Skip to main content
×
Home
    • Aa
    • Aa

Role of substrate utilization and thermogenesis on body-weight control with particular reference to alcohol*

  • Yves Schutz (a1)
Abstract

Alcohol (ethanol; EtOH) provides fuel energy to the body (29·7 kJ (7·1 kcal)/g, 23·4 kJ (5·6 kcal)/ml), as do other macronutrients, but no associated essential nutrients. The thermogenic effect of EtOH (on average 15 % of its metabolizable value) is much greater than that of the main substrates utilized by the body, i.e. fat and carbohydrates (CHO), suggesting a lower net efficiency of energy utilization for EtOH than for fat and CHO. EtOH cannot be stored in the body and is toxic, so that there is an obligatory continuous oxidation of EtOH and it becomes the priority fuel to be metabolized. In contrast to CHO, its rate of oxidation does not depend on the dose ingested. As with CHO intake, it engenders a shift in postprandial substrate utilization (decrease in fat oxidation), but by a non-insulin-mediated mechanism. A limited amount of EtOH can be converted to fatty acids by hepatic de novo lipogenesis (as occurs with high levels of CHO feeding) from acetate production, which inhibits lipolysis in peripheral tissues. There is no evidence that EtOH consumed under normoenergetic conditions (i.e. isoenergetically replacing CHO or fat) leads to greater body fat storage than fat or CHO. However, there is still a lack of experimental studies on the influence of EtOH on the level of spontaneous physical activity in man. This effect may well depend on the dose of EtOH consumed as well as other intrinsic factors.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Role of substrate utilization and thermogenesis on body-weight control with particular reference to alcohol*
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Role of substrate utilization and thermogenesis on body-weight control with particular reference to alcohol*
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Role of substrate utilization and thermogenesis on body-weight control with particular reference to alcohol*
      Available formats
      ×
Copyright
Corresponding author
Corresponding author:Dr Yves Schutz, fax +41 21 692 55 05, email Yves.Schutz@iphysiol.unil.ch
*The other papers presented at this meeting were published in Proceedings of the Nutrition Society (2000) 59 no.3
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

K Berneis , R Ninnis , & U Keller (1997) Ethanol exerts acute protein-sparing effects during postabsorptive but not during anabolic conditions in man. Metabolism 46, 750755.

CA Camargo , KM Vranizan , DM Dreon , B Frey-Hewitt & PD Wood (1987) Alcohol, calorie intake, and adiposity in overweight men. Journal of the American College of Nutrition 6, 271278.

P De Feo , E Volpi , P Lucidi , G Cruciani , F Monacchia , G Reboldi , F Santeusanio , GB Bolli & P Brunetti (1995) Ethanol impairs post-prandial hepatic protein metabolism. Journal of Clinical Investigation 95, 14721479.

J Delarue , P Schneiter , S Henry , C Cayeux , E Jéquier & L Tappy (1997) Effects of adrenergic blockade on hepatic glucose production during ethanol administration. Clinical Physiology 17, 509521.

RW Foltin , TH Kelly & MW Fischman (1993) Ethanol as an energy source in humans: comparison with dextrose-containing beverages. Appetite 20, 95110.

KN Frayn & HA Whitley (1997) Carbohydrate and fat balance: separate existences or an intimate relationship? European Journal of Clinical Nutrition 51, 789.

MK Hellerstein (1999) De novo lipogenesis in humans: metabolic and regulatory aspects. European Journal of Clinical Nutrition 53, S53S65.

SD Poppitt , JW Eckhardt , J McGonagble , PR Murgatroyd & A Prentice (1996) Short-term effects of alcohol consumption on appetite and energy intake. Physiology and Behavior 60, 10631070.

G Razay , KW Heaton , CH Bolton & AO Hughes (1992) Alcohol consumption and its relation to cardiovascular risk factors in British women. British Medical Journal 304, 8083.

JJ Shelmet , GA Reichard , CL Skutches , RD Hoeldtke , OE Owen & G Boden (1988) Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. Journal of Clinical Investigation 81, 11371145.

PM Suter , E Hasler & W Vetter (1997) Effects of alcohol on energy metabolism and body weight regulation: is alcohol a risk factor for obesity? Nutrition Reviews 55, 157171.

PM Suter , Y Schutz & E Jéquier (1992) The effect of ethanol on fat storage in healthy subjects. New England Journal of Medicine 326, 983987.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: