Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 31
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kumar, Anil Metwal, Mamta Kaur, Sanveen Gupta, Atul K. Puranik, Swati Singh, Sadhna Singh, Manoj Gupta, Supriya Babu, B. K. Sood, Salej and Yadav, Rattan 2016. Nutraceutical Value of Finger Millet [Eleusine coracana (L.) Gaertn.], and Their Improvement Using Omics Approaches. Frontiers in Plant Science, Vol. 7,


    Carvalho, Joana Marques, Elisa and Moreira, Pedro 2015. Anti-ageing nutrients.


    Cluskey, Mary Wong, Siew Sun Richards, Rickelle Ballejos, Miriam Reicks, Marla Auld, Garry Boushey, Carol Bruhn, Christine Misner, Scottie Olson, Beth and Zaghloul, Sahar 2015. Dietary Sources of Calcium Among Parents and Their Early Adolescent Children in the United States by Parent Race/Ethnicity and Place of Birth. Journal of Immigrant and Minority Health, Vol. 17, Issue. 2, p. 432.


    Pampaloni, Barbara Cianferotti, Luisella Gronchi, Giorgio Bartolini, Elisa Fabbri, Sergio Tanini, Annalisa and Brandi, Maria 2015. Growing Strong and Healthy with Mister Bone: An Educational Program to Have Strong Bones Later in Life. Nutrients, Vol. 7, Issue. 12, p. 9985.


    Park, Gun Hee Ju, Hyun-Mok Park, Yoon Jung Lee, Eun Hye Kim, Han Sol Ma, Ri Na Kim, Hyun Hee Kim, Hyo Bin Seo, Dong Jun Min, Hae Rin Kang, Gug In Kim, Da Young Park, Soohyeon Kim, Ju Hyeon Kil, Gayoung Kim, Jina Baek, Geumbi and Kwon, Ki Han 2015. Antioxidant Activity of Korean Rice Cake Added Cicer arietinum for Post-Menopausal Women. Pakistan Journal of Nutrition, Vol. 14, Issue. 10, p. 686.


    Rai, Deshanie Bird, Julia K McBurney, Michael I and Chapman-Novakofski, Karen M 2015. Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?. Public Health Nutrition, Vol. 18, Issue. 09, p. 1658.


    El-Najjar, Nahed Gali-Muhtasib, Hala Vuorela, Pia Urtti, Arto and Vuorela, Heikki 2014. Encyclopedia of Analytical Chemistry.


    Das, Asankur Sekhar Banerjee, Maitrayee Das, Dolan Mukherjee, Sandip and Mitra, Chandan 2013. Black Tea May Be a Prospective Adjunct for Calcium Supplementation to Prevent Early Menopausal Bone Loss in a Rat Model of Osteoporosis. Journal of Osteoporosis, Vol. 2013, p. 1.


    Lanham-New, S.A. Alghamdi, M. and Jalal, J. 2013. Encyclopedia of Human Nutrition.


    Park, Yongsoon Kim, Sang-Hee Lim, Yong-Taek Ha, Yong-Chan Chang, Jae-Suk Kim, I-Seok Min, Yong-Ki and Chung, Ho-Yeon 2013. Validation of a New Food Frequency Questionnaire for Assessment of Calcium and Vitamin D Intake in Korean Women. Journal of Bone Metabolism, Vol. 20, Issue. 2, p. 67.


    TYMCZYNA, Barbara TATARA, Marcin R. KRUPSKI, Witold TYMCZYNA-SOBOTKA, Monika and BACHANEK, Teresa 2013. Interrelationships between Tooth Properties and Biochemical Bone Turnover Markers Investigated on Six-Month-Old Pig Model. Journal of Veterinary Medical Science, Vol. 75, Issue. 3, p. 269.


    Caroli, A. Poli, A. Ricotta, D. Banfi, G. and Cocchi, D. 2011. Invited review: Dairy intake and bone health: A viewpoint from the state of the art1. Journal of Dairy Science, Vol. 94, Issue. 11, p. 5249.


    El-Najjar, Nahed Gali-Muhtasib, Hala Ketola, Raimo A. Vuorela, Pia Urtti, Arto and Vuorela, Heikki 2011. The chemical and biological activities of quinones: overview and implications in analytical detection. Phytochemistry Reviews, Vol. 10, Issue. 3, p. 353.


    Hagen, Shelly 2011. Osteoporosis: Nutrition and lifestyle. Canadian Pharmacists Journal, Vol. 144, Issue. sp1, p. S14.


    Irie, Sumiko Hayashida, Naomi Shinkawa, Tetsuko Taira, Yasuyuki Sekitani, Yui Teraoka, Seitaro Hashiguchi, Kanami Yoshida, Koji Morishita, Michiko and Takamura, Noboru 2011. Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals. The Tohoku Journal of Experimental Medicine, Vol. 224, Issue. 2, p. 105.


    McCrorie, Tracy A. Keaveney, Edel M. Wallace, Julie M. W. Binns, Nino and Livingstone, M. Barbara E. 2011. Human health effects of conjugated linoleic acid from milk and supplements. Nutrition Research Reviews, Vol. 24, Issue. 02, p. 206.


    Sioen, I Goemare, S Ahrens, W De Henauw, S De Vriendt, T Kaufman, J-M Ottevaere, C Roggen, I Swolin-Eide, D Tubić, B Vyncke, K and Mårild, S 2011. The relationship between paediatric calcaneal quantitative ultrasound measurements and dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) as well as body composition. International Journal of Obesity, Vol. 35, p. S125.


    Steffensen, Linn H. Jørgensen, Lone Straume, Bjørn Mellgren, Svein Ivar and Kampman, Margitta T. 2011. Can vitamin D3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial. Journal of Neurology, Vol. 258, Issue. 9, p. 1624.


    2011. A Guide to Evidence-based Integrative and Complementary Medicine.


    2011. A Guide to Evidence-based Integrative and Complementary Medicine.


    ×

Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment: Symposium on ‘Diet and bone health’

  • Susan A. Lanham-New (a1)
  • DOI: http://dx.doi.org/10.1017/S0029665108007003
  • Published online: 01 April 2008
Abstract

Throughout the life cycle the skeleton requires optimum development and maintenance of its integrity to prevent fracture. Bones break because the loads placed on them exceed the ability of the bone to absorb the energy involved. It is now estimated that one in three women and one in twelve men aged >55 years will suffer from osteoporosis in their lifetime and at a cost in the UK of >£1·7×109 per year. The pathogenesis of osteoporosis is multifactorial. Both the development of peak bone mass and the rate of bone loss are determined by key endogenous and exogenous factors. Ca supplements appear to be effective in reducing bone loss in women late post menopause (>5 years post menopause), particularly in those with low habitual Ca intake (<400 mg/d). In women early post menopause (<5 years post menopause) who are not vitamin D deficient, Ca supplementation has little effect on bone mineral density. However, supplementation with vitamin D and Ca has been shown to reduce fracture rates in the institutionalised elderly, but there remains controversy as to whether supplementation is effective in reducing fracture in free-living populations. Re-defining vitamin D requirements in the UK is needed since there is evidence of extensive hypovitaminosis D in the UK. Low vitamin D status is associated with an increased risk of falling and a variety of other health outcomes and is an area that requires urgent attention. The role of other micronutrients on bone remains to be fully defined, although there are promising data in the literature for a clear link between vitamin K nutrition and skeletal integrity, including fracture reduction.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment
      Available formats
      ×
Copyright
Corresponding author
Corresponding author: Dr Susan Lanham-New, fax +44 1483 686401, email s.lanham-new@surrey.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

4.Consensus Development Conference (1991) Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 90, 107110.

5.Consensus Development Conference (1993) Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94, 646650.

6.RP Heaney , S Abrams , B Dawson-Hughes , A Looker , R Marcus , V Matkovic & C Weaver (2000) Peak bone mass. Osteoporos Int 11, 9851009.

7.TP van Staa , EM Dennison , HG Leufkens & C Cooper (2001) Epidemiology of fractures in England and Wales. Bone 29, 517522.

11.SA Abrams (2003) Normal acquisition and loss of bone mass. Horm Res 60, 7176.

18.A Prentice , I Schoenmakers , MA Laskey , S de Bono , F Ginty & GR Goldberg (2006) Nutrition and bone growth and development. Proc Nutr Soc 65, 348360.

19.SA Abrams (2005) Calcium supplementation during childhood: long-term effects on bone mineralization. Nutr Rev 63, 251255.

20.KA Ward , SA Roberts , JE Adams , SA Lanham-New & MZ Mughal (2007) Calcium supplementation and weight bearing physical activity – do they have a combined effect on the bone density of pre-pubertal children? Bone 41, 496504.

22.E Seeman & J Hopper (1997) Genetic and environmental components of the population variance in bone density. Osteoporos Int 7, S10S16.

23.CB Langman (2005) Genetic regulation of bone mass: from bone density to bone strength. Pediatr Nephrol 20, 352355; Epublication 5 January 2005.

24.M Lorentzon , D Mellstrom & C Ohlsson (2005) Age of attainment of peak bone mass is site specific in Swedish men – The GOOD study. J Bone Miner Res 20, 12231227; Epublication 7 March 2005.

27.JP Bonjour , P Ammann , T Chevalley , S Ferrari & R Rizzoli (2003) Nutritional aspects of bone growth: an overview. In Nutritional Aspects of Bone Health, pp. 111128 [SA New and JP Bonjour editors]. Cambridge: Royal Society of Chemistry.

28.T Chevalley , R Rizzoli , D Hans , S Ferrari & JP Bonjour (2005) Interaction between calcium intake and menarcheal age on bone mass gain: an eight-year follow-up study from prepuberty to postmenarche. J Clin Endocrinol Metab 90, 4451; Epublication 26 October 2004.

29.SA Abrams , KC Copeland , SK Gunn , CM Gundberg , KO Klein & KJ Ellis (2000) Calcium absorption, bone mass accumulation and kinetics increase during early pubertal development in girls. J Clin Endocrin Metab 85, 18051809.

31.HM Frost (1987) Bone ‘mass’ and the ‘mechanostat’: a proposal. Anat Rec 219, 19.

32.JA Nurmi-Lawton , ADJ Baxter-Jones , R Mirwald , JA Bishop , P Taylor , C Cooper & SA New (2004) Evidence of sustained skeletal benefits from impact-loading exercise in young adolescent females: a 3-year longitudinal study. J Bone Miner Res 19, 314322.

33.RK Fuchs , JJ Bauer & CM Snow (2001) Jumping improves hip and lumbar spine bone mass in prepubescent children: A randomized controlled trial. J Bone Miner Res 16, 148156.

34.O Valdimarsson , C Linden , O Johnell , P Gardsell & M Karlsson (2006) Daily physical education in the school curriculum in prepubertal girls during 1 year is followed by an increase in bone mineral accrual and bone width – Data from the Prospective Controlled Malmo Pediatric Osteoporosis Prevention Study. Calcif Tissue Int 78, 6571.

35.BL Specker (1996) Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res 11, 15391544.

36.B Specker & T Binkley (2003) Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children. J Bone Miner Res 18, 885892.

37.SL Bass , G Naughton , L Saxon , S Iuliano-Burns , R Daly , EM Briganti , C Hume & C Nowson (2007) Exercise and calcium combined results in a greater osteogenic effect than either factor alone: A blinded randomized placebo-controlled trial in boys. J Bone Miner Res 22, 458464.

38.B Dawson-Hughes (2004) Calcium and vitamin D for bone health in adults. In Nutrition and Bone Health, pp. 197210 [MF Holick and B Dawson-Hughes editors]. Totowa, NJ: Humana Press.

40.B Dawson-Hughes , GE Dallal , EA Krall , L Sadowski , N Sahyoun & S Tannenbaum (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323, 878883.

43.SC Ho , YM Chen , JL Woo & SS Lam (2004) High habitual calcium intake attenuates bone loss in early post-menopausal Chinese women: an 18-month follow up study. J Clin Endocrinol 89, 21662170.

46.MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266281.

56.SA Lanham-New , RL Thompson , J More , K Brooke-Wavell , P Hunking & E Medici (2007) Importance of vitamin D, calcium and exercise to bone health with specific reference to children and adolescents. Nutr Bull 32, 364377.

58.M Ashwell , E Stone , J Mathers (2008) Review of the nutrition and bone health projects funded by the Food Standards Agency – have they helped to inform public health policy? Br J Nutr (In the Press).

60.R Boland (1986) Role of vitamin D in skeletal muscle function. Endocr Rev 7, 434447.

61.RP Heaney , MS Dowell & CA Hale (2003) Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 22, 142146.

66.G El-Hajj Fuleihan , M Nabulsi , M Choucair , M Salamoun , C Hajj Shahine , A Kizirian & R Tannous (2001) Hypovitaminosis D in healthy schoolchildren. Pediatrics 107, E53.

67.HT Viljakainen , AM Natri , M Karkkainen , MM Huttunen , A Palssa , J Jakobsen , KD Cashman , C Molgaard & C Lamberg-Allardt (2006) A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res 21, 836844.

68.MC Chapuy , ME Arlot , F Duboeuf , J Brun , B Crouzet , S Arnaud , PD Delmas & PJ Meunier (1992) Vitamin D and calcium to prevent hip fractures in elderly women. N Engl J Med 327, 16371642.

69.B Dawson-Hughes , SS Harris , EA Krall & GE Dallal (1997) Effect of Ca and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337, 670676.

70.ER Larsen , L Mosekilde & A Foldspang (2004) Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res 19, 370378.

71.HE Meyer , GB Smedshaug , E Kvaavik , JA Falch , A Tverdal & JI Pedersen (2002) Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. J Bone Miner Res 17, 709715.

72.HA Bischoff-Ferrari , WC Willett , JB Wong , E Giovannucci , T Dietrich & B Dawson-Hughes (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomised controlled trials. JAMA 293, 22572264.

73.H Smith , F Anderson , H Raphael , P Maslin , S Crozier & C Cooper (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women – a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 46, 18521857.

74.DP Trivedi , R Doll & KT Khaw (2003) Effect of four monthly oral vitamin D3 supplementation on fractures and mortality in men and women living in the community: a randomised double blind controlled trial. Br Med J 326, 469474.

75.J Porthouse , S Cockrayne , C King (2005) Randomised controlled trial of calcium supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. Br Med J 330, 10031006.

77.P Sambrook (2005) Vitamin D and fractures: quo vadis? Lancet 365, 15991600.

79.BM Tang , GD Eslick , C Nowson , C Smith & A Bensoussan (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370, 657666.

80.H Dam (1935) The antihaemorrhagic factor of the chick. Biochem J 29, 12731285.

83.S Booth (2003) Dietary vitamin K and bone health. In Nutritional Aspects of Bone Health, pp. 323338 [SA New and JP Bonjour editors]. Cambridge: Royal Society of Chemistry.

84.P Szulc , M-C Chapuy , PJ Meunier & PD Delmas (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow up study. Bone 18, 487488.

86.P Weber (2001) Vitamin K and bone health. Nutrition 17, 880887.

87.C Bolton-Smith , ME McMurdo , CR Paterson , PA Mole , JM Harvey , ST Fenton , CJ Prynne , GD Mishra & MJ Shearer (2007). A two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 22, 509519.

88.LA Braam , MH Knapen , P Geusens , F Brouns , K Hamulyák , MJ Gerichhausen & C Vermeer (2003) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int 73, 2126.

89.MHJ Knapen , LJ Schurgers & C Vermeer (2007) Vitamin K2 improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18, 963972; Epublication 8 February 2007.

90.R Cockrayne , J Adamson , SA Lanham-New , MJ Shearer , S Gilbody & DJ Torgerson (2006) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166, 12561261.

92.TLN Jarvinen , H Sievanen , KM Khan , A Heinonen & P Kannus (2008) Shifting the focus in fracture prevention from osteoporosis to falls. Br Med J 336, 124126.

96.N Sasaki , E Kusano , H Takahashi , Y Ando , K Yano , E Tsuda & Y Asano (2005) Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab 23, 4147.

97.M Shiraki , Y Shiraki , C Aoki & M Miura (2000) Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15, 515522.

98.J Iwamoto , T Takeda & S Ichimura (2001) Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison of with the effect of etidronate. J Orthop Sci 6, 487492.

99.Y Ishida & S Kawai (2004) Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study. Am J Med 117, 549555.

100.Y Sato , Y Honda , H Kuno & K Oizumi (1998) Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D and K-deficient stroke patients. Bone 23, 291296.

101.Y Sato , Y Honda , T Asho , K Hosokawa , I Kondo & K Satoh (2002) Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 31, 114118.

102.Y Sato , T Kanoko , K Satoh & J Iwanmoto (2005) Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fractures in elderly women with Alzheimer's disease. Bone 36, 6168.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: