diamond, B & Green, PHR (2003) Changing presentation of adult celiac disease. Digestive Diseases and Sciences 48, 395398.CrossRefGoogle ScholarPubMed
Logan, RF, Rifkind, EA, Turner, IE & Ferguson, A (1989) Mortality in celiac disease. Gastroenterology 97, 265271.CrossRefGoogle ScholarPubMed
Lundin, KEA, Nilsen, EM, Scott, HG, Loberg, EM, Gjoen, A, Bratlie, J, Skar, V, Mendez, E, Lovik, A & Kett, K (2003) Oats induced villous atrophy in coeliac disease. Gut 52, 16491652.CrossRefGoogle ScholarPubMed
McFarlane, XA, Bhalla, AK, Reeves, DE, Morgan, LM & Robertson, DAF (1995) Osteoporosis in treated adult coeliac disease. Gut 36, 710714.CrossRefGoogle ScholarPubMed
Maki, M, Mustalahti, K, Kokkonen, J, Kulmala, P, Haapalahti, M, Karttunen, T et al. (2003) Prevalence of celiac disease among children in Finland. New England Journal of Medicine 348, 25172524.CrossRefGoogle ScholarPubMed
Marsh, MN (1992) Gluten, major histocompatibility complex, and the small intestine. Gastroenterology 102, 330354.CrossRefGoogle ScholarPubMed
Martin-Villa, JM, Lopez-Suarez, JC, Perez-Blas, M, Martinez-Laso, J, Ferre-Lopez, S, Garcia-Torre, C, Lledo, G, Manzanares, J, Arnaiz-Villena, A (2001) Coeliac- and enteropathy-associated autoantibodies in Spanish insulin-dependent diabetes mellitus patients and their relation to HLA antigens. Journal of Diabetes and Its Complications 15, 3843.CrossRefGoogle ScholarPubMed
Martinelli, P, Troncone, R, Paparo, F, Torre, P, Trapanese, E, Fasano, C, Lamberti, A, Budillon, G, Nardone, G & Greco, L (2000) Coeliac disease and unfavourable outcome of pregnancy. Gut 46, 332335.CrossRefGoogle ScholarPubMed
Mason, JB (2002) Diet, folate, and colon cancer. Current Opinion in Gastroenterology 18, 229234.CrossRefGoogle ScholarPubMed
Matysiak-Budnik, T, Candalh, C, Dugave, C, Namane, A, Cellier, C, Cerf-Bensussan, N & Heyman, M (2003) Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 125, 696707.CrossRefGoogle ScholarPubMed
Mayer, M, Greco, L, Troncone, R, Auricchio, S & Marsh, MN (1991) Compliance of adolescents with celiac-disease with a gluten free diet. Gut 32, 881885.CrossRefGoogle ScholarPubMed
Meloni, GF, Dessole, S, Vargiu, N, Tomasi, PA & Musumeci, S (1999) The prevalence of coeliac disease in infertility. Human Reproduction 14, 27592761.CrossRefGoogle ScholarPubMed
Meyer, D, Stravropolous, S, Diamond, B, Shane, E & Green, PHR (2001) Osteoporosis in a North American adult population with celiac disease. American Journal of Gastroenterology 96, 112119.Google Scholar
Midhagen, G, Aberg, AK, Olcen, P, Jarnergot, G, Valdimarsson, T, Dahlbom, I, Hansson, T & Strom, M (2004) Antibody levels in adult patients with coeliac disease during gluten-free diet: a rapid initial decrease of clinical importance. Journal of Internal Medicine 256, 519524.CrossRefGoogle ScholarPubMed
Moreno, ML, Vazquez, H, Mazure, R, Smecuol, E, Niveloni, S, Pedreira, S, Sugai, E, Maurino, E, Gomez, JC & Bai, JC (2004) Stratification of bone fracture risk in patients with celiac disease. Clinical Gastroenterology and Hepatology 2, 127134.CrossRefGoogle ScholarPubMed
Morris, AM, Yiannakou, JY, King, AL, Brett, PM, Biagi, F, Vaughan, R, Curtis, D & Ciclitira, PJ (2000) Coeliac disease and Down syndrome: Associations not due to genetic linkage on chromosome 21. Scandinavian Journal of Gastroenterology 35, 177180.CrossRefGoogle Scholar
Mowat, AM (2003) Coeliac disease – a meeting point for genetics, immunology, and protein chemistry. Lancet 361, 12901292.CrossRefGoogle ScholarPubMed
Myhre, AG, Aarsetoy, H, Undlien, DE, Hovdenak, N, Aksnes, L & Husebye, ES (2003) High frequency of coeliac disease among patients wtih autoimmune adrenocortical failure. Scandinavian Journal of Gastroenterology 38, 511515.CrossRefGoogle Scholar
Norgard, B, Fonager, K, Sorensen, HT & Olsen, J (1999) Birth outcomes of women with celiac disease: A nationwide historical cohort study. American Journal of Gastroenterology 94, 24352440.CrossRefGoogle ScholarPubMed
Norris, JM, Barriga, K, Hoffenberg, EJ, Taki, I, Miao, D, Haas, JE, Emery, LM, Sokol, RJ, Erlich, HA, Eisenbarth, GS & Rewers, M (2005) Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. Journal of the American Medical Association 293, 23422351.Google Scholar
Not, T, Horvath, K, Hill, ID, Partanen, J, Hammed, A, Maguzzu, G & Fasano, A (1998) Celiac disease in the USA: High prevalence of antiendomysium antibodies in healthy blood donors. Scandinavian Journal of Gastroenterology 33, 494498.Google ScholarPubMed
Not, T, Tommasini, A, Tonini, G, Buratti, E, Pocecco, M, Tortul, C et al. (2001) Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus. Diabetologia 44, 151155.CrossRefGoogle ScholarPubMed
O'Leary, C, Walsh, CH, Wieneke, P, O'Regan, P, Buckley, B, O'Halloran, DJ, Ferriss, JB, Quigley, EMM, Annis, P, Shanahan, F & Cronin, CC (2002) Coeliac disease and autoimmune Addison's disease: a clinical pitfall. QJM: Monthly Journal of the Association of Physicians 95, 7982.CrossRefGoogle ScholarPubMed
Olesen, M, Eriksson, S, Bhor, J, Jarnerot, G & Tysk, C (2004) Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. Gut 53, 536541.CrossRefGoogle ScholarPubMed
Pazianas, M, Butcher, GP, Subhani, JM, Finch, PJ, Ang, L, Collins, C, Heaney, RP, Zaidi, M & Maxwell, JD (2005) Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake. Osteoporosis International 16, 5663.CrossRefGoogle ScholarPubMed
Peraaho, M, Kaukinen, K, Paasikivi, K, Sievanen, H, Lohiniemi, S, Maki, M & Collin, P (2003) Wheat-starch-based gluten-free products in the treatment of newly detected coeliac disease: prospective and randomized study. Alimentary Pharmacology and Therapeutics 17, 587594.CrossRefGoogle ScholarPubMed
Peters, U, Askling, J, Gridley, G, Ekbom, A & Linet, M (2003) Causes of death in patients with celiac disease in a population-based Swedish cohort. Archives of Internal Medicine 163, 15661572.CrossRefGoogle Scholar
Peters, U, Schneeweiss, S, Trautwein, EA & Erbersdobler, HF (2001) A case-control study of the effect of infant feeding on celiac disease. Annals of Nutrition and Metabolism 45, 135142.CrossRefGoogle ScholarPubMed
Pietzak, MM (2005) Follow-up of patients with celiac disease: Achieving compliance with treatment. Gastroenterology 128, S135S141.CrossRefGoogle ScholarPubMed
Pratesi, R, Gandolfi, L, Garcia, SG, Modelli, IC, de Almeida, PL, Bocca, AL & Catassi, C (2003) Prevalence of coeliac disease: Unexplained age-related variation in the same population. Scandinavian Journal of Gastroenterology 38, 747750.Google ScholarPubMed
Prescription Pricing Authority (2005) Drug Tariff Part XV – Borderline substances. Gluten-free products – Google Scholar
Pynnonen, PA, Isometsa, ET, Aronen, ET, Verkasalo, MA, Savilahti, E & Aalberg, VA (2004) Mental disorders in adolescents with celiac disease. Psychosomatics 45, 325335.CrossRefGoogle ScholarPubMed
Pynnonen, PA, Isometsa, ET, Verkasalo, MA, Kahkonen, SA, Sipila, I, Savilahti, E & Aalberg, VA (2005) Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series sudy. BMC Psychiatry 5, 14.CrossRefGoogle Scholar
Rampertab, SD, Forde, KA & Green, PHR (2003) Small bowel neoplasia in coeliac disease. Gut 52, 12111214.CrossRefGoogle ScholarPubMed
Rawashdeh, MO, Khalil, B & Raweily, E (1996) Celiac disease in Arabs. Journal of Pediatric Gastroenterology and Nutrition 23, 415418.CrossRefGoogle ScholarPubMed
Reif, S & Lerner, A (2004) Tissue transglutaminase – the key player in celiac disease: a review. Autoimmunity Reviews 3, 4045.CrossRefGoogle ScholarPubMed
Rostami, K, Mulder, CJ, van Overbeek, FM, Kerckhaert, J, Meijer, JW, von Blomberg, MB & Heymans, HS (2000) Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology. European Journal of Gastroenterology and Hepatology 12, 5155.CrossRefGoogle ScholarPubMed
Royal College of Obstetricians and Gynaecologists (1999) Alcohol consumption in pregnancy. Google Scholar
Saadah, OI, Zacharin, M, O'Callaghan, A, Oliver, MR, Catto-Smith, A (2004) Effect of gluten-free diet and adherence on growth and diabetic control in diabetics with coeliac disease. Archives of Disease in Childhood 89, 871876.CrossRefGoogle ScholarPubMed
Sanders, DS, Hurlstone, DP, McAlindon, ME, Hadjivassiliou, M, Cross, SS, Wild, G & Atkins, CJ (2005) Antibody negative coeliac disease presenting in elderly people – an easily missed diagnosis. British Medical Journal 330, 775776.CrossRefGoogle ScholarPubMed
Sategna-Guidetti, C, Grosso, SB, Grosso, S, Mengozzi, G, Aimo, G, Zaccaria, T, Di Stefano, M, Isaia, GC (2000) The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients. Alimentary Pharmacology and Therapeutics 14, 3543.CrossRefGoogle Scholar
Saukkonen, T, Ilonen, J, Akerblom, HK & Savilahti, E (2001) Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of of DQB1*02 allele. Diabetologia 44, 10511053.CrossRefGoogle ScholarPubMed
Schweizer, JJ, von Blomberg, BME, Bueno-de Mesquita, HB, Mearin, ML (2004) Coeliac disease in the Netherlands. Scandinavian Journal of Gastroenterology 39, 359364.CrossRefGoogle ScholarPubMed
Scott, EM, Gaywood, I & Scott, BB (2000) Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut 46, i1i8.CrossRefGoogle ScholarPubMed
Shan, L, Molberg, O, Parrot, I, Hausch, F, Filiz, F, Gray, GM, Sollid, LM & Khosla, C (2002) Structural basis for gluten intolerance in Celiac sprue. Science 297, 22752279.CrossRefGoogle ScholarPubMed
Skovbjerg, H, Hansen, GH, Niels-Christiansen, LL, Anthonsen, D, Ascher, H, Midhagen, G, Hallert, C, Noren, O & Sjostrom, H (2004) Intestinal tissue transglutaminase in coeliac disease of children and adults: Ultrastructural localization and variation in expression. Scandinavian Journal of Gastroenterology 39, 12191227.CrossRefGoogle ScholarPubMed
Smedby, KE, Akerman, M, Hildebrand, H, Glimelius, B, Ekbom, A & Askling, J (2005) Malignant lymphomas in coeliac disease: evidence of increased risks of lymphoma types other than enteropath-type T cell lymphoma. Gut 54, 5459.CrossRefGoogle ScholarPubMed
Sumnik, Z, Kolouskova, S, Malcova, H, Vavrinec, J, Venhacova, J, Lebl, J & Cinek, O (2005) High prevalence of coeliac disease in siblings of children with type 1 diabetes. European Journal of Pediatrics 164, 912.CrossRefGoogle ScholarPubMed
Szodoray, P, Barta, Z, Lakos, G, Szakall, S & Zeher, M (2004) Coeliac disease in Sjogren's syndrome – a study of 111 Hungarian patients. Rheumatology International 24, 278282.CrossRefGoogle ScholarPubMed
Tata, LJ, Card, TR, Logan, RFA, Hubbard, RB, Smith, CJP & West, J (2005) Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 128, 849855.CrossRefGoogle ScholarPubMed
Tatar, G, Elsurer, R, Simsek, H, Balaban, YH, Hascelik, G, Ozcebe, OI, Buyukasik, Y & Sokmensuer, C (2004) Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population. Digestive Diseases and Sciences 49, 14791484.CrossRefGoogle ScholarPubMed
Thomason, K, West, J, Logan, RF, Coupland, C & Holmes, GKT (2003) Fracture experience of patients with coeliac disease: a population based survey. Gut 52, 518522.CrossRefGoogle ScholarPubMed
Thompson, T (1999) Thiamin, riboflavin, and niacin contents of the gluten-free diet: Is there cause for concern. Journal of the American Dietetic Association 99, 858862.CrossRefGoogle ScholarPubMed
Thompson, T (2000) Folate, iron, and dietary fiber contents of the gluten-free diet. Journal of the American Dietetic Association 100, 13891396.CrossRefGoogle ScholarPubMed
Thompson, T (2005) Contaminated oats and other gluten-free foods in the United States. Journal of the American Dietetic Association 105, 348.CrossRefGoogle ScholarPubMed
Treem, WR (2004) Emerging concepts in celiac disease. Current Opinion in Pediatrics 16, 552559.CrossRefGoogle ScholarPubMed
Tursi, A, Brandimarte, G & Giorgetti, G (2003) Lack of usefulness of anti-transglutaminase antibodies in assessing histologic recovery after gluten-free diet in celiac disease. Journal of Clinical Gastroenterology 37, 387391.CrossRefGoogle ScholarPubMed
Tursi, A, Giorgetti, G, Brandimarte, G, Rubino, E, Lombardi, D & Gasbarrini, G (2001) Prevalence and clinical presentation of subclinical/silent celiac disease in adults: An analysis on a 12-year observation. Hepato-Gastroenterology 48, 462464.Google ScholarPubMed
Vader, LW, Stepniak, DT, Bunnik, EM, Kooy, YMC, De Haan, W, Drijfhout, JW, Van Veelen, PA & Koning, F (2003) Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. Gastroenterology 125, 11051113.CrossRefGoogle ScholarPubMed
Vahedi, K, Mascart, F, Mary, JY, Laberenne, JE, Bouhnik, Y, Morin, MC, Ocmant, A, Velly, C, Colombel, JF & Matuchansky, C (2003) Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. American Journal of Gastroenterology 98, 10791087.CrossRefGoogle ScholarPubMed
Valdes, I, Garcia, E, Llorente, M & Mendez, E (2003) Innovative approach to low-level gluten determination in foods using a novel sandwich enzyme-linked immunosorbent assay protocol. European Journal of Gastroenterology and Hepatology 15, 465474.CrossRefGoogle ScholarPubMed
Valdimarsson, T, Franzen, L, Grodzinsky, E, Skogh, T & Strom, M (1996) Is small bowel biopsy necessary in adults with suspected celiac disease and IgA anti-endomysium antibodies? 100% positive predictive value for celiac disease in adults. Digestive Diseases and Sciences 41, 8387.CrossRefGoogle ScholarPubMed
Valdimarsson, T, Toss, G, Lofman, G & Strom, M (2000) Three years' follow-up of bone density in adult coeliac disease: Significance of secondary hyperparathyroidism. Scandinavian Journal of Gastroenterology 35, 274280.CrossRefGoogle ScholarPubMed
Valentino, R, Savastano, S, Maglio, M, Paparo, F, Ferrara, F, Dorato, M, Lombardi, G & Troncone, R (2002) Markers of potential coeliac disease in patients with Hashimoto's thyroiditis. European Journal of Endocrinology 146, 479483.CrossRefGoogle ScholarPubMed
Valerio, G, Maiuri, L, Troncone, R, Buono, P, Lombardi, F, Palmieri, R & Franzese, A (2002) Severe clinical onset of diabetes and increased prevalence of other autoimmune diseases in children with coeliac disease diagnosed before diabetes mellitus. Diabetologia 45, 17191722.Google ScholarPubMed
Van Belzen, MJ, Meijer, JWR, Sandkuijl, LA, Bardoel, AFJ, Mulder, CJJ, Pearson, PL, Houwen, RHJ & Wijmenga, C (2003) A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology 125, 10321041.CrossRefGoogle Scholar
van Odijk, J, Hulthen, L, Ahlstedt, S & Borres, MP (2004) Introduction of food during the infant's first year: a study with emphasis on introduction of gluten and of egg, fish and peanut in allergy-risk families. Acta Paediatrica 93, 464470.CrossRefGoogle ScholarPubMed
Vazquez, H, Mazure, R, Gonzalez, D, Flores, D, Pedreira, S, Niveloni, S, Smecuol, E, Maurino, E & Bai, JC (2000) Risk of fractures in celiac disease patients: A cross-sectional, case-control study. American Journal of Gastroenterology 95, 183189.CrossRefGoogle Scholar
Verkasalo, M, Savilahti, E, Raitakari, O & Viikari, J (2003) Silent coeliac disease – a risk for career. Journal of Pediatric Gastroenterology and Nutrition 36, 535.Google Scholar
Vestergaard, P & Mosekilde, L (2002) Fracture risk in patients with celiac disease, Crohn's disease, and ulcerative colitis: A nationwide follow-up study of 16, 416 patients in Denmark. American Journal of Epidemiology 156, 110.CrossRefGoogle ScholarPubMed
Wahab, PJ, Crusius, JB, Meijer, JW & Mulder, CJ (2001) Gluten challenge in borderline gluten-sensitive enteropathy. American Journal of Gastroenterology 96, 14641469.CrossRefGoogle ScholarPubMed
Walker-Smith, J (1990) Revised criteria for diagnosis of celiac disease: report of working group of European Society of Pediatric Gastroenterology and Nutrition (ESPAGN). Archives of Disease in Childhood 65, 909911.Google Scholar
West, J, Logan, RFA, Card, TR, Smith, C & Hubbard, R (2003a) Fracture risk in people with celiac disease: A population-based cohort study. Gastroenterology 125, 429436.CrossRefGoogle ScholarPubMed
West, J, Logan, RFA, Card, TR, Smith, C & Hubbard, R (2004a) Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study. Alimentary Pharmacology and Therapeutics 20, 17.CrossRefGoogle ScholarPubMed
West, J, Logan, RFA, Hill, PG, Lloyd, A, Lewis, S, Hubbard, R, Reader, R & Holmes, GKT (2003b) Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 52, 960965.CrossRefGoogle ScholarPubMed
West, J, Logan, RFA, Smith, CJ, Hubbard, RB & Card, TR (2004b) Malignancy and mortality in people with coeliac disease: population based cohort study. British Medical Journal 329, 716718.CrossRefGoogle ScholarPubMed
Westman, E, Ambler, GR, Royle, M, Peat, J & Chan, A (1999) Children with coeliac disease and insulin dependent diabetes mellitus – growth, diabetes control and dietary intake. Journal of Pediatric Endocrinology and Metabolism 12, 433442.CrossRefGoogle ScholarPubMed
Whitehead, R (1995) Gastrointestinal and Oesophageal Pathology. Hong Kong: Churchill Livingstone.Google Scholar
WhoWhorwell, PJ, Alderson, MR, Foster, KJ & Wright, R (2004) Death from ischaemic heart disease and malignancy in adult patients with coeliac disease. Alimentary Pharmacology and Therapeutics 20, 17.Google Scholar
Wylie, C, Geldart, S & Winwood, P (2005) Dietitian-led coeliac clinic: a successful change in working practice in modern healthcare. Gastroenterology Today 15, 1112.Google Scholar
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