Adami GF, Campostano A, Ravera G, Cella F & Ligas B (1998) Relationship between body mass index and serum leptin concentration. Diabetes Nutrition and Metabolism 11, 17–19.
Ahima RS, Campostano A, Ravera G, Cella F & Ligas B (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252.
Ahren B, Mansson S, Gingerich RL & Havel PJ (1997) Regulation of plasma leptin in mice: Influence of age, high-fat diet, and fasting. American Journal of Physiology 42, R113-R120.
Andersson B & Wyrwicka W (1957) The elicitation of a drinking motor conditioned reaction by electrical stimulation of the 'drinking area' in the goat. Acta Physiologica Scandinavica 41, 194–198.
Annand BK & Brobeck JR (1951) Hypothalamic control of food intake in rats and cats. Yale Journal of Biology and Medicine 24, 123–140.
Barsh GS, Farooqi SI & O'Rahilly S (2000) Genetics of body-weight regulation. Nature 404, 644–651.
Baskin DG, Wilcox BJ, Figlewic DP & Dorsa DM (1988) Insulin and insulin-like growth factors in the CNS. Trends in Neuroscience 11, 107–111.
Bennett FI (1998) Are serum leptin correlations influenced by fat placement? Reply. American Journal of Clinical Nutrition 68, 755–756.
Bennett FI, McFarlaneAnderson N, Wilks R, Luke A, Cooper RS & Forrester TE (1997) Leptin concentration in women is influenced by regional distribution of adipose tissue. American Journal of Clinical Nutrition 66, 1340–1344.
Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S & Fournier G (1990) The response to long term overfeeding in identical twins. New England Journal of Medicine 322, 1477–1482.
Broberger C, Johansen J, Johansson C, Schalling M & Holiman S (1998) The neuropeptide Y/agouti gene-related protein (ACRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proceedings of the National Academy of Sciences USA 95, 15043–15048.
Bultman SJ, Michaud EJ & Woychik RP (1992) Molecular characterization of the mouse agouti locus. Cell 71, 1204.
Campfield LA, Smith FJ & Burn P (1997) OB protein: A hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinology and Metabolism 4, 81–102.
Campfield LA, Smith FJ, Guisez Y, Devos R & Burn P (1995) Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 280, 546–549.
Campostano A, Grillo G, Bessarione D, De Grandi R & Adami GF (1998) Relationships of serum leptin to body composition and resting energy expenditure. Hormone and Metabolic Research 30, 646–647.
Cassy S, Dridi S, Picard M & Taouis M (2001) Leptin in chicken. Productions Animales 14, 161–169.
Chehab FE, Lim ME & Lu RH (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12, 318–320.
Chen P, Li C, Haskell-Luevano C, Cone RD & Smith MS (1999) Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology 140, 2645–2650.
Cheung CC, Clifton DK & Steiner RA (1997) Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138, 4489–4492.
Clark G (1939) The use of the Horsley-Clarke instrument on the rat. Science 90, 92.
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassato D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P & Guy-Grand #B (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398–401.
Coleman DL (1973) Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294–298.
Coleman DL (1978) Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141–148.
Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA & Surwit RS (1996) Role of leptin in fat regulation. Nature 380, 677.
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL & Caro JF (1996) Serum immunoreactive leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292–295.
Coppack SW, Pinkney JH & Mohamed-Ali V (1998) Leptin production in human adipose tissue. Proceedings of the Nutrition Society 57, 461–470.
de Lecca L, Kilduff TS, Peyron C, Gao XB, Foye PE, Danielson PE, Fukuhara C, Battenberg ELF, Gautvik VT, Bartlett FS, Frankel WN, Van Den Pol AN, Bloom FE, Gautvik KM & Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences USA 95, 322–327.
Doring H et al. (1997) Leptin effects in free-feeding and food-restricted mice. Pflugers Archiv - European Journal of Physiology 433, 640.
Doring H et al. (1998) Leptin selectively increases energy expenditure of food-restricted lean mice. International Journal of Obesity 22, 83–88.
Elia M (1992a) Energy expenditure in the whole body. In Energy Metabolism: Tissue Determinants and Cellular Corollaries, pp. 19–60 [Kinney JM and Tucker HN, editors]. New York: Raven.
Elia M (1992b) Organ and tissue contributions to metabolic rate. In Energy Metabolism: Tissue Determinants and Cellular Corollaries, pp. 61–80 [Kinney JM and Tucker HN, editors]. New York: Raven.
Elia M, Stubbs RJ & Henry CJK (1998) Differences in fat, carbohydrate and protein metabolism between lean and obese subjects undergoing total starvation. Obesity Research 76, 597–604.
Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB & Elmquist JK (1998) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21, 1385.
Erickson JC, Ahima RS, Hollopeter G, Flier JS & Palmiter RD (1997) Endocrine function of neuropeptide Y knockout mice. Regulatory Peptides 70, 199–202.
Evans EM, Saunders MJ, Spano MA, Arngrimsson SA, Lewis RD & Cureton KJ (1999) Body-composition changes with diet and exercise in obese women: a comparison of estimates from clinical methods and a 4-compartment model. American Journal of Clinical Nutrition 70, 5–12.
Farooqi S, Rau H, Whitehead J & O'Rahilly S (1998) ob gene mutations and human obesity. Proceedings of the Nutrition Society 57, 471–475.
Field J, Belding HS & Martin AW (1939) An analysis of the relation between basal metabolism and summated tissue respiromation in the rat. I. The post-pubertal albino rat. Journal of Cellular and Comparative Physiology 14, 143–157.
Forbes GB (1987) Human Body Composition . New York: Springer Verlag.
Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB & Flier JS (1995) Leptin levels reflect body lipid content in mice - evidence for diet induced resistance to leptin action. Nature Medicine 1, 1311–1314.
Friedman JM (2000) Obesity in the new millennium. Nature 404, 632–634.
Friedman JM & Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763–770.
Gantz I, Bagnol D, Lu XY, Kaelin CB, Day HE, Ollman M, Gantz I, Akil H, Barsh GS & Watson SJ (1999) Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. Journal of Neuroscience 19, RC26.
Garrow JS (1988) Obesity and Related Diseases . London: Churchill Livingstone.
Gibbs J, Young RC & Smith GP (1973) Cholecystokinin decreases food intake in rats. Journal of Comparative Physiology and Psychology 84, 488–495.
Greenberg JA (1999) Organ metabolic rates and aging: two hypotheses. Medical Hypotheses 52, 15–22.
Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma ZM, Vignati L, Bowsher R, Herzog D & Klibanski A (1996) Serum leptin levels in women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism 81, 3861–3863.
Hahn TM, Breininger JF, Baskin DG & Schwartz MW (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neuroscience 1, 271–272.
Halaas JC, Coajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK & Friedmann JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546.
Halaas JL, Boozer C, BlairWest J, Fidahusein N, Denton DA & Friedman JM (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proceedings of the National Academy of Sciences USA 94, 8878–8883.
Hamann A & Matthaei S (1996) Regulation of energy balance by leptin. Experimental and Clinical Endocrinology and Diabetes 104, 293–300.
Havel PJ, Stern JS & Keim NL (1998) Circulating leptin concentrations are related to eating behavior, and to appetite during energy restriction in women. FASEB Journal 12, 1181.
Hebebrand J, Blum WF, Barth N, Coners H, Englaro P, Juul A, Ziegler A, Warnke A, Rascher W & Remschmidt H (1997) Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration. Molecular Psychiatry 2, 330–334.
Herpertz S, Wagner R, Albers N, Blum WF, Pelz B, Langkafel M, Kopp W, Henning A, Oberste-Berghaus C, Mann K, Senf W & Hebebrand #J (1998) Circadian plasma leptin levels in patients with anorexia nervosa: Relation to insulin and cortisol. Hormone Research 50, 197–204.
Herpertz S, Wagner R, Pelz B, Blum W, Hebebrand J, Mann K & Senf W (1997) Disproportionally low serum leptin levels and abolition of nocturnal rise in patients with anorexia nervosa. Diabetes 46, 970.
Hethrington AW & Ranson SW (1940) Hypothalamic lesions and adiposity in the rat. Anatomical Record 78, 149–161.
Hethrington AW & Ranson SW (1942) The spontaneous activity and food intake of rats with hypothalamic lesions. American Journal of Physiology 136, 609–617.
Hickey MS, Considine RV, Israel RG, Mahar TL, McCammon MR, Tyndall GL, Houmard JA & Caro JF (1996) Leptin is related to body fat content in male distance runners. American Journal of Physiology 34, E938-E940.
Hinney A, Becker I, Heibult O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H & Hebebrand J (1998) Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes. Journal of Clinical Endocrinology and Metabolism 83, 3737–3741.
Hirvonen MD & Keesey RE (2000) The regulation of body weight: set-points and obesity. Handbook of Experimental Pharmacology 149, 133–151.
Hoebel BG & Teitelbaum P (1966) Weight regulation in normal and hypothalamic hyperphagic rats. Journal of Comparative Physiology and Psychology 61, 189–193.
Horvath TL, Diano S, Sotonyi P, Heiman M & Tschop M (2001) Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 142, 4163–6169.
Johnson MS, Thomson SC & Speakman JR (2001) Limits to sustained energy intake. II. Inter-relationships between resting metabolic rate, life-history traits and morphology in Mus musculus. Journal of Experimental Biology 204, 1937–1946.
Kalra SP, Dube MG, Sahu A, Phelps CP & Kalra P (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proceedings of the National Academy of Sciences USA 88, 10931–10935.
Keesey RE & Hirvonen MD (1997) Body weight set-points: determination and adjustment. Journal of Nutrition 127, 1875S-1883S.
Kennedy GC (1953) The role of depot fat in the hypothalamic control of food intake in the rat. Proceedings of the Royal Society of London 140, 578–592.
Kolaczynski JW, Considine RV, Ohannesian JP, Marco CC, Nyce MR, Opentanova I, Sinha MK, Zhang PL & Caro JF (1996) Responses of leptin to fasting and refeeding in man: Evidence for dual mechanism of regulation of circulating leptin levels. Diabetes 45, 145.
Krebs HA (1950) Body size and tissue respiration. Biochimica et Biophysica acta 4, 269.
Kristensen P, Judge ME, Thim U, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jense PB, Madsen OD, Vrang N, Larsen PJ & Hastrup S (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393, 72–76.
Krude H, Biebermann H, Luck W, Horn R, Brabant G & Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics 19, 155–157.
Lahlou N, Landais P, DeBoissieu D & Bougneres PF (1997) Circulating leptin in normal children and during the dynamic phase of juvenile obesity - Relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes 46, 989–993.
Leibel R, Rosenbaum M & Hirsch J (1995a) Changes in energy expenditure resulting from altered body weight. New England Journal of Medicine 332, 621.
Leibel RL, Rosenbaum M & Hirsch J (1995b) Changes in energy expenditure resulting from altered bodyweight. New England Journal of Medicine 332, 621–628.
Levin BE (2002) Metabolic sensors: viewing glucose sensing neurons from a broader perspective. Physiology and Behavior 76, 397–401.
Levin BE & Keesey RE (1998) Defense of differing body weight set-points in diet-induced obese and resistant rats. American Journal of Physiology 274, R412-R419.
Li H, Matheny M, Tumer N & Scarpace PJ (1998) Effects of aging and fasting on the regulation of leptin gene expression and hypothalamic neuropeptide Y gene expression. FASEB Journal 12, 3209.
Lowell BB & Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652–660.
Luheshi GN, Gardner JD, Rushforth DA, Loudon AS & Rothwell NJ (1999) Leptin actions on food intake and body temperature are mediated by IL-1. Proceedings of the National Academy of Sciences USA 96, 7047–7052.
Maes HH, Neale MC & Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics 27, 325–351.
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA & Friedman JM (1995) Leptin levels on human and rodent - measurement of plasma leptin and Ob RNA in obese and weight reduced subjects. Nature Medicine 1, 1155–1161.
Margules DL & Olds J (1962) Identical 'feeding' and 'rewarding' systems in the lateral hypothalamus of rats. Science 135, 374–375.
Mayer A (1955) Regulation of energy intake and body weight: the glucostatic theory and the lipostatic hypothesis. Annals of the New York Academy of Science 63, 15–42.
Mellinkoff S, Franklin M, Boyle D & Geipell G (1956) Relationship between serum amino acid concentration and fluctuation in appetite. Journal of Applied Physiology 8, 535–538.
Mercer JG (1998) Regulation of appetite and body weight in seasonal mammals. Comparative Biochemistry and Physiology 119, 295–303.
Mercer JG, Hoggard N, Lawrence CB, Rayner DV & Trayhurn P (1996a) Localization of leptin receptor (OB-R) gene expression in mouse brain by in situ hybridization. Journal of Physiology 495, 113P.
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ & Trayhurn P (1996b) Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. Journal of Neuroendocrinology 8, 733–735.
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT & Trayhurn P (1996c) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters 387, 113–116.
Mercer JG, Moar KM & Hoggard N (1998) Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139, 29–34.
Mercer JG, Moar KM, Logie TJ, Findlay PA, Adam CL & Morgan PJ (2001) Seasonally-inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters. Endocrinology 142, 4173–4181.
Mercer JG & Speakman JR (2001) Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesity. Neuroscience and Biobehavioral Reviews 25, 101–116.
Miller M, Duhl DM, Vrieling H, Cordes SP, Ollmann MM, Winkes BM & Barsh GS (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes and Development 7, 454–467.
Miyawaki T, Hosoda K, Masuzaki H, Natsui K, Hanaoka I, Hiraoka J, Matsuoka N, Matsuda JI, Murata M, Matsuo T, Sugawara A & Nishi S (1997) Regulation of plasma leptin levels by nutritional status in humans. Diabetes 46, 989.
Mizuno TM & Mobbs CV (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by feeding. Endocrinology 140, 814–817.
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB & O'Rahilly S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903–908.
Montague CT, Prins JB, Sanders L, Zhang JL, Sewter CP, Digby J, Byrne CD & O'Rahilly S (1998) Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes 47, 1384–1391.
Moran TH (2000) Cholecystokinin and satiety: current perspectives. Nutrition 16, 858–865.
Morgan PJ & Mercer JG (2001) The regulation of body weight: lessons from the seasonal animal. Proceedings of the Nutrition Society 60, 127–134.
Mueller W, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS & Havel PJ (1998) Evidence that glucose metabolism regulates leptin secretion from cultural rat adipocytes. Endocrinology 139, 551–558.
Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen YR, Gantz I & Barsh GS (1997) Antagonism of central melanocortin receptors in vitro and in vivo by Agouti-related protein. Science 278, 135–138.
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T & Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540–543.
Powley TL & Keesey RE (1970) Relationship of body weight to the lateral hypothalamic feeding syndrome. Journal of Comparative Physiology and Psychology 70, 25–36.
Price RA & Gottesman II (1991) Body fat in identical twins reared apart - roles for genes and environment. Behavior Genetics 21, 1–7.
Qu D, Ludwig S, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R & Maratos-Flier E (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243–247.
Russell CD, Petersen RN, Rao SP, Ricci MR, Prasad A, Zhang Y, Brolin RE & Fried SK (1998) Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. American Journal of Physiology 38, E507-E515.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92, 575–585.
Saltzman E & Roberts SB (1995) The role of energy expenditure in energy regulation - findings from a decade of research. Nutrition Reviews 53, 209–220.
Satoh N, Katsuura G, Hayase M, Tsuji T, Takaya K & Ogawa Y (1997) Dual effects of leptin on body weight regulation via the arcuate nucleus (Arc) and the ventromedial hypothalamus (VMH). Diabetes 46, 978.
Schoeller DA, Cella LK, Sinha MK & Caro JF (1997) Entrainment of the diurnal rhythm of plasma leptin to meal timing. Journal of Clinical Investigation 100, 1882–1887.
Schwartz GJ (2000) The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16, 866–873.
Schwartz MW (1997) Regulation of appetite and body weight. Hospital Practice 32, 117–119.
Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D, Woods SC, Seeley RJ & Weigle DS (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531–535.
Schwartz MW, Sipols AJ, Grubin CE & Baskin DG (1993) Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Research Bulletin 31, 361–367.
Schwartz MW, Woods SC, Porte D, Seeley RJ & Baskin DG (2000) Central nervous system control of food intake. Nature 404, 661–671.
Speakman JR, Trayhurn P & Rayner DV (1999) Leptin inhibits the starvation responses of mice. FASEB Journal 13, A1027.
Stanley BG, Kyrkouli SE, Lampert S & Leibowitz SF (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189–1192.
St Jeor ST (1997) New trends in weight management. Journal of the American Dietetic Association 97, 1096–1098.
Steinlechner S, Heldmaier G & Becker H (1983) The seasonal cycle of body weight in the Djungarian hamster: Photoperiodic control and influence of starvation and melatonin. Oecologia 60, 401–405.
Taouis M, Dridi S, Cassy S, Benomar Y, Raver N, Rideau N, Picard M, Williams J & Gertler A (2001) Chicken leptin: properties and actions. Domestic Animal Endocrinology 21, 319–327.
Tappy L, Binnert C & Schneiter Ph (2003) Effects of nutrients intake on energy expenditure. Proceedings of the Nutrition Society 62 (In the Press).
Tartaglia LA, Dembski M, Weng X, Deng NH, Culpepper J, Devos R et al. (1995) Identification and expression cloning of a leptin receptor, OB- R. Cell 83, 1263–1271.
Tasaka Y, Yanagisawa K, Kawahara R & Omori Y (1997) Plasma human leptin in obese and diabetic subjects and its diurnal variation. Diabetologia 40, 1051.
Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J & Bloom SR (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 69–72.
Vaisse C, Clement K, Guy-Grand B & Froguel P (1998) A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics 20, 113–114.
van Aggel-Leijssen DPC, Saris WHM, Hul GB &van Baak MA (2001) short-term effects of weight loss with or without low intensity exercise training on fat metabolism in obese men. American Journal of Clinical Nutrition 73, 523–531.
Vinten J, Stoving R, Handberg A & Hagen C (1996) Diurnal variation of the plasma leptin concentration in anorexia nervosa patients and control subjects. Diabetologia 39, 550.
Vogler GP, Sorensen TIA, Stunkard AJ, Srinivasan MR & Rao DC (1995) Influences of genes and shared family environment on adult body mass index assessed on an adoption study by a comprehensive path model. International Journal of Obesity 19, 40–45.
Wadden TA (1993) Treatment of obesity by moderate and severe calorific restriction. Results of clinical research trials. Annals of Internal Medicine 119, 688–693.
Wang TL, Hartzell DL, Flatt WP, Martin RJ & Baile CA (1998) Responses of lean and obese Zucker rats to centrally administered leptin. Physiology and Behavior 65, 333–341.
Weigle DS (1994) Appetite and the regulation of body composition. Nature 8, 302–310.
Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Loftonday CE, Prunkard DE, Raymond C & Gertler A (1995) Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. Journal of Clinical Investigation 96, 2065–2070.
Weinsier RL, Hunter GR, Gower BA, Schutz Y, Darnell BE & Zuckerman PA (2001) Body fat distribution in white and black women: different patterns of intra-abdominal and sub-cutaneous adipose tissue utilisation with weight loss. American Journal of Clinical Nutrition 74, 631–636.
Weintraub M (1992) Long-term weight control study: conclusions. Clinical Pharmacology Theory 51, 642–646.
Wilding JPH, Gilbey SG, Bailey CJ, Batt RA, Williams G, Ghatei MA & Bloom SR (1993) Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 132, 1939–1944.
Wirtshafter D & Davis JD (1977) Set points, settling points, and the control of body weight. Physiology and Behavior 19, 75–78.
Woods S, Seeley R, Porte DJ & Schwartz M (1998) Signals that regulate food intake and energy homeostasis. Science 280, 1378–1383.
Woods SC, Seeley RJ & Schwartz MW (1997) Leptin as an adiposity signal. Endocrinology and Metabolism 4, 77–79.
Yaswen L, Diehl N, Brennan MB & Hochgeschwender U (1999) Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature Medicine 5, 1066–1070.
Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG & O'Rahilly S (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genetics 20, 111–112.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432.