Agarwal, S, Long, P, Seyedain, A, Piesco, N, Shree, A & Gassner, R (2003) A central role for the nuclear factor-kappaB pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB Journal 17 899–901.
Albrand, G, Munoz, F, Sornay-Rendu, E, DuBoeuf, F & Delmas, PD (2003) Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. Bone 32 78–85.
Andrade, PB, Oliveira, BM, Seabra, RM, Ferreira, MA, Ferreres, F & Garcia-Viguera, C (2001) Analysis of phenolic compounds in Spanish Albrarino and Portuguese Alvarinho and Loureiro wines by capillary zone electrophoresis and high-performance liquid chromatography. Electrophoresis 22 1568–1572.
Andreou, V, D'Addario, M, Zohar, R, Sukhu, B, Casper, RF, Ellen, RP & Tenenbaum, HC (2004) Inhibition of osteogenesis in vitro by a cigarette smoke-associated hydrocarbon combined with Porphyromonas gingivalis lipopolysaccharide: reversal by resveratrol. Journal of Periodontology 75 939–948.
Bainbridge, KE, Sowers, M, Lin, X & Harlow, SD (2004) Risk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women. Osteoporosis International 15 439–446.
Banse, X, Devogelaer, JP, Lafosse, A, Sims, TJ, Grynpas, M & Bailey, AJ (2002) Cross-link profile of bone collagen correlates with structural organization of trabeculae. Bone 31 70–76.
Baron, JA, Farahmand, BY, Weiderpass, E, Michaelsson, K, Alberts, A, Persson, I & Ljunghall, S (2001) Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Archives of Internal Medicine 161 983–988.
Bauer, DC, Browner, WS, Cauley, JA, Orwoll, ES, Scott, JC, Black, DM, Tao, JL & Cummings, SR (1993) Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Annals of Internal Medicine 118 657–665.
Beck, GR Jr, Moran, E & Knecht, N (2003) Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2. Experimental Cell Research 288 288–300.
Beck, GR Jr, Zerler, B & Moran, E (2001) Gene array analysis of osteoblast differentiation. Cell Growth and Differentiation 12 61–83.
Bellia, JP, Birchall, JD & Roberts, NB (1994) Beer: a dietary source of silicon. Lancet 343 235
Bessho, M (2003) Prediction of the strength and fracture location of the femoral neck by means of the CT based finite element method: a preliminary study on the patients with hip fracture. Bone 32 S80
Borah, B, Dufresne, TE, Chmielewski, PA, Manhart, MD & Watts, NB (2003) Risedronate preserves trabecular architecture in early post-menopausal women in just 1 year; a paired biopsy study using 3-dimentional microcomputed tomography. Bone 32 S78
Bowers, JL, Tyulmenkov, VV, Jernigan, SC & Klinge, CM (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 141 3657–3667.
Boyan, BD, Lohmann, CH, Sisk, M, Liu, Y, Sylvia, VL, Cochran, DL, Dean, DD & Schwartz, Z (2001) Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness. Journal of Biomedical Materials Research 55 350–359.
Boyce, BF, Li, P, Yao, Z, Zhang, Q, Badell, IR, Schwarz, EM, O'Keefe, RJ & Xing, L (2005) TNF-alpha and pathologic bone resorption. The Keio Journal of Medicine 54 127–131.
Burns, J, Gardner, PT, Matthews, D, Duthie, GG, Lean, ME & Crozier, A (2001) Extraction of phenolics and changes in antioxidant activity of red wines during vinification. Journal of Agricultural and Food Chemistry 49 5797–5808.
Burr, DB (2002) The contribution of the organic matrix to bone's material properties. Bone 31 8–11.
Carando, S, Teissedre, PL, Pascual-Martinez, L & Cabanis, JC (1999) Levels of flavan-3-ols in French wines. Journal of Agricultural and Food Chemistry 47 4161–4166.
Cefalu, CA (2004) Is bone mineral density predictive of fracture risk reduction. Current Medical Research and Opinion 20 341–349.
Chae, HJ, Chae, SW, Reed, JC & Kim, HR (2004) Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. Immunopharmacology and Immunotoxicology 26 75–91.
Chen, CY, Jang, JH, Li, MH & Surh, YJ (2005) Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochemical and Biophysical Research 331 993–1000.
Chen, XL, Dodd, G, Thomas, S, Zhang, X, Wasserman, MA, Rovin, BH & Kunsch, C (2006) Activation of the Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. American Journal of Physiology (In the Press).
Chen, XL & Kunsch, C (2004) Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Current Pharmaceutical Design 10 879–891.
Choi, EM & Hwang, JK (2003) Effects of (+)-catechin on the function of osteoblastic cells. Biological and Pharmaceutical Bulletin 26 523–526.
Colantoni, A, Emanuele, MA, Kovacs, EJ, Villa, E & Van Thiel, DH (2002) Hepatic estrogen receptors and alcohol intake. Molecular and Cellular Endocrinology 193 101–104.
Coutelle, C, Hohn, B, Benesova, M, Oneta, CM, Quattrochi, P, Roth, HJ, Schmidt-Gayk, H, Schneeweiss, A, Bastert, G & Seitz, HK (2004) Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens. International Journal of Oncology 25 1127–1132.
Cumming, RG & Klineberg, RJ (1994) Case-control study of risk factors for hip fractures in the elderly. American Journal of Epidemiology 139 493–503.
Cummings, SR, Bates, D & Black, DM (2005) Clinical use of bone densitometry: scientific review. Journal of the American Medical Association 288 1889–1897.
da Luz, PL & Coimbra, SR (2004) Wine, alcohol and atherosclerosis: clinical evidences and mechanisms. Brazilian Journal of Medical and Biological Research 37 1275–1295.
Dawson, DA (2003) Methodological issues in measuring alcohol use. Alcohol Research and Health 27 18–29.
de Lorimier, AA (2000) Alcohol, wine, and health. American Journal of Surgery 180 357–361.
Delaisse, JM, Eeckhout, Y & Vaes, G (1986) Inhibition of bone resorption in culture by (+)-catechin. Biochemical Pharmacology 35 3091–3094.
Diez, F (2002) Guidelines for the diagnosis of osteoporosis by densitometric methods. Journal of Manipulative and Physiological Therapeutics 25 403–415.
Dugo, G, Salvo, F, Dugo, P, La Torre, GL & Mondello, L (2003) Antioxidants in Sicilian wines: analytic and compositive aspects. Drugs under Experimental and Clinical Research 29 189–202.
Eastell, R, Barton, I, Hannon, RA, Chines, A, Garnero, P & Delmas, PD (2003) Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. Journal of Bone and Mineral Research 18 1051–1056.
Ebeling, PR & Akesson, K (2001) Role of biochemical markers in the management of osteoporosis. Best Practice and Research Clinical Rheumatology 15 385–400.
Effenberger, KE, Johnsen, SA, Monroe, DG, Spelsberg, TC & Westendorf, JJ (2005) Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens. Journal of Steroid Biochemistry and Molecular Biology 96 387–399.
Eisinger, J & Clairet, D (1993) Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: A retrospective study. Magnesium Research 6 247–249.
Elliott, ME & Binkley, N (2004) Evaluation and measurement of bone mass. Epilepsy and Behaviour 5, Suppl. 2 S16–S23.
Epstein, E (1999) Silicon. Annual review of plant physiology and plant molecular biology. Annual Reviews 50 641–664.
Estrov, Z, Shishodia, S, Faderl, S, Harris, D, Van, Q, Kantarjian, HM, Talpaz, M & Aggarwal, BB (2003) Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102 987–995.
Fan, S, Meng, Q, Gao, B, Grossman, J, Yadegari, M, Goldberg, ID & Rosen, EM (2000) Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines. Cancer Research 60 5635–5639.
Fehily, AM, Coles, RJ, Evans, WD & Elwood, PC (1992) Factors affecting bone density in young adults. American Journal of Clinical Nutrition 56 579–586.
Felsenberg, D & Boonen, S (2005) The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clinical Therapeutics 27 1–11.
Felson, DT, Zhang, Y, Hannan, MT, Kannel, WB & Kiel, DP (1995) Alcohol intake and bone mineral density in elderly men and women. The Framingham Study. American Journal of Epidemiology 142 485–492.
Feskanich, D, Korrick, SA, Greenspan, SL, Rosen, HN & Colditz, GA (1999) Moderate alcohol consumption and bone density among postmenopausal women. Journal of Women's Health 8 65–73.
Fukunaga, M (2003) Assessing bone density. Bone 32 S70–S71.
Ganry, O, Baudoin, C & Fardellone, P (2000) Effect of alcohol intake on bone mineral density in elderly women: The EPIDOS Study. Epidemiologie de l'Osteoporose. American Journal of Epidemiology 151 773–780.
Garcia-Sanchez, A, Gonzalez-Calvin, JL, Diez-Ruiz, A, Casals, JL, Gallego-Rojo, F & Salvatierra, D (1995) Effect of acute alcohol ingestion on mineral metabolism and osteoblastic function. Alcohol and Alcoholism 30 449–453.
Garnero, P & Delmas, PD (2004) Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women. Journal of Musculoskeletal and Neuronal Interactions 4 50–63.
Garnero, P, Ferreras, M, Karsdal, MA, Nicamhlaoibh, R, Risteli, J, Borel, O, Qvist, P, Delmas, PD, Foged, NT & Delaisse, JM (2003a) The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. Journal of Bone and Mineral Research 18 859–867.
Garnero, P, Mulleman, D, Munoz, F, Sornay-Rendu, E & Delmas, PD (2003b) Long-term variability of markers of bone turnover in postmenopausal women and implications for their clinical use: the OFELY study. Journal of Bone and Mineral Research 18 1789–1794.
Gavaler, JS & Love, K (1992) Detection of the relationship between moderate alcoholic beverage consumption and serum levels of estradiol in normal postmenopausal women: effects of alcohol consumption quantitation methods and sample size adequacy. Journal of Studies on Alcohol 53 389–394.
Gavaler, JS, Love, K, Van Thiel, D, Farholt, S, Gluud, C, Monteiro, E, Galvao-Teles, A, Ortega, TC & Cuervas-Mons, V (1991) An international study of the relationship between alcohol consumption and postmenopausal estradiol levels. Alcohol and Alcoholism 1 Suppl. 327–330.
Gerdhem, P, Ivaska, KK, Alatalo, SL, Halleen, JM, Hellman, J, Isaksson, A, Pettersson, K, Vaananen, HK, Akesson, K & Obrant, KJ (2004) Biochemical markers of bone metabolism and prediction of fracture in elderly women. Journal of Bone and Mineral Research 19 386–393.
Gerhauser, C & Frank, N (2005) Xanthohumol, a new all-rounder. Molecular Nutrition and Food Research 49 821–823.
Ginsburg, ES (1999) Estrogen, alcohol and breast cancer risk. Journal of Steroid Biochemistry and Molecular Biology 69 299–306.
Ginsburg, ES, Mello, NK, Mendelson, JH, Barbieri, RL, Teoh, SK, Rothman, M, Gao, X & Sholar, JW (1996) Effects of alcohol ingestion on estrogens in postmenopausal women. Journal of the American Medical Association 276 1747–1751.
Goldberg, DM, Yan, J & Soleas, GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clinical Biochemistry 36 79–87.
Goodin, MG, Fertuck, KC, Zacharewski, TR & Rosengren, RJ (2002) Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro. Toxicological Sciences 69 354–361.
Graafmans, WC, Lips, P, Ooms, ME, Van Leeuwen, JP, Pols, HA & Uitterlinden, AG (1997) The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. Journal of Bone and Mineral Research 12 1241–1245.
Grainge, MJ, Coupland, CA, Cliffe, SJ, Chilvers, CE & Hosking, DJ (1998) Cigarette smoking, alcohol and caffeine consumption, and bone mineral density in postmenopausal women. The Nottingham EPIC Study Group. Osteoporosis International 8 355–363.
Guillemant, J, Le, HT, Accarie, C, du Montcel, ST, Delabroise, AM, Arnaud, MJ & Guillemant, S (2000) Mineral water as a source of dietary calcium: acute effects on parathyroid function and bone resorption in young men. American Journal of Clinical Nutrition 71 999–1002.
Guillemant, JA, Accarie, CM, de la Gueronniere, V & Guillemant, SE (2003) Different acute responses of serum type I collagen telopeptides, CTX, NTX and ICTP, after repeated ingestion of calcium. Clinica Chimica Acta 337 35–41.
Ha, H, Kwak, HB, Lee, SW, Jin, HM, Kim, HM, Kim, HH & Lee, ZH (2004) Reactive oxygen species mediate RANK signaling in osteoclasts. Experimental Cell Research 301 119–127.
Hankinson, SE, Willett, WC, Manson, JE, Hunter, DJ, Colditz, GA, Stampfer, MJ, Longcope, C & Speizer, FE (1995) Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. Journal of the National Cancer Institute 87 1297–1302.
Hoidrup, S, Gronbaek, M, Gottschau, A, Lauritzen, JB & Schroll, M (1999) Alcohol intake, beverage preference, and risk of hip fracture in men and women. Copenhagen Centre for Prospective Population Studies. American Journal of Epidemiology 149 993–1001.
Holbrook, TL & Barrett-Connor, E (1993) A prospective study of alcohol consumption and bone mineral density. British Medical Journal 306 1506–1509.
Horcajada-Molteni, MN, Crespy, V, Coxam, V, Davicco, MJ, Remesy, C & Barlet, JP (2000) Rutin inhibits ovariectomy-induced osteopenia in rats. Journal of Bone and Mineral Research 15 2251–2258.
Hott, M, de Pollak, C, Modrowski, D & Marie, PJ (1993) Short term effects of organic silicon on trabecular bone structure in mature ovariectimised rats. Calcified Tissue International 53 174–179.
Huang, Z & Himes, JH, McGovern PG (1996) Nutrition and subsequent hip fracture risk among a national cohort of white women. American Journal of Epidemiology 144 124–134.
Huopio, J, Kroger, H, Honkanen, R, Saarikoski, S & Alhava, E (2000) Risk factors for perimenopausal fractures: a prospective study. Osteoporosis International 11 219–227.
Ilich, JZ, Brownbill, RA, Tamborini, L & Crncevic-Orlic, Z (2002) To drink or not to drink: how are alcohol, caffeine and past smoking related to bone mineral density in elderly women. Journal of the American College of Nutrition 21 536–544.
International Center for Alcohol Policies (2003) International Drinking Guidelines. International Center for Alcohol Policies Reports, issue 14. Washington, DC: ICAP.
Ioannidis, JP, Stavrou, I, Trikalinos, TA, Zois, C, Brandi, ML, Gennari, L, Albagha, O, Ralston, SH & Tsatsoulis, A (2002) Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis. Journal of Bone and Mineral Research 17 2048–2060.
Johnell, O, Kanis, JA, Oden, A, Johansson, H, De Laet, C & Delmas, P, et al. (2005) Predictive value of BMD for hip and other fractures. Journal of Bone and Mineral Research 20 1185–1194.
Jugdaohsingh, R, Anderson, SHC, Tucker, KL, Elliott, H, Kiel, DP, Thompson, RPH & Powell, JJ (2002) Dietary silicon intake and absorption. American Journal of Clinical Nutrition 75 887–893.
Jugdaohsingh, R, Tucker, KL, Qiao, N, Cupples, LA, Kiel, DP & Powell, JJ (2004) Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. Journal of Bone and Mineral Research 19 297–307.
Kamel, S, Fardellone, P, Meddah, B, Lorget-Gondelmann, F, Sebert, JL & Brazier, M (1998) Response of several markers of bone collagen degradation to calcium supplementation in postmenopausal women with low calcium intake. Clinical Chemistry 44 1437–1442.
Kanis, JA, Johansson, H, Johnell, O, Oden, A, De Laet, C, Eisman, JA, Pols, H & Tenenhouse, A (2005) Alcohol intake as a risk factor for fracture. Osteoporosis International 16 737–742.
Katsouyanni, K, Boyle, P & Trichopoulos, D (1991) Diet and urine estrogens among postmenopausal women. Oncology 48 490–494.
Khosla, S (2003) Surrogates for fracture endpoints in clinical trials. Journal of Bone and Mineral Research 18 1146–1149.
Klatsky, AL (2003) Drink to your health. Scientific American 288 74–81.
Kleerekoper, M & Nelson, DA (1997) Which bone density measurement. Journal of Bone and Mineral Research 12 712–714.
Klinge, CM, Risinger, KE, Watts, MB, Beck, V, Eder, R & Jungbauer, A (2003) Estrogenic activity in white and red wine extracts. Journal of Agricultural and Food Chemistry 51 1850–1857.
Kroger, H, Tuppurainen, M, Honkanen, R, Alhava, E & Saarikoski, S (1994) Bone mineral density and risk factors for osteoporosis–a population-based study of 1600 perimenopausal women. Calcified Tissue International 55 1–7.
Laitinen, K, Tahtela, R & Valimaki, M (1992) The dose-dependency of alcohol-induced hypoparathyroidism, hypercalciuria, and hypermagnesuria. Bone and Mineral 19 75–83.
Laitinen, K, Valimaki, M & Keto, P (1991) Bone mineral density measured by dual-energy X-ray absorptiometry in healthy Finnish women. Calcified Tissue International 48 224–231.
Liu, ZP, Li, WX, Yu, B, Huang, J, Sun, J, Huo, JS & Liu, CX (2005) Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. Journal of Medicinal Food 8 14–19.
Longnecker, MP (1993) Do hormones link alcohol with breast cancer. Journal of the National Cancer Institute 85 692–693.
Lugasi, A & Hovari, J (2003) Antioxidant properties of commercial alcoholic and nonalcoholic beverages. Die Nahrung 47 79–86.
McGartland, CP, Robson, PJ, Murray, LJ, Cran, GW, Savage, MJ, Watkins, DC, Rooney, MM & Boreham, CA (2004) Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Hearts Project. American Journal of Clinical Nutrition 80 1019–1023.
Macdonald, HM, Hardcastle, AE, Jugdaohsingh, R, Reid, DM & Powell, JJ (2005) Dietary silicon intake is associated with bone mineral density in premenopausal women and postmenopausal women taking HRT. Journal of Bone and Mineral Research 20 S393
Macdonald, HM, New, SA, Golden, MH, Campbell, MK & Reid, DM (2004) Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. American Journal of Clinical Nutrition 79 155–165.
Madhan, B, Subramanian, V, Rao, JR, Nair, BU & Ramasami, T (2005) Stabilization of collagen using plant polyphenol: role of catechin. International Journal of Biological Macromolecules 37 47–53.
Malavolta, N, Mule, R & Frigato, M (2004) Quantitative ultrasound assessment of bone. Aging Clinical and Experimental Research 16, Suppl. 23–28
Manach, C, Williamson, G, Morand, C, Scalbert, A & Remesy, C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. American Journal of Clinical Nutrition 81 230S–242S.
Manolagas, SC, Kousteni, S & Jilka, RL (2002) Sex steroids and bone. Recent Progress in Hormone Research 57 385–409.
Marie, PJ & Hott, M (1986) Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. Metabolism: Clinical and Experimental 35 574–551.
Martin, CA, Mainous, AG 3rd, Curry, T & Martin, D (1999) Alcohol use in adolescent females: correlates with estradiol and testosterone. American Journal on Addictions 8 9–14.
Marx, J (2004) Coming to grips with bone loss. Science 305 1420–1422.
May, H, Murphy, S & Khaw, KT (1995) Alcohol consumption and bone mineral density in older men. Gerontology 41 152–158.
Melton, LJ 3rd, Crowson, CS, O'Fallon, WM, Wahner, HW & Riggs, BL (2003) Relative contributions of bone density, bone turnover, and clinical risk factors to long-term fracture prediction. Journal of Bone and Mineral Research 18 312–318.
Miller, PD, Hochberg, MC, Wehren, LE, Ross, PD & Wasnich, RD (2005) How useful are measures of BMD and bone turnover. Current Medical Research and Opinion 21 545–554.
Miyamoto, M, Matsushita, Y, Kiyokawa, A, Fukuda, C, Iijima, Y, Sugano, M & Akiyama, T (1998) Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism. Planta Medica 64 516–519.
Mizutani, K, Ikeda, K, Kawai, Y & Yamori, Y (1998) Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochemical and Biophysical Research Comunications 253 859–863.
Mizutani, K, Ikeda, K, Kawai, Y & Yamori, Y (2000) Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology 46 78–83.
Muhlbauer, RC & Fleisch, H (1990) A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm. American Journal of Physiology 259 R679–R689.
Muhlbauer, RC, Lozano, A, Reinli, A & Wetli, H (2003) Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats. Journal of Nutrition 133 3592–3597.
Muti, P, Trevisan, M, Micheli, A, Krogh, V, Bolelli, G, Sciajno, R, Schunemann, HJ & Berrino, F (1998) Alcohol consumption and total estradiol in premenopausal women. Cancer Epidemiology, Biomarkers & Prevention 7 189–193.
Nakagawa, H, Wachi, M, Woo, JT, Kato, M, Kasai, S, Takahashi, F, Lee, IS & Nagai, K (2002) Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochemical and Biophysical Research Comunications 292 94–101.
Nardini, M, Natella, F, Scaccini, C & Ghiselli, A (2006) Phenolic acids from beer are absorbed and extensively metabolized in humans. Journal of Nutritional Biochemistry 17 14–22.
New, SA, Bolton-Smith, C, Grubb, DA & Reid, DM (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. American Journal of Clinical Nutrition 65 1831–1839.
Nguyen, TV, Eisman, JA, Kelly, PJ & Sambrook, PN (1996) Risk factors for osteoporotic fractures in elderly men. American Journal of Epidemiology 144 255–263.
Nookandeh, A, Frank, N, Steiner, F, Ellinger, R, Schneider, B, Gerhauser, C & Becker, H (2004) Xanthohumol metabolites in faeces of rats. Phytochemistry 65 561–570.
Park, YH, Han, DW, Suh, H, Ryu, GH, Hyon, SH, Cho, BK & Park, JC (2003) Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast. Cell Biology and Toxicology 19 325–337.
Paschalis, EP, Shane, E, Lyritis, G, Skarantavos, G, Mendelsohn, R & Boskey, AL (2004) Bone fragility and collagen cross-links. Journal of Bone and Mineral Research 19 2000–2004.
Pennington, JAT (1991) Silicon in food and diets. Food Additives and Contaminants 8 97–118.
Powell, JJ, McNaughton, SA, Jugdaohsingh, R, Anderson, S, Dear, J & Khot, F, et al. (2005a) A provisional database for the silicon content of foods in the United Kingdom. British Journal of Nutrition 94 804–812.
Powell, JJ, Sripanyakorn, S & Jugdaohsingh, R (2005b) Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTx in a PTH-independent fashion. Osteoporosis International 16, Suppl. 4 S31.
Prentice, A, Parsons, TJ & Cole, TJ (1994) Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. American Journal of Clinical Nutrition 60 837–842.
Promberger, A, Dornstauder, E, Fruhwirth, C, Schmid, ER & Jungbauer, A (2001) Determination of estrogenic activity in beer by biological and chemical means. Journal of Agricultural and Food Chemistry 49 633–640.
Prouillet, C, Maziere, JC, Maziere, C, Wattel, A, Brazier, M & Kamel, S (2004) Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochemical Pharmacology 67 1307–1313.
Prynne, C, Mishra, GD, O'Connell, M, Muniz-Terrera, G, Laskey, MA, Yan, L, Prentice, A & Ginty, F (2006) Fruit and vegetable consumption and bone mineral status: a cross sectional study across five age/gender cohorts. American Journal of Clinical Nutrition 83 1419–1427.
Purohit, V (1998) Moderate alcohol consumption and estrogen levels in postmenopausal women: a review. Alcoholism, Clinical and Experimental Research 22 994–997.
Purohit, V (2000) Can alcohol promote aromatization of androgens to estrogens? A review. Alcohol 22 123–127.
Rapuri, PB, Gallagher, JC, Balhorn, KE & Ryschon, KL (2000) Alcohol intake and bone metabolism in elderly women. American Journal of Clinical Nutrition 72 1206–1213.
Rapuri, PB, Kinyamu, HK, Gallagher, JC & Haynatzka, V (2002) Seasonal changes in calciotropic hormones, bone markers, and bone mineral density in elderly women. Journal of Clinical Endocrinology and Metabolism 87 2024–2032.
Rassi, CM, Lieberherr, M, Chaumaz, G, Pointillart, A & Cournot, G (2005) Modulation of osteoclastogenesis in porcine bone marrow cultures by quercetin and rutin. Cell and Tissue Research 319 383–393.
Reffitt, DM, Ogston, N, Jugdaohsingh, R, Cheung, HJF, Evans, BAJ, Thompson, RPH, Powell, JJ & Hampson, GN (2003) Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone 32 127–135.
Reid, DM & New, SA (1997) Nutritional influences on bone mass. Proceedings of the Nutrition Society 56 977–987.
Rico, H (1990) Alcohol and bone disease. Alcohol and Alcoholism 25 345–352.
Rico, H, Gallego-Lago, JL, Hernandez, ER, Villa, LF, Sanchez-Atrio, A, Seco, C & Gervas, JJ (2000) Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcified Tissue International 66 53–55.
Robbins, JA, Schott, AM, Garnero, P, Delmas, PD, Hans, D & Meunier, PJ (2005) Risk factors for hip fracture in women with high BMD: EPIDOS study. Osteoporosis International 16 149–154.
Robins, SP & New, SA (1997) Markers of bone turnover in relation to bone health. Proceedings of the Nutrition Society 56 903–914.
Roux, C, Garnero, P, Thomas, T, Sabatier, JP, Orcel, P & Audran, M (2005) Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Joint, Bone, Spine: Revue du Rhumatisme 72 26–31.
Ruefer, CE, Gerhauser, C, Frank, N, Becker, H & Kulling, SE (2005) In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases. Molecular Nutrition and Food Research 49 851–856.
Saltman, PD & Strause, LG (1993) The role of trace minerals in osteoporosis. Journal of the American College of Nutrition 12 384–389.
Sangster, AG, Hodson, MJ & Tubb, MJ (1986) Silica in higher plants. In Silicon Biochemistry. Ciba Foundation Symposium no. 121, pp. 90–111 [Williams, RJP, editor]. Chichester, West Sussex: John Wiley and Sons.
Sarkar, S, Reginster, JY, Crans, GG, Diez-Perez, A, Pinette, KV & Delmas, PD (2004) Relationship between changes in biochemical markers of bone turnover and BMD to predict vertebral fracture risk. Journal of Bone and Mineral Research 19 394–401.
Sarkola, T, Makisalo, H, Fukunaga, T & Eriksson, CJ (1999) Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcoholism, Clinical and Experimental Research 23 976–982.
Sato, M, Kulkarni, PM, Jerome, C, Brommage, R & Turner, C (2003) Bone mineral density under-represents the skeletal efficacy of teripretide [recombinant human parathyroid hormone (1–34)] in ovariectomized monkeys. Bone 32 S77
Schiano, A, Eisinger, F, Detolle, P, Laponche, AM, Brisou, B & Eisinger, J (1979) Silicium, tissu osseux et immunite (Silicon, bone tissue and immunity). Revue du Rhumatisme et des Maladies Osteoarticulaires 46 483–486.
Shaw, CK (1993) An epidemiologic study of osteoporosis in Taiwan. Annals of Epidemiology 3 264–271.
Shearman, AM, Karasik, D, Gruenthal, KM, Demissie, S, Cupples, LA, Housman, DE & Kiel, DP (2004) Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study. Journal of Bone and Mineral Research 19 773–781.
Sierksma, A, Sarkola, T, Eriksson, CJ, van der Gaag, MS, Grobbee, DE & Hendriks, HF (2004) Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: a diet-controlled intervention study. Alcoholism, Clinical and Experimental Research 28 780–785.
Singh, SU, Casper, RF, Fritz, PC, Sukhu, B, Ganss, B, Girard, B Jr, Savouret, JF & Tenenbaum, HC (2000) Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. Journal of Endocrinology 167 183–195.
Singletary, KW, Frey, RS & Yan, W (2001) Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells. Cancer Letters 165 131–137.
Smeets-Goevaers, CG, Lesusink, GL, Papapoulos, SE, Maartens, LW, Keyzer, JJ, Weerdenburg, JP, Beijers, LM, Zwinderman, AH, Knottnerus, JA, Pols, HA & Pop, VJ (1998) The prevalence of low bone mineral density in Dutch perimenopausal women: the Eindhoven perimenopausal osteoporosis study. Osteoporosis International 8 404–409.
Soares, MP, Seldon, MP, Gregoire, IP, Vassilevskaia, T, Berberat, PO, Yu, J, Tsui, TY & Bach, FH (2005) Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. Journal of Immunology 172 3553–3563.
Spector, TD, Calomme, MR, Anderson, S, Swaminathan, R, Jugdaohsingh, R, Vanden Berghe, DA & Powell, JJ (2005) Effect of bone turnover and BMD of low dose oral silicon as an adjunct to calcium/vitamin D3 in a randomized placebo-controlled trial. Journal of Bone and Mineral Research 20 S172
Sripanyakorn, S, Jugdaohsingh, R, Elliott, H, Walker, C, Mehta, P, Shouker, S, Thompson, RPH & Powell, JJ (2004) The silicon content of beer and its bioavailability in healthy volunteers. British Journal of Nutrition 91 403–409.
Sripanyakorn, S, Jugdaohsingh, R, Thompson, RPH & Powell, JJ (2005) Dietary silicon and bone health. British Nutrition Foundation Nutrition Bulletin 30 222–230.
Srivastava, AK, Vliet, EL, Lewiecki, EM, Maricic, M, Abdelmalek, A, Gluck, O & Baylink, DJ (2005) Clinical use of serum and urine bone markers in the management of osteoporosis. Current Medical Research and Opinion 21 1015–1026.
Stevens, JF & Page, JE (2004) Xanthohumol and related prenylflavonoids from hops and beer: to your good health. Phytochemistry 65 1317–1330.
Stevens, JF, Taylor, AW, Clawson, JE & Deinzer, ML (1999) Fate of xanthohumol and related prenylflavonoids from hops to beer. Journal of Agricultural and Food Chemistry 47 2421–2428.
Stoss, H, Pesch, HJ & Spranger, J (1979) Therapie der Osteogenesis imperfecta mit (+)-Catechin. Elektronenmikroskopische und klinische Befunde (Treatment of osteogenesis imperfecta with (+)-catechin. Electromicroscopic and clinical findings). Deutsche Medizinische Wochenschrift 104 1777–1778.
Suganuma, M, Okabe, S, Oniyama, M, Tada, Y, Ito, H & Fujiki, H (1998) Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 19 1771–1776.
Tedesco, I, Nappo, A, Petitto, F, Iacomino, G, Nazzaro, F, Palumbo, R & Russo, GL (2005) Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line. Nutrition and Cancer 52 74–83.
Teegarden, D, Lyle, RM, Proulx, WR, Johnston, CC & Weaver, CM (1999) Previous milk consumption is associated with greater bone density in young women. American Journal of Clinical Nutrition 69 1014–1017.
Teti, A (2005) New concepts in osteoclast pathophysiology. BoneKEy-Osteovision 6 17–22.
Tobe, H, Muraki, Y, Kitamura, K, Komiyama, O, Sato, Y, Sugioka, T, Maruyama, HB, Matsuda, E & Nagai, M (1997) Bone resorption inhibitors from hop extract. Bioscience, Biotechnology, and Biochemistry 61 158–159.
Tsang, C, Higgins, S, Duthie, GG, Duthie, SJ, Howie, M, Mullen, W, Lean, ME & Crozier, A (2005) The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers. British Journal of Nutrition 93 233–240.
Tucker, KL, Hannan, MT, Chen, H, Cupples, LA, Wilson, PW & Kiel, DP (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. American Journal of Clinical Nutrition 69 727–736.
Tudor-Locke, C & McColl, RS (2000) Factors related to variation in premenopausal bone mineral status: a health promotion approach. Osteoporosis International 11 1–24.
Turner, RT, Evans, GL, Zhang, M, Maran, A & Sibonga, JD (1999) Is resveratrol an estrogen agonist in growing rats. Endocrinology 140 50–54.
Turner, RT, Kidder, LS, Kennedy, A, Evans, GL & Sibonga, JD (2001) Moderate alcohol consumption suppresses bone turnover in adult female rats. Journal of Bone and Mineral Research 16 589–594.
Varo, P & Koivistoinen, P (1980) Mineral element composition of Finish foods: XII. General discussion and nutritional evaluation. Acta Agriculturae Scandinavica 22 Suppl. 166–171
Walle, T, Hsieh, F, DeLegge, MH, Oatis, JE Jr & Walle, UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metabolism and Disposition 32 1377–1382.
Wattel, A, Kamel, S, Mentaverri, R, Lorget, F, Prouillet, C, Petit, JP, Fardelonne, P & Brazier, M (2003) Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochemical Pharmacology 65 35–42.
Wattel, A, Kamel, S, Prouillet, C, Petit, JP, Lorget, F, Offord, E & Brazier, M (2004) Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. Journal of Cellular Biochemistry 92 285–295.
Wehren, LE & Siris, ES (2004) Beyond bone mineral density: can existing clinical risk assessment instruments identify women at increased risk of osteoporosis. Journal of Internal Medicine 256 375–380.
Williams, FM, Cherkas, LF, Spector, TD & MacGregor, AJ (2004) A common genetic factor underlies hypertension and other cardiovascular disorders. BMC Cardiovascular Disorders 4 20
Williamson, G & Manach, C (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. American Journal of Clinical Nutrition 81 243S–255S.
Woitge, HW, Scheidt-Nave, C, Kissling, C, Leidig-Bruckner, G, Meyer, K, Grauer, A, Scharla, SH, Ziegler, R & Seibel, MJ (1998) Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. Journal of Clinical Endocrinology and Metabolism 83 68–75.
Woo, JT, Nakagawa, H, Notoya, M, Yonezawa, T, Udagawa, N, Lee, IS, Ohnishi, M, Hagiwara, H & Nagai, K (2004) Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biological & Pharmaceutical Bulletin 27 504–509.
World Health Organization (2003) Prevention and Management of Osteoporosis. WHO Technical Report Series no. 921. Geneva: WHO.
Wu, CC, Hsu, MC, Hsieh, CW, Lin, JB, Lai, PH & Wung, BS (2005) Upregulation of heme oxygenase-1 by epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sciences (Epublication ahead of print version).
Yamaguchi, M & Jie, Z (2001) Effect of polyphenols on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro. Biological and Pharmaceutical Bulletin 24 1437–1439.
Yamamoto, K, Wang, J, Yamamoto, S & Tobe, H (2000) Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Letters 465 103–106.
Yang, F, Oz, HS, Barve, S, de Villiers, WJ, McClain, CJ & Varilek, GW (2001) The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology 60 528–533.
Yun, JH, Pang, EK, Kim, CS, Yoo, YJ, Cho, KS, Chai, JK, Kim, CK & Choi, SH (2004) Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts. Journal of Periodontal Research 39 300–307.
Zafrilla, P, Morillas, J, Mulero, J, Cayuela, JM, Martinez-Cacha, A, Pardo, F & Lopez Nicolas, JM (2003) Changes during storage in conventional and ecological wine: phenolic content and antioxidant activity. Journal of Agricultural and Food Chemistry 51 4694–4700.
Zwerina, J, Tzima, S, Hayer, S, Redlich, K, Hoffmann, O, Hanslik-Schnabel, B, Smolen, JS, Kollias, G & Schett, G (2005) Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB Journal 19 2011–2013.