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Fat-soluble vitamins and atopic disease: what is the evidence?

  • Augusto A. Litonjua (a1)
  • DOI: http://dx.doi.org/10.1017/S002966511100334X
  • Published online: 25 November 2011
Abstract

The prevalence of asthma and other atopic disorders continues to increase worldwide. Examination of the epidemiologic patterns has revealed that this rise has occurred primarily in western, industrialised countries and countries transitioning to this lifestyle. While many changes have occurred in human populations over the years, it has been hypothesised that some of the relevant changes that have led to the rise in asthma and atopic disorders have been the changes from a traditional diet to a more western diet consisting of decreased intake of fruits and vegetables (sources of antioxidant vitamins and carotenoids) leading to decreased intakes of vitamins E and A, and a decrease in sun exposure (e.g. greater time spent indoors and heavy use of sunscreen) leading to decreased circulating levels of vitamin D. This review will examine the evidence for an effect of fat-soluble vitamins (vitamins A, D and K) on the development and severity of assthma and allergies. While observational studies suggest that these vitamins may play a salutary role in asthma and allergies, large, well-designed clinical trials are lacking. Of the fat-soluble vitamins, vitamin D holds great promise as an agent for primary and secondary prevention of disease. Ongoing clinical trials will help determine whether results of observational studies can be applied to the clinical setting.

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Corresponding author
Corresponding author: Dr Augusto A. Litonjua, fax +1 617 525 0958, email augusto.litonjua@channing.harvard.edu
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7.SB Barnett & TA Nurmagambetov (2011) Costs of asthma in the United States: 2002–2007. J Allergy Clin Immunol 127, 145152.

9.PJ Gergen , SJ Arbes Jr., A Calatroni (2009) Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol 124, 447453.

11.DC Malone , KA Lawson , DH Smith (1997) A cost of illness study of allergic rhinitis in the United States. J Allergy Clin Immunol 99, 2227.

20.RD Semba (1998) The role of vitamin A and related retinoids in immune function. Nutr Rev 56, S38S48.

21.MA Riedl & AE Nel (2008) Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol 8, 4956.

25.A Ertesvag , N Engedal , S Naderi (2002) Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion. J Immunol 169, 55555563.

27.T Feng , Y Cong , H Qin (2010) Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol 185, 59155925.

28.F Geissmann , P Revy , N Brousse (2003) Retinoids regulate survival and antigen presentation by immature dendritic cells. J Exp Med 198, 623634.

31.D Mucida , Y Park , G Kim (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256260.

33.GU Schuster , NJ Kenyon & CB Stephensen (2008) Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol 180, 18341842.

39.U Singh & S Devaraj (2007) Vitamin E: inflammation and atherosclerosis. Vitam Horm 76, 519549.

40.D Pekmezci (2011) Vitamin E and immunity. Vitam Horm 86, 179215.

44.S Devaraj & I Jialal (1999) Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase. Arterioscl Thromb Vasc Biol 19, 11251133.

45.A Munteanu & JM Zingg (2007) Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Mol Asp Med 28, 538590.

46.M Li-Weber , M Giaisi , MK Treiber (2002) Vitamin E inhibits IL-4 gene expression in peripheral blood T cells. Eur J Immunol 32, 24012408.

47.R Dworski , W Han , TS Blackwell (2011) Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med 51, 516521.

49.I Romieu & C Trenga (2001) Diet and obstructive lung diseases. Epidemiol Rev 23, 268287.

54.I Romieu , JJ Sienra-Monge , M Ramirez-Aguilar (2002) Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med 166, 703709.

57.MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266281.

61.H Sahota , H Barnett , M Lesosky (2008) Association of vitamin D related information from a telephone interview with 25-hydroxyvitamin D. Cancer Epidemiol Biomarkers Prev 17, 232238.

64.RP Heaney & MF Holick (2011) Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res 26, 455457.

65.MF Holick (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81, 353373.

70.BA Raby , R Lazarus , EK Silverman (2004) Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 170, 10571065.

71.A Saadi , G Gao , H Li (2009) Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study. BMC Med Genet 10, 71.

72.C Vollmert , T Illig , J Altmuller (2004) Single nucleotide polymorphism screening and association analysis–exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. Clin Exp Allergy 34, 18411850.

73.M Wjst (2005) Variants in the vitamin D receptor gene and asthma. BMC Genet 6, 2.

76.A Wittke , A Chang , M Froicu (2007) Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Arch Biochem Biophys 460, 306313.

79.AS Dusso , AJ Brown & E Slatopolsky (2005) Vitamin D. Am J Physiol Renal Physiol 289, F8–28.

80.SV Ramagopalan , A Heger , AJ Berlanga ( 2010)A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res 20, 13521360.

82.AA Litonjua (2009) Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol 9, 202207.

88.N Akeno , S Saikatsu , T Kawane (1997) Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. Endocrinology 138, 22332240.

89.BD Mahon , A Wittke , V Weaver (2003) The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 89, 922932.

97.YA Taher , BC van Esch , GA Hofman (2008) 1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta. J Immunol 180, 52115221.

98.PH Burri (1984) Fetal and postnatal development of the lung. Annu Rev Physiol 46, 617628.

100.L Marin , ME Dufour , C Tordet 1,25(OH)2D3 stimulates phospholipid biosynthesis and surfactant release in fetal rat lung explants. Biol Neonate 57, 257260.

104.VK Rehan , JS Torday , S Peleg (2002) 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Mol Genet Metab 76, 4656.

108.B Lunghi , E Meacci , M Stio (1995) 1,25-dihydroxyvitamin D3 inhibits proliferation of IMR-90 human fibroblasts and stimulates pyruvate kinase activity in confluent-phase cells. Mol Cell Endocrinol 115, 141148.

110.PN Black & R Scragg (2005) Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 128, 37923798.

112.AM Tolppanen , D Williams , J Henderson (2011) Serum 25-hydroxy-vitamin D and ionised calcium in relation to lung function and allergen skin tests. Eur J Clin Nutr 65, 493500.

113.F Li , M Peng , L Jiang (2011) Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration 81, 469475.

114.SO Shaheen , KA Jameson , SM Robinson (2011) Relationship of vitamin D status to adult lung function and COPD. Thorax 66, 692698.

119.M Erkkola , M Kaila , BI Nwaru (2009) Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 39, 875882.

120.Y Miyake , S Sasaki , K Tanaka (2010) Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J 35, 12281234.

122.CR Gale , SM Robinson , NC Harvey (2007) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62, 6877.

123.CA Camargo Jr, T Ingham , K Wickens (2011) Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics 127, e180e187.

124.J Hill , A Micklewright , S Lewis (1997) Investigation of the effect of short-term change in dietary magnesium intake in asthma. Eur Respir J 10, 22252229.

126.JM Brehm , B Schuemann , AL Fuhlbrigge (2010) Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 126, 5258 e5.

128.DA Searing , Y Zhang , JR Murphy (2010) Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 125, 995–1000.

129.M Urashima , T Segawa , M Okazaki (2010) Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 91, 12551260.

130.P Majak , M Olszowiec-Chlebna , K Smejda (2011) Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 127, 12941296.

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